The pseudorapidity density and anisotropic flow of charged-particles provide fundamental information about global variables and correlations in heavy-ion collisions. The pseudorapidity density is ...related to the energy available for particle production while the anisotropic flow is related to collective effects from interactions between these particles. Extending these measurements to very forward pseudorapidities yields information about the longitudinal expansion of the system. The first measurements performed at the LHC over more than 8 units of pseudorapidity are presented. The longitudinal scaling of the measurements is analyzed and comparison to models is performed.
Forward Diffractive Detector control system for Run 3 in the ALICE experiment Mejía Camacho, J.M.; Rodríguez Ramírez, S.A.; Cabanillas Noris, J.C. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
05/2023, Letnik:
1050
Journal Article
Recenzirano
The ALICE experiment went through major upgrades in preparation for Runs 3 and 4 at the CERN LHC, which foresee a significant increase in the data stream rate. To cope with it, a new Computing System ...Online–Offline (O2) was developed by ALICE and several detectors were upgraded. One of these upgrades corresponded to the ALICE Diffractive (AD) detector, which was replaced by the new Forward Diffractive Detector (FDD). A fundamental system that allows for recording of data as well as for the stable and safe operation of the experimental setup is the Detector Control System (DCS). The DCS controls, monitors, and configures detectors’ hardware and their subsystems among which are commercial hardware and specific custom equipment. In this work, we describe the implementation of the DCS of FDD, which was designed and developed using the SCADA commercial software WinCC Open Architecture (WinCC-OA®) and the Joint Controls Project (JCOP) Framework. We also describe the modeling of FDD-DCS as a finite state machine to be integrated into the ALICE Central DCS, and to be operated by DCS shifters in the run control center and, remotely, by detector experts. This new DCS was developed to comply with the new LHC operational standards that allow for processing the increased luminosity due to collisions at a higher energy, and for fulfilling the specific requirements of the ALICE experiment, in order to address the scientific challenges of its physics program.
A novel method for measuring particle multiplicity correlations is presented. The method takes reduced acceptance and detection efficiency into account, in a purely statistical manner. The method ...does therefore not require any information from simulations - only knowledge of the detectors capability. The method provides the ability to measure forward-backward particle multiplicity correlations with high accuracy and negligible bias. The validity of the method is provided through numerous simulations. The correlation values calculated from carefully selected detection acceptances and efficiencies are compared to the correlation values at the event-generator level. Further validity to the method is given by incorporating different event generators into the simulations. Although the emphasis is on fwd-bwd correlations, the method can be extended to other multiplicity correlation measurements.
OBJECTIVES
To assess the short‐term effects of feeding distinct salmon oil sources in healthy dogs.
METHODS
A diet containing chicken fat as major fat source was fed to 17 dogs for 14 days. For the ...next 14 days, dogs received one of two diets, both with 1% of chicken fat exchanged for 1% salmon oil; Norwegian or Scottish salmon oil, harvested using a distinct procedure. Finally, all dogs were fed chicken fat again for 14 days.
RESULTS
Salmon oil increased serum phospholipid total n‐3 polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic acid and decreased total n‐6 polyunsaturated fatty acids and n‐6:n‐3. The phospholipid fatty acid profile returned to initial values within 2 weeks of discontinuing salmon oil administration. Blood coagulation, acute phase response and plasma immunoglobulin concentrations were not affected by salmon oil and no differences were detected for the measured indices between the two salmon oils.
CLINICAL SIGNIFICANCE
Low‐dose salmon oil administration alters serum phospholipid fatty acid profile within 2 weeks, but without affecting selected immunologic and coagulation indices. Salmon oil sources from different sources and harvested using a distinct procedure did not induce different effects, most probably because of their similar fatty acid profiles.
ABSTRACT
Salmon released to seawater as different smolt types differed significantly in the total collagen content and the solubility of the collagen present. A 11/2 smolt contained more total ...collagen than 1/2 and 1 smolt types. Less insoluble collagen and more of the pepsin soluble collagen was generally present in 11/2 smolt type as compared with both 1/2 and 1 types, with the exception of prerigor type 1 salmon. No differences between smolt types in acetic soluble collagen were present. Fish with the higher amount of collagen also had the lowest end pH. Although the bled body weight differed, no correlation between body weight and collagen content or its solubility was found. Fish with higher end pH had lower total collagen and pepsin soluble collagen (r = ‐0.77, P = 0.0001 and r = ‐0.51, P = 0.04, respectively, and more insoluble collagen (r = 0.72, P = 0.002).
For several decades, lithium has been the drug of choice in the long-term treatment of manic-depressive illness, but the molecular mechanism(s) mediating its therapeutic effects remain to be ...determined. The enzyme myo-inositol monophosphatase (IMPase) in the phospholipase C signaling system is inhibited by lithium at therapeutically relevant concentrations, and is a candidate target of lithium's mood-stabilizing action. Two genes encoding human IMPases have so far been isolated, namely IMPA1 on chromosome 8q21. 13-21.3 and IMPA2 on chromosome 18p11.2. Interestingly, several studies have indicated the presence of a susceptibility locus for bipolar disorder on chromosome 18p11.2. IMPA2 is therefore a candidate for genetic studies on both etiology and lithium treatment of manic-depressive illness. Here we report that the genomic structure of IMPA2 is composed of eight exons, ranging in size from 46 bp to 535 bp. The promoter region contains several Sp1 elements and lacks a TATA-box, features typical for housekeeping genes. By a preliminary polymorphism screening of exons 2-8 in a sample of 23 Norwegian bipolar patients, we have identified nine single nucleotide polymorphisms (SNPs). Seven of the polymorphisms were located in the introns, one was a silent transition in exon 2 (159T>C) and one was a transition in exon 5 (443G>A) resulting in a predicted amino acid substitution (R148Q). Our data show that even in a small sample of bipolar patients, several variants of the IMPA2 gene can be identified. IMPA2 is therefore an intriguing candidate gene for future association studies of manic-depressive illness.
The cytochrome P450 enzyme debrisoquine 4-hydroxylase (CYP2D6) metabolizes many different classes of commonly used drugs. In Caucasian populations, 5-10% are classified as poor metabolizers (PM) due ...to autosomal recessive inheritance of two mutant CYP2D6 null alleles. In contrast, up to 5% may demonstrate ultrarapid metabolism (UM) of debrisoquine caused by inherited amplification of functional CYP2D6 genes in the CYP2D6 locus. Poor metabolizer subjects may develop toxic plasma concentrations and adverse drug reactions, whereas UMs may suffer from therapeutic failure. Moreover, mutant CYP2D6 alleles have been implicated as a predictor of susceptibility for diseases such as cancer and neurological disorders. The break points and molecular mechanisms involved in the generation in the PM-associated CYP2D6(D) gene deletion allele and the UM-related CYP2D6 amplification have not been clarified. Here we demonstrate the presence of a 2.8 kb repeated region (CYP-REP) which flanks the active CYP2D6 gene in the wild type allele. The CYP-REP unit may be itself predispose to homologous unequal cross-over and contains the Alu element and a tandem 10 bp direct repeat, which could both serve as hotspots for recombination. The break points of the CYP2D6(D) deletion allele are present within the repeated 2.8 kb region, but the exact positions are non-determinable due to perfect recombination of the misaligned, homologous CYP-REP elements. We also propose that the alleles with multiple copies of CYP2D6, which represent the first example of inherited amplification of an active gene in man, can be explained by unequal cross-over events involving the CYP-REP units. In our model, the CYP2D6 deletion and amplification alleles are reciprocal to each other, generated through homologous unequal recombination of no-allelic CYP-REP elements.
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