Reported is a macrocyclic diacetylene that assembled into columns to afford porous crystals. Heating this assembly initiated a topochemical polymerization of the preorganized diacetylene units to ...give covalent conjugated polydiacetylenes. These stable conjugated materials maintained permanent porosity as evidenced by their type I gas adsorption isotherms with CO2 (g). Such conjugated polymeric nanotubes could possess unusual properties for sensing and electronics.
Urea is a versatile building block that can be modified to self-assemble into a multitude of structures. One-dimensional nanochannels with zigzag architecture and cross-sectional dimensions of only ...∼3.7 Å × 4.8 Å are formed by the columnar assembly of phenyl ether bis-urea macrocycles. Nanochannels formed by phenylethynylene bis-urea macrocycles have a round cross-section with a diameter of ∼9.0 Å. This work compares the Xe atom packing and diffusion inside the crystalline channels of these two bis-ureas using hyperpolarized Xe-129 NMR. The elliptical channel structure of the phenyl ether bis-urea macrocycle produces a Xe-129 powder pattern line shape characteristic of an asymmetric chemical shift tensor with shifts extending to well over 300 ppm with respect to the bulk gas, reflecting extreme confinement of the Xe atom. The wider channels formed by phenylethynylene bis-urea, in contrast, present an isotropic dynamically average electronic environment. Completely different diffusion dynamics are revealed in the two bis-ureas using hyperpolarized spin-tracer exchange NMR. Thus, a simple replacement of phenyl ether with phenylethynylene as the rigid linker unit results in a transition from single-file to Fickian diffusion dynamics. Self-assembled bis-urea macrocycles are found to be highly suitable materials for fundamental molecular transport studies on micrometer length scales.
This manuscript investigates how incorporation of benzophenone, a well-known triplet sensitizer, within a bis-urea macrocycle, which self-assembles into a columnar host, influences its photophysical ...properties and affects the reactivity of bound guest molecules. We further report the generation of a remarkably stable organic radical. As expected, UV irradiation of the host suspended in oxygenated solvents efficiently generates singlet oxygen similar to the parent benzophenone. In addition, this host can bind guests such as 2-methyl-2-butene and cumene to form stable solid host–guest complexes. Subsequent UV irradiation of these complexes facilitated the selective oxidation of 2-methyl-2-butene into the allylic alcohol, 3-methyl-2-buten-1-ol, at 90% selectivity as well as the selective reaction of cumene to the tertiary alcohol, α,α′-dimethyl benzyl alcohol, at 63% selectivity. However, these products usually arise through radical pathways and are not observed in the presence of benzophenone in solution. In contrast, typical reactions with benzophenone result in the formation of the reactive singlet oxygen that reacts with alkenes to form endoperoxides, diooxetanes, or hydroperoxides, which are not observed in our system. Our results suggest that the confinement, the formation of a stable radical species, and the singlet oxygen photoproduction are responsible for the selective oxidation processes. A greater understanding of the mechanism of this selective oxidation could lead to development of greener oxidants.
A one-dimensional crystalline solid built from pillars of self-assembled bis-urea pyridyl macrocycles affords a close packed structure with no pores. These organic pillars contain unsatisfied urea ...oxygen lone pairs that can be used to drive the absorption of alcohols including trifluoroethanol, phenol, pentafluorophenol, and ethylene glycol to give well-ordered host:guest complexes with repeatable stoichiometry. The driving force for reversible solid transitions appears to be the formation of hydrogen bonds between the guest and an unsatisfied hydrogen bond acceptor, which is a lone pair of the urea oxygen. Halogen bonding with the electrophilic iodide in pentafluoroiodobenzene can also drive absorption by the host to give a well-ordered host:guest complex. These results suggest that the organic solid-state is surprisingly dynamic and may have potential applications for sorbents.
Co-crystals formed from pyridyl bis-urea macrocycles and iodopentafluorobenzene or diiodotetrafluoroethane show surprisingly short, strong halogen bonds. The shortest interactions were observed ...between the carbonyl oxygen and the iodide and were 78% of the sum of the van der Waals radii for O...I, with distances ranging from 2.719(2) to 2.745(2) Aa.
One-dimensional nanochannels, hundreds of microns in persistence length but with elliptical cross-sectional dimensions of only ∼3.7 Å × 4.8 Å, are formed by the columnar assembly of phenylether ...bis-urea macrocycles. Hyperpolarized Xe-129 NMR is utilized to investigate the Xe atom packing and Xe diffusion inside the needle shaped crystals. The elliptical channel structure produces a Xe-129 powder pattern characteristic of an asymmetric chemical shift tensor extending to well over 300 ppm with respect to the gas phase, reflecting the highly anisotropic electronic environment and extreme confinement of the atom. Consistent with the simple geometrical criterion, hyperpolarized tracer exchange NMR data reveals single-file diffusion in the bis-urea nanochannels.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Herein we synthesized a bis-urea macrocycle from 2,7-dimethylnaphthalene that displays an unusual parallel urea conformation. The naphthalenes also adopt a bowl shape over the anticipated parallel ...planar orientation. Crystallization of the macrocycle from different solvent systems affords two solvated forms. 1middle dotDMSOmiddle dot(H2O)2 has an extended columnar structure where parallel macrocycles are linked by intervening hydrogen bonded water molecules. In 1middle dot(MeOH)2 direct hydrogen-bonds link the macrocycles into chains, which hydrogen-bond with methanol molecules to form a layered structure.
Organometallic compounds offer broad scope for the design of therapeutic agents, but this avenue has yet to be widely explored. A key concept in the design of anticancer complexes is optimization of ...chemical reactivity to allow facile attack on the target site (e.g., DNA) yet avoid attack on other sites associated with unwanted side effects. Here, we consider how this result can be achieved for monofunctional "piano-stool" ruthenium(II) arene complexes of the type $(\eta^6-arene)Ru(ethylenediamine)(X)^{n+}$. A potentially important activation mechanism for reactions with biomolecules is hydrolysis. Density functional calculations suggested that aquation (substitution of X by H2O) occurs by means of a concerted ligand interchange mechanism. We studied the kinetics and equilibria for hydrolysis of 21 complexes, containing, as X, halides and pseudohalides, pyridine (py) derivatives, and a thiolate, together with benzene (bz) or a substituted bz as arene, using UV-visible spectroscopy, HPLC, and electrospray MS. The x-ray structures of six complexes are reported. In general, complexes that hydrolyze either rapidly {e.g., X = halide arene = hexamethylbenzene (hmb)} or moderately slowly e.g., X = azide, dichloropyridine (arene = hmb) are active toward A2780 human ovarian cancer cells, whereas complexes that do not aquate (e.g., X = py) are inactive. An intriguing exception is the X = thiophenolate complex, which undergoes little hydrolysis and appears to be activated by a different mechanism. The ability to tune the chemical reactivity of this class of organometallic ruthenium arene compounds should be useful in optimizing their design as anticancer agents.