This paper takes 30 provinces in China from 2004 to 2015 as research samples, using the Tapio decoupling models, differential GMM methods and peak forecasting models to analyze the effect of ...environmental regulation on carbon emissions, and subdividing the research sample from the regional and temporal dimensions to analyze the effectiveness of environmental regulations in different regions and at different time periods. The analysis results show that, with the advancement of environmental regulation, the dependence of China's economic growth on fossil energy has experienced a process from weak to strong and weak. There is a significant inverted U-shaped curve relationship between environmental regulation and CO2 emissions and CO2 emissions intensity. As the intensity of environmental regulation changes from weak to strong, the impact effect changes from "green paradox" effect to "back-forced reduction" effect. The effect of environmental regulation in the eastern region is better than that in the central and western regions. However, with the implementation of environmental regulation, the inverted U-shaped curve between environmental regulation and carbon emissions gradually becomes flat. The results of the peak forecast show that China has crossed the peak of CO2 emissions intensity, but has not exceeded the peak of CO2 emissions. By further optimizing environmental regulations, China may reach its CO2 emissions peak by 2030. Overall, China's environmental regulations at the current stage can effectively curb carbon emissions and achieve the desired goals.
In order to improve the mechanical property prediction accuracy of AZ80 magnesium alloy, sparrow search algorithm (SSA) is optimized by the tent chaotic mapping (TCM) algorithm, yielding TCMSSA, and ...TCMSSA is employed to improve extreme learning machine (ELM) model for obtaining TCMSSA-ELM model. TCMSSA-ELM model, along with the traditional ELM model, are both utilized to predict the stress of AZ80 magnesium alloy in a temperature range of 523 K to 673 K and a strain rate range of 0.001s
− 1
to 1s
− 1
. Comparative analysis is conducted to evaluate the performance differences between the two models. The results indicate that compared with ELM model, the predicted values of TCMSSA-ELM model are closer to the experimental data and the ideal 45° line, proving the higher prediction accuracy of TCMSSA-ELM model. In addition, through algorithmic improvements, the maximum reduction of MAPE is 85.422% and the maximum determination coefficient reaches 0.99956, implying that TCMSSA greatly improves the prediction precision of ELM model. The related results offer a new optimization strategy and model to predict the mechanical property of AZ80 magnesium alloy in each molding stage, and provide a technical reference for applying intelligent algorithms to alloy design.
Stereo digital image correlation technique (stereo-DIC or 3D-DIC) has been widely used in three-dimensional (3D) shape and deformation measurement due to its high accuracy and flexibility. But it is ...a tough task for it to deal with complex structure components because of the severe perspective distortion in two views. This paper seeks to resolve this issue using a single-camera system based on DIC-assisted fringe projection profilometry (FPP). A pixel-wise and complete 3D geometry of complex structures can be reconstructed using the robust and efficient Gray-coded method based on a FPP system. And then, DIC is just used to perform the temporal matching and complete full-field pixel-to-pixel tracking. The in- and out-of-plane deformation are obtained at the same time by directly comparing the accurate and complete 3D data of each corresponding pixel. Speckle pattern design and fringe denoising methods are carefully compared and chosen to simultaneously guarantee the measuring accuracy of 3D shape and deformation. Experimental results demonstrate the proposed method is an effective means to achieve full-field 3D shape and deformation measurement on complex parts, such as honeycomb structure and braided composite tube, which are challenging and even impossible for the traditional stereo-DIC method.
An innovative approach based on a surface functional monomer-directing strategy for the construction of a sensitive and selective molecularly imprinted electrochemical sensor for patulin recognition ...is described. A patulin imprinted platinum nanoparticle (PtNP)-coated poly(thionine) film was grown on a preformed thionine tailed surface of PtNP-nitrogen-doped graphene (NGE) by electropolymerization, which provided high capacity and fast kinetics to uptake patulin molecules. Thionine acted not only as a functional monomer for molecularly imprinted polymer (MIP), but also as a signal indicator. Enhanced sensitivity was obtained by combining the excellent electric conductivity of PtNPs, NGE, and thionine with multisignal amplification. The designed sensor displayed excellent performance for patulin detection over the range of 0.002–2 ng mL–1 (R2 = 0.995) with a detection limit of 0.001 ng mL–1 for patulin. In addition, the resulting sensor showed good stability and high repeatability and selectivity. Furthermore, the feasibility of its applications has also been demonstrated in the analysis of real samples, providing novel tactics for the rational design of MIP-based electrochemical sensors to detect a growing number of deleterious substances.
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•A fast reconstruction method for three-dimensional shape measurement.•Utilizing dual-frequency grating to expand measureable depth with high accuracy.•Mapping the height from the ...wrapped phase without phase unwrapping.•Realization of high-speed dynamic 3D shape measurement by GPU.
Phase-to-height mapping is indispensable part of three-dimensional (3D) shape measurement system based on phase analysis, which guarantees the accuracy of 3D reconstruction. In this paper, a fast 3D shape reconstruction method based on dual-frequency grating projection and phase-to-height lookup table is proposed. In this proposed method, the reference plane is moved with known interval along the measurement depth direction to establish the mapping lookup table between the phase of the high and low frequency projected grating and their corresponding spatial height pixel by pixel respectively. Then, two methods to establish the lookup table with the unwrapped and the wrapped phase have been respectively introduced according to the characteristics of dual-frequency grating. The actual experimental results show that the two methods can effectively extend the measurement range of the current wrapped phase-to-height lookup method, and the reconstruction accuracy is better than the traditional phase-to-height quadratic fitting method. At the same time, the consumed time for 3D shape reconstruction of the tested object by the two methods is compared and analyzed. Finally, combining the high performance parallel computation of GPU, the fast 3D shape reconstruction is realized with the speed of 60fps.
Not all patients with unresectable hepatocellular carcinoma (uHCC) benefit from treatment with immune checkpoint inhibitors and molecular-targeted agents. The aim of this retrospective study was to ...assess the efficacy and safety of pembrolizumab plus lenvatinib plus hepatic arterial infusion chemotherapy (HAIC) versus pembrolizumab plus lenvatinib in selected populations of patients with treatment-naive uHCC exhibiting programmed cell death ligand-1 (PD-L1) staining.
Consecutive patients with treatment-naive uHCC exhibiting PD-L1 staining who were treated with pembrolizumab plus lenvatinib plus HAIC (PLH) or pembrolizumab plus lenvatinib (PL) were retrospectively identified from our medical centres from 2018 to 2021. HAIC involved oxaliplatin, fluorouracil, and leucovorin (FOLFOX). Follow-up occurred every 3 weeks for 1 year and then every 6 weeks thereafter. The primary endpoints included overall survival (OS) and progression-free survival (PFS). Secondary endpoints were the frequency of key adverse events (AEs).
In total, 248 treatment-naive patients were retrospectively reviewed, 78 of whom were ineligible on the basis of the current criteria. Thus, 170 patients (PLH: n = 84, median age 52 years range, 42-67; PL: n = 86, 53 years range, 43-69) were eligible for the analysis. The median follow-up was 18.6 months (range, 1-26). At the final follow-up, the median OS was 17.7 months (95% confidence interval CI, 15.2-18.3) in the PLH group versus 12.6 months (95% CI, 11.1-13.7) in the PL group (hazard ratio HR 0.52; 95% CI, 0.36-0.75; p = 0.001). A significant difference was also detected in the median PFS (10.9 months 95% CI, 8.7-11.4 for PLH vs. 6.8 months (95% CI, 5.2-7.4) for PL; HR 0.61, 95% CI, 0.43-0.85; p = 0.001). Significant differences in the rate of the key AEs were noted between groups (79.8% for PLH vs. 62.8% for PL, p = 0.015), but these AEs were controllable.
Among selected populations of patients with treatment-naive uHCC exhibiting PD-L1 staining, the PLH regimen may substantially improve the survival benefits compared with the PL regimen with a controllable safety profile.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A convenient and efficient method for oxidative coupling of tetrahydroisoquinoline derivatives with trimethyl(trifluoromethyl)silane and terminal alkynes to 1-trifluoromethylated or 1-alkynylated ...tetrahydroisoquinolines via CH activation was developed using visible light irradiation. The protocol uses Rose Bengal as the catalyst, air as terminal oxidant, and the trifluoromethylation or alkynylation was selectively performed at the α-position of nitrogen under extremely mild conditions. Display omitted
► Rose Bengal catalyzed α-trifluoromethylation and α-alkynylation of tetrahydroisoquinolines under visible light irradiation. ► The reaction via CH activation. ► The reaction uses air as terminal oxidant under transition-metal-free reaction conditions.
A convenient and efficient method for oxidative coupling of tetrahydroisoquinoline derivatives with trimethyl(trifluoromethyl)silane and terminal alkynes to 1-trifluoromethylated or 1-alkynylated tetrahydroisoquinolines via CH activation was developed using visible light irradiation. The protocol uses Rose Bengal as the catalyst, air as terminal oxidant, and the trifluoromethylation or alkynylation was selectively performed at the α-position of nitrogen under extremely mild conditions.
Mantle tectonics, such as asthenospheric upwelling and lithospheric decoupling, usually controls subsequent fluid formation and migration from deep to shallow levels in the lower lithosphere and ...promotes rock failure and deformation. Based on the concept whereby the fluid migration location defines the structural inheritance, we aim to relate crustal processes to mantle tectonics using fluids revealed by a new magnetotelluric (MT) array across the Ailao Shan-Red River belt. As imaged via a 3D resistivity model, two lower-lithospheric conductive anomalies are determined as consistent with the Dian-Qiong (DQ) suture and Song Da (SD) belt and interpreted to contain interconnected melt. Because potassic magmatism was enabled by partial melting in the lower lithosphere, we could infer that the DQ and SD have reworked as the major fluid migration channels. Fluid migration is considered to drive lithospheric decoupling at a low-viscosity conductive layer, which is inferred feeding by aqueous and melt fluids originating from the two channels and diffusing at depths from 15 to 20 km. Constrained by the geochronology results, this weak layer could have provided convenience to induce the entirely upper crustal translation-rotation within the time interval between potassic magmatism and strike-slip of the Red River fault. This translation-rotation process is inherited from the underlying mantle processes and may further be remotely affected by the upper crustal movement of the Tibetan Plateau, conforming with the crustal rotation observed to the north of our study region. This work provides a compelling example of the tectonic control of the mantle on inherited responses in the crust.
Plain Language Summary Crustal deformation is usually controlled by mantle tectonic processes, especially the southeastern Tibetan Plateau. Some models have proposed that lithospheric shearing and lower-crustal flow have controlled the crustal deformation in the Cenozoic. However, crustal rotation models show less possibility of a channel flow and relate the crustal deformation to the remote effect of India-Asia collision. Our study investigates above hypotheses by imaging the electrical resistivity of rocks beneath the major Red River Fault area in southeastern Tibet, using magnetotelluric data with high quality in a dense array. The lithosphere of the study area is interpreted to have been divided into two horizontal systems by a fluid diffusion layer at the bottom of upper crust. Resistivity low in the lower lithosphere is inferred due to partial melting of deep lithosphere and reworking of the paleo sutures in the Late Cenozoic, which have spread at the bottom of upper crust. Rather than the channel flow, this fluid migration process sensitively reflected in our model relates the mantle tectonics to crustal rotation by providing rheological conditions. We, hence, propose an inherited structure model featured by lithospheric decoupling and upper-crustal translation-rotation that may occur before the major strike-slip event.
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•A new 3D model reveals electrical structures on the southeastern Tibetan Plateau.•The Red River fault is discontinuous at a depth of ∼20 km and may move away from the palaeo-suture.•Palaeo-suture was reconstructed into two activated zones and reworked as channels for fluid migration.•Fluid migration has driven the lithospheric decoupling and upper crustal inheritance.•The upper crust experienced a translation-rotation process before the internal strike-slip event.
With the rapid development of the Internet, cybersecurity situation is becoming more and more complex. At present, surface web and dark web contain numerous underground forums or markets, which play ...an important role in cybercrime ecosystem. Therefore, cybersecurity researchers usually focus on hacker-centered research on cybercrime, trying to find key hackers and extract credible cyber threat intelligence from them. The data scale of underground forums is tremendous and key hackers only represent a small fraction of underground forum users. It takes a lot of time as well as expertise to manually analyze key hackers. Therefore, it is necessary to propose a method or tool to automatically analyze underground forums and identify key hackers involved. In this work, we present HackerRank, an automatic method for identifying key hackers. HackerRank combines the advantages of content analysis and social network analysis. First, comprehensive evaluations and topic preferences are extracted separately using content analysis. Then, it uses an improved Topic-specific PageRank to combine the results of content analysis with social network analysis. Finally, HackerRank obtains users’ ranking, with higher-ranked users being considered as key hackers. To demonstrate the validity of proposed method, we applied HackerRank to five different underground forums separately. Compared to using social network analysis and content analysis alone, HackerRank increases the coverage rate of five underground forums by 3.14% and 16.19% on average. In addition, we performed a manual analysis of identified key hackers. The results prove that the method is effective in identifying key hackers in underground forums.
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