Introduction and hypothesis
There has been an increasing need for the terminology on the conservative management of female pelvic floor dysfunction to be collated in a clinically based consensus ...report.
Methods
This Report combines the input of members and elected nominees of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA) and the International Continence Society (ICS), assisted at intervals by many external referees. An extensive process of nine rounds of internal and external review was developed to exhaustively examine each definition, with decision-making by collective opinion (consensus). Before opening up for comments on the webpages of ICS and IUGA, five experts from physiotherapy, neurology, urology, urogynecology, and nursing were invited to comment on the paper.
Results
A Terminology Report on the conservative management of female pelvic floor dysfunction, encompassing over 200 separate definitions, has been developed. It is clinically based, with the most common symptoms, signs, assessments, diagnoses, and treatments defined. Clarity and ease of use have been key aims to make it interpretable by practitioners and trainees in all the different specialty groups involved in female pelvic floor dysfunction. Ongoing review is not only anticipated, but will be required to keep the document updated and as widely acceptable as possible.
Conclusion
A consensus-based terminology report for the conservative management of female pelvic floor dysfunction has been produced, aimed at being a significant aid to clinical practice and a stimulus for research.
Este artigo trata da Inquisição no Brasil e a atuação dos inquisidores no modus operandi processual do tribunal eclesiástico do Santo Oficio em Lisboa. Os documentos fontes indicam parte do que foi a ...inquisição portuguesa no Brasil no processo de colonização do território. Busca-se compreender o rito processual por meio da atuação dos inquisidores, topo da organização hierárquica do Santo Oficio da Inquisição Portuguesa. Para tal, se fez necessária à análise de fontes documentais como regimentos, manual de inquisidores, e processos de réus acusados por diversos crimes no tribunal de Lisboa. O estudo foi realizado a partir de fontes primárias e ilustrado por um caso na colônia brasileira, além de fornecer dados sobre os variados processos, julgados no tribunal do Santo Ofício de Lisboa, uma vez que a colônia portuguesa na América não teve tribunal próprio. Espera-se que esse estudo abra caminho para as outras investigações sobre o objeto no leque dos mais variados processos da Inquisição no Brasil no período colonial.
Despite its strategic importance at the furthermost edge of the Neolithic expansion in Europe, archaeogenetic data from Mesolithic and Neolithic human remains from Portugal are still very limited. ...Here we present ancient mtDNA evidence (mostly unpublished) to fill the gap and discuss the pattern of “genetic resurgence” of hunter-gatherer (Mesolithic) ancestry, widely reported elsewhere in Europe, among the first megalith builders (Middle Neolithic) of western Iberia.
A total of 11 Mesolithic and Neolithic necropolises located in the central and southern regions of Portugal dated to ca. 6200–3000 BC were studied. These sites comprise all Mesolithic–Neolithic cultural stages and include several funerary architectures and spaces. Reproducible mtDNA HVRI haplotypes were obtained from 23 individuals from six different archaeological sites spread across a >3000-year transect, from the Late Mesolithic to the Late Neolithic.
Our results support a three-stage explanatory demographic and populational model: i) local hunter-gatherer populations constituted a highly homogeneous genetic pool; ii) the first farming practices were introduced by human groups carrying new, extraneous haplogroups and exhibiting the signature of admixture events occurring at the time of first contact with local hunter-gatherers; iii) the genetic pattern detected among the megalith-building populations, showing hunter-gatherer along with farming ancestry, may be explained by the segmentary principles, and attendant endogamic practices, that structured Neolithic societies.
The dairy industry can contribute to global food security in a sustainable way by efficiently converting milk into dairy ingredients and products, even though they are polluting on a large scale. In ...this context, this study aimed to conduct a systematic literature review on sustainable indicators and dairy industries. The methodology used has a qualitative and quantitative approach and its technical procedure was the systematic literature review. The bases of journals consulted, using the keywords “sustainability indicator” and “dairy industry” which resulted in 130 valid scientific articles. The main results show that the sustainability indicators in the dairy industry are emerging and lacking research; being found seven papers, that highlight 12 indicators of the environmental, 11 of the social and eight economic dimensions, that may be considered fragile and initial. The studied problems are related to wastewater treatment methods, electric power consumption, efficiency of the industrial plant, among others, and the benefits on the theme are related to solutions to the difficulties, such as electricity reduction, sustainable practices. Among others, it is concluded that the dairy industries address the sustainability theme since 2011, with an ambiguous trend, being found evidence of the fragility of the sustainability indicators was found, mainly in the initial stage of their conception, when considering holistic approach (triple bottom line).
Snake venom serine proteases (SVSPs) act primarily on plasma proteins related to blood clotting and are considered promising for the treatment of several hemostatic disorders. We report the ...heterologous expression of a serine protease from Crotalus durissus collilineatus, named collinein-1, in Pichia pastoris, as well as the enzymatic comparative characterization of the toxin in native and recombinant forms. The complementary DNA (cDNA) encoding collinein-1 was amplified from cDNA library of C. d. collilineatus venom gland and cloned into the pPICZαA vector. The recombinant plasmid was used to transform cells of KM71H P. pastoris. Heterologous expression was induced by methanol and yielded 56 mg of recombinant collinein-1 (rCollinein-1) per liter of culture. The native collinein-1 was purified from C. d. collilineatus venom, and its identity was confirmed by amino acid sequencing. The native and recombinant enzymes showed similar effects upon bovine fibrinogen by releasing preferentially fibrinopeptide A. Although both enzymes have induced plasma coagulation, native Colinein-1 has shown higher coagulant activity. The serine proteases were able to hydrolyze the chromogenic substrates S-2222, S-2238, and S2302. Both enzymes showed high stability on different pH and temperature, and their esterase activities were inhibited in the presence of Zn²⁺ and Cu²⁺. The serine proteases showed similar k cₐₜ/K ₘ values in enzyme kinetics assays, suggesting no significant differences in efficiency of these proteins to hydrolyze the substrate. These results demonstrated that rCollinein-1 was expressed with functional integrity on the evaluated parameters. The success in producing a functionally active recombinant SVSP may generate perspectives to their future therapeutic applications.
The objective of this study was to propose a multidimensional model capable of evaluating, in a participatory method, the pressures agricultural production systems cause to aquatic ecosystems. The ...model was structured with information compiled from scientific articles, doctoral theses, public documents, and field research performed with the participation of stakeholders through interviews, questionnaires, and group evaluations. The evaluation matrix combines seven criteria and twenty-five sub-criteria with different weights to evaluate two main aspects: (i) land occupation and soil management and (ii) agricultural waste production and disposal. The model was tested in 14 agricultural farms, representing four productive arrangements, in a large watershed (2400 km2) in southern Brazil. The geophysical characteristics of the site (18.3%), land use and occupation (28.2%), management practices (soil and water) (25.4%), manure and fertilizers (12.6%), pesticides (14.1%), agricultural waste and discards (1.4%) were the criteria and their respective weights used in the structure of the proposed evaluation model. The evaluation showed that the combination of the fragility of cultivated environments and the absence of conservation practices represented the greatest risks (72.9%) to maintaining the sound environmental conditions of aquatic ecosystems. For future research, it is recommended that a cost-effectiveness analysis be carried out to evaluate environmental conflicts.
Partiendo de las críticas formuladas por Friedrich Kittler hacia Walter Benjamin, específicamente en lo concerniente a la presunta falta de conocimientos tecnológicos de Benjamin, el presente texto ...tiene como objetivo demonstrar la forma en la que Benjamin estructura algunos de sus conceptos desde una perspectiva medial. En particular, el artículo se enfoca en el concepto de «dialéctica en reposo» y en su relación intrínseca con un dispositivo estereoscópico al que Benjamin alude en repetidas ocasiones: el Kaiserpanorama. Contraponiendo fragmentos de su Infancia en Berlín hacia 1900 y algunos apuntes del Libro de los pasajes, se evidencia cómo la noción de dialéctica en reposo se articula con el fenómeno de la estereoscopía.
According to the Report on Carcinogens, formaldehyde ranks 25th in the overall U.S. chemical production, with more than 5 million tons produced each year. Given its economic importance and widespread ...use, many people are exposed to formaldehyde environmentally and/or occupationally. Presently, the International Agency for Research on Cancer classifies formaldehyde as carcinogenic to humans (Group 1), based on sufficient evidence in humans and in experimental animals. Manyfold in vitro studies clearly indicated that formaldehyde can induce genotoxic effects in proliferating cultured mammalian cells. Furthermore, some in vivo studies have found changes in epithelial cells and in peripheral blood lymphocytes related to formaldehyde exposure.
A study was carried out in Portugal, using 80 workers occupationally exposed to formaldehyde vapours: 30 workers from formaldehyde and formaldehyde-based resins production factory and 50 from 10 pathology and anatomy laboratories. A control group of 85 non-exposed subjects was considered. Exposure assessment was performed by applying simultaneously two techniques of air monitoring: NIOSH Method 2541 and Photo Ionization Detection equipment with simultaneously video recording. Evaluation of genotoxic effects was performed by application of micronucleus test in exfoliated epithelial cells from buccal mucosa and peripheral blood lymphocytes.
Time-weighted average concentrations not exceeded the reference value (0.75 ppm) in the two occupational settings studied. Ceiling concentrations, on the other hand, were higher than reference value (0.3 ppm) in both. The frequency of micronucleus in peripheral blood lymphocytes and in epithelial cells was significantly higher in both exposed groups than in the control group (p<0.001). Moreover, the frequency of micronucleus in peripheral blood lymphocytes was significantly higher in the laboratories group than in the factory workers (p < 0.05). A moderate positive correlation was found between duration of occupational exposure to formaldehyde (years of exposure) and micronucleus frequency in peripheral blood lymphocytes (r=0.401; p<0.001) and in epithelial cells (r=0.209; p < 0.01).
The population studied is exposed to high peak concentrations of formaldehyde with a long-term exposure. These two aspects, cumulatively, can be the cause of the observed genotoxic endpoint effects. The association of these cytogenetic effects with formaldehyde exposure gives important information to risk assessment process and may also be used to assess health risks for exposed workers.
Smart cities are aimed at connecting urban infrastructures to enhance the efficiency of their operation and services while taking sustainability goals into consideration. As a result of the ...intermittency associated with renewable generation, smart city systems such as smart grids and microgrids may not be able to ensure the security of supply. This can be mitigated by allowing these systems to trade surplus energy with other neighboring systems through local energy markets based on peer-to-peer schemes. Such an approach can play an important role on achieving sustainability due to the positive impacts at the economic, social, and environmental level. Therefore, this work explores the design of local energy markets to help determine how they are relevant to smart grid and microgrid applications and what their contributions are to sustainability in smart cities. Essentially, this is achieved by performing a literature review to address key characteristics related to the design of local energy markets while considering their relationship with urban sustainability. In addition, the concept of game theory and its potential to evaluate market designs are also introduced and discussed. Finally, the suitability of centralized, decentralized, and distributed market designs for each dimension of sustainability is estimated based on their design characteristics.
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