A new class of alpha-helix mimetics, based on the phenyl-pyrazole-phenyl (6-5-6) system, has been designed and synthesized. The ability of the new compounds to inhibit PPIs was confirmed using an ...MDM2-p53 binding assay. The library, containing completely new compounds, revealed an excellent hit rate of 15%, had satisfactory physicochemical properties (~38% soluble compounds), and the ligand efficiency of the best compound was 0.21 (0.22 for nutlin-3 in the same assay). Dual mode of action of these inhibitors was suggested based on computer modeling: depending on the nature of their substituents they could act as either an alpha-helix backbone mimetic or an alpha-helix binding epitope mimetic.
Dual mode of action was suggested for a new class of alpha-helix mimetics - inhibitors of MDM2/p53 interactions: depending on the nature of their substituents they could act as either an alpha-helix backbone mimetic or an alpha-helix binding epitope mimetic.
A new class of alpha-helix mimetics, based on the phenyl-pyrazole-phenyl (6-5-6) system, has been designed and synthesized. The ability of the new compounds to inhibit PPIs was confirmed using an ...MDM2-p53 binding assay. The library, containing completely new compounds, revealed an excellent hit rate of 15%, had satisfactory physicochemical properties (~38% soluble compounds), and the ligand efficiency of the best compound was 0.21 (0.22 for nutlin-3 in the same assay). Dual mode of action of these inhibitors was suggested based on computer modeling: depending on the nature of their substituents they could act as either an alpha-helix backbone mimetic or an alpha-helix binding epitope mimetic.
Shkurenko et al carry out comparative quantitative studies of the influence of suture thread and its pharmacological filling on the process of healing of wound surfaces with account taken of the ...nature of operative intervention. Analyzing the results of investigations of antimicrobial polyamide suture thread with doxicyclin on animals and in clinical studies, they assert that the given suture material has a considerable positive effect on the strength properties, nature, and healing time of operation wounds and consequently makes it possible to improve the results of complex healing of patients under conditions of infection of the wound surface of the operation field, including the economic indices.
Effective sorbents based on nonwoven polymer materials have been synthesized for cleaning up oil and oil products spills from the water surface. The influence of structural characteristics of ...materials (a width of fabrics, a fiber diameter, a density of fiber packing in fabric) on their sorption capacity has been revealed. It has been shown that the materials based on polypropylene and polyether fibers exhibited the high sorption capacities in respect to oil and oil products.
Duct size detection and estimation in breast tissue Donohue, K.D.; Huang, L.; Genis, V. ...
1999 IEEE Ultrasonics Symposium. Proceedings. International Symposium (Cat. No.99CH37027),
1999, Letnik:
2
Conference Proceeding
This paper presents results from ultrasonic simulation and phantom studies to demonstrate the performance of generalized spectrum techniques in detecting and estimating duct structures on the order ...of those in breast tissue. Results demonstrate accurate estimation (about 12% mean square error) and reliable detection (90% or greater) in the presence of diffuse scatterers and system noise.
The optimum design of nozzle devices that provide for maximum aerodynamic drawing and stable web formation in manufacture of fibre nonwovens from polymer solutions is selected. The effect of the ...specific viscosity of the spinning solution on the diameter of the fibres in the nonwoven material is assessed. The conditions of manufacturing fibre materials of sufficiently high strength consisting of fibres of minimum diameter are determined.PUBLICATION ABSTRACT
The primary goal of the Environmental Control Plasma Educational Laboratory is to introduce students to the engineering principles of non-thermal plasma application for air cleaning from Volatile ...Organic Compounds (VOC) and other methods of VOC control and measurements, by combining hands-on laboratory experience with lectures. Specifically, during the laboratory sessions, the students learn the engineering and physical principles of non-equilibrium plasma systems operation using the unique pulsed corona system of the Drexel Plasma Institute Environmental Laboratory, carry out experiments on plasma cleaning of VOC contaminated air, measure dependence of Destruction and Removal Efficiency (DRE) of particular VOC on plasma power and other system parameters, and calculate the energy cost of VOC removal. In addition, the students are able to determine the air flow rate and VOC concentration in air stream before the treatment, after the scrubber, after the pulsed corona, and after the mist separator. Efficiency of VOC control by scrubbing is also discussed in details. The work in the laboratory enhances the fundamentals taught in the classroom sessions. Another goal of this laboratory course is to improve the students’ data gathering and communication skills. Therefore, a concise written report clearly describing all conclusions and comments is required within 7 days after completion of the laboratory session, upon which the students become familiar with basic VOC control techniques, gain hands-on experience with scrubbing and low-temperature plasma equipment, and are able to demonstrate the basic principles of low temperature plasma cleaning.
