Active search for candidate genes whose polymorphisms are associated with human cognitive functions has been in progress in the past years. The study focused on the role that the insulin-like growth ...factor II (
IGF2
) gene may play in the variation of cognitive processes related to executive functions. The
ApaI
polymorphism of the
IGF2
gene was tested for association with selective attention during visual search, working memory/mental control, and semantic verbal fluency in a group of 182 healthy individuals. The
ApaI
polymorphism was associated with the general cognitive index and selective attention measure. Carriers of genotype AA displayed higher values of the two parameters than carriers of genotype GG. It was assumed that the
ApaI
polymorphism of the
IGF2
gene influences the human cognitive functions, acting possibly via modulation of the IGF-II level in the central nervous system.
Electron and hole transport mechanisms in amorphous silicon oxide, silicon nitride, and aluminum oxide, dielectric materials of high relevance to silicon device technology, are reviewed. It is ...established that the widely accepted Frenkel model provides a formal description of transport in trap-containing insulators, but nonphysical model parameters must be introduced in order to obtain quantitative agreement. It is shown that the multiphonon model of trap ionization consistently describes charge transport in insulators with traps.
Liquid chromatography coupled with mass spectrometry (LC‐MS) is widely used to identify and quantify peptides in complex biological samples. In particular, label‐free shotgun proteomics is highly ...effective for the identification of peptides and subsequently obtaining a global protein profile of a sample. As a result, this approach is widely used for discovery studies. Typically, the objective of these discovery studies is to identify proteins that are affected by some condition of interest (e.g. disease, exposure). However, for complex biological samples, label‐free LC‐MS proteomics experiments measure peptides and do not directly yield protein quantities. Thus, protein quantification must be inferred from one or more measured peptides. In recent years, many computational approaches to relative protein quantification of label‐free LC‐MS data have been published. In this review, we examine the most commonly employed quantification approaches to relative protein abundance from peak intensity values, evaluate their individual merits, and discuss challenges in the use of the various computational approaches.
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•Polarization-dependent surface ablation was performed in natural diamond by single femtosecond laser pulses.•Ablation radii and thresholds exhibit polar plots with 4 and 3 patterns ...for (001) and (111) planes, respectively.•The azimuthal patterns are related to specific crystallographic directions and bandgap widths in the Brillouin zone.•Anti-correlating azimuthal dependences were observed for bulk photoluminescence and transmittance.
Single-shot surface ablation of (001) and (111) oriented natural diamond plates was performed by tightly focused (numerical aperture NA = 0.65) 1030 nm 0.3-picosecond laser pulses with variable polarization azimuth. Surface craters were characterized by scanning electron microscopy in terms of characteristic ablation 1/e-radii and threshold fluences. Azimuthal polar dependences of the radii and threshold fluences exhibit distinct patterns, coinciding with specific crystallographic directions and corresponding bandgap widths in the Brillouin zone, and implying multiphoton-excitation seeding process. For comparison, anti-correlating azimuthal dependences were also observed in the bulk diamond for side-viewed A-band photoluminescence yield and forward non-linear transmittance.
In this work we demonstrate the fabrication protocol of 2
D
-magnetoplasmonic crystals consisting of permalloy column arrays. Dependences of morphological, magnetic, optical, and magneto-optical ...properties of 2
D-
magnetoplasmonic crystals on the e-beam exposition dose are studied. Proposed protocol is suitable for the fabrication of 2
D-
structures with controllable dimensions and morphology of individual columns having substantial potential for applications as sensitive magnetic field probes.
We study the moduli spaces of polarised irreducible symplectic manifolds. By a comparison with locally symmetric varieties of orthogonal type of dimension 20, we show that the moduli space of ...polarised deformation K32 manifolds with polarisation of degree 2d and split type is of general type if d≥12.
Active search for candidate genes whose polymorphisms are associated with human cognitive functions has been in progress in the past years. The study focused on the role that the insulin-like growth ...factor II (IGF2) gene may play in the variation of cognitive processes related to executive functions. The ApaI polymorphism of the IGF2 gene was tested for association with selective attention during visual search, working memory/mental control, and semantic verbal fluency in a group of 182 healthy individuals. The ApaI polymorphism was associated with the general cognitive index and selective attention measure. Carriers of genotype AA displayed higher values of the two parameters than carriers of genotype GG. It was assumed that the ApaI polymorphism of the IGF2 gene influences the human cognitive functions, acting possibly via modulation of the IGF-II level in the central nervous system.
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