The choroid is a vascular tissue which plays a range of critical roles in the normal physiology of the eye, such as supplying the outer retina with oxygen and nutrients and the regulation of ...intraocular pressure. There is also substantial evidence, particularly from animal studies, that the choroid plays an important role in the regulation of eye growth and the development of common refractive errors like myopia. In recent years, advances in optical coherence tomography technology have improved our ability to image and measure the choroid in the human eye. Research using this technology over the past decade has dramatically improved our knowledge of the normal choroid, and its potential role in the regulation of eye growth and refractive error development. This review aims to provide an overview of recent work examining the normal human choroid, its changes with myopia and the possible role of the choroid in the mechanism regulating eye growth. Studies have demonstrated that choroidal thinning accompanies the development and progression of myopia, and have established a close link between eye growth and choroidal thickness changes. Dramatic thinning of the choroid is seen with high myopia, and associations are also observed between choroidal thinning and reduced vision, and the development of retinal pathology associated with high myopia. In the short-term, environmental factors known to be associated with myopia development and more rapid eye growth typically lead to a thinning of the choroid, whereas factors linked to a slowing of eye growth are typically associated with short-term choroidal thickening. Collectively, these findings suggest that the choroid is an important biomarker of eye growth in the human eye, and additional research to better understand the human choroid is likely to further our knowledge of the signals and pathways regulating eye growth, myopia development and progression.
Background and Purpose
The development of endometriotic lesions is crucially dependent on the formation of new blood vessels. In the present study, we analysed whether this process is regulated by ...erythropoietin‐producing hepatoma receptor B4 (EphB4) signalling.
Experimental Approach
We first assessed the anti‐angiogenic action of the EphB4 inhibitor NVP‐BHG712 in different in vitro angiogenesis assays. Then, endometriotic lesions were surgically induced in the dorsal skinfold chamber and peritoneal cavity of NVP‐BHG712‐ or vehicle‐treated BALB/c mice. This allowed to study the effect of EphB4 inhibition on their vascularisation and growth by means of intravital fluorescence microscopy, high‐resolution ultrasound imaging, histology and immunohistochemistry.
Key Results
Non‐cytotoxic doses of NVP‐BHG712 suppressed the migration, tube formation and sprouting activity of both human dermal microvascular endothelial cells (HDMEC) and mouse aortic rings. Accordingly, we also detected a lower blood vessel density in NVP‐BHG712‐treated endometriotic lesions. This was associated with a reduced lesion growth due to a significantly lower number of proliferating stromal cells when compared to vehicle‐treated controls.
Conclusions and Implications
Inhibition of EphB4 signalling suppresses the vascularisation and growth of endometriotic lesions. Hence, EphB4 represents a promising pharmacological target for the treatment of endometriosis.
The COSINUS (Cryogenic Observatory for SIgnatures seen in Next-generation Underground Searches) experiment aims at the detection of dark matter-induced recoils in sodium iodide (NaI) crystals ...operated as scintillating cryogenic calorimeters. The detection of both scintillation light and phonons allows performing an event-by-event signal to background discrimination, thus enhancing the sensitivity of the experiment. The choice of using NaI crystals is motivated by the goal of probing the long-standing DAMA/LIBRA results using the same target material. The construction of the experimental facility is foreseen to start by 2021 at the INFN Gran Sasso National Laboratory (LNGS) in Italy. It consists of a cryostat housing the target crystals shielded from the external radioactivity by a water tank acting, at the same time, as an active veto against cosmic ray-induced events. Taking into account both environmental radioactivity and intrinsic contamination of materials used for cryostat, shielding and infrastructure, we performed a careful background budget estimation. The goal is to evaluate the number of events that could mimic or interfere with signal detection while optimising the geometry of the experimental setup. In this paper we present the results of the detailed Monte Carlo simulations we performed, together with the final design of the setup that minimises the residual amount of background particles reaching the detector volume.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
COSINUS is a dark matter (DM) direct search experiment that uses sodium iodide (NaI) crystals as cryogenic calorimeters. Thanks to the low nuclear recoil energy threshold and event-by-event ...discrimination capability, COSINUS will address the long-standing DM claim made by the DAMA/LIBRA collaboration. The experiment is currently under construction at the Laboratori Nazionali del Gran Sasso, Italy, and employs a large cylindrical water tank as a passive shield to meet the required background rate. However, muon-induced neutrons can mimic a DM signal therefore requiring an active veto system, which is achieved by instrumenting the water tank with an array of photomultiplier tubes (PMTs). This study optimizes the number, arrangement, and trigger conditions of the PMTs as well as the size of an optically invisible region. The objective was to maximize the muon veto efficiency while minimizing the accidental trigger rate due to the ambient and instrumental background. The final configuration predicts a veto efficiency of 99.63 ± 0.16% and 44.4 ± 5.6% in the tagging of muon events and showers of secondary particles, respectively. The active veto will reduce the cosmogenic neutron background rate to 0.11 ± 0.02 cts
·
kg
-
1
·
year
-
1
,
corresponding to less than one background event in the region of interest for the whole COSINUS-1
π
exposure of 1000 kg
·
days.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The CRESST (Cryogenic Rare Event Search with Superconducting Thermometers) dark matter search experiment aims for the detection of dark matter particles via elastic scattering off nuclei in
CaWO
4
...crystals. To understand the CRESST electromagnetic background due to the bulk contamination in the employed materials, a model based on Monte Carlo simulations was developed using the Geant4 simulation toolkit. The results of the simulation are applied to the TUM40 detector module of CRESST-II phase 2. We are able to explain up to
(
68
±
16
)
%
of the electromagnetic background in the energy range between 1 and
40
keV
.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
COSINUS (Cryogenic Observatory for SIgnatures seen in Next-generation Underground Searches) is an experiment employing cryogenic calorimeters, dedicated to direct dark matter search in underground ...laboratories. Its goal is to cross-check the annual modulation signal the DAMA collaboration has been detecting for about 20 years (Bernabei et al. in Nucl Part Phys Proc 303–305:74–79, 2018.
https://doi.org/10.1016/j.nuclphysbps.2019.03.015
) and which has been ruled out by other experiments in certain dark matter scenarios. COSINUS can provide a model-independent test by the use of the same target material (NaI), with the additional chance of discriminating
β
/
γ
events from nuclear recoils on an event-by-event basis, by the application of a well-established temperature sensor technology developed within the CRESST collaboration. Each module is constituted by two detectors: the light detector, that is a silicon beaker equipped with a transition edge sensor (TES), and the phonon detector, a small cubic NaI crystal interfaced with a carrier of a harder material (e.g.
CdWO
4
), also instrumented with a TES. This technology had so far never been applied to NaI crystals because of several well-known obstacles, and COSINUS is the first experiment which succeeded in operating NaI crystals as cryogenic calorimeters. Here, we present the COSINUS project, describe the achievements and the challenges of the COSINUS prototype development and discuss the status and the perspectives of this NaI-based cryogenic frontier.
The increasing statistical significance of the DAMA/LIBRA annual modulation signal is a cause for tension in the field of dark matter direct detection. The COSINUS experiment aims at a ...model-independent cross-check of the DAMA/LIBRA signal claim, using NaI crystals operated as cryogenic scintillating calorimeters at millikelvin temperatures. Such a setup enables measurement of phonon and scintillation light signals via Transition Edge Sensors (TESs) and allows particle discrimination on an event-by-event basis. The non-standard properties of NaI cause an obstacle when attaching a TES directly onto the surface of the crystal. This can be overcome with the "remoTES" design, where the TES is attached to an external wafer crystal. We present the results from a first successful operation of NaI and other crystals as cryogenic calorimeters with the remoTES design.
For over twenty-five years the DAMA/LIBRA experiment has reported an annual modulation signal that is consistent with a dark matter explanation. This signal is, currently, in tension with the null ...results observed by other searches that utilize different target detectors. The COSINUS experiment will perform a model-independent cross-check of the DAMA/LIBRA result by using the same target material, NaI crystals, operated as scintillating calorimeters. By measuring both temperature and light the NaI crystals in COSINUS will be able to distinguish between electron and nuclear recoils on an event-by-event basis. However, background events induced by cosmic-rays, environmental radioactivity or the intrinsic contamination of the materials used in the crystal, shielding and infrastructure can pose an issue to any analysis and must be fully understood. We report on the status of the development of the simulation for an active water Cherenkov muon veto, as well as the results of the beginning radiogenic material screening.
The CRESST-III experiment aims at the direct detection of dark matter particles via their elastic scattering off nuclei in a scintillating CaWO
_4
4
target crystal. For many years CaWO
_4
4
crystals ...have successfully been produced in-house at Technische Universität München with a focus on high radiopurity. To further improve the CaWO
_4
4
crystals, an extensive chemical purification of the raw materials has been performed and the crystal TUM93 was produced from this powder. We present results from an
\alpha
α
-decay rate analysis performed on 344 days of data collected in the ongoing CRESST-III data-taking campaign. The
\alpha
α
-decay rate could significantly be reduced.
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