The quantum clustering (QC) algorithm suffers from the issues of getting stuck in local extremes and computational bottleneck when handling large-size image segmentation. By embedding a potential ...evolution formula into affinity function calculation of multi-elitist immune clonal optimization, and updating the cluster center based on the distance matrix, the multi-elitist immune clonal quantum clustering algorithm (ME-ICQC) is proposed in this paper. In the proposed framework, elitist population is composed of the individuals with high affinity, which is considered to play dominant roles in the evolutionary process. It can help to find the global optimal solution or near-optimal solution for most tested tasks. The diversity of population can be well maintained by general subgroup evolution of ME-ICQC. These different functions are implemented by the dissimilar mutation strategies or crossover operators. The bi-group exchanges the information of excellence antibodies using the hypercube co-evolution operation. Compared with existing algorithms, the ME-ICQC achieves an improved clustering accuracy with more stable convergence, but it is not significantly better than other optimization techniques combined with QC. Also, the experimental results also show that our algorithm performs well on multi-class, parameters-sensitive and large-size datasets.
Abstract Background: Glucagon-like peptide-1 (GLP-1) receptor agonists are a new class of hypoglycemic drugs, including exenatide, liraglutide, albiglutide, lixisenatide, and taspoglutide. Insulin ...glargine is a standard agent used to supplement basal insulin in type 2 diabetes mellitus (T2DM). Objective: The aim of this study was to review the efficacy and safety profiles of GLP-1 receptor agonists versus insulin glargine in type 2 diabetic patients who have not achieved treatment goals with oral hypoglycemic agents. Methods: The Cochrane Library, MEDLINE, EMBASE, Science Citation Index Expanded, and the database of ongoing trials were searched from inception through April 2010. Additional data were sought from relevant Web sites, the American Diabetes Association, reference lists of included trials and related (systematic) reviews, and industry. Randomized controlled trials (RCTs) were selected if they were ≥3 months in duration, compared GLP-1 receptor agonists with insulin glargine in patients with T2DM, and included ≥1 of the following outcomes: mortality, complications of T2DM, glycemie control, weight, lipids, blood pressure, adverse effects, and health-related quality of life. Quasirandomized controlled trials were excluded. The quality of the eligible studies was assessed on the basis of the following aspects: randomization procedure, allocation concealment, blinding, incomplete outcome data (intent-to-treat ITT analysis), selective outcome reporting, and publication bias. Results: A total of 410 citations were retrieved; 5 multicenter RCTs that met the inclusion criteria were identified. They were all open-label designs with an insulin glargine arm, predefined outcomes reported, and ITT analysis. One trial had an unclear randomization procedure and allocation concealment. Publication bias was not able to be determined. No data wete found with regard to mortality or diabetes-associated complications, and few data were found on quality of life. The results of the metaanalysis suggest that insulin glargine was significantly better in reducing the fasting blood glucose (mean difference MD 95% CI, 1.31 1.04 to 1.58; P < 0.001), but exhibits greater incidence of nocturnal hypoglycemia (risk ratio RR 95% CI, 0.40 0.23 to 0.71; P = 0.002) and influenza (RR 95% CI, 0.56 0.32 to 0.98; P = 0.04). GLP-1 receptor agonists are more conducive to reducing weight (MD 95% CI, −3.96 −5.14 to -2.77; P < 0.001), postprandial blood glucose (after breakfast, P < 0.001; after dinner, P < 0.001), and LDL-C (MD 95% CI, −0.18 −0.28 to −0.08; P < 0.001), but have significantly more gastrointestinal adverse effects (eg, nausea/ vomiting, P < 0.001). There were no significant differences between GLP-1 receptor agonists and insulin glargine in reducing glycosylated hemoglobin (HbA1c ) levels (MD 95% CI, −0.03 −0.13 to 0.08) and the overall incidence of hypoglycemia (RR 95% CI, 0.69 0.42 to 1.14). Conclusions: Compared with insulin glargine, GLP-1 receptor agonists did not have a significant difference in regard to reducing HbA1c levels and they were significantly associated with decreased weight but increased gastrointestinal adverse events. It remains unclear whether GLP-1 receptor agonists influence mortality or diabetes-associated complications in patients with T2DM. More trials with longer follow-up are needed to determine the exact long-term efficacy and safety profiles of this new class of hypoglycemic drugs.
The objective of this study was to investigate the prognostic value of preoperative mean platelet volume to plateletcrit (MPV/PCT) ratio in patients with osteosarcoma.
The retrospective study ...included 188 consecutive osteosarcoma patients who experienced neoadjuvant chemotherapy and surgical resection of tumor. The relationships between MPV/PCT and clinicopathological characteristics were analyzed. The Kaplan-Meier analysis and Cox regression proportional hazard model were applied to assess the prognostic value of MPV/PCT ratio.
MPV/PCT ratio was found to be significantly associated with platelet count, platelet distribution width, and PCT (all
<0.001). Kaplan-Meier analysis showed that high MPV/PCT ratio (≥43.58) was associated with a prolonged disease-free survival (DFS,
=0.035). The multivariate Cox revealed that only good chemotherapy response was an independent predictor of better DFS in the overall population. However, the stratification analysis showed that a high MPV/PCT ratio (≥43.58) was indicated as an independent prognostic factor for a favorable DFS (HR =0.137, 95%CI =0.029-0.644,
=0.012) in the male osteosarcoma patients but not in female patients.
The high preoperative MPV/PCT ratio may serve as an independent prognostic factor for a favorable prognosis in male osteosarcoma patients. Further studies are needed to confirm the findings.
A
bstract
A study of the polarisation and CP properties in
ZZ
production is presented. The used data set corresponds to an integrated luminosity of 140 fb
−
1
of proton-proton collisions at a ...centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the Large Hadron Collider. The
ZZ
candidate events are reconstructed using two same-flavour opposite-charge electron or muon pairs. The production of two longitudinally polarised
Z
bosons is measured with a significance of 4.3 standard deviations, and its cross-section is measured in a fiducial phase space to be 2.45 ± 0.60 fb, consistent with the next-to-leading-order Standard Model prediction. The inclusive differential cross-section as a function of a CP-sensitive angular observable is also measured. The results are used to constrain anomalous CP-odd neutral triple gauge couplings.
In 2017, the document No.1 of the Central Committee of the CPC explicitly proposed the construction of modernization irrigation district, the large-scale of modernization irrigation district is an ...important link to achieve the modernization of water conservancy and realize the socialist modernization. In the new era this paper expounded the connotation and characteristic of modernization irrigation district, put forward "safe"," Sound "," advanced "," efficient "and" green "modernization irrigation district, and established the evaluation system of 5 first level indexes and 23 second level indexes.The threshold value of the evaluation index of the modernization irrigation district in 2035 was discussed. Binary fuzzy comparative analysis was used to determine the weight of indexes, and the degree of modernization irrigation district was divided into four levels, which provide a reference for the evaluation of the modernization of large-scale irrigation district.
A new facility to study plasmas interacting with flowing liquid lithium surface was designed and is constructing in Sichuan University. The integrated setup includes the liquid lithium circulating ...part and linear high density plasma generator. The circulating part is consisted of main loop, on-line monitor system, lithium purification system and temperature programmed desorption system. In our group a linear high density plasma generator was built in 2012. Three coils were mounted along the vessel to produce an axial magnetic field inside. The magnetic field strength is up to 0.45T and work continuously. Experiments on plasmas interacting with free flowing liquid lithium surface will be performed.
Abstract Spinal muscular atrophy (SMA) is a motoneuron disorder characterized by deletions or specific mutations in the Survival Motor Neuron gene ( SMN ). SMN is ubiquitously expressed and has a ...general role in the assembly of small nuclear ribonucleoprotein (snRNP) and pre-mRNA splicing requirements. However, in motoneuron axons SMN deficiency results in inappropriate levels of certain transcripts in the distal axon, suggesting that the specific susceptibility of motoneurons to SMN deficiency is related to a specialized function in these cells. Although mouse models of SMA have been generated and are useful for in vivo and in vitro studies, the limited number of isolated MNs that could be obtained from them makes it difficult to perform biochemical, genetic and pharmacological approaches. We describe here an in vitro model of isolated embryonic mouse motoneurons in which the cellular levels of endogenous SMN are reduced. These cells show neurite degeneration and cell death after several days of SMN knockdown. We found that the over-expression of the anti-apoptotic protein Bcl-xL into motoneurons rescues these cells from the phenotypic changes observed. This result demonstrates that Bcl-xL signaling could be a possible pharmacological target of SMA therapeutics.
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