We quantify the fraction of the cosmic infrared background (CIB) that originates from galaxies identified in the UV/optical/near-infrared by stacking 81,250 (~35.7 arcmin super(-2)) K-selected ...sources (K sub(AB) < 24.0) split according to their rest-frame U - V versus V - J colors into 72,216 star-forming and 9034 quiescent galaxies, on maps from Spitzer/MIPS (24 mu m), Herschel/PACS (100, 160 mu m), Herschel/SPIRE (250, 350, 500 mu m), and AzTEC (1100 mu m). Of that total, about 95% originates from star-forming galaxies, while the remaining 5% is from apparently quiescent galaxies. The CIB at lambda lap 200 mu m appears to be sourced predominantly from galaxies at z lap 1, while at lambda gap 200 mu the bulk originates from 1 lap z lap 2. Stacking analyses were performed using simstack, a novel algorithm designed to account for possible biases in the stacked flux density due to clustering. It is made available to the public at www.astro.caltech.edu/~viero/viero_homepage/toolbox.html.
Efforts to model human pancreatic neuroendocrine tumors (PanNETs) in animals have been moderately successful, with minimal evidence for glucagonomas or metastatic spread. The renin gene, although ...classically associated with expression in the kidney, is also expressed in many other extrarenal tissues including the pancreas. To induce tumorigenesis within rennin-specific tissues, floxed alleles of p53 and Rb were selectively abrogated using Cre-recombinase driven by the renin promoter. The primary neoplasm generated is a highly metastatic islet cell carcinoma of the pancreas. Lineage tracing identifies descendants of renin-expressing cells as pancreatic alpha cells despite a lack of active renin expression in the mature pancreas. Both primary and metastatic tumors express high levels of glucagon; furthermore, an increased level of glucagon is found in the serum, identifying the pancreatic cancer as a functional glucagonoma. This new model is highly penetrant and exhibits robust frequency of metastases to the lymph nodes and the liver, mimicking human disease, and provides a useful platform for better understanding pancreatic endocrine differentiation and development, as well as islet cell carcinogenesis. The use of fluorescent reporters for lineage tracing of the cells contributing to disease initiation and progression provides an unique opportunity to dissect the timeline of disease, examining mechanisms of the metastatic process, as well as recovering primary and metastatic cells for identifying cooperating mutations that are necessary for progression of disease.
Wheat grain protein concentration is an important determinant of wheat quality for human nutrition that is often overlooked in efforts to improve crop production. We tested and applied a ...32‐multi‐model ensemble to simulate global wheat yield and quality in a changing climate. Potential benefits of elevated atmospheric CO2 concentration by 2050 on global wheat grain and protein yield are likely to be negated by impacts from rising temperature and changes in rainfall, but with considerable disparities between regions. Grain and protein yields are expected to be lower and more variable in most low‐rainfall regions, with nitrogen availability limiting growth stimulus from elevated CO2. Introducing genotypes adapted to warmer temperatures (and also considering changes in CO2 and rainfall) could boost global wheat yield by 7% and protein yield by 2%, but grain protein concentration would be reduced by −1.1 percentage points, representing a relative change of −8.6%. Climate change adaptations that benefit grain yield are not always positive for grain quality, putting additional pressure on global wheat production.
Potential benefits of elevated atmospheric CO2 concentration by 2050 on global wheat grain and protein yield are likely to be negated by impacts from rising temperature and changes in rainfall, but with considerable disparities between regions. Grain and protein yields are expected to be lower and more variable in most low‐rainfall regions, with nitrogen availability limiting growth stimulus from elevated CO2. Introducing genotypes adapted to warmer temperatures could boost global wheat yield by 7% and protein yield by 2%, but grain protein concentration would be reduced by −1.1% points, representing a relative change of −8.6%.
Aim
To assess and compare the effect of small doses of fructose and allulose on postprandial blood glucose regulation in type 2 diabetes.
Methods
A double‐blind, multiple‐crossover, randomized, ...controlled, acute feeding, equivalence trial in 24 participants with type 2 diabetes was conducted. Each participant was randomly assigned six treatments separated by >1‐week washouts. Treatments consisted of fructose or allulose at 0 g (control), 5 g or 10 g added to a 75‐g glucose solution. A standard 75‐g oral glucose tolerance test protocol was followed with blood samples at −30, 0, 30, 60, 90 and 120 minutes. The primary outcome measure was plasma glucose incremental area under the curve (iAUC).
Results
Allulose significantly reduced plasma glucose iAUC by 8% at 10 g compared with 0 g (717.4 ± 38.3 vs. 777.5 ± 39.9 mmol × min/L, P = 0.015) with a linear dose response gradient between the reduction in plasma glucose iAUC and dose (P = 0.016). Allulose also significantly reduced several related secondary and exploratory outcome measures at 5 g (plasma glucose absolute mean and total AUC) and 10 g (plasma glucose absolute mean, absolute and incremental maximum concentration Cmax, and total AUC) (P < .0125). There was no effect of fructose at any dose. Although allulose showed statistically significant reductions in plasma glucose iAUC compared with fructose at 5 g, 10 g and pooled doses, these reductions were within the pre‐specified equivalence margins of ±20%.
Conclusion
Allulose, but not fructose, led to modest reductions in the postprandial blood glucose response to oral glucose in individuals with type 2 diabetes. There is a need for long‐term randomized trials to confirm the sustainability of these improvements.
Background Infection is a common cause of hospitalization in adults receiving hemodialysis. Limited data are available about downstream events resulting from or following these hospitalizations. ...Study Design Retrospective cohort study using the US Renal Data System. Setting & Participants Medicare beneficiaries initiating in-center hemodialysis therapy in 2005 to 2008. Factors Demographics, dual Medicare/Medicaid eligibility, body mass index, comorbid conditions, initial vascular access type, nephrology care prior to dialysis therapy initiation, residence in a care facility, tobacco use, biochemical measures, and type of infection. Outcomes 30-day hospital readmission or death following first infection-related hospitalization. Results 60,270 Medicare beneficiaries had at least one hospitalization for infection. Of those who survived the initial hospitalization, 15,113 (27%) were readmitted and survived the 30 days following hospital discharge, 1,624 (3%) were readmitted to the hospital and then died within 30 days of discharge, and 2,425 (4%) died without hospital readmission. Complications related to dialysis access, sepsis, and heart failure accounted for 12%, 9%, and 7% of hospital readmissions, respectively. Factors associated with higher odds of 30-day readmission or death without readmission included non-Hispanic ethnicity, lower serum albumin level, inability to ambulate or transfer, limited nephrology care prior to dialysis therapy, and specific types of infection. In comparison, older age, select comorbid conditions, and institutionalization had stronger associations with death without readmission than with readmission. Limitations Findings limited to Medicare beneficiaries receiving in-center hemodialysis. Conclusions Hospitalizations for infection among patients receiving in-center hemodialysis are associated with exceptionally high rates of 30-day hospital readmission and death without readmission.
Abstract
The discovery in deep near-infrared surveys of a population of massive quiescent galaxies at
z
> 3 has given rise to the question of how they came to be quenched so early in the history of ...the universe. Measuring their molecular gas properties can distinguish between physical processes where they stop forming stars due to a lack of fuel versus those where the star formation efficiency is reduced and the gas is retained. We conducted Atacama Large Millimeter/submillimeter Array observations of four quiescent galaxies at
z
= 3.5–4.0 found by the Fourstar Galaxy Evolution Survey and a serendipitous optically dark galaxy at
z
= 3.71. We aim to investigate the presence of dust-obscured star formation and their gas content by observing the dust continuum emission at Band 7 and the atomic carbon C
i
(
3
P
1
–
3
P
0
) line at 492.16 GHz. Among the four quiescent galaxies, only one source is detected in the dust continuum at
λ
obs
= 870
μ
m. The submillimeter observations confirm their passive nature, and all of them are located more than four times below the main sequence of star-forming galaxies at
z
= 3.7. None of the targets are detected in C
i
, constraining their gas-mass fractions to be <20%. These gas-mass fractions are more than 3 times lower than the scaling relation for star-forming galaxies at
z
= 3.7. These results support scenarios where massive galaxies at
z
= 3.5–4.0 quench by consuming/expelling all the gas rather than by reducing the efficiency of the conversion of their gas into stars.
The authors' objective was to determine whether scientific evidence supports the use of oral premedication to increase the efficacy of inferior alveolar nerve block (IANB) and to decrease endodontic ...treatment pain in patients with diagnosed irreversible pulpitis.
The authors included randomized controlled trials that involved enteral premedication and 2% lidocaine IANB for adults with irreversible pulpitis compared with placebo. In particular, the authors reviewed studies comparing nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines, acetaminophen, and corticosteroids with placebo. The authors searched the following electronic databases: the Cochrane Library, MEDLINE, and Web of Science.
The authors analyzed 9 randomized controlled clinical trials. Patients who took the NSAIDs under study, including ibuprofen, ketorolac, diclofenac, indomethacin, and lornoxicam, 1 hour before endodontic treatment showed statistically significant improvement in the outcome of having "little or no pain" during endodontic treatment compared with patients who took a placebo 1 hour before endodontic treatment (risk ratio RR, 1.989; 95% confidence interval CI, 1.495-2.646; P < .001). Benzodiazepines were not as well represented in the literature, but the 2 included studies did not show a significant improvement in patients' having "little or no pain" during endodontic treatment over placebo (RR, 0.989; 95% CI, 0.677-1.444; P = .954).
There is moderate evidence to support the use of oral NSAIDs-in particular, ibuprofen (600 milligrams)-1 hour before the administration of IANB local anesthetic (1.8-3.6 milliliters of 2% lidocaine) to provide additional analgesia to the patient.
Introduction: The global disease burden of major depressive disorder urgently requires prevention in high-risk individuals, such as recently discovered insomnia subtypes. Previous studies targeting ...insomnia with fully automated eHealth interventions to prevent depression are inconclusive: dropout was high and likely biased, and depressive symptoms in untreated participants on average improved rather than worsened. Objective: This randomized controlled trial aimed to efficiently prevent the worsening of depressive symptoms by selecting insomnia subtypes at high risk of depression for internet-based circadian rhythm support (CRS), cognitive behavioral therapy for insomnia (CBT-I), or their combination (CBT-I+CRS), with online therapist guidance to promote adherence. Methods: Participants with an insomnia disorder subtype conveying an increased risk of depression (n = 132) were randomized to no treatment (NT), CRS, CBT-I, or CBT-I+CRS. The Inventory of Depressive Symptomatology – Self Report (IDS-SR) was self-administered at baseline and at four follow-ups spanning 1 year. Results: Without treatment, depressive symptoms indeed worsened (d = 0.28, p = 0.041) in high-risk insomnia, but not in a reference group with low-risk insomnia. Therapist-guided CBT-I and CBT-I+CRS reduced IDS-SR ratings across all follow-up assessments (respectively, d = –0.80, p = 0.001; d = –0.95, p < 0.001). Only CBT-I+CRS reduced the 1-year incidence of clinically meaningful worsening (p = 0.002). Dropout during therapist-guided interventions was very low (8%) compared to previous automated interventions (57–62%). Conclusions: The findings tentatively suggest that the efficiency of population-wide preventive strategies could benefit from the possibility to select insomnia subtypes at high risk of developing depression for therapist-guided digital CBT-I+CRS. This treatment may provide effective long-term prevention of worsening of depressive symptoms. Trial registration: the Netherlands Trial Register (NL7359).
ABSTRACT We investigate the dependence of galaxy sizes and star formation rates (SFRs) on their environment using a mass-limited sample of quiescent and star-forming galaxies with log(M*/ ) ≥ 9.5 at ...selected from the NEWFIRM medium-band Survey (NMBS). Using the Galaxy Environment Evolution Collaboration 2 spectroscopic cluster catalog and the accurate photometric redshifts from the NMBS, we select quiescent and star-forming cluster ( km s−1) galaxies within two virial radius, Rvir, intervals of 2 > Rvir > 0.5 and Rvir < 0.5. Galaxies residing outside of the 2 Rvir of both the cluster centers and the additional candidate over-densities are defined as our field sample. Galaxy structural parameters are measured from the COSMOS legacy Hubble Space Telescope/ACS F814W image. The sizes and Sérsic indices of quiescent field and cluster galaxies have the same distribution regardless of Rvir. However, cluster star-forming galaxies within 0.5 Rvir have lower mass-normalized average sizes by , and a higher fraction of Sérsic indices with , than field star-forming galaxies. The average SFRs of star-forming cluster galaxies show a trend of decreasing SFR with clustocentric radius. The mass-normalized average SFR of cluster star-forming galaxies is a factor of ( ) lower than that of star-forming galaxies in the field. While we find no significant dependence on environment for quiescent galaxies, the properties of star-forming galaxies are affected, which could be the result of environment acting on their gas content.
Photoplethysmography (PPG) signal quality as a proxy for accuracy in heart rate (HR) measurement is useful in various public health contexts, ranging from short-term clinical diagnostics to ...free-living health behavior surveillance studies that inform public health policy. Each context has a different tolerance for acceptable signal quality, and it is reductive to expect a single threshold to meet the needs across all contexts. In this study, we propose two different metrics as sliding scales of PPG signal quality and assess their association with accuracy of HR measures compared to a ground truth electrocardiogram (ECG) measurement.
We used two publicly available PPG datasets (BUT PPG and Troika) to test if our signal quality metrics could identify poor signal quality compared to gold standard visual inspection. To aid interpretation of the sliding scale metrics, we used ROC curves and Kappa values to calculate guideline cut points and evaluate agreement, respectively. We then used the Troika dataset and an original dataset of PPG data collected from the chest to examine the association between continuous metrics of signal quality and HR accuracy. PPG-based HR estimates were compared with reference HR estimates using the mean absolute error (MAE) and the root-mean-square error (RMSE). Point biserial correlations were used to examine the association between binary signal quality and HR error metrics (MAE and RMSE).
ROC analysis from the BUT PPG data revealed that the AUC was 0.758 (95% CI 0.624 to 0.892) for signal quality metrics of STD-width and 0.741 (95% CI 0.589 to 0.883) for self-consistency. There was a significant correlation between criterion poor signal quality and signal quality metrics in both Troika and originally collected data. Signal quality was highly correlated with HR accuracy (MAE and RMSE, respectively) between PPG and ground truth ECG.
This proof-of-concept work demonstrates an effective approach for assessing signal quality and demonstrates the effect of poor signal quality on HR measurement. Our continuous signal quality metrics allow estimations of uncertainties in other emergent metrics, such as energy expenditure that relies on multiple independent biometrics. This open-source approach increases the availability and applicability of our work in public health settings.
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