The H7 system was populated in the H2(He8,He3)H7 reaction with a 26 AMeV He8 beam. The H7 missing mass energy spectrum, the H3 energy and angular distributions in the H7 decay frame were ...reconstructed. The H7 missing mass spectrum shows a peak, which can be interpreted either as unresolved 5/2+ and 3/2+ doublet or one of these states at 6.5(5) MeV. The data also provide indications of the 1/2+ ground state of H7 located at 1.8(5) MeV with quite a low population cross section of ∼25 μb/sr within angular range θc.m.≃(17°-27°).
Growing evidence shows that clinical and molecular subtypes of prostate cancer (PCa) have specific risk factors. Observational studies suggest that physical activity may lower the risk of aggressive ...PCa. To our knowledge, the association between physical activity and PCa defined by TMPRSS2:ERG has not been evaluated.
To prospectively examine the association between physical activity and risk of PCa defined by clinical features and TMPRSS2:ERG.
We studied 49160 men aged 40–75 yr in the Health Professionals Follow-up Study from 1986 to 2012. Data was collected at baseline and every 2 yr with >90% follow-up. Total and vigorous physical activity were measured in metabolic equivalent of task (MET)-h/wk.
Advanced PCa was defined as stage T3b, T4, N1, or M1 at diagnosis and lethal PCa as distant metastases or death due to disease over follow-up. Presence of TMPRSS2:ERG was estimated by immunohistochemistry of ERG protein expression. Cox proportional hazards models were used to obtain multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for incidence of subtype-specific PCa.
During 26 yr of follow-up, 6411 developed PCa overall and 888 developed lethal disease. There were no significant associations between total physical activity and risk of PCa in the overall cohort. In multivariable-adjusted models, men in the highest quintile of vigorous activity had a significant 30% lower risk of advanced PCa (HR: 0.70, 95% CI: 0.53–0.92) and 25% lower risk of lethal PCa (HR: 0.75, 95% CI: 0.59–0.94) than men in the lowest quintile of vigorous activity. The association was independent of screening history. Vigorous activity was not associated with total PCa in the overall cohort but was inversely associated among highly screened men (top vs bottom quintile, HR: 0.83, 95% CI: 0.70–0.97). Of all cases, 945 were assayed for ERG (48% ERG-positive). Men with higher vigorous activity had a lower risk of ERG-positive PCa (top vs bottom quintile, HR: 0.71, 95% CI: 0.52–0.97). There was no significant association with the risk of ERG-negative disease (p heterogeneity=0.09).
Our study confirms that vigorous physical activity is associated with lower risk of advanced and lethal PCa and provides novel evidence for a lower risk of TMPRSS2:ERG-positive disease.
The identification of modifiable lifestyle factors for prevention of clinically important prostate cancer (PCa) is needed. In this report, we compared risk of PCa in men with different levels of physical activity. Men with higher vigorous activity had a lower risk of developing advanced and lethal PCa and PCa with the common TMPRSS2:ERG gene fusion.
In this prospective study of physical activity and prostate cancer among 49160 men, vigorous activity was associated with lower risk of lethal and TMPRSS2:ERG-positive disease. Long-term vigorous activity may be beneficial in prevention of lethal prostate cancer and may involve pathways specific to TMPRSS2:ERG-positive disease.
The proton and deuteron pickup reactions
and
were studied with the
radioactive beam produced by the new fragment separator ACCULINNA-2 at FLNR, JINR. These measurements were initially motivated as ...the test reactions intended for the elucidation of results obtained in the study of the extremely neutron-rich
H and
H systems created in the
and
reactions with the use of the same setup. In the
reaction the
Li ground-state (
) and its first excited state (2.69 MeV,
) were identified in the low-energy region of its excitation spectrum. The differential cross sections for the
population were extracted at the forward center-of-mass angles (
) and compared with the FRESCO calculations. Spectroscopic factor of
, derived by a model suggesting the
clustering was found in accord with the experimental data. The energy spectrum of
Li populated in the
reaction shows the strong peak which corresponds to the excitation of the second excited state of
Li (2.25 MeV,
). The fact that the ground and the first excited states of
Li were not observed in this reaction is consistent with the shell-model structure of the nuclei involved.
The extremely neutron-rich systems 7H, 6H were studied in the 2H(8He, 3He)7H and 2H(8He, 4He)6H proton and deuteron pickup reactions with a 26 AMeV secondary 8He beam produced at the new ACCULINNA-2 ...fragment separator. In addition, the same proton and deuteron pickup reactions were generated using the 42 AMeV 10Be beam, and the population of low-lying 9Li and 8Li states was measured in reactions 2H(10Be,3He)9Li and 2H(10Be,4He)8Li, respectively. The latter were used as reference measurements in order to check the setup calibration over the excitation energy of 7,6H and to determine the real experimental energy resolution which was compared with Monte Carlo calculations. The corresponding results obtained for the superheavy hydrogen systems 7H, 6H are presented and discussed. Typical excitation spectra of the 9Li and 8Li nuclei are also shown.
The commissioning of the new fragment separator ACCULINNA-2 at FLNR JINR is accomplished. The separator is destined to expand the possibilities in studies of dripline nuclei performed with the exotic ...secondary radioactive ion beams (RIBs) at energies of (5 - 50) AMeV. The projected high transmission and purification level were confirmed experimentally for a number of RIBs in the last two years. The ACCULINNA-2 setup will become a backbone facility at FLNR for the research in the field of light exotic nuclei. This report shows the current status of the separator, describes the obtained RIBs parameters and first experiments as well, provides the overview of the developing detection, monitoring and control subsystems.
The thick target inverse kinematics (TTIK) approach was used to measure excitation functions for the elastic
O (
) scattering at the initial
O beam energy of 54.4 MeV. We observed strong peaks ...corresponding to highly excited
-cluster states in the
Ne excitation energy region of 8–16 MeV, which have never been investigated before. Additional tests were done at a
O beam energy of 56.4 MeV to estimate a possible contribution of resonance inelastic scattering.
The start of operation of a new separator ACCULINNA-2 makes an important upgrade for the Radioactive-Ion Beam (RIB) research done at the Flerov Laboratory of Nuclear Reactions (FLNR, JINR). Test ...results indicate that the separator meets the project specifications. Intensities obtained for the 6,8He, 9,11Li, 12Be RIBs are 15 times higher in comparison with the results achieved at the old separator ACCULINNA. An overview of the design, construction and commissioning studies of the ACCULINNA-2 separator is presented. The separator will be equipped with some key facilities: a cryogenic tritium target, zero degree spectrometer following the physical target bombarded by the RIBs, and with a neutron detector array, and the Time Projection Chamber (TPC). This opens a wide range of experimental possibilities. Overview is presented on the two first experiments devoted to the study of d + 6He elastic scattering and search for a 7H low-lying resonance state populated in the 2H(8He,3He)7H reaction.
A new way of measuring the excitation function for reactions with neutron emission is presented. A trial experiment is performed using a DC-60 heavy ion accelerator at the Interdisciplinary ...Scientific Research Complex in Nur-Sultan, Kazakhstan. The excitation function of the
13
C(α
, n
) reaction is measured at 180° c.m. in the
E
c.m.
= 1.7–2.6 MeV range of energies. The results are compared to data from other works, and the prospects of the new approach are discussed.
A neutron spectrometer based on stilbene crystals has been developed by the Flerov Laboratory of Nuclear Reactions at the Joint Institute for Nuclear Research (Dubna, Russia). The timing resolution ...is determined as a function of the signal amplitude (σ
T
= 0.18 ns at an amplitude of 1 MeV in the electron equivalent). The measured energy resolution of the detecting modules for γ rays is σ
E
/
E
= 4.5% at
E
= 1 MeV. The quality of the
n
–γ discrimination is investigated. It is shown that reliable discrimination is possible, beginning with a deposited energy of 100 keV in the electron equivalent, which corresponds to the kinetic energy of recoil protons of ∼700 keV. The neutron spectrometer helps to significantly expand the experimental capabilities and to carry out correlation experiments with radioactive beams on the ACCULINNA-2 fragment separator at a new level of quality.
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