Arterial stiffening, hypertension and left ventricular (LV) remodelling are associated with increased risk of cardiovascular disease. Cardiorespiratory fitness is associated with cardiovascular ...function and reduced risk of cardiovascular disease. This cross-sectional study was carried out to determine the relationships between cardiorespiratory fitness, arterial stiffness, blood pressure (BP) and LV remodelling in women. On the basis of peak oxygen uptake, a total of 159 premenopausal (young) and postmenopausal (older) women were categorized into either low (unfit) or high (fit) cardiorespiratory fitness groups. The arterial stiffness and LV remodelling were measured by brachial-ankle pulse wave velocity (baPWV) and carotid augmentation index (AI) and LV relative wall thickness (RWT). Two-way analysis of variance indicated a significant interaction between age and cardiorespiratory fitness in baPWV, carotid AI, BP and RWT. In the older group, arterial stiffness (baPWV; 1401+/-231 vs 1250+/-125 cm s(-1), P<0.01, AI; 32.9+/-9.9 vs 24.8+/-10.1%, P<0.01), systolic blood pressure (SBP) (130+/-22 vs 117+/-15 mm Hg, P<0.01) and RWT (0.47+/-0.08 vs 0.42+/-0.04, P<0.05) in fit women were lower than in unfit women. In older women, RWT was significantly related to baPWV (r=0.46, P<0.01), carotid AI (r=0.29, P<0.05), SBP (r=0.57, P<0.01) \V(2peak) (r=-0.32, P<0.05). In young women, they were not significant correlations, except for a weak correlation between RWT and SBP (r=0.21, P<0.05). These results suggest that higher cardiorespiratory fitness is associated with lower arterial stiffness, BP and RWT in older women.
Abstract
We report on a search for electron antineutrinos (
ν
¯
e
) from astrophysical sources in the neutrino energy range 8.3–30.8 MeV with the KamLAND detector. In an exposure of 6.72 kton-year of ...the liquid scintillator, we observe 18 candidate events via the inverse beta decay reaction. Although there is a large background uncertainty from neutral current atmospheric neutrino interactions, we find no significant excess over background model predictions. Assuming several supernova relic neutrino spectra, we give upper flux limits of 60–110 cm
−2
s
−1
(90% confidence level, CL) in the analysis range and present a model-independent flux. We also set limits on the annihilation rates for light dark matter pairs to neutrino pairs. These data improve on the upper probability limit of
8
B solar neutrinos converting into
ν
¯
e
,
P
ν
e
→
ν
¯
e
<
3.5
×
10
−
5
(90% CL) assuming an undistorted
ν
¯
e
shape. This corresponds to a solar
ν
¯
e
flux of 60 cm
−2
s
−1
(90% CL) in the analysis energy range.
In this paper, we present a precision measurement of the $^{136}$Xe two-neutrino $\beta\beta$ electron spectrum above 0.8 MeV, based on high-statistics data obtained with the KamLAND-Zen experiment. ...An improved formalism for the two-neutrino $\beta\beta$ rate allows us to measure the ratio of the leading and subleading $2\nu\beta\beta$ nuclear matrix elements (NMEs), $\xi^{2\nu}_{31} = -0.26^{+0.31}_{-0.25}$. Theoretical predictions from the nuclear shell model and the majority of the quasiparticle random-phase approximation (QRPA) calculations are consistent with the experimental limit. However, part of the $\xi^{2\nu}_{31}$ range allowed by the QRPA is excluded by the present measurement at the 90%25 C.L. Our analysis reveals that predicted $\xi^{2\nu}_{31}$ values are sensitive to the quenching of NMEs and the competing contributions from low- and high-energy states in the intermediate nucleus. Since these aspects are also at play in neutrinoless $\beta\beta$ decay, $\xi^{2\nu}_{31}$ provides new insights towards reliable neutrinoless $\beta\beta$ NMEs.
Objective: To evaluate the possibility that measurement of the magnitude and distribution of fundamental somatic heat-producing units using dual-energy X-ray absorptiometry (DXA) can be used to ...estimate resting energy expenditure (REE) in both young and elderly women with different aerobic fitness levels. Subjects and methods: Peak oxygen uptake (VO2 peak) and REEm were directly measured in 116 young (age: 22.32.1 years) and 72 elderly (63.36.4 years) women. The subjects were divided into four groups according to categories of age and VO2 peak; young: high fitness (YH, n=58); low fitness (YL, n=58); elderly: high fitness (EH, n=37) and low fitness (EL, n=35). Using DXA, systemic and regional body compositions were measured, and REEe was estimated from the sum of tissue organ weights multiplied by corresponding metabolic rate. Results: Although there were remarkable differences in systemic and regional body compositions, no significant differences were observed between REEm and REEe in the four groups. REEe significantly correlated with REEm in elderly as well as young women; the slopes and intercepts of the two regression lines were statistically not different between the elderly and young groups (elderly: y=0.60x+472, r=0.667; young: y=0.78x+250, r=0.798; P<0.001, respectively). A Bland-Altman analysis did not indicate bias in calculation of REE for all the subjects. Conclusion: These results suggest that REE can be estimated from tissue organ components in women regardless of age and aerobic fitness.
Abstract
We present the results of a search for MeV-scale electron antineutrino events in KamLAND coincident with the 60 gravitational wave events/candidates reported by the LIGO/Virgo collaboration ...during their second and third observing runs. We find no significant coincident signals within a ±500 s timing window from each gravitational wave and present 90% C.L. upper limits on the electron antineutrino fluence between 10
8
and 10
13
cm
−2
for neutrino energies in the energy range of 1.8–111 MeV.
Particle dark matter could belong to a multiplet that includes an electrically charged state. WIMP dark matter (χ0) accompanied by a negatively charged excited state (χ−) with a small mass difference ...(e.g. < 20 MeV) can form a bound-state with a nucleus such as xenon. This bound-state formation is rare and the released energy is O(1−10) MeV depending on the nucleus, making large liquid scintillator detectors suitable for detection. We searched for bound-state formation events with xenon in two experimental phases of the KamLAND-Zen experiment, a xenon-doped liquid scintillator detector. No statistically significant events were observed. For a benchmark parameter set of WIMP mass mχ0=1 TeV and mass difference Δm=17 MeV, we set the most stringent upper limits on the recombination cross section times velocity 〈σv〉 and the decay-width of χ− to 9.2×10−30cm3/s and 8.7×10−14 GeV, respectively at 90% confidence level.
Cosmic-ray muons produce various radioisotopes when passing through material. These spallation products can be backgrounds for rare event searches such as in solar neutrino, double-β decay, and dark ...matter search experiments. The KamLAND-Zen experiment searches for neutrinoless double-β decay in 745 kg of xenon dissolved in liquid scintillator. The experiment includes dead-time-free electronics with a high efficiency for detecting muon-induced neutrons. The production yields of different radioisotopes are measured with a combination of delayed coincidence techniques, newly developed muon reconstruction, and xenon spallation identification methods. The observed xenon spallation products are consistent with results from the FLUKA and GEANT4 simulation codes.
Objective: To investigate the relationships between regional skeletal muscle mass (SM mass) and bone mineral indices and to examine whether bone mineral content (BMC) normalized to SM mass shows a ...similar decrease with age in young through old age. Subjects/Methods: One hundred and thirty-eight young and postmenopausal women aged 20-76 years participated in this study and were divided into three groups: 61 young women, 49 middle-aged postmenopausal women and 28 older postmenopausal women. Muscle thickness (MTH) was determined by ultrasound, and regional SM mass (arm, trunk and leg) was estimated based on nine sites of MTH. Whole-body and regional lean soft tissue mass (LSTM), bone mineral density (BMD) and BMC (whole body, arms, legs and lumbar spine) were measured using dual-energy X-ray absorptiometry. Results: Ultrasound spectroscopy indicated that SM mass is significantly correlated with site-matched regional bone mineral indices and these relationships correspond to LSTM. The BMC and BMD in older women were significantly lower than those in middle-aged women. When BMC was normalized to site-matched regional SM mass, BMC normalized to SM mass in arm and trunk region were significantly different with age; however, whole-body and leg BMC normalized to SM mass showed no significant difference between middle-aged and older postmenopausal women. Conclusions: The age-related differences in BMC were found to be independent of the ageing of SM mass in the arm and trunk region. However, differences in BMC measures of the leg and whole body were found to correspond to age-related decline of SM mass in postmenopausal women.
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