Background
The aim of this study was to evaluate whether adjuvant chemotherapy is associated with improved survival in patients with resectable gastric neuroendocrine carcinomas (G‐NECs) or mixed ...adenoneuroendocrine carcinomas (G‐MANECs).
Methods
The study included patients with G‐NECs or G‐MANECs who underwent surgery in one of 21 centres in China between 2004 and 2016. Propensity score matching analysis was used to reduce selection bias, and overall survival (OS) in different treatment groups was estimated by the Kaplan–Meier method.
Results
In total, 804 patients with resectable G‐NECs or G‐MANECs were included, of whom 490 (60·9 per cent) received adjuvant chemotherapy. After propensity score matching, OS in the chemotherapy group was similar to that in the no‐chemotherapy group. Among patients with G‐NECs, survival in the fluorouracil (5‐FU)‐based chemotherapy group and the non‐5‐FU‐based chemotherapy group was similar to that in the no‐chemotherapy group. Similarly, etoposide plus cisplatin or irinotecan plus cisplatin was not associated with better OS in patients with G‐NECs. Among patients with G‐MANECs, OS in the non‐5‐FU‐based chemotherapy group was worse than that in the no‐chemotherapy group. Patients with G‐MANECs did not have better OS when platinum‐based chemotherapy was
used.
Conclusion
There was no survival benefit in patients who received adjuvant chemotherapy for G‐NECs or G‐MANECs.
Antecedentes
El objetivo de este estudio fue evaluar si la quimioterapia adyuvante mejoraba la supervivencia en pacientes con carcinomas gástricos resecables neuroendocrinos (gastric neuroendocrine carcinomas, G‐NECs) y carcinomas adenoneuroendocrinos mixtos (mixed adenoneuroendocrine carcinomas, G‐MANECs).
Métodos
Se incluyeron pacientes con G‐NECs y G‐MANECs tratados quirúrgicamente en 21 centros en China entre 2004 y 2016. Se utilizó un análisis de emparejamiento por puntaje de propensión para reducir el sesgo de selección y el método de Kaplan‐Meier para estimar la supervivencia global (overall survival, OS) de los pacientes en los diferentes grupos de tratamiento.
Resultados
En total, se incluyeron en el estudio 804 pacientes con G‐NECs y G‐MANECs resecables y 490 pacientes (60,9%) recibieron quimioterapia adyuvante. Después del emparejamiento por puntaje de propensión, la OS del grupo con quimioterapia fue similar a la del grupo sin quimioterapia. En los pacientes con G‐NECs, la supervivencia en los grupos con quimioterapia basada en 5‐FU (fluorouracilo) y de quimioterapia sin 5‐FU fue similar a la del grupo sin quimioterapia. Asimismo, la combinación de etopósido y cisplatino o de irinotecán y cisplatino no se asoció con una mejor OS en pacientes con G‐NECs. En pacientes con G‐MANECs, la OS del grupo con quimioterapia sin 5‐FU fue peor que la del grupo sin quimioterapia. Los pacientes con G‐MANECs no presentaron una mejor OS cuando se administró quimioterapia basada en platinos.
Conclusión
La administración de quimioterapia adyuvante en pacientes con G‐NECs y G‐MANECs no mejoró la supervivencia.
This multicentre study enrolled 804 patients with resectable gastric neuroendocrine carcinomas and gastric mixed adenoneuroendocrine carcinomas. In propensity score matching analysis, there were no associations between the use of adjuvant chemotherapy and improved overall survival. Similar results were obtained in stratified analysis according to different chemotherapy regimens.
No benefit
The present work investigated the effect of Ag additives on the consumption of cathode Cu pad under electromigration in a current-stressed Cu/Sn3.5Ag/Cu flip-chip structure. The consumption rate of a ...cathode Cu pad in a pure Sn system is faster than that of a cathode Cu pad in a Sn3.5Ag system at 80℃ by a factor of 10. Using the kinetics of the consumption equation, the activation energy in the consumption of a cathode Cu pad was calculated. The activation energy (0.65 eV) of the consumption of a cathode Cu pad in a Cu/Sn3.5Ag/Cu flip-chip structure under electromigration (EM) is slightly greater than that (0.62 eV) of the consumption of a cathode Cu pad in a Cu/Sn/Cu flip-chip structure under EM. The dissolution of Cu flux is discussed, and the possible effect of Ag additives on the consumption rate of a cathode Cu pad under EM is proposed. The Ag additives reduced the deficiency of Cu solubility in a solder matrix near the cathode Cu/solder interface, which is the main factor in the reduction of Cu pad consumption. Moreover, the Ag
3
Sn phase forming on the cathode Cu
6
Sn
5
interface protects Cu
6
Sn
5
from dissolving into the Sn3.5Ag solder matrix under EM.
Human parvovirus 4 (PARV4), a recently discovered parvovirus found exclusively in human plasma and liver tissue, was considered phylogenetically distinct from other parvoviruses. Here, we report the ...discovery of two novel parvoviruses closely related to PARV4, porcine hokovirus (PHoV) and bovine hokovirus (BHoV), from porcine and bovine samples in Hong Kong. Their nearly full-length sequences were also analysed. PARV4-like viruses were detected by PCR among 44.4 % (148/333) of porcine samples (including lymph nodes, liver, serum, nasopharyngeal and faecal samples), 13 % (4/32) of bovine spleen samples and 2 % (7/362) of human serum samples that were sent for human immunodeficiency virus and hepatitis C virus antibody tests. Three distinct parvoviruses were identified, including two novel parvoviruses, PHoV and BHoV, from porcine and bovine samples and PARV4 from humans, respectively. Analysis of genome sequences from seven PHoV strains, from three BHoV strains and from one PARV4 strain showed that the two animal parvoviruses were most similar to PARV4 with 61.5-63 % nt identities and, together with PARV4 (HHoV), formed a distinct cluster within the family Parvoviridae. The three parvoviruses also differed from other parvoviruses by their relatively large predicted VP1 protein and the presence of a small unique conserved putative protein. Based on these results, we propose a separate genus, Hokovirus, to describe these three parvoviruses. The co-detection of porcine reproductive and respiratory syndrome virus, the agent associated with the recent 'high fever' disease outbreaks in pigs in China, from our porcine samples warrants further investigation.
Because of their relatively high efficiency, high photostability, abundance, low cost, and nontoxic qualities, titania‐based photocatalysts are still the most extensively studied materials for the ...photocatalytic production of hydrogen from water. The effects of the chemical and physical properties of titania, including crystal phase, crystallinity, particle size, and surface area, on its photoactivity towards hydrogen generation have been identified by various investigations. The high overpotential for hydrogen generation, rapid recombination of photogenerated electrons and holes, rapid reverse reaction of molecular hydrogen and oxygen, and inability to absorb visible light are considered the most important factors that restrict the photoactivity of titania, and strategies to overcome these barriers have been developed. These issues and strategies are carefully reviewed and summarized in this Minireview. We aim to provide a critical, up‐to‐date overview of the development of titania‐based photocatalysts for hydrogen production, as well as a comprehensive background source and guide for future research.
Titania‐based materials form the most extensively studied class of compounds for the production of hydrogen from water by photocatalysis. Several strategies have been developed to further improve their photoactivity and to extend their absorption range from the UV into the visible‐light region of the spectrum. This Minireview provides a critical, up‐to‐date overview of these works, and also serves as a comprehensive source of background information and guide for future research.
Aims/hypothesis
Sympathetic nerves influence islet hormone levels in the circulation. Insights into islet sympathetic innervation and its remodelling in diabetes may impact future therapeutics. ...However, standard immunohistochemistry and microtome-based microscopy cannot provide an integral view of the islet neurovascular complex. We prepared transparent islet specimens to investigate the spatial relationship between sympathetic nerves, blood vessels and islet cells in normal, streptozotocin-injected and non-obese diabetic mouse models.
Methods
Cardiac perfusion of fluorescent lectin was used to label pancreatic blood vessels. Tyrosine hydroxylase and nuclear staining were used to reveal islet sympathetic innervation and microstructure. Optical clearing (i.e. use of immersion solution to reduce scattering) was applied to enable 3-dimensional confocal microscopy of islets to visualise the sympathetic neurovascular complex in space.
Results
Unlike previously reported morphology, we observed perfusive intra-islet, perivascular sympathetic innervation, in addition to peri-islet contacts of sympathetic nerves with alpha cells and sympathetic fibres encircling the adjacent arterioles. The intra-islet axons became markedly prominent in streptozotocin-injected mice (2 weeks after injection). In non-obese diabetic mice, lymphocytic infiltration remodelled the peri-islet sympathetic axons in early insulitis.
Conclusions/interpretation
We have established an imaging approach to reveal the spatial features of mouse islet sympathetic innervation. The neurovascular complex and sympathetic nerve–alpha cell contact suggest that sympathetic nerves modulate islet hormone secretion through blood vessels, in addition to acting directly on alpha cells. In islet injuries, sympathetic nerves undergo different remodelling in response to different pathophysiological cues.
Embryonic development is largely conserved among mammals. However, certain genes show divergent functions. By generating a transcriptional atlas containing >30,000 cells from post-implantation ...non-human primate embryos, we uncover that ISL1, a gene with a well-established role in cardiogenesis, controls a gene regulatory network in primate amnion. CRISPR/Cas9-targeting of ISL1 results in non-human primate embryos which do not yield viable offspring, demonstrating that ISL1 is critically required in primate embryogenesis. On a cellular level, mutant ISL1 embryos display a failure in mesoderm formation due to reduced BMP4 signaling from the amnion. Via loss of function and rescue studies in human embryonic stem cells we confirm a similar role of ISL1 in human in vitro derived amnion. This study highlights the importance of the amnion as a signaling center during primate mesoderm formation and demonstrates the potential of in vitro primate model systems to dissect the genetics of early human embryonic development.
The growth model of the interfacial Cu
6
Sn
5
compound at the circular Cu/Sn3.5Ag interface has been established in this work. The present developed growth model can predict well the interfacial Cu
6
...Sn
5
compound growth curve at the circular-interface. We found that the interfacial Cu
6
Sn
5
compound growth rate at the circular-interface is slower than that at the planar-interface. The major factor for the slower interfacial Cu
6
Sn
5
compound growth rate at the circular-interface attributes to the increase of the interfacial reaction area at the circular Cu
6
Sn
5
/solder interface with the annealing time. It causes a larger driving force for the interfacial Cu
6
Sn
5
compound to dissolve into the solder matrix, which reduces the growth of the interfacial Cu
6
Sn
5
compound layer. Moreover, the effect of the Ag concentration on the reaction mechanism for the circular reaction interface was also studied. For the Ag-rich Sn5Ag solder matrix, smaller Sn grain size (larger grain boundary density) was observed. The larger grain boundary density promotes more Cu dissolution from the interfacial Cu
6
Sn
5
compound layer into the Sn5Ag solder matrix. Hence, the growth of the interfacial Cu
6
Sn
5
compound layer in the Ag-rich Sn5Ag system is slightly slower than that of the Sn3.5Ag system.
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