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•A novel metal–organic framework, (BTC)Yn (YS-1) is synthesized solvothermally.•The adsorption capacity for I2(aq) and I2(vap) was 114.56 and 142 mg/g, respectively.•YS-1 showed a ...high sensitivity for hazardous metal ion detection at ppm levels.•Cr6+ is detected based on the inner filter effect (IFE).
For environmental protection, it is essential to effectively capture radioiodine that is produced or released as a result of nuclear fission. In this situation, metal–organic frameworks (MOFs) may be effective materials to help with the challenging environmental problem. The solvothermal reaction of Yttrium metal ions (Y3+) with trimesic acid (H3BTC, benzene-1,3,5-tricarboxylic acid) in H2O and ethanol in a 1:1 ratio builds a novel MOF, C9H5O7Y or (BTC)Yn (YS-1). According to single crystal XRD, YS-1 has a 3D framework with rare rnb topology of MOF with SBUs: C6H3, C, H2OY. The as-prepared MOF was carefully characterized, and UV–Vis spectroscopy was used to investigate its iodine adsorption in the vapor and solution phases. This revealed that the MOF had a very high adsorption capacity. YS-1 has a maximum sorption capacity of around 142 mg/g and 114.56 mg/g in the vapor and solution phases, respectively. Iodine binds to MOF in the forms of I2 and I3− species, according to Raman spectra. It is interesting to note that the YS-1 has the highest fluorescence potential and is the most sensitive to Cr6+ ions in a liquid medium. As a result, the current MOF functions as a promising material for greater iodine uptake as well as Cr6+ ions sensing.
Nowadays, the fabrication of 2D metal–organic nanosheets (2D MONs) has entered the research arena fascinating researchers worldwide. However, a lack of efficient and facile methods has remained a ...bottleneck for the manufacturing of these 2D MONs. Herein, a 2D metal–organic framework (MOF), i.e., 2D Cu-MOF, was synthesized using a facile and convenient stirring method by using 4,4′-trimethylenedipyridine (TMDP) as an organic linker. The as-prepared MOF was characterized in detail and based on single crystal X-ray diffraction analysis, it was established that tangled layers in the 2D Cu-MOF are interconnected to produce thick strands. These tangled layers could be easily separated via ultrasonication-induced liquid phase exfoliation (UILPE) to give the 2D Cu-MON as illustrated through Tyndall light scattering and exhaustive microscopic exploration such as scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The application of this 2D Cu-MON was assessed in the field of drug delivery revealing exceptional drug loading for the drug lansoprazole (LPZ) by 2D Cu-MONs as well as drug release in the acidic and neutral medium demonstrating that the 2D Cu-MON is an excellent carrier for antiulcer drug delivery. For environmental protection, the application of 2D Cu-MON was also examined toward the removal of various cationic and anionic dyes with excellent selectivity toward cationic dye removal. The plausible mechanism for dye removal indicated the involvement of cation−π and π–π interactions, for the effective adsorption of cationic dyes as well as a increase in the surface area of 2D Cu-MON by UILPE. Remarkably, the high drug loading and dye removal are imputed to the increase in surface area by UILPE. In a nutshell, the developed 2D Cu-MON will prove to be beneficial for application in the field of drug delivery as well as for wastewater treatment.
The synthesis and antibacterial studies of polysubstituted pyrrolo3,4‐bpyridine derivatives have been described. The preparation of pyrrolo3,4‐bpyridine derivatives was carried out by the reaction of ...enamino imides, aromatic aldehydes and malononitrile/ethyl cyanoacetate using 10 mol % of DBU (1,8‐diazabicyclo5.4.0undec‐7‐ene) in ethanol at 78 °C in good yields. The compounds were characterized by standard spectroscopic techniques including IR, 1H & 13C NMR and elemental analysis and also final confirmation was done by single crystal X‐ray. The antibacterial activity of all the synthesized compounds was tested against two Gram positive (S. pneumoniae MTCC 655 and E. faecalis MTCC 439) and three Gram negative (E. coli ATCC 25922, S. typhimurium MTCC 3224, and P. aeruginosa MTCC 2453) bacterial strains. Most of the tested compounds showed moderate to good antibacterial activity. Compounds pyrrolo3,4‐bpyridine derivatives (4 j and 4 l) were the most potent and displayed bactericidal activities against E. coli strain with MIC (minimum inhibitory concentration) values of 62.5 μg/mL and 125.0 μg/mL respectively. Growth kinetic studies against E. coli, toxicity studies using human RBCs (red blood cells) and also docking studies of the selected compounds 4 j and 4 l supported that these compounds inhibit the growth of bacterial cells, non‐toxic in nature and interact with key amino residues of DNA (deoxyribonucleic acid) duplex (PDBID: 1BNA) and have drug‐like properties.
Herein, we developed a three‐component reaction of enamino imides, aryl aldehydes and malononitrile for the synthesis of functionalized pyrrolo3,4‐bpyridines as an antibacterial agent. In silico ADMET predictions and docking studies were carried out to investigate the mode of interaction of the lead molecules with DNA and also their drug‐like properties.
