Methods A cross-sectional observational study that included patients attending the allergy clinic with symptoms of rhinitis (34.18% male and 65.81% female, mean age 31-45 years). For demographic ...data, concomitant diseases and allergic symptoms, frequency tables were used for nominal variables.
Somatic human cells can divide a finite number of times, a phenomenon known as the Hayflick limit. It is based on the progressive erosion of the telomeric ends each time the cell completes a ...replicative cycle. Given this problem, researchers need cell lines that do not enter the senescence phase after a certain number of divisions. In this way, more lasting studies can be carried out over time and avoid the tedious work involved in performing cell passes to fresh media. However, some cells have a high replicative potential, such as embryonic stem cells and cancer cells. To accomplish this, these cells express the enzyme telomerase or activate the mechanisms of alternative telomere elongation, which favors the maintenance of the length of their stable telomeres. Researchers have been able to develop cell immortalization technology by studying the cellular and molecular bases of both mechanisms and the genes involved in the control of the cell cycle. Through it, cells with infinite replicative capacity are obtained. To obtain them, viral oncogenes/oncoproteins, myc genes, ectopic expression of telomerase, and the manipulation of genes that regulate the cell cycle, such as p53 and Rb, have been used.
Rationale A nasal allergen provocation test (NAPT) is performed to confirm the diagnosis of allergic rhinitis to house dust mite, in the situation of discrepancy between the symptoms and the results ...of skin prick test (SPT) and/or serum specific immunoglobulin E. In Cuba, sensitization to house dust mites (Dermatophagoides pteronyssinus (Dp), Dermatophagoides siboney and Blomia tropicalis) is a major cause of allergic rhinitis. Conclusions Nasal allergen provocation test with the Dermatophagoides pteronyssinus is effective and safety by the diagnosis of allergic rhinitis to this mite.
La alergia al veneno de abejas provoca reacciones de leves a severas con compromiso para la vida. La inmunoterapia con veneno de himenópteros es un tratamiento eficaz y protege a los pacientes ...alérgicos de sufrir reacciones sistémicas ante nuevas picaduras. Nos propusimos caracterizar los pacientes alérgicos a picaduras de abeja que reciben inmunoterapia. Se realizó un estudio observacional descriptivo de corte longitudinal en pacientes alérgicos a las picaduras de abeja tratados con inmunoterapia de extracto de abeja en el Hospital Universitario “General Calixto García” de La Habana, Cuba. La muestra fue de 17 pacientes que cumplieron los criterios de inclusión. Usamos técnicas de estadística descriptiva: promedio, probabilidad y puntaje estandarizado, así como técnicas de estadística inferencial tales como Chi cuadrado, verificando asociación significativa entre las variables; el nivel de significación empleado fue del 5% (p˂0,05). La tercera década de la vida fue la edad promedio de los pacientes. Se observó predominio del sexo masculino y residencia en zona urbana. Alrededor de la mitad de los pacientes tenían rinitis y antecedentes familiares de asma. Todos los pacientes tuvieron reacciones locales, la mayoría se re-expusieron a la picadura; de ellos, solo el 20% presentaron reacciones alérgicas sistémicas después de la inmunoterapia. Se concluye que la reactividad cutánea al extracto de abeja se redujo con el tratamiento de inmunoterapia.
Las enfermedades alérgicas van en aumento importante en todo el mundo. La rinitis alérgica es una enfermedad inflamatoria crónica de la mucosa nasal IgE mediada, alérgeno-específica con participación ...de diversas células. Nos propusimos caracterizar la rinitis alérgica en pacientes atendidos en el Hospital Universitario “General Calixto García”. Se realizó un estudio observacional descriptivo de corte transversal, no aleatorizado, entre octubre 2016 y octubre 2017. En una muestra de 100 pacientes que cumplieron los criterios de inclusión, se realizó historia clínica alergológica empleando variables como: edad, sexo, antecedentes patológicos personales y familiares, procedencia, manifestaciones clínicas, y prueba cutánea por punción. Predominó el sexo femenino entre 30 y 39 años de edad, de área urbana, antecedentes patológicos familiares y personales de asma y conjuntivitis. La rinitis intermitente leve prevaleció en nuestro estudio, así como la sensibilidad a Dermatophagoides pteronyssinus. La tercera década de la vida fue la edad promedio de los pacientes. Se concluye que los pacientes presentaron una alta sensibilidad a Dermatophagoides pteronyssinus. La rinitis persistente leve, con la mitad de los casos, obtuvo mayor predominio por la duración de los síntomas.
Background: acquired immunodeficiency syndrome (AIDS) is the final stage in human immunodeficiency virus (HIV) infection. Knowing the immune status of the patients infected with the virus permits a ...better treatment.Objective: to characterize immunological variables in patients with HIV/AIDS of the municipality Regla, Havana, Cuba, in 2018.Methods: an observational, descriptive, retrospective study was carried out at the aforementioned place and during the period herein declared. A sample of 143 patients of both sexes and older than 15 years was deliberately made up. The following variables were assessed: age, sex, CD4 T-lymphocyte count, viral load, time between lab tests. The information was totally gathered from the patients’ medical records.Results: there was a higher incidence of patients aged 35 to 44 years (28,7 %), 25-34 years (24,5 %) and 15-24 years (23,1 %), in that order. The male sex prevailed with 81,8 % of the cases. The CD4 T-lymphocyte count was higher than 500 cells/mL3 in 39,2 % of the patients. Those with viral load with less than 1000 copies/mL3 predominated, 49,7 %; 10 patients did not show control of the viral load.Conclusions: immunological variables were characterized in these patients, with a predominance of the male sex, they were not upset.
A nivel mundial, los aeroalérgenos más frecuentes causantes de enfermedades alérgicas son los granos de polen anemófilos. Estos han sido capaces de desencadenar crisis que han reflejado una elevada ...morbilidad. En Cuba los estudios de sensibilización a granos de polen han sido escasos. Con el objetivo de determinar la sensibilización a granos de polen en pacientes alérgicos y su relación con la presencia de enfermedades alérgicas, se realizó un estudio observacional descriptivo de corte transversal, no aleatorizado, de marzo a junio del 2019. La muestra se constituyó de 33 pacientes con asma, rinitis, rinoconjuntivitis alérgica, dermatitis atópica y conjuntivitis alérgica. A todos los pacientes se les realizó historia clínica alergológica y prueba cutánea por punción con extractos alergénicos de: Helianthus annus, Cosmos bipinnatus, Cynodon dactylon, Quercus sp, Eucaliptus sp. Se aplicaron las frecuencias absolutas, porcientos, desviación estándar, promedio, edad media y test de Spearman para su análisis. La edad media de la muestra fue de 36,9 años, con predominio de mujeres. Más del 50% de los pacientes presentaron sensibilización a granos de polen; y de ellos, el 24,24% resultaron polisensibilizados. El mayor porcentaje de sensibilización fue a Cynodon dactylon. La rinitis alérgica fue la enfermedad que prevaleció en la población estudiada.
Introduction: The brain derived neurotrophic factor is a neurotrophin modulator of cognitive processes. Current studies in Alzheimer’s disease patients show alterations in biomarkers at outlying ...levels. Objective: To analyze the association between the serum brain-derived neurotrophic factor levels and the cognitive markers in Alzheimer’s disease subjects. Material and Methods: A correlational transversal study was conducted in subjects aged 64 years, distributed into three groups: group 1ː16 controls, group 2ː27 with mild cognitive impairment, and group 3ː21 with Alzheimer’s disease. A neuropsychological test battery, and the immunoenzymatic method (ELISA), Promega Emax Kit were applied to determine the serum brain-derived neurotrophic factor levels. The statistical analysis of data was performed using the one-way ANOVA test, the post-hoc Dunnett´s test and the Pearson’s correlation coefficient (p<0.05). Results: The serum brain-derived neurotrophic factor levels were lower in the groups with Alzheimer’s disease and mild cognitive impairment. The factor levels were correlated with the episodic memory, the executive functions, and the global cognitive function in Alzheimer’s disease patients. In the mild cognitive impairment group, the serum brain-derived neurotrophic factor was only associated with the executive functionl. Conclusions: The serum brain-derived neurotrophic factor levels diminish in association with cognitive impairment in Alzheimer’s disease. Furthermore, this factor linked to the executive domain dysfunction is suggested as a potential biomarker of neuroplasticity in the preclinical detection of this pathology.
Background: the quality system is defined as a set of policies, objectives, processes, documents and resources that lead to quality assurance, not only of the product but of the organization as a ...whole, seeking the maximum satisfaction of the clients or the users. Objective: to spread theoretical elements on the importance of the implementation of a management system to ensure quality in teaching, research and medical assistance. Methods: with the descriptors health quality and quality management system, a bibliographic search was carried out in the access platforms to databases of the Cuban health information network Infomed, within them in EBSCOhost, PubMed/Medline and SciELO, and a documents’ review of the normative bases that establish the requirements to be met for the implementation of the system. Development: it is addressed the importance of the implementation of a Quality Management System at the University of Medical Sciences and the many advantages it offers; the most indicated are a greater optimization of resources, and improvement of internal communication and the external image of the organization. Conclusions: the system of evaluation and accreditation of university institutions and programs is the driving force of the University Quality Management, demonstrating the importance of implementing a quality management system in the medical university to achieve superior results in the process of training and development of health professionals. DeCS:QUALITY MANAGEMENT; UNIVERSITIES; HEALTH FACILITY ACCREDITATION; EDUCATIONAL PERSONNEL; PROGRAMS OF STUDY.
PDF
