Warthin-like papillary thyroid cancer (WL-PTC) is an uncommon variant of PTC, usually associated with lymphocytic thyroiditis. Scarce evidence suggests that WL-PTC has similar clinical presentation ...to classic PTC (C-PTC), with no studies comparing risks of recurrence and response to treatment between both variants. Our objective was to describe the clinical presentation and prognosis of WL-PTC and compare it to C-PTC.
Retrospective analysis of a prospective cohort, including 370 (96%) patients with C-PTC and 17 (4%) with WL-PTC, consecutively treated with total thyroidectomy with or without RAI, followed for at least 6 months. We compared clinical presentation, risk of mortality and recurrence, as well as response to treatment between both variants.
Of the total cohort: 317 (82%) female, 38 ± 13.5 years, median follow-up 4 years (0.5-28.5); most of them stage I and low/intermediate risk of recurrence. We found no differences regarding clinical-pathological data and risk of recurrence. WL-PTC was associated with a higher rate of anti-thyroglobulin antibodies (TgAb) (65%
36%, p = 0.016) and lymphocytic thyroiditis (59%
34%, p = 0.03). The rates of biochemical and structural incomplete responses were similar in both variants. WL-PTC had a lower rate of excellent response (23%
54%, p = 0.01), which became non-significant when performing analysis by TgAb presence (50%
67%, p = NS).
WL-CPT and C-CPT have similar clinical presentation and rate of recurrence. The lower rate of excellent response to treatment in WL-PTC is due to a higher frequency of TgAb. WL-PCT should not be considered an aggressive variant of PTC.
Introduction and objectives
Vaccines against SARS-CoV-2 have been a major scientific and medical achievement in the control of the COVID-19 pandemic. However, very infrequent cases of inflammatory ...heart disease have been described as adverse events, leading to uncertainty in the scientific community and in the general population.
Methods
The Vaccine–Carditis Registry has included all cases of myocarditis and pericarditis diagnosed within 30 days after COVID-19 vaccination since August 1, 2021 in 29 centers throughout the Spanish territory. The definitions of myocarditis (probable or confirmed) and pericarditis followed the consensus of the Centers for Disease Control and the Clinical Practice Guidelines of the European Society of Cardiology. A comprehensive analysis of clinical characteristics and 3-month evolution is presented.
Results
From August 1, 2021, to March 10, 2022, 139 cases of myocarditis or pericarditis were recorded (81.3% male, median age 28 years). Most cases were detected in the 1st week after administration of an mRNA vaccine, the majority after the second dose. The most common presentation was mixed inflammatory disease (myocarditis and pericarditis). 11% had left ventricular systolic dysfunction, 4% had right ventricular systolic dysfunction, and 21% had pericardial effusion. In cardiac magnetic resonance studies, left ventricular inferolateral involvement was the most frequent pattern (58%). More than 90% of cases had a benign clinical course. After a 3-month follow-up, the incidence of adverse events was 12.78% (1.44% mortality).
Conclusions
In our setting, inflammatory heart disease after vaccination against SARS-CoV-2 predominantly affects young men in the 1st week after the second dose of RNA-m vaccine and presents a favorable clinical course in most cases.
Graphical abstract
The present work analyzes how an aqueous suspension of graphene oxide (GO), as a surface treatment, can influence the properties of conventional concrete. The results show that the application of a ...GO surface coating on concrete improves its resistance to carbonation and chloride ion penetration, and also increases its electrical resistivity. In the best case, the GO coating can reduce carbonation by 40% and chloride ion diffusion by 75%. An increase of up to 75% in concrete resistivity was also achieved. The application of GO promotes the hydration process and densifies the microstructure of the concrete surface, and this is verified by scanning electron microscopy analysis. In addition, no color modification occurred after application of the treatment.
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•Graphene oxide (GO) surface coating is used as a new surface sealer for concrete.•GO could physically and chemically adhere to the concrete surface creating a dense layer on its surface.•GO effectively attenuated the carbonation process and the penetration of chloride ions.•GO is proposed as a surface coating for concrete to increase its durability and prolong its useful life.
To create and test psychometrically a paediatric version of the Physical Restraint-Theory of Planned Behaviour Questionnaire to assess paediatric critical care nurses' intention to use physical ...restraint.
A psychometric study.
Five medical-surgical Paeditric Intensive care Units from five hospitals in Spain.
The study took place in three phases. In phase 1, the questionnaire was adapted. In phase 2, the content validity of each item was determined, and a pilot test was conducted. In phase 3, we administered the questionnaire and determined its psychometric properties.
The assessment of the intention to use physical restraint was extended to all critical paediatric patients, two items were eliminated from the initial questionnaire, four new items were included, and the clinical scenarios of the intention subscale were expanded from three to six. Overall content validity index for the full instrument of 0.96 out of 1. The Paediatric Physical Restraint-Theory of Planned Behaviour Questionnaire is made up of four subscales (attitude, subjective norms (SN), perceived behavioural control (PBC), and intention) subdivided into 7 factors and 51 items. The internal consistency for the attitude subscale obtained a Cronbach's Alpha of 0.80 to 0.73, for the SN it was 0.72 to 0.89, for the PBC it was from 0.80 to 0.73 and for the intention subscale it was 0.75.
The Paediatric Physical Restraint-Theory of Planned Behaviour Questionnaire is an instrument composed of seven factors and 51 items that validly and reliably assesses the intention of paediatric nurses to apply PR in PICUs.
Having this instrument will help health centres move towards restraint-free care by allowing managers to assess professionals' attitudes, beliefs, and intentions around the use of PR in PICUs.
Transparent conducting films (TCFs) are made of different single-walled (SW) or multi-walled (MW) carbon nanotubes (CNTs), some of them previously modified by chemical or physical processes. The TCFs ...are prepared by spray-coating of CNT surfactant dispersions over glass substrates. Among pristine CNTs, laser-grown SWCNTs lead to the lowest resistivity, even though good results can be achieved with other selected SW or MWCNTs. Ultracentrifugation of the SWCNT dispersions can be utilized for improving the characteristic SWCNT spectroscopic signals. Controlled oxidation, acid treatment, and covalent functionalization with aromatic organic groups can be applied to CNT solid powders without substantially increasing the resulting TCF resistivity. The oxidative transformation of arc-discharge MWCNTs into graphene nanoribbons relatively improves their TCF performance. The positive effects of TCF washing with water or oxidant acids are quantified for various SWCNT types. Red and green inks, enriched in metallic or semiconducting SWCNTs, are obtained by the gel-chromatographic method, all the fractions being useful for the preparation of TCFs. Thus, it is shown that different physical and chemical processes can be performed on CNTs before or after their deposition, demonstrating a great chemical versatility for CNT-TCFs.
•Transparent conducting films are fabricated of eight carbon nanotube materials.•Carbon nanotubes for the films can bear many physicochemical transformations.•Certain nanotube electronic properties can vary without losing film conductivity.•Single-walled carbon nanotubes are sorted by the gel chromatography method.•Graphene nanoribbons are also tested.
Aims
To compare short-term outcomes after an episode of acute heart failure (AHF) in patients with reduced and preserved ejection fractions (HFrEF, < 40%; and HFpEF, > 49%; respectively) according to ...their destinations after emergency department (ED) care.
Methods and results
This secondary analysis of the EAHFE Registry (consecutive AHF patients diagnosed in 41 Spanish EDs) investigated 30-day all-cause mortality, in-hospital all-cause mortality, prolonged hospitalisation (> 7 days), and 30-day post-discharge ED revisit due to AHF, all-cause death, and combined endpoint (ED revisit/death) in 5829 patients with echocardiographically documented HFrEF and HfpEF (HFrEF/HFpEF: 1,442/4,387). Adjusted ratios were calculated for patients admitted to internal medicine (IM), short stay unit (SSU), and discharged from the ED without hospitalisation (DEDWH) and compared with those admitted to cardiology. For HFrEF, the only significant differences were lower in-hospital mortality (OR = 0.26; 95% CI 0.08–0.81;
p
= 0.021) and prolonged hospitalisation (OR = 0.07; 95% CI 0.04–0.13;
p
< 0.001) related to SSU admission. For HFpEF, IM admission had a higher post-discharge 30-day mortality (HR = 1.85; 95% CI 1.05–3.25;
p
= 0.033) and combined endpoint (HR = 1.24; 95% CI 1.01–1.64;
p
= 0.044); SSU admission had a lower in-hospital mortality (OR = 0.43; 95% CI 0.23–0.80;
p
= 0.008) and prolonged hospitalisation (OR = 0.17; 95% CI 0.13–0.23;
p
< 0.001) but a higher post-discharge 30-day combined endpoint (HR = 1.29; 95% CI 1.01–1.64;
p
= 0.041); and DEDDWH had a lower 30-day mortality (HR = 0.46; 95% CI 0.28–0.75;
p
= 0.002) but higher post-discharge ED revisit (HR = 1.62; 95% CI 1.31–2.00;
p
< 0.001).
Conclusion
While HFrEF patients have similar short-term outcomes irrespective of the destination after ED care for an AHF episode, HFpEF patients present worse short-term outcomes when managed by non-cardiology departments, despite adjustment for different clinical patient profiles. Reasons for this heterogeneous specialty-related performance should be investigated.
We report for the first time the use of single-walled carbon nanotubes (SWCNT) covalently functionalized with polytyrosine (Polytyr) (SWCNT-Polytyr) as a new electrode material for the development of ...nicotinamide adenine dinucleotide (NADH)-based biosensors. The oxidation of glassy carbon electrodes (GCE) modified with SWCNT-Polytyr at potentials high enough to oxidize the tyrosine residues have allowed the electrooxidation of NADH at low potentials due to the catalytic activity of the quinones generated from the primary oxidation of tyrosine without any additional redox mediator. The amperometric detection of NADH at 0.200V showed a sensitivity of (217±3)µAmM−1cm−2 and a detection limit of 7.9nM. The excellent electrocatalytic activity of SWCNT-Polytyr towards NADH oxidation has also made possible the development of a sensitive ethanol biosensor through the immobilization of alcohol dehydrogenase (ADH) via Nafion entrapment, with excellent analytical characteristics (sensitivity of (5.8±0.1)µAmM−1cm−2, detection limit of 0.67µM) and very successful application for the quantification of ethanol in different commercial beverages.
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•The oxidation of SWCNT-Polytyr generates surface quinone groups that facilitates the oxidation of NADH.•NADH is catalytically oxidized at GCE/SWCNT-Polytyr(oxidized).•GCE/SWCNT-Polytyr(oxidized) is a robust platform for further immobilization of ADH.•GCE/SWCNT-Polytyr(oxidized)//ADH/Naf allows the quantification of ethanol in alcoholic beverages.
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