The aim of the study is to assess the prognostic value of pretreatment lymphocyte, neutrophil, platelet counts, mean platelet volume (MPV), platelet to lymphocyte ratio (PLR) and neutrophil to ...lymphocyte ratio (NLR) in patients with pancreatic cancer.
A total of 65 eligible patients were included in the study and retrospectively reviewed. Pre-treatment hematological parameters (platelet, lymphocyte, neutrophil counts, and mean platelet volume) and tumor marker (CA 19-9) levels were recorded. NLR was calculated by dividing the neutrophil count value by the number of lymphocytes. PLR was also calculated in a similar manner by dividing the platelet count value by the number of lymphocytes.
One-year survival was 22.3% and the median survival time was 7 months (95% CI, 5.7-8.2) in the study group. Patients with a NLR value of < 5 had a significantly higher median survival duration compared to those with a NLR value of > or = 5 (p = 0.015). All other hematological variables were not significantly different.
In patients with pancreatic cancer, pretreatment NLR may be use as a prognostic factor in pancreatic cancer patients. Further studies with larger patient cohorts are warranted to to better clarify the prognostic value of pre-treatment peripheral blood counts in patients with cancer.
AIM： To evaluate the neuroprotective effect of rosuvastatin, in a rat experimental glaucoma model. METHODS： Ocular hypertension was induced in right eyes of Long-Evans rats （n=30） by cauterization of ...three episcleral veins. Left eyes were defined as controls. Rats were divided into five groups： oral rosuvastatin, intravitreal rosuvastatin, oral ＋intravitreal rosuvastatin, intravitreal sham and glaucoma without intervention. Rats were sacrificed at day 14. Retinal ganglion cell （RGC） number was assessed by histopathological analysis. Terminal deoxynucleotidyl transferase-mediated dUTP-nick end-labeling （TUNEL） staining and the expression of glial fibrillary acidic protein （GFAP） in RGC layer was also examined. RESULTS： A significant intraocular pressure （lOP） elevation was seen （P=0.002）. Elevated lOP resulted in a significant decrease in number of RGCs in group 5 （70.33 ±8.2 cells/mm2） when compared with controls （92.50 ±13.72 cells/mm2; P=0.03）. The RGC number in group 1 （92.4±7.3 cells/mm2） was significantly higher than group 5 （ρ=0.03）. The numbers of RGC in groups 2, 3 （57.3±8.2 cells/mm2, 60.5±12.9 cells/mm2） were comparable with that of group 5 （ρ=0.18 and P=0.31）. The apoptosis rates with TUNEL staining were also parallel to RGC number. Animals with experimentally induced glaucoma showed an increase in retinal GFAP immunoreacUvity. CONCLUSION： Decrease in RGC loss and apoptosis suggest the neuroprotective potential of oral rosuvastatin treatment in a rat model of ocular hypertension. Howeverintravitreal rosuvastatin showed a contrary effect and further studies are required.
Malignant pericardial effusion may affect almost 15 of the patients with underlying malignancies which deteriorates the prognosis. The prognostic significance of pericardial fluid cytology is ...under-represented in previous studies.
A total of 73 patients with symptomatic pericardial effusion treated with pericardiocentesis were included in this retrospective analysis. Macroscopic appearance, biochemical features, and cytological findings were obtained. Patients were divided into 3 groups: (i) without malignancy, (ii) with malignancy and negative cytology, and (iii) with malignancy and positive cytology. Survival data were searched via governmental death notification system.
Mean age of the study group was 62 ± 15, and 54% (40) of the patients were female. On the cytological evaluation, 17 patients (23.3%) revealed positive cancer cytology, whereas 56 patients (76.7%) revealed negative cancer cytology. The median follow-up period was 840 days, and 34 patients (46.5%) died during follow-up. The survival rate of Group 3 was found to be significantly worse compared to Groups 1 and 2, no statistical difference was found between Groups 1 and 2 in terms of survival (Group 1 vs. Group 2 P =.078; Group 1 vs. Group 3 P <.001; Group 2 vs. Group 3 P =.041).
Cytological evaluation is an important step in patients with malignant pericardial effusion. Positive pericardial fluid cytology indicates a poorer prognosis.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
To evaluate the neuroprotective effect of rosuvastatin, in a rat experimental glaucoma model.
Ocular hypertension was induced in right eyes of Long-Evans rats (n=30) by cauterization of three ...episcleral veins. Left eyes were defined as controls. Rats were divided into five groups: oral rosuvastatin, intravitreal rosuvastatin, oral+intravitreal rosuvastatin, intravitreal sham and glaucoma without intervention. Rats were sacrificed at day 14. Retinal ganglion cell (RGC) number was assessed by histopathological analysis. Terminal deoxynucleotidyl transferase-mediated dUTP-nick end-labeling (TUNEL) staining and the expression of glial fibrillary acidic protein (GFAP) in RGC layer was also examined.
A significant intraocular pressure (IOP) elevation was seen (P=0.002). Elevated IOP resulted in a significant decrease in number of RGCs in group 5 (70.33±8.2 cells/mm(2)) when compared with controls (92.50±13.72 cells/mm(2); P=0.03). The RGC number in group 1 (92.4±7.3 cells/mm(2)) was significantly higher than group 5 (P=0.03). The numbers of RGC in groups 2, 3 (57.3±8.2 cells/mm(2), 60.5±12.9 cells/mm(2)) were comparable with that of group 5 (P=0.18 and P=0.31). The apoptosis rates with TUNEL staining were also parallel to RGC number. Animals with experimentally induced glaucoma showed an increase in retinal GFAP immunoreactivity.
Decrease in RGC loss and apoptosis suggest the neuroprotective potential of oral rosuvastatin treatment in a rat model of ocular hypertension. However intravitreal rosuvastatin showed a contrary effect and further studies are required.
Presence of iridescent particles is a well-known clinical condition in phacolytic glaucoma patients with severe high intraocular pressure. Several articles stated that hyperchromatic crystalline ...deposits were cholesterol crystalline deposits. However, some articles focus on the possible oxalate content of the hyperchromatic crystalline material. Nevertheless, there are few articles which provide information about these crystalline structures at the microscopic level. The purpose of this manuscript was to report the case of a phacolytic glaucoma patient with intense crystalline accumulation in the anterior chamber and to present the microscopic features of these crystalline deposits. (Turk J Ophthalmol 2014; 44: 490-2) Key Words: Phacolytic glaucoma, hyperchromatic crystalline, lens protein, hypermature cataract Ciddi goz ici basinc yukseklikleri ile giden fakolitik glokomlu olgularda iridesan partikullerin mevcudiyeti iyi bilinmekte olan bir klinik durumdur. Bu hiperkromatik kristallerin kolesterol kristalleri oldugu konusunda cesitli yayinlar mevcuttur. Fakat bazi yayinlarda bu kristallerin okzalat icerikli olabilecegi uzerinde durulmustur. Ayrica bu kristallerin yapisini mikroskopik olarak gosteren cok az sayida yayin mevcuttur. Bu olgu sunumunda amacimiz on kamarada yaygin kristal birikimleri olan fakolitik glokomlu bir olgunun sunulmasi ve bu kristallerin mikroskobik ozelliklerinin ortaya konmasidir. (Turk J Ophthalmol 2014; 44: 490-2) Anahtar Kelimeler: Fakolitik glokom, hiperkromatik kristal, lens protein, hipermatur katarakt
Presence of iridescent particles is a well-known clinical condition in phacolytic glaucoma patients with severe high intraocular pressure. Several articles stated that hyperchromatic crystalline ...deposits were cholesterol crystalline deposits. However, some articles focus on the possible oxalate content of the hyperchromatic crystalline material. Nevertheless, there are few articles which provide information about these crystalline structures at the microscopic level. The purpose of this manuscript was to report the case of a phacolytic glaucoma patient with intense crystalline accumulation in the anterior chamber and to present the microscopic features of these crystalline deposits. (Turk J Ophthalmol 2014; 44: 490-2)
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