The 2016 revision of the
mandates codeletion of chromosomes 1p and 19q for the diagnosis of oligodendroglioma. We studied whether conventional MR imaging features could predict 1p/19q status.
...Patients with previous 1p/19q testing were identified through pathology department records, typically performed on the basis of an oligodendroglial component on routine histology; 69 patients met the inclusion criteria. Preoperative imaging of patients with grade II or III gliomas was retrospectively assessed by 2 neuroradiologists, blinded to the 1p/19q status. Thirteen MR imaging features were first assessed in a small initial cohort (
= 10), after which the criteria were narrowed for the remaining patients as a validation cohort.
There was 85% agreement between radiologists for the overall prediction of 1p/19q status in the validation cohort, with an accuracy of 84%. The presence of >50% T2-FLAIR mismatch and calcification was found to be the most useful for predicting 1p/19q status. The >50% T2-FLAIR mismatch variable was demonstrated in 14 tumors and had 100% specificity for identifying a noncodeleted tumor (
= .001), with 97% interobserver correlation. Calcification was visualized in 7 tumors, 6 of which were 1p/19q codeleted (specificity, 97%;
= .006), with 100% interobserver correlation.
The presence of >50% T2-FLAIR mismatch is highly predictive of a noncodeleted tumor, while calcifications suggest a 1p/19q codeleted tumor. If formal 1p/19q testing is not possible, a combined MR imaging-histologic assessment may improve the diagnostic accuracy over histology alone.
Summary
Background
Crohn's disease recurs in the majority of patients after intestinal resection.
Aim
To compare the relative efficacy of thiopurines and anti‐TNF therapy in patients at high risk of ...disease recurrence.
Methods
As part of a larger study comparing post‐operative management strategies, patients at high risk of recurrence (smoker, perforating disease, ≥2nd operation) were treated after resection of all macroscopic disease with 3 months metronidazole together with either azathioprine 2 mg/kg/day or mercaptopurine 1.5 mg/kg/day. Thiopurine‐intolerant patients received adalimumab induction then 40 mg fortnightly. Patients underwent colonoscopy at 6 months with endoscopic recurrence assessed blind to treatment.
Results
A total of 101 patients 50% male; median (IQR) age 36 (25–46) years were included. There were no differences in disease history between thiopurine‐ and adalimumab‐treated patients. Fifteen patients withdrew prior to 6 months, five due to symptom recurrence (of whom four were colonoscoped). Endoscopic recurrence (Rutgeerts score i2–i4) occurred in 33 of 73 (45%) thiopurine vs. 6 of 28 (21%) adalimumab‐treated patients intention‐to‐treat (ITT); P = 0.028 or 24 of 62 (39%) vs. 3 of 24 (13%) respectively per‐protocol analysis (PPA); P = 0.020. Complete mucosal endoscopic normality (Rutgeerts i0) occurred in 17/73 (23%) vs. 15/28 (54%) (ITT; P = 0.003) and in 27% vs. 63% (PPA; P = 0.002). The most advanced disease (Rutgeerts i3 and i4) occurred in 8% vs. 4% (thiopurine vs. adalimumab).
Conclusions
In Crohn's disease patients at high risk of post‐operative recurrence adalimumab is superior to thiopurines in preventing early disease recurrence.
Abstract
The article assumes that in the Sverdlovsk region, breeding bulls of the Holstein breed with high efficiency according to their maternal ancestors were used on the breeding stock of the ...black-mottled breed of the Ural spawn. Animals of this type are of high efficiency. The efficiency evaluation of Ural type cows is urgent. The aim of the work is to evaluate the efficiency of the new genotype cows in terms of their milk yield qualities. It has been found that dairy cows show high milk yields. In accordance with physiological laws, they increase until the fourth lactation, and then gradually go down. The first insemination of replacement heifers on the farm is carried out at the age of 18-19 months with a live weight of over 400 kg. This makes it possible to breed healthy strong animals capable of breeding for a long time and having high milk yield. The maximum milk yield is from 21 kg to 1986 kg (from 0.2% to 35.3%); it is more than the actual one. The farm has reserves for increasing milk yield due to measures for the milk efficiency of the first-year heifers and other cows. It will significantly increase the milk yield in the third and further lactation. The authors calculated the life-long milk yield. It turned out that in fact, 84,450 kg of milk can be obtained from a dairy cow during 10 lactations. The efficiency potential of lifetime productivity, based on the maximum milk yield per lactation, was 7077 kg or 8.4% higher. The predicted potential shows that 104 101 kg of milk can be obtained from a dairy cow during 11 lactations. The efficiency fluctuations by lactation are significant; and from the first to the 5th lactation they exceed 150% of the minimum milk yield of dairy cows to the maximum in the same lactation. So, it is possible to make a conclusion about the great changeability of this feature in the herd and the great possibilities of selection at carrying out selection and breeding work on the farm.
Background
Patients presenting with emergency surgical conditions place significant demands on healthcare services globally. The need to improve emergency surgical care has led to establishment of ...consultant‐led emergency surgery units. The aim of this study was to determine the effect of a changed model of service on outcomes.
Methods
A retrospective observational study of all consecutive emergency general surgical admissions in 2009–2012 was performed. A 2‐year time frame before and after the establishment of the emergency general surgery (EGS) service was used to determine the number of admissions and operations, emergency department and hospital length of stay, as well as complication rates.
Results
The study included 7233 acute admissions. The EGS service managed 4468 patients (61·6 per cent increase) and performed 1804 operations (41·0 per cent increase). The most common diagnoses during the EGS period included acute appendicitis (532, 11·9 per cent), biliary disease (361, 8·1 per cent) and abdominal pain (561, 12·6 per cent). Appendicectomy (536, 29·7 per cent), cholecystectomy (239, 13·2 per cent) and laparotomy (226, 12·5 per cent) were the most commonly performed procedures. In the EGS period, time in the emergency department was reduced (from 8·0 to 6·0 h; P < 0·001), as was length of hospital stay (from 3·0 to 2·0 days; P < 0·001). The number of complications was reduced by 46·8 per cent, from 172 (6·2 per cent) to 147 (3·3 per cent) (P < 0·001), with a 53 per cent reduction in the number of deaths in the EGS period, from 29 (16·9 per cent) to seven (8 per cent) (P = 0·039).
Conclusion
The establishment of a consultant‐led emergency surgical service has been associated with improved provision of care, resulting in timely management and improved clinical outcomes.
Improvements with new service
Photochromic hybrid compounds based on coumarins with reversible fluorescence modulation have been synthesized for the first time. It was shown that UV irradiation leads to spectral and fluorescent ...changes due to the structure of the compounds.
Abstract
For insemination of cattle’s broodstock, the bulls’ seed is used, both domestic and foreign selection, that is, the increase in blood count of received heifers for the Holstein breed ...continues. The growth of animals, despite general growth patterns, is influenced by many factors, including their origin. The research aim is to assess weight growth characteristics of replacement heifers, depending on their origin, namely the father – the servicing bull. It was found that the difference in live weight at birth between heifers of different seed bulls was insignificant and amounted to 1.4 kg or 4.7%. The highest live weight at 18 months of age had heifers from the Sayan bull – 425.3 kg, slightly 3.6-5.3 kg inferior to them were the heifers from the Cassio and Mers bulls. Heifers grew unevenly over the periods. The uneven growth of heifers of different seed bulls, although it has a general pattern, but differs in groups. If in the period from 6 to 12 months of age there is a decrease in absolute growth in all groups, then already in the next period we can note the peculiarities in absolute growth change. So, the absolute growth of the heifers from the Das bull remained at the same level; the absolute growth of the heifers from the Sayan, De-Su, Tuareg, Cassio bulls continued to decline, and the absolute growth of the heifers from the seed bulls Havano, Mers and Bentley increased. On average, for the entire growing period, it ranged from 21.0 to 22.0 kg per month. Thus, the culture system of replacement heifers on the farm allows to get good results. The age of the first heifers’ insemination, depending on belonging to the seed bull, ranges from 14.3 to 16.9 months, which allows us to speak about using early terms of the first heifers’ insemination. The live weight at the time of the first insemination meets the requirements.
The Ural type of the domestic black-and-white breed is distinguished by high productivity indicators, good suitability for use in the conditions of industrial milk technology. To obtain modern dairy ...cattle, related breeds were used in the herds, a significant number of animals obtained as a result of closely related breeding were revealed. the study of the influence of the degree of inbreeding on the growth and development of repair young is relevant and has practical significance. It was found that the live weight of heifers in all accounting periods practically did not differ, that is, it can be said that the method of obtaining heifers using unrelated or related selection did not affect the dynamics of live weight during their cultivation. The average daily gains in live weight differed slightly by growth periods and by groups. So they were higher in the periods from the first to the first fruitful insemination and from 10 to 12 months, lower gains were noted in the period from the moment of fruitful insemination to 18 months of age. The highest milk yield for lactation was obtained from the first heifers with a remote degree of inbreeding.
Summary
The study aimed to explore determinants of bone parameters in young women. Most bone parameters were associated with height and lean mass. Bone parameters were not associated with vitamin D ...status. Future research should address whether interventions aimed at improving lean mass are beneficial to bone health in young women.
Introduction
The implementation of prevention strategies during young adulthood may be crucial for osteoporosis prevention in later life, yet literature examining the determinants of bone health in premenopausal women is limited. We aimed to assess determinants of bone health, including serum 25-hydroxyvitamin D (25OHD), in females aged 16–25 years, living in Victoria, Australia, recruited through Facebook advertising.
Methods
Serum 25OHD was measured by liquid chromatography-tandem mass spectrometry and bone health was measured using dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) in 326 participants.
Results
Mean (± standard deviation) serum 25OHD was 69 ± 28 nmol/L and the prevalence of vitamin D deficiency (serum 25OHD <50 nmol/L) was 26%. Seven percent of participants (
n
= 23) reported taking a vitamin D supplement. Two percent of participants had low lumbar spine bone mineral density (Z-score <−2.0), 5% at the hip and 7% at the femoral neck. Serum 25OHD levels were not associated with DXA bone parameters, nor with pQCT bone parameters. Most bone parameters were positively associated with height and lean mass.
Conclusion
Vitamin D status was not associated with bone health in young women in the current study. Our findings suggest that targeting other modifiable factors, such as lean body mass, is likely to be beneficial to bone health in young women. Longitudinal studies examining the association between vitamin D status and bone health in young women are necessary to confirm our findings. In addition, whether raising 25OHD levels is advantageous for young women’s bone health is yet to be determined.
The parent flock is updated by the introduction of the hatching egg or day-old chicks from the producing country. Renewal of the parent flock through the delivery of daily chickens reduces the stress ...resistance of this category of bird, which has a negative role in the morphophysiological status and growth of chickens. In the blood of two linear chickens (group I), the number of red blood cells was 3.25± 0.06 1012/l, hemoglobin 67.61 ± 2.49 g/l; Group II, the number of red blood cells in the peripheral blood was 3.80 ± 0.06 1012/l, hemoglobin 83.91±1.86 g/l. The red blood cells and erythropoiesis organs in the body of chickens obtained at the poultry farm (group II) were highly reactive, which allowed the body to quickly compensate for the lack of oxygen and metabolic substrates, and thereby restore the state of homeostasis. In chickens imported from Germany, the reactivity of the blood-forming organs was reduced, which was a consequence not so much of the linearity of the cross, but of the presence of transportation at the age of 1 day. Four linear chickens for the repair of an industrial herd grew better and more intensively. On day 40 they had a live weight of 85 g or 19.4% more than two-line chickens subjected to transport stress in the first days of life. Therefore, they reliably exceeded their peers from the first series in the indicator and other growth indicators (p≤0.01). The safety indicator in the first 5 days was higher in the group of four-line hybrids (repair young stock of the industrial herd) by 19.7%. Chickens from Germany had a low safety rate of only 66.7.
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