We present experimental results from the first systematic study of performance scaling with drive parameters for a magnetoinertial fusion concept. In magnetized liner inertial fusion experiments, the ...burn-averaged ion temperature doubles to 3.1 keV and the primary deuterium-deuterium neutron yield increases by more than an order of magnitude to 1.1 × 1013 (2 kJ deuterium-tritium equivalent) through a simultaneous increase in the applied magnetic field (from 10.4 to 15.9 T), laser preheat energy (from 0.46 to 1.2 kJ), and current coupling (from 16 to 20 MA). Individual parametric scans of the initial magnetic field and laser preheat energy show the expected trends, demonstrating the importance of magnetic insulation and the impact of the Nernst effect for this concept. A drive-current scan shows that present experiments operate close to the point where implosion stability is a limiting factor in performance, demonstrating the need to raise fuel pressure as drive current is increased. Simulations that capture these experimental trends indicate that another order of magnitude increase in yield on the Z facility is possible with additional increases of input parameters.
Magnetizing the fuel in inertial confinement fusion relaxes ignition requirements by reducing thermal conductivity and changing the physics of burn product confinement. Diagnosing the level of fuel ...magnetization during burn is critical to understanding target performance in magneto-inertial fusion (MIF) implosions. In pure deuterium fusion plasma, 1.01 MeV tritons are emitted during deuterium-deuterium fusion and can undergo secondary deuterium-tritium reactions before exiting the fuel. Increasing the fuel magnetization elongates the path lengths through the fuel of some of the tritons, enhancing their probability of reaction. Based on this feature, a method to diagnose fuel magnetization using the ratio of overall deuterium-tritium to deuterium-deuterium neutron yields is developed. Analysis of anisotropies in the secondary neutron energy spectra further constrain the measurement. Secondary reactions also are shown to provide an upper bound for the volumetric fuel-pusher mix in MIF. The analysis is applied to recent MIF experiments M. R. Gomez et al., Phys. Rev. Lett. 113, 155003 (2014) on the Z Pulsed Power Facility, indicating that significant magnetic confinement of charged burn products was achieved and suggesting a relatively low-mix environment. Both of these are essential features of future ignition-scale MIF designs.
Introduction
This narrative review focusing on critical care echocardiography (CCE) has been written by a group of experts in the field, with the aim of outlining the state of the art in CCE in the ...10 years after its official recognition and definition.
Results
In the last 10 years, CCE has become an essential branch of critical care ultrasonography and has gained general acceptance. Its use, both as a diagnostic tool and for hemodynamic monitoring, has increased markedly, influencing contemporary cardiorespiratory management. Recent studies suggest that the use of CCE may have a positive impact on outcomes. CCE may be used in critically ill patients in many different clinical situations, both in their early evaluation of in the emergency department and during intensive care unit (ICU) admission and stay. CCE has also proven its utility in perioperative settings, as well as in the management of mechanical circulatory support. CCE may be performed with very simple diagnostic objectives. This application, referred to as basic CCE, does not require a high level of training. Advanced CCE, on the other hand, uses ultrasonography for full evaluation of cardiac function and hemodynamics, and requires extensive training, with formal certification now available. Indeed, recent years have seen the creation of worldwide certification in advanced CCE. While transthoracic CCE remains the most commonly used method, the transesophageal route has gained importance, particularly for intubated and ventilated patients.
Conclusion
CCE is now widely accepted by the critical care community as a valuable tool in the ICU and emergency department, and in perioperative settings.
AbstractMicrobially induced calcite precipitation (MICP) is a promising biocementation process that can improve the geotechnical properties of granular soils through the precipitation of calcite. In ...this study, a large-scale biocementation experiment was completed to evaluate differences in improvement obtained using a bioaugmentation approach with S. pasteurii and a biostimulation approach, which stimulated native ureolytic microorganisms to complete the process. Two identical 1.7-m-diameter soil tank specimens containing a 0.3-m-thick layer of sand were treated using three wells at a well-to-well spacing of 1.2 m. Treatments were applied daily over 12 days and were designed to evaluate differences between tanks by creating a nonuniform spatial distribution of improvement. During treatment, shear wave velocity and biogeochemical changes were monitored spatially and temporally. Post-treatment, cone penetration tests were completed to assess improvement, and samples were obtained for calcite content measurements. Similar final improvement was observed between tanks, with highly cemented regions achieving shear wave velocities over 960 m/s and increases in tip resistances of over 419%. Results suggest that biostimulation may enable comparable biocementation improvement at the meter scale.
A variant of the autophagy gene
is associated with Crohn's disease, an inflammatory bowel disease (IBD), and poor survival in allogeneic hematopoietic stem cell transplant recipients. We demonstrate ...that ATG16L1 in the intestinal epithelium is essential for preventing loss of Paneth cells and exaggerated cell death in animal models of virally triggered IBD and allogeneic hematopoietic stem cell transplantation. Intestinal organoids lacking ATG16L1 reproduced this loss in Paneth cells and displayed TNFα-mediated necroptosis, a form of programmed necrosis. This cytoprotective function of ATG16L1 was associated with the role of autophagy in promoting mitochondrial homeostasis. Finally, therapeutic blockade of necroptosis through TNFα or RIPK1 inhibition ameliorated disease in the virally triggered IBD model. These findings indicate that, in contrast to tumor cells in which autophagy promotes caspase-independent cell death, ATG16L1 maintains the intestinal barrier by inhibiting necroptosis in the epithelium.
Enhanced implosion stability has been experimentally demonstrated for magnetically accelerated liners that are coated with 70 μm of dielectric. The dielectric tamps liner-mass redistribution from ...electrothermal instabilities and also buffers coupling of the drive magnetic field to the magneto-Rayleigh-Taylor instability. A dielectric-coated and axially premagnetized beryllium liner was radiographed at a convergence ratio CR=Rin,0/Rin(z,t) of 20, which is the highest CR ever directly observed for a strengthless magnetically driven liner. The inner-wall radius Rin(z,t) displayed unprecedented uniformity, varying from 95 to 130 μm over the 4.0 mm axial height captured by the radiograph.
Sarcopenia is a major component of the frailty syndrome, both being considered as strong predictors of morbidity, disability, and death in older people.
In this review, we explore the definitions of ...sarcopenia and frailty and summarize the current knowledge on their relationship with oxidative stress and the possible therapeutic interventions to prevent or treat them, including exercise-based interventions and multimodal strategies. We highlight the relevance of the impairment of the nervous system and of the anabolic response (protein synthesis) in muscle aging leading to frailty and sarcopenia. We also discuss the importance of malnutrition and physical inactivity in these geriatric syndromes. Finally, we propose multimodal interventions, including exercise programs and nutritional supplementation, as the strategies to prevent and treat both sarcopenia and frailty.
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•Sarcopenia and frailty share common etiology.•Aging is associated with and altered redox signaling in skeletal muscle.•Modifiable risk factors improve protein synthesis and prevent muscle loss in aging.•Multidomain strategies are effective in the management of frailty and sarcopenia.
Inertial confinement fusion (ICF) has existed as a field of study since the 1970s, but the field was born out of the Cold War. In the decades since the 1960s, pioneering research developing the ...principles and technologies of ICF has culminated in the creation of three major Department of Energy facilities that still exist today: the National Ignition Facility (NIF) at Lawrence Livermore National Laboratory, the OMEGA laser at the Laboratory for Laser Energetics, and the Z pulsed power facility at Sandia National Laboratories. While the technology of ICF facilities themselves is interesting, this review concentrates upon the physics principles of the targets fielded on U.S. ICF facilities and upon results from the last decade of research. While there have been periods of frustration on the road to ICF ignition, recent research has demonstrated great leaps in understanding what aspects of the implosions need more control. Tangible progress in ICF is evident as burning plasmas and ignited plasmas have recently been generated, repeatedly, on the NIF stemming from decades of science and engineering understanding generated from work at the three previously mentioned facilities and in the international community.
We present James Webb Space Telescope (JWST) NIRCam and NIRSpec observations of a Type Ic supernova (SN Ic) and its host galaxy (JADES-GS+53.13533-27.81457) at z = 2.83. This SN (named SN 2023adta) ...was identified in deep JWST/NIRCam imaging from the JWST Advanced Deep Extragalactic Survey (JADES) program. Follow-up observations with JWST/NIRSpec provided a spectroscopic redshift of z = 2.83 and the classification as an SN Ic-BL. The light curve of SN 2023adta matches well with other stripped-envelope SNe, and we find a high peak luminosity, MV = −19.0 ± 0.2 mag, based on the distribution of best-fit SNe. The broad absorption features in its spectrum are consistent with other SNe Ic-BL 1–3 weeks after peak brightness. We measure a Ca ii near-IR triplet expansion velocity of 29,000 ± 2000 km s−1. The host galaxy of SN 2023adta is irregular, and modeling of its spectral energy distribution indicates a metallicity of Z=0.35−0.08+0.16Z⊙. This environment is consistent with the population of low-z SNe Ic-BL that prefer lower metallicities relative to other stripped-envelope SNe and track long-duration γ-ray burst environments. We do not identify any γ-ray bursts that are coincident with SN 2023adta. Given the rarity of SNe Ic-BL in the local Universe, the detection of an SN Ic-BL at z = 2.83 could indicate that their rates are enhanced at high redshift.
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