The Tunka-Grande experiment Monkhoev, R.D.; Budnev, N.M.; Chiavassa, A. ...
Journal of instrumentation,
06/2017, Letnik:
12, Številka:
6
Journal Article
Recenzirano
The investigation of energy spectrum and mass composition of primary cosmic rays in the energy range 1016–1018 eV and the search for diffuse cosmic gamma rays are of the great interest for ...understanding mechanisms and nature of high-energy particle sources, the problem of great importance in modern astrophysics. Tunka-Grande scintillator array is a part of the experimental complex TAIGA (Tunka Advanced Instrument for Cosmic Ray and Gamma Astronomy) which is located in the Tunka Valley, about 50 km from Lake Baikal. The purpose of this array is the study of diffuse gamma rays and cosmic rays of ultra-high energies by detecting extensive air showers. We describe the design, specifications of the read-out, data acquisition (DAQ) and control systems of the array.
The Cherenkov light array for the registration of extensive air showers (EAS) Tunka-133 collected data during 5 winter seasons from 2009 to 2014. The differential energy spectrum of all particles and ...the dependence of the average maximum depth on the energy in the range of 6 ⋅ 1015–1018 eV measured for 1540 hours of observation are presented.
Background: The aim of this study was to evaluate the degree of agreement among endosonographers for EUS diagnosis of neoplastic versus non-neoplastic pancreatic cystic lesions and the specific type ...of cystic lesion. Methods: Videotapes of EUS procedures from 31 consecutive cases of a range of histopathologically proven lesions, including mucinous cystic neoplasm, serous cystadenoma, neuroendocrine tumor, intraductal papillary mucinous tumor, and pseudocyst, were used to make a study videotape, which was reviewed by 8 experienced endosonographers. The reviewers, blinded to clinical and surgical histopathology results, reviewed each case for the presence or absence of the following features: abnormality of pancreatic duct and parenchyma, margins, solid component, debris, and septations. They were asked to identify each lesion as neoplastic or non-neoplastic and to give a specific diagnosis for each lesion. Results: There was fair agreement between endosonographers for diagnosis of neoplastic versus non-neoplastic lesions (κ = 0.24). Agreement for individual types of lesions was moderately good for serous cystadenomas (κ = 0.46) but fair for the remainder. Agreement was moderately good for presence or absence of solid component (κ = 0.43); fair for presence or absence of abnormal pancreatic duct (κ = 0.29), debris (κ = 0.21), and septations (κ = 0.30); and slight for presence or absence of margins (κ = 0.01) and abnormal pancreatic parenchyma (κ = 0.01). Accuracy rates of EUS for the diagnosis of neoplastic versus non-neoplastic lesions ranged from 40% to 93%. Conclusions: There is little more than chance interobserver agreement among experienced endosonographers for diagnosis of neoplastic versus non-neoplastic, specific type, and EUS features of pancreatic cystic lesions. (Gastrointest Endosc 2003;58:59-64.)
Status of the Baikal-GVD project Avrorin, A.V.; Aynutdinov, V.M.; Bannasch, R. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
11/2012, Letnik:
692
Journal Article
Recenzirano
Odprti dostop
The construction of a km3-scale neutrino telescope – the Gigaton Volume Detector (GVD) in Lake Baikal – is the central goal of the Baikal collaboration. During the R&D phase of the GVD project in ...2008–2010 years the basic elements of GVD – new optical modules, FADC readout units, underwater communications and trigger systems – have been developed, produced and tested in situ by long-term operating prototype strings in Lake Baikal. The prototyping phase of the GVD project has been started in April 2011 with the installation of a three string array (prototype cluster) which comprises all basic elements and systems of the GVD-telescope in Lake Baikal. We describe configuration and technical design of the GVD, present selected results obtained during 2008–2010 with prototype strings, and describe configuration and design of the 2011 prototype cluster.
Rapid recovery of CD4+ T cells after intensive chemotherapy is limited by an age-dependent decline in thymopoiesis. Here we sought to determine whether similar limitations exist for CD8+ T-cell ...regeneration. After intensive chemotherapy, CD8+ T cells had a faster effective doubling time than CD4+ T cells (median, 12.6 v 28.2 days, P < .05). Accordingly, at 3 months posttherapy, mean CD8+ T-cell number had returned to baseline, whereas mean CD4+ T-cell number was only 35% of pretherapy values (P < .05). These differences were primarily due to very rapid expansion of CD8+CD57+ and CD8+CD28- subsets. At 3 months posttherapy, there was no relationship between age and CD8+ T-cell number (R = -.02), whereas CD4+ T-cell number was inversely related to age (R = -.66) and there were no discernible differences in CD8+ recovery among patients with or without thymic enlargement, whereas CD4+ recovery was enhanced in patients with thymic enlargement after chemotherapy (P < .01). Therefore thymic-independent pathways of T-cell regeneration appear to rapidly regenerate substantial numbers of CD8+, but not CD4+ T cells, resulting in prolonged T-cell subset imbalance after T-cell depletion. These inherent distinctions between CD4+ v CD8+ T-cell regeneration may have significant implications for immunotherapeutic strategies undertaken to eradicate minimal residual neoplastic disease after cytoreductive chemotherapy.
ABSTRACT
The existence of high-energy astrophysical neutrinos has been unambiguously demonstrated, but their sources remain elusive. IceCube reported an association of a 290-TeV neutrino with a ...gamma-ray flare of TXS 0506 + 056, an active galactic nucleus with a compact radio jet pointing to us. Later, radio-bright blazars were shown to be associated with IceCube neutrino events with high statistical significance. These associations remained unconfirmed with the data of independent experiments. Here, we report on the detection of a rare neutrino event with the estimated energy of 224 ± 75 TeV from the direction of TXS 0506 + 056 by the new Baikal Gigaton Volume Detector (Baikal-GVD) in April 2021. This event is the highest energy cascade detected so far by the Baikal-GVD neutrino telescope from a direction below horizon. The result supports previous suggestions that radio blazars in general, and TXS 0506 + 056 in particular, are the sources of high-energy neutrinos, and opens up the cascade channel for the neutrino astronomy.
The more correct recalculation from the measured Cherenkov light fluxes at distances of 200 (Q200) and 100 (Q100) m from the Extensive Air Shower (EAS) core to the energy of the primary particle has ...been developed using the results of M-C simulation by the CORSIKA code, assuming a light primary composition of cosmic rays. Using the new conversion expressions, a differential energy spectrum was obtained according to the data of the Tunka-133 array for 7 years of operation and the TAIGA-HiSCORE array for 2 years of operation.
An analysis is performed of the spectrum of gamma rays from the Crab Nebula in the 4–100 TeV range of energies, obtained using data from two Atmospheric Cherenkov Telescopes that are part of the ...TAIGA complex. A way of selecting and restoring the energy of gamma rays is described that includes a procedure for restoring the energy spectrum.
Main Results from the TUNKA-GRANDE Experiment Monkhoev, R. D.; Astapov, I. I.; Bezyazeekov, P. A. ...
Bulletin of the Russian Academy of Sciences. Physics,
07/2023, Letnik:
87, Številka:
7
Journal Article
Recenzirano
The Tunka-Grande scintillation array is described. Scientific results obtained over the first five years of its operation are presented. Prospects for studying cosmic rays in the 10
16
–10
18
eV ...range of energies are discussed.
Recently we have observed an increased incidence of opportunistic infections in patients treated with intensive chemotherapy for cancer. Because T-cell depletion is associated with similar clinical ...events in human immunodeficiency virus infection and after bone marrow transplantation, we have analyzed peripheral blood lymphocyte populations in a series of patients during treatment with intensive chemotherapy for cancer. Although neutrophil, monocyte, and platelet numbers consistently recovered to greater than 50% of pretreatment values after each sequential cycle of therapy, lymphocyte numbers did not recover within the same time period. B cells decreased rapidly from a mean value of 149 ± 46/mm3 before chemotherapy to 4 ± 1/mm3 during chemotherapy (P = .011. CD4+ T cells decreased from a mean of 588 ± 76/mm3 before chemotherapy to 105 ± 28/mm3 during chemotherapy (P= .0002) and CD8+ T cells decreased from a mean of 382 ± 41/mm3 before chemotherapy to 150 ± 46/mm3 during chemotherapy (P = .0009). Natural killer cell numbers did not show significant declines (171 ± 30/ mm3 before, 114 ± 24/mm3 during, P = .19). Based on the history of opportunistic complications in patients with other disorders who display similar degrees of CD4+ T-cell lymphopenia and preliminary observations in this population, immune incompetence could surface as a dose-limiting toxicity for highly dose-intensive chemotherapy regimens.
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