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  • Mutant IDH inhibits HNF-4[a... Mutant IDH inhibits HNF-4[alpha] to block hepatocyte differentiation and promote biliary cancer
    Saha, Supriya K; Parachoniak, Christine A; Ghanta, Krishna S ... Nature (London), 09/2014, Letnik: 513, Številka: 7516
    Journal Article
    Recenzirano

    Mutations inisocitrate dehydrogenase 1 (IDH1) and IDH2 are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly liver cancer1-5. Mutant IDH proteins in IHCC ...
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  • Mutant IDH inhibits HNF4α t... Mutant IDH inhibits HNF4α to block hepatocyte differentiation and promote biliary cancer
    Saha, Supriya K.; Parachoniak, Christine A.; Ghanta, Krishna S. ... Nature (London), 07/2014, Letnik: 513, Številka: 7516
    Journal Article
    Recenzirano

    Mutations in Isocitrate dehydrogenase 1 ( IDH1 ) and IDH2 are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly liver cancer 1 – 5 . Mutant IDH proteins in ...
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17.
  • Counteraction Effects of Am... Counteraction Effects of Ammonium-Based Ionic Liquids on Urea-Induced Denaturation of α‑Lactalbumin: A Comprehensive Molecular Simulation Study
    Ghanta, Krishna Prasad; Bandyopadhyay, Sanjoy The journal of physical chemistry. B, 08/2023, Letnik: 127, Številka: 33
    Journal Article
    Recenzirano

    Ionic liquids (ILs) are known to stabilize protein conformations in aqueous medium. Importantly, ILs can also act as refolding additives in urea-driven denaturation of proteins. However, despite the ...
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19.
  • An Exploration of the Properties of Repair Template DNA that Promote Precision Genome Editing
    Ghanta, Krishna S
    Dissertation

    CRISPR/Cas9 induced DNA breaks can be precisely repaired by cellular homology-directed repair (HDR) pathways using exogenously provided template DNA (donor). However, the full potential of precision ...
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20.
  • Exploring the Dynamic Heter... Exploring the Dynamic Heterogeneity at the Interface of a Protein in Aqueous Ionic Liquid Solutions
    Ghanta, Krishna Prasad; Mondal, Sandip; Bandyopadhyay, Sanjoy The journal of physical chemistry. B, 09/2022, Letnik: 126, Številka: 38
    Journal Article
    Recenzirano

    Room temperature molecular dynamics (MD) simulations of the globular protein α-lactalbumin in aqueous solutions containing BMIM (1-butyl-3-methylimidazolium) based ionic liquids (ILs) with a series ...
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