The Messinian salinity crisis (5.96 to 5.33 million years ago) was caused by reduced water inflow from the Atlantic Ocean to the Mediterranean Sea resulting in widespread salt precipitation and a ...decrease in Mediterranean sea level of about 1.5 kilometres due to evaporation. The reduced connectivity between the Atlantic and the Mediterranean at the time of the salinity crisis is thought to have resulted from tectonic uplift of the Gibraltar arc seaway and global sea-level changes, both of which control the inflow of water required to compensate for the hydrological deficit of the Mediterranean. However, the different timescales on which tectonic uplift and changes in sea level occur are difficult to reconcile with the long duration of the shallow connection between the Mediterranean and the Atlantic needed to explain the large amount of salt precipitated. Here we use numerical modelling to show that seaway erosion caused by the Atlantic inflow could sustain such a shallow connection between the Atlantic and the Mediterranean by counteracting tectonic uplift. The erosion and uplift rates required are consistent with previous mountain erosion studies, with the present altitude of marine sediments in the Gibraltar arc and with geodynamic models suggesting a lithospheric slab tear underneath the region. The moderate Mediterranean sea-level drawdown during the early stages of the Messinian salinity crisis can be explained by an uplift of a few millimetres per year counteracted by similar rates of erosion due to Atlantic inflow. Our findings suggest that the competition between uplift and erosion can result in harmonic coupling between erosion and the Mediterranean sea level, providing an alternative mechanism for the cyclicity observed in early salt precipitation deposits and calling into question previous ideas regarding the timing of the events that occurred during the Messinian salinity crisis.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Quantified balanced and restored crustal cross-sections across the NW Zagros Mountains are presented in this work integrating geological and geophysical local and global datasets. The balanced ...crustal cross-section reproduces the surficial folding and thrusting of the thick cover succession, including the near top of the Sarvak Formation (~90 Ma) that forms the top of the restored crustal cross-section. The base of the Arabian crust in the balanced cross-section is constrained by recently published seismic receiver function results showing a deepening of the Moho from 42 ± 2 km in the undeformed foreland basin to 56 ± 2 km beneath the High Zagros. The internal parts of the deformed crustal cross-section are constrained by new seismic tomographic sections imaging a ~50° NE-dipping sharp contact between the Arabian and Iranian crusts. These surfaces bound an area of 10800 km2 that should be kept constant during the Zagros orogeny. The Arabian crustal cross-section is restored using six different tectonosedimentary domains according to their sedimentary facies and palaeobathymetries, and assuming Airy isostasy and area conservation. While the two southwestern domains were directly determined from well-constrained surface data, the reconstruction of the distal domains to the NE was made using the recent margin model of Wrobel-Daveau et al. (2010) and fitting the total area calculated in the balanced cross-section. The Arabian continental–oceanic boundary, at the time corresponding to the near top of the Sarvak Formation, is located 169 km to the NE of the trace of the Main Recent Fault. Shortening is estimated at ~180 km for the cover rocks and ~149 km for the Arabian basement, including all compressional events from Late Cretaceous to Recent time, with an average shortening rate of ~2 mm yr−1 for the last 90 Ma.
The dimensions, the geographical position and the complex geological history of the Iberian Peninsula makes it a unique and singular target to study its crustal and upper mantle structure and ...geodynamical evolution using geophysical methods. The lithospheric structure beneath Iberia has been investigated since the 1970’s using deep multichannel seismic reflection and refraction/wide-angle reflection profiling. Gravimetric and magnetic data were acquired following the deployment of permanent and temporary stations, mostly during the 1990’s. Beginning in the late 1990’s, the progressive use of Global Navigation Satellite Systems (GNSS) instruments contributed to monitor the present-day motions. During the last decades, numerous geological and geophysical surveys have investigated the Iberian lithosphere and upper mantle in the onshore and offshore regions, the most recent ones related to the TopoIberia project. The approach developed in this contribution is twofold. Firstly, we summarize the available geophysical information over Iberia, from focusing on the upper crust to the lithosphere-asthenosphere boundary and the transition zone marking the bottom of the upper mantle. Results of GNSS data, potential fields, controlled source seismic profiles, magnetotelluric data, body and surface wave tomography, receiver functions and 2D and 3D lithospheric modeling are reviewed and compared. Secondly, we focus on the areas of greater geodynamic interest and the regions where inconsistencies within the geophysical results, or contradictions in their tectonic interpretation exist, identifying the major questions that are still under debate. Besides shedding light to the state of knowledge and pointing out present-day research challenges, this review provides a tool for the integration of the diverse geophysical datasets with the surface geology and geodynamical processes that are interpreted to have built the complex geology of the Iberian Peninsula.
Health-related quality of life (HRQOL) is affected by numerous clinical variables, including disease activity, damage, fibromyalgia, depression and anxiety. However, these associations have not yet ...been described in Mexican patients with systemic lupus erythematosus (SLE).
To evaluate the relationship between disease activity, damage, depression and fibromyalgia and HRQOL measured by the LupusQoL-instrument in Mexican patients with SLE.
A cross-sectional study was conducted in women fulfilling the 1997 ACR classification criteria for SLE. HRQOL was evaluated using a disease-specific instrument for SLE, the LupusQoL (validated for the Spanish-speaking population). Patients were evaluated clinically to determine the degree of disease activity and damage using the Mexican Systemic Lupus Erythematosus Disease Activity Index (Mex-SLEDAI) and Systemic Lupus International Collaborating Clinics-Damage Index (SLICC), respectively. Fibromyalgia and depression were assessed using the ACR criteria and the CES-D scale, respectively. The relationship between HRQOL and these variables was measured using Spearman's rank correlation coefficient and linear regression analysis.
A total of 138 women with SLE, age 40.3±11 years, disease duration 8.8±6.4 years, with disease activity in 51.4%, depression in 50%, damage in 43% and fibromyalgia in 19.6% were included. Poorer HRQOL correlated with depression (r = -0.61; p< 0.005), fibromyalgia (r = -0.42; p< 0.005), disease activity (r = -0.37; p < 0.005) and damage (r = -0.31; p < 0.005). In the multivariate linear regression analysis, damage (β = -3.756, p<0.005), fibromyalgia (β = -0.920, p<0.005), depression (β = -0.911, p<0.005) and disease activity (β = -0.911, p<0.005) were associated with poor HRQOL.
SLE disease activity, damage, fibromyalgia and depression were associated with poor HRQOL in our sample of Mexican SLE patients.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A ~1000-km-long lithospheric transect running from the North-Iberian Margin to the Alboran Basin (W-Mediterranean) is investigated. The main goal is to image the changes in the crustal and upper ...mantle structure occurring in: i) the North-Iberian margin, whose deformation in Alpine times gave rise to the uplift of the Cantabrian Mountains related to Iberia–Eurasia incipient subduction; ii) the Spanish Meseta, characterized by the presence of Cenozoic basins on top of a Variscan basement with weak Alpine deformation in the Central System, and localized Neogene–Quaternary deep volcanism; and iii) the Betic–Alboran system related to Africa–Iberia collision and the roll-back of the Ligurian–Tethyan domain. The modeling approach, combines potential fields, elevation, thermal, seismic, and petrological data under a self-consistent scheme. The crustal structure is mainly constrained by seismic data whereas the upper mantle is constrained by tomographic models. The results highlight the lateral variations in the topography of the lithosphere–asthenosphere boundary (LAB), suggesting a strong lithospheric mantle strain below the Cantabrian and Betic mountain belts. The LAB depth ranges from 180km beneath the Cantabrian Mountains to 135–110km beneath Iberia Meseta deepening again to values of 160km beneath the Betic Cordillera. The Central System, with a mean elevation of 1300m, has a negligible signature on the LAB depth. We have considered four lithospheric mantle compositions: a predominantly average Phanerozoic in the continental mainland, two more fertile compositions in the Alboran Sea and in the Calatrava Volcanic Province, and a hydrated uppermost mantle in the North-Iberian Margin. These compositional differences allowed us to reproduce the main trends of the geophysical observables as well as the inferred P- and S-wave seismic velocities from tomography models and seismic experiments available in the study transect. The high mean topography of Iberia can be partly consistent with a low-velocity/high-temperature/low-density layer in the sublithospheric mantle.
•New model of the crust and upper mantle structure from North Iberia to the Alboran basin•Model incorporates petrophysical and geochemical constraints in the upper mantle•Model fits gravity, geoid, elevation, tomography, heat-flow and xenolith data•The lithospheric mantle shows 4 different compositional domains.•Iberian high mean topography can be due to a low-velocity/high-temperature/low-density layer
Dietary fat sources modulate fasting serum concentration of adipokines, particularly adiponectin. However, previous studies utilized obese animals in which adipose tissue function is severely ...altered. Thus, the present study aimed to assess the postprandial regulation of adipokine secretion in nonobese rats that consumed high-fat diet (HFD) composed of different types of fat for a short time.
The rats were fed a control diet or a HFD containing coconut, safflower or soybean oil (rich in saturated fatty acid, monounsaturated fatty acid or polyunsaturated fatty acid, respectively) for 21 days. The serum concentrations of adiponectin, leptin, retinol, retinol-binding protein-4 (RBP-4), visfatin and resistin were determined at fasting and after refeeding. Adiponectin multimerization and intracellular localization, as well as the expression of endoplasmic reticulum (ER) chaperones and transcriptional regulators, were evaluated in epididymal white adipose tissue.
In HFD-fed rats, serum adiponectin was significantly decreased 30 min after refeeding. With coconut oil, all three multimeric forms were reduced; with safflower oil, only the high-molecular-weight (HMW) and medium-molecular-weight (MMW) forms were decreased; and with soybean oil, only the HMW form was diminished. These reductions were due not to modifications in mRNA abundance or adiponectin multimerization but rather to an increment in intracellular localization at the ER and plasma membrane. Thus, when rats consumed a HFD, the type of dietary fat differentially affected the abundance of endoplasmic reticulum resident protein 44 kDa (ERp44), sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor-γ (PPARγ) mRNAs, all of which are involved in the post-translational processing of adiponectin required for its secretion.Leptin, RBP-4, resistin and visfatin serum concentrations did not change during fasting, whereas modest alterations were observed after refeeding.
The short-term consumption of a HFD affected adiponectin localization in adipose tissue, thereby decreasing its secretion to a different magnitude depending on the dietary fat source. Evaluating the fasting serum concentration of adipokines was not sufficient to identify alterations in their secretion, whereas postprandial values provided additional information as dynamic indicators.
Introduction Patients with epilepsy seem particularly liable to certain major psychiatric disorders. Prevalence of schizophrenia within an epileptic population varies between 3% and 7% (1% in general ...population). The aetiology is possibly multifactorial (drugs and neurosurgery). Objectives To study comorbidity between psychoses and epilepsy and management in the literature and in our patients. Aims To analyze factors that might influence the onset of psychoses within an epileptic population and how this potential association could influence our practice. Methods PubMed search was conducted with interest in psychoses of epilepsy, pharmacology, and comorbidity. Up to 10 variables related with factors influencing psychotic episodes that required hospital admission in three patients with epilepsy were studied. Results Unlike published data, our patients did not have postictal psychoses. All cases had early onset temporal lobe epilepsy with no seizure activity since diagnosis (more than 20 years). No family history of either epilepsy or psychoses. Management included lamotrigine, oxcarbazepine, carbamazepine, zonisamide, and levetiracetam in conventional doses. The psychosis, which comprised affective, schizophrenic, and confusional elements, lasted longer and was more troublesome than psychosis in non-epileptic patients. Response to neuroleptics was poorer than in non-epileptic patients with psychoses. Consultation with Neurology Unit resulted in end of treatment with zonisamide and levetiracetam. Conclusions Less than perfect evidence suggests the association between psychosis and epilepsy. In our patients, no postictal cases were recorded. Management showed poorer effect of neuroleptics when compared with non-epileptics, and zonisamide and levetiracetam were changed for other drugs with presumably lower association with psychoses.
Introduction In prospective and controlled studies followed up until adult age of patients diagnosed with ADHD in their childhood, the most frequent comorbid disorders were major depressive disorder, ...personality disorder (borderline and antisocial), substance use disorder and, less frequently, panic disorder and obsessive compulsive disorder. Objectives We report the case of a male patient aged 60, diagnosed with obsessive-compulsive disorder from his adolescence. His psychopathological progress has become aggravated over the years. Nowadays, he presents an important restlessness, which has led him to social isolation and family claudication. Methodology Our patient is admitted to the Psychiatric Day Hospital with an appropriated treatment for his OCD (sertraline and aripiprazole). After several days under observation, we used the scales ASRS-V1.1 y WURS finding results that suggested adult ADHD. Extended release methylphenidate was prescribed, with a fast improving of our patient's symptoms of restlessness, insecurity and impulsion phobia. He was discharged from the Centre for Psychosocial Rehabilitation showing a good evolution. Results – Anankastic personality disorder (F60.5); – Dependent personality disorder (F60.7); – Hyperkinetic disorders (F90). Conclusions Seventy-five percent of adults diagnosed with ADHD have comorbid disorders that should be used as severity rates, since they may cover up the ADHD symptoms or complicate the response to treatment. Adults with ADHD present high score on the scales “social maladjustment” and an often concomitant and polymorphic psychiatric pathology, object of varied diagnoses.
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