We report the discovery and characterisation of a super-Earth and a sub-Neptune transiting the bright (
K
= 8.8), quiet, and nearby (37 pc) M3V dwarf TOI-1266. We validate the planetary nature of ...TOI-1266 b and c using four sectors of TESS photometry and data from the newly-commissioned 1-m SAINT-EX telescope located in San Pedro Mártir (México). We also include additional ground-based follow-up photometry as well as high-resolution spectroscopy and high-angular imaging observations. The inner, larger planet has a radius of
R
= 2.37
−0.12
+0.16
R
⊕
and an orbital period of 10.9 days. The outer, smaller planet has a radius of
R
= 1.56
−0.13
+0.15
R
⊕
on an 18.8-day orbit. The data are found to be consistent with circular, co-planar and stable orbits that are weakly influenced by the 2:1 mean motion resonance. Our TTV analysis of the combined dataset enables model-independent constraints on the masses and eccentricities of the planets. We find planetary masses of
M
p
= 13.5
−9.0
+11.0
M
⊕
(<36.8
M
⊕
at 2-
σ
) for TOI-1266 b and 2.2
−1.5
+2.0
M
⊕
(<5.7
M
⊕
at 2-
σ
) for TOI-1266 c. We find small but non-zero orbital eccentricities of 0.09
−0.05
+0.06
(<0.21 at 2-
σ
) for TOI-1266 b and 0.04 ± 0.03 (< 0.10 at 2-
σ
) for TOI-1266 c. The equilibrium temperatures of both planets are of 413 ± 20 and 344 ± 16 K, respectively, assuming a null Bond albedo and uniform heat redistribution from the day-side to the night-side hemisphere. The host brightness and negligible activity combined with the planetary system architecture and favourable planet-to-star radii ratios makes TOI-1266 an exquisite system for a detailed characterisation.
We report the development of a high-time resolution, 3-colour, simultaneous optical imaging system for the 2.1 m telescope in the San Pedro Mártir Observatory, México. OPTICAM will be equipped with ...three 2,048×2,048 pixel Andor Zyla 4.2-Plus sCMOS cameras and a set of SDSS filters allowing optical coverage in the 320–1,100 nm range. OPTICAM will nominally allow sub-second exposures. Given its instrumental design, a wide range of fast-variability astrophysical sources can be targeted with OPTICAM including X-ray binaries, pulsating white dwarfs, accreting compact objects, eclipsing binaries and exoplanets. OPTICAM observations will be proprietary for only six months and will then be made publicly available to the astronomical community.
We report the development of a high-time resolution, 3-colour, simultaneous optical imaging system for the 2.1 m telescope in San Pedro Mártir Observatory, México. OPTICAM will be equipped with three ...Andor Zyla 4.2-Plus sCMOS cameras and a set of SDSS filters allowing optical coverage in the 320-1,100 nm range. OPTICAM will nominally allow sub-second exposures. Given its instrumental design, a wide range of fast-variability astrophysical sources can be targeted with OPTICAM including X-ray binaries, pulsating white dwarfs, accreting compact objects, eclipsing binaries and exoplanets. OPTICAM observations will be proprietary for only six months and will then be made publicly available for the astronomical community.
We report the discovery and characterisation of a super-Earth and a sub-Neptune transiting the bright (\(K=8.8\)), quiet, and nearby (37 pc) M3V dwarf TOI-1266. We validate the planetary nature of ...TOI-1266 b and c using four sectors of TESS photometry and data from the newly-commissioned 1-m SAINT-EX telescope located in San Pedro Mártir (Mexico). We also include additional ground-based follow-up photometry as well as high-resolution spectroscopy and high-angular imaging observations. The inner, larger planet has a radius of \(R=2.37_{-0.12}^{+0.16}\) R\(_{\oplus}\) and an orbital period of 10.9 days. The outer, smaller planet has a radius of \(R=1.56_{-0.13}^{+0.15}\) R\(_{\oplus}\) on an 18.8-day orbit. The data are found to be consistent with circular, co-planar and stable orbits that are weakly influenced by the 2:1 mean motion resonance. Our TTV analysis of the combined dataset enables model-independent constraints on the masses and eccentricities of the planets. We find planetary masses of \(M_\mathrm{p}\) = \(13.5_{-9.0}^{+11.0}\) \(\mathrm{M_{\oplus}}\) (\(<36.8\) \(\mathrm{M_{\oplus}}\) at 2-\(\sigma\)) for TOI-1266 b and \(2.2_{-1.5}^{+2.0}\) \(\mathrm{M_{\oplus}}\) (\(<5.7\) \(\mathrm{M_{\oplus}}\) at 2-\(\sigma\)) for TOI-1266 c. We find small but non-zero orbital eccentricities of \(0.09_{-0.05}^{+0.06}\) (\(<0.21\) at 2-\(\sigma\)) for TOI-1266 b and \(0.04\pm0.03\) (\(<0.10\) at 2-\(\sigma\)) for TOI-1266 c. The equilibrium temperatures of both planets are of \(413\pm20\) K and \(344\pm16\) K, respectively, assuming a null Bond albedo and uniform heat redistribution from the day-side to the night-side hemisphere. The host brightness and negligible activity combined with the planetary system architecture and favourable planet-to-star radii ratios makes TOI-1266 an exquisite system for a detailed characterisation.
Multifunctionality of PAI-1 in fibrogenesis: Evidence from obstructive nephropathy in PAI-1–overexpressing mice.
Plasminogen activator inhibitor-1 (PAI-1) has been implicated in the pathogenesis of ...chronic kidney disease based on its up-regulated expression and on the beneficial effects of PAI-1 inhibition or depletion in experimental models. PAI-1 is a multifunctional protein and the mechanisms that account for its profibrotic effects have not been fully elucidated.
The present study was designed to investigate PAI-1–dependent fibrogenic pathways by comparing the unilateral ureteral obstruction model (UUO) (days 3, 7, and 14) in PAI-1–overexpressing mice (PAI-1 tg) to wild-type mice, both on a C57BL6 background.
Following UUO, total kidney PAI-1 mRNA and/or protein levels were significantly higher in the PAI-1 tg mice (N = 6 to 8/group) and fibrosis severity was significantly worse (days 3, 7, and 14), measured both as Sirius red–positive interstitial area (e.g., 10 ± 3.2% vs. 4.5 ± 1.0%) (day 14) and total kidney collagen (e.g., 11.1 ± 1.7 vs. 6.2 ± 1.3 μg/mg) (day 14). By day 14, the expression of two normal tubular proteins, E-cadherin and Ksp-cadherin, were significantly lower in the PAI-1 tg mice (3.2 ± 0.5% vs. 11.7 ± 5.9% and 2.6 ± 1.6) vs. 6.2 ± 0.8%, respectively), implying more extensive tubular damage. At least four fibrogenic pathways were differentially expressed in the PAI-1 tg mice. First, interstitial macrophage recruitment was more intense (P < 0.05 days 3 and 14). Second, interstitial myofibroblast density was greater (P < 0.05 days 3 and 7) despite similar numbers of proliferating tubulointerstitial cells. Third, transforming growth factor-β1 (TGF-β1) and collagen I mRNA were significantly higher. Finally, urokinase activity was significantly lower (P < 0.05 days 7 and 14) despite similar mRNA levels. Gene microarray studies documented that that the deletion of this single profibrotic gene had far-reaching consequences on renal cellular responses to chronic injury.
These data provide further evidence that PAI-1 is directly involved in interstitial fibrosis and tubular damage via two primary overlapping mechanisms: early effects on interstitial cell recruitment and late effects associated with decreased urokinase activity.
The urokinase cellular receptor (uPAR) recognizes the N-terminal growth factor domain of urokinase-type plasminogen activator (uPA) and is expressed by several cell types. The present study was ...designed to test the hypothesis that uPAR regulates the renal fibrogenic response to chronic injury. Groups of uPAR wild-type (+/+) and deficient (-/-) mice were investigated between 3 and 14 d after unilateral ureteral obstruction (UUO) or sham surgery. Not detected in normal kidneys, uPAR mRNA was expressed in response to UUO in the +/+ mice. By in situ hybridization, uPAR mRNA transcripts were detected in renal tubules and interstitial cells of the obstructed uPAR+/+ kidneys. The severity of renal fibrosis, based on the measurement of total collagen (13.5 +/- 1.5 versus 9.8 +/- 1.0 microg/mg kidney on day 14; -/- versus +/+) and interstitial area stained by Masson trichrome (22 +/- 4% versus 14 +/- 3% on day 14; -/- versus +/+) was significantly greater in the uPAR-/- mice. In the absence of uPAR, renal uPA activity was significantly decreased compared with the wild-type animals after UUO (62 +/- 20 versus 135 +/- 13 units at day 3 UUO; 74 +/- 17 versus 141 +/- 16 at day 7 UUO; 98 +/- 20 versus 165 +/- 10 at day 14 UUO; -/- versus +/+). In contrast, renal expression of several genes that regulate plasmin activity were similar in both genotypes, including uPA, tPA, PAI-1, protease nexin-1, and alpha2-antiplasmin. Worse renal fibrosis in the uPAR-/- mice appears to be TGF-beta-independent, as TGF-beta activity was actually reduced by 65% in the -/- mice despite similar renal TGF-beta1 mRNA levels. Significantly lower levels of the major 2.3-kb transcript and the 69-kd active protein of hepatocyte growth factor (HGF), a known anti-fibrotic growth factor, in the uPAR-/- mice suggests a potential link between HGF and the renoprotective effects of uPAR. These data suggest that renal uPAR attenuates the fibrogenic response to renal injury, an outcome that is mediated in part by urokinase-dependent but plasminogen-independent functions.
Interstitial cells have been implicated in the pathogenesis of renal fibrosis. Given that the urokinase receptor (uPAR) is known to play a role in cell adhesion, migration, and angiogenesis, the ...present study was designed to evaluate the role of uPAR in the regulation of the phenotypic composition of interstitial cells (macrophages, myofibroblasts, capillaries) in response to chronic renal injury. Groups of uPAR wild-type (+/+) and knockout (-/-) mice were investigated between 3 and 14 d after unilateral ureteral obstruction (UUO) or sham surgery (n = 8 mice per group). The density of F4/80+ interstitial macrophages (Mphi) was significantly lower in the -/- mice (3.3 +/- 0.4 versus 6.9 +/- 1.7% area at day 3 UUO; 10.8 +/- 1.6 versus 15.7 +/- 1.0% at day 14 UUO; -/- versus +/+). In contrast, in the -/- mice there were significantly more alpha smooth muscle actin (alphaSMA)-positive cells (12.9 +/- 3.2 versus 7.8 +/- 1.5% area at day 3 UUO; 21.0 +/- 4.7 versus 9.7 +/- 1.9% at day 14 UUO) and CD34-positive endothelial cells (8.4 +/- 1.9 versus 4.0 +/- 1.1% area at day 14 UUO). These differences were associated with significantly more interstitial fibrosis in the -/- mice based on Sirius red staining (4.6 +/- 0.9 versus 2.3 +/- 0.9% area at 14 d UUO). Absence of the uPAR scavenger receptor was associated with significantly greater accumulation of plasminogen activator inhibitor-1 protein (PAI-1) (20.5 +/- 3.5 versus 9.1 +/- 2.9% area, day 14 UUO) and vitronectin protein (2.4 +/- 1.1 versus 0.9 +/- 0.4% area, day 14 UUO). By immunostaining alphaSMA+ cells, CD34+ cells, vitronectin and PAI-1 co-localized to the same tubulointerstitial area. The number of apoptotic cells increased in response to UUO but was significantly higher in the -/- mice (2.0 +/- 0.2 versus 1.2 +/- 0.2 per 100 tubulointerstitial cells, day 14 UUO) while the number of proliferating cells was significantly lower in the uPAR-/- mice. These data suggest that uPAR deficiency suppresses renal Mphi recruitment, but the absence of this scavenger receptor actually accentuates the fibrogenic response, likely due in part to the delayed clearance of angiogenic/profibrotic molecules such as PAI-1 and decreased receptor-associated uPA activity.
We report the first measurement of the parity-violating asymmetry A(PV) in the elastic scattering of polarized electrons from 208Pb. A(PV) is sensitive to the radius of the neutron distribution ...(R(n)). The result A(PV)=0.656±0.060(stat)±0.014(syst) ppm corresponds to a difference between the radii of the neutron and proton distributions R(n)-R(p)=0.33(-0.18)(+0.16) fm and provides the first electroweak observation of the neutron skin which is expected in a heavy, neutron-rich nucleus.
The “standard” Hall A apparatus at Jefferson Lab (TOF and aerogel threshold Cherenkov detectors) does not provide complete identification for proton, kaon and pion. To this aim, a proximity focusing ...C
6F
14/CsI RICH (Ring Image CHerenkov) detector has been designed, built, tested and operated to separate kaons from pions with a pion contamination of a few percent up to 2.4
GeV/
c. Two quite different experimental investigations have benefitted of the RICH identification: on one side, the high-resolution hypernuclear spectroscopy series of experiments on carbon, beryllium and oxygen, devoted to the study of the lambda-nucleon potential. On the other side, the measurements of the single spin asymmetries of pion and kaon on a transversely polarized
3He target are of utmost interest in understanding QCD dynamics in the nucleon. We present the technical features of such a RICH detector and comment on the presently achieved performance in hadron identification.
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