The general model of epitope‐type MDM2 inhibitor was developed based on the structural information on the complexes between MDM2 and various low molecular weight ligands found in the PDB database. ...Application of this model to our in‐house library has led us to a new scaffold capable of interrupting protein–protein interactions. A synthetic library based on this and related scaffolds resulted in new classes of compounds that possess biochemical and cellular activity and good pharmacokinetic properties. We assume that such general approach to PPI inhibitors design may be useful for the development of inhibitors of various PPI types, including Bcl/XL.
The general model of epitope‐type MDM2 inhibitor was developed based on the structural information on the complexes between MDM2 and various low molecular weight ligands found in the PDB database. Application of this model to our in‐house library has led us to a new scaffold capable of PPIs. A synthetic library based on this and related scaffolds resulted in new classes of compounds that possess biochemical and cellular activity and good pharmacokinetic properties.
The main relationships governing the production of combined filter/sorption materials by plying-up with the application of adhesive melts have been studied. It has been established that the use of ...single-stage bonding technology makes it possible to improve the physical and physicomechanical properties of multilayer non-woven mats. The possibility of optimising the plying-up process by using multiple non-linear regression analysis has been demonstrated. Materials with service properties suitable for use in protective clothing have been obtained.
The spinnability of filled spinning compositions with different dispersion of the filler was investigated. The effect of the dispersion of the filler on the performance characteristics of ...carbon-filled fibre materials was assessed.
The aerodynamic solution spinning conditions that allow production of composite nonwovens with minimal elementary fibre diameter in the presence of a sorption-active filler are optimized. A ...statistical model is used to assess the efficiency of various elementary fibre diameter control techniques. It is demonstrated that a more preferable technique for reducing fibre diameter in composite nonwovens is the one that increases the frequency of copolymer solution jet stretching. The elementary fibre diameter can be reduced further by using finely divided activated carbon as filler.
Studies were conducted on separation of organic substances with different boiling points and polarity when simultaneously present in water by capillary gas-liquid chromatography on a Kristall 2000 m ...chromatograph. The effect of the column phase and temperature conditions on the separation factor and component exit time was investigated. Column temperature programming was used to reduce the component, especially heavy component, retention time. The chromatography regime was selected and a fast method was developed for determining components with different volatility in water during one analysis with sufficiently high reproducibility and reliability of the results. It was shown that the time of the analysis decreased by more than two times with the same accuracy as with the standard methods. The method can be recommended for fast analysis of wastewaters for making a decision on the treatment method.
A list of the main physical and colloid-chemical properties of industrial surfactants used as components of oiling agents for processes in the production of high-strength synthetic fibres is proposed.
The influence of the structure and filler content of non-woven materials on their sorption properties under dynamic conditions was studied. The possibility of further increasing the sorption activity ...of carbon-filled materials while retaining their strength was shown.
The major lines of activities of the Scientific Research Institute of Synthetic Fibre (FGUP VNIISV) with an experimental plant are reviewed, the main types of products manufactured are listed, the ...priority areas of scientific and production activities of the enterprise are analyzed, and the achievements and the problems needed to be solved in the course of development of science-intensive technological (high-tech) processes are shown.
The parameters of the Nakagami distribution have been utilized in the past to classify lesions in breast tissue as benign or malignant. To avoid the effect of operator-gain settings on the parameters ...of the Nakagami distribution, normalized parameters were utilized for the classification. The normalized parameter was defined as the ratio of the parameter at the site of the lesion to its average value over several regions away from the site. This technique, however, was very time consuming. In this paper, the application of frequency diversity and compounding is explored to achieve this normalization. Lesions are classified using these normalized parameters at the site. A receiver operating characteristic (ROC) analysis of the parameters of the Nakagami distribution has been conducted before and after compounding on a data set of 60 benign and 65 malignant lesions. The ROC results indicate that this technique can reasonably classify lesions in breast tissue as benign or malignant.
The ultrasound nondestructive evaluation (NDE) of materials course was developed for applied engineering technology students at Drexel University's Goodwin College of Professional Studies. This ...three-credit, hands-on laboratory course consists of two parts: the first part with an emphasis on the foundations of NDE, and the second part during which ultrasound NDE techniques are utilized in the evaluation of parts and materials. NDE applications are presented and applied through real-life problems, including calibration and use of the latest ultrasonic testing instrumentation. The students learn engineering and physical principles of measurements of sound velocity in different materials, attenuation coefficients, material thickness, and location and dimensions of discontinuities in various materials, such as holes, cracks, and flaws. The work in the laboratory enhances the fundamentals taught during classroom sessions. This course will ultimately result in improvements in the educational process "The greater expectations," national panel report, http://www.greaterexpectations.org (last viewed February, 2008); R. M. Felder and R. Brent "The intellectual development of Science and Engineering Students. Part 2: Teaching to promote growth," J. Eng. Educ. 93, 279-291 (2004) since industry is becoming increasingly reliant on the effective application of NDE technology and the demand on NDE specialists is increasing. NDE curriculum was designed to fulfill levels I and II NDE in theory and training requirements, according to American Society for Nondestructive Testing, OH, Recommended Practice No. SNT-TC-1A (2006).
