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zadetkov: 178
1.
  • Methyl Substitution of a Re... Methyl Substitution of a Rexinoid Agonist Improves Potency and Reveals Site of Lipid Toxicity
    Atigadda, Venkatram R; Xia, Gang; Desphande, Anil ... Journal of medicinal chemistry, 06/2014, Letnik: 57, Številka: 12
    Journal Article
    Recenzirano
    Odprti dostop

    (2E,4E,6Z,8E)-8-(3′,4′-Dihydro-1′(2′H)-naphthalen-1′-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid, 9cUAB30, is a selective rexinoid that displays substantial chemopreventive capacity with little ...
Celotno besedilo
Dostopno za: PNG, UM

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2.
  • Conformationally Defined Re... Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers
    Atigadda, Venkatram R.; Kashyap, Mahendra P.; Yang, Zhengrong ... Journal of medicinal chemistry, 11/2022, Letnik: 65, Številka: 21
    Journal Article
    Recenzirano

    Compound 1 is a potent rexinoid that is highly effective in cancer chemoprevention but elevates serum triglycerides. In an effort to separate the lipid toxicity from the anticancer activity of 1, we ...
Celotno besedilo
Dostopno za: PNG, UM
3.
  • Evaluation of the STAT3 inh... Evaluation of the STAT3 inhibitor GLG‑302 for the prevention of estrogen receptor‑positive and ‑negative mammary cancers
    Shoemaker, Robert H; Fox, Jennifer T; Juliana, Margaret M ... Oncology reports, 09/2019, Letnik: 42, Številka: 3
    Journal Article
    Odprti dostop

    Signal transducer and activator of transcription 3 (STAT3) plays a key role in the transformation of normal cells to cancerous cells. Although inhibitors of STAT3 have been shown to suppress the ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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4.
  • Translation of a Tissue-Selective Rexinoid, UAB30, to the Clinic for Breast Cancer Prevention
    Muccio, Donald D; Atigadda, Venkatram R; Brouillette, Wayne J ... Current topics in medicinal chemistry, 01/2017, Letnik: 17, Številka: 6
    Journal Article
    Recenzirano

    This review focuses on our efforts to translate a low-toxicity retinoid X receptor-selective agonist, UAB30, to the clinic for the prevention of breast cancers. The review is divided into several ...
Preverite dostopnost
5.
  • Novel Non-Cyclooxygenase In... Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats
    Tinsley, Heather N; Mathew, Bini; Chen, Xi ... Cancers, 01/2023, Letnik: 15, Številka: 3
    Journal Article
    Recenzirano
    Odprti dostop

    The nonsteroidal anti-inflammatory drug (NSAID) sulindac demonstrates attractive anticancer activity, but the toxicity resulting from cyclooxygenase (COX) inhibition and the suppression of ...
Celotno besedilo
Dostopno za: IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
6.
  • Daily or weekly dosing with... Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKt inhibitor MK2206 in mammary cancer models
    Lubet, Ronald A; Steele, Vernon E; Juliana, M M ... Oncology reports, 09/2018, Letnik: 40, Številka: 3
    Journal Article
    Odprti dostop

    Daily vs. weekly dosing with EGFR inhibitors (gefitinib and lapatinib) and an AKT inhibitor (MK2206) were compared in two rodent breast cancer models. Female Sprague-Dawley rats were administered ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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7.
  • The retinoid X receptor ago... The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis
    Chou, Chu-Fang; Hsieh, Yu-Hua; Grubbs, Clinton J. ... Journal of dermatological science, 06/2018, Letnik: 90, Številka: 3
    Journal Article
    Recenzirano
    Odprti dostop

    •9-cis UA30 (UAB30) induces apoptosis and suppresses proliferation in CTCL cells.•Inhibition of G1 cell-cycle checkpoint by UAB30 involves the SKP2-p27kip1 axis.•UAB30, a RXR-selective agonist, may ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP

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8.
  • Effect of Withania somnifer... Effect of Withania somnifera root extract on spontaneous estrogen receptor-negative mammary cancer in MMTV/Neu mice
    Khazal, Kamel F; Hill, Donald L; Grubbs, Clinton J Anticancer research 34, Številka: 11
    Journal Article
    Recenzirano

    The cancer-preventive activity of an extract of Withania somnifera (WS) roots was examined in female transgenic (MMTV/Neu) mice that received a diet containing the extract (750 mg/kg of diet) for 10 ...
Celotno besedilo
Dostopno za: UL
9.
  • Rosiglitazone, a PPAR gamma... Rosiglitazone, a PPAR gamma agonist: Potent promoter of hydroxybutyl(butyl)nitrosamine‐induced urinary bladder cancers
    Lubet, Ronald A.; Fischer, Susan M.; Steele, Vernon E. ... International journal of cancer, 15 November 2008, Letnik: 123, Številka: 10
    Journal Article
    Recenzirano
    Odprti dostop

    In an initial study to determine if rosiglitazone had chemopreventive activity, Fischer‐344 female rats were administered twice weekly doses of hydroxybutyl(butyl)nitrosamine (OH‐BBN), a urinary ...
Celotno besedilo
Dostopno za: BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK

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10.
  • Conformationally Defined Re... Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers
    Atigadda, Venkatram R.; Xia, Gang; Deshpande, Anil ... Journal of medicinal chemistry, 10/2015, Letnik: 58, Številka: 19
    Journal Article
    Recenzirano
    Odprti dostop

    (2E,4E,6Z,8Z)-8-(3′,4′-Dihydro-1′(2H)-naphthalen-1′-ylidene)-3,7-dimethyl-2,3,6-octatrienoinic acid (UAB30) is currently undergoing clinical evaluation as a novel cancer prevention agent. In efforts ...
Celotno besedilo
Dostopno za: PNG, UM

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zadetkov: 178

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