To develop a new efficient catalyst for contaminant removal and sustainable environment, series Z-scheme WO3/MIL-100(Fe) (MxWy) composites were easily prepared by ball-milling strategy, which were ...affirmed by various characterization techniques. All the as-prepared MxWy composites displayed superior photocatalytic Cr(VI) reduction and photo-Fenton bisphenol A(BPA) degradation performances under LED visible light, in which the M80W120 could accomplish 100% Cr(VI) reduction via photocatalysis treatment within 60 min and 100% BPA degradation with the aid of photo-Fenton process in 20 min. The influences of different initial pH, co-existing foreign ions, low weight organic molecules and H2O2 dosage on photocatalytic/photo-Fenton performances were clarified. Moreover, M80W120 displayed outstanding stability and reusability during five successive cycling experiments on Cr(VI) sequestration and BPA degradation, respectively. Also, the possible degradation pathway of BPA degradation over M80W120 was clarified. Finally, a Z-scheme mechanism was put forward, which was further confirmed by active species capture, photo-deposition of PbO2 along with electron spin-resonance spectroscopy determination. The combination of MIL-100(Fe) and WO3 was confirmed to be an effective strategy for pollutant removal and cleaner production.
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•The WO3/MIL-100(Fe) (MxWy) composites were facilely fabricated by ball-milling.•M80W120 photocatalyst displayed enhanced Cr(VI) sequestration under visible light.•M80W120 exhibited excellent photo-Fenton degradation activity toward bisphenol A.•The bisphenol A degradation pathway during the photo-Fenton process was proposed.•M80W120 displayed good recyclability and reusability.
Gastric cancer (GC) is a common form of malignant cancer in worldwide which has a poor prognosis. Despite recent improvements in the treatment of GC, the prognosis is not yet satisfactory for GC ...patients. CYT997, a novel microtubule-targeting agent, recently has been identified to be a promising anticancer candidate for the treatment of cancers; however, the effects of CYT997 in GC remain largely unknown.
Cell proliferation and apoptosis were detected by CCK8 assay and flow cytometry. The mitochondrial ROS were detected by confocal microscope and flow cytometry. Gastric cancer patient-derived xenograft (PDX) model was used to evaluate its antitumor activity of CYT997 in vivo.
CYT997 inhibited gastric cancer cell proliferation and induced cell apoptosis and triggered autophagy. CYT997 induced apoptosis through triggering intracellular mitochondrial ROS generation in GC cells. ROS scavengers N-acetylcysteine (NAC) and Mitoquinone (MitoQ) distinctly weakened CYT997-induced cell cycle G2/M arrest and apoptosis in GC cells. Pretreatment with autophagy inhibitor 3-MA promoted the effect of CYT997 on cells apoptosis. Mechanistically, CYT997 performed its function through regulation of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in GC cells. In addition, CYT997 inhibited growth of gastric cancer patient-derived xenograft (PDX) tumors.
CYT997 induces autophagy and apoptosis in gastric cancer by triggering mitochondrial ROS accumulation to silence JAK2/STAT3 pathway. CYT997 might be a potential antitumor drug candidate to treat GC.
The role of epithelial-mesenchymal transition (EMT) in metastasis remains controversial. EMT has been postulated as an absolute requirement for tumor invasion and metastasis. Three different models ...including incomplete EMT, mesenchymal-epithelial transition (MET), and collective migration have been proposed for the role of EMT in cancer invasion and metastasis. However, skepticism remains about whether EMT truly occurs during cancer progression, and if it does, whether it plays an indispensible role in metastasis. Our recent findings suggest that EMT cells are responsible for degrading the surrounding matrix to enable invasion and intravasation of both EMT and non-EMT cells. Only non-EMT cells that have entered the blood stream are able to re-establish colonies in the secondary sites. Here, we discuss an alternative model for the role of EMT in cancer metastasis in which EMT and non-EMT cells cooperate to complete the entire process of spontaneous metastasis.
In this work we measure two important phenomenological parameters of corona (and hot accretion flow) in black hole X-ray binaries: the photon index Γ and the electron temperature . Thanks to the ...capability of the Nuclear Spectroscopic Telescope Array in hard X-rays, we measure these two parameters over six orders of magnitude in the 0.1-100 keV X-ray luminosity , from ∼5 × 1038 down to as low as ∼5 × 1032 . We confirm the existence of a "V"-shaped correlation between Γ and . Surprisingly, we observe a "Λ"-shaped correlation between and . The "cooler when brighter" branch in the high-luminosity regime ( 3 × 1036 ) agrees with previous results and can be understood under the existing model of Compton scattering in the corona. On the other hand, the apparent "cooler when fainter" (positive - correlation) branch in the low-luminosity regime ( 3 × 1036 ) is unexpected, thus it puts a new challenge to existing models of hot accretion flow/corona.
•The cryogenic magnetocaloric effect in different magnetic systems is discussed.•The assembly strategies toward 3d-, 4f- and 3d–4f based molecular magnetic coolants are described.•The recent advance ...in cryogenic molecular magnetic coolants is summarized.•The different nature of 3d and 4f ions must be considered in the design of molecular magnetic coolants.
This review outlines recent advances in the design of 3d-, 4f-, and 3d–4f type magnetic molecules for use as excellent cryogenic magnetic coolants based on the magnetocaloric effect (MCE), and the structure-magnetocaloric correlations of reported molecular coolants. Further improvements in the MCE values of molecular magnetic materials are also proposed based on assembly strategies from molecular chemistry and crystal engineering.
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