The nuclear proteome is rich in stress-sensitive proteins, which suggests that effective protein quality control mechanisms are in place to ensure conformational maintenance. We investigated the role ...of the nucleolus in this process. In mammalian tissue culture cells under stress conditions, misfolded proteins entered the granular component (GC) phase of the nucleolus. Transient associations with nucleolar proteins such as NPM1 conferred low mobility to misfolded proteins within the liquid-like GC phase, avoiding irreversible aggregation. Refolding and extraction of proteins from the nucleolus during recovery from stress was Hsp70-dependent. The capacity of the nucleolus to store misfolded proteins was limited, and prolonged stress led to a transition of the nucleolar matrix from liquid-like to solid, with loss of reversibility and dysfunction in quality control. Thus, we suggest that the nucleolus has chaperone-like properties and can promote nuclear protein maintenance under stress.
Gamma-ray bursts (GRBs) are flashes of high-energy radiation arising from energetic cosmic explosions. Bursts of long (greater than two seconds) duration are produced by the core-collapse of massive ...stars
, and those of short (less than two seconds) duration by the merger of compact objects, such as two neutron stars
. A third class of events with hybrid high-energy properties was identified
, but never conclusively linked to a stellar progenitor. The lack of bright supernovae rules out typical core-collapse explosions
, but their distance scales prevent sensitive searches for direct signatures of a progenitor system. Only tentative evidence for a kilonova has been presented
. Here we report observations of the exceptionally bright GRB 211211A, which classify it as a hybrid event and constrain its distance scale to only 346 megaparsecs. Our measurements indicate that its lower-energy (from ultraviolet to near-infrared) counterpart is powered by a luminous (approximately 10
erg per second) kilonova possibly formed in the ejecta of a compact object merger.
Fast radio bursts (FRBs) are brief radio emissions from distant astronomical sources. Some are known to repeat, but most are single bursts. Nonrepeating FRB observations have had insufficient ...positional accuracy to localize them to an individual host galaxy. We report the interferometric localization of the single-pulse FRB 180924 to a position 4 kiloparsecs from the center of a luminous galaxy at redshift 0.3214. The burst has not been observed to repeat. The properties of the burst and its host are markedly different from those of the only other accurately localized FRB source. The integrated electron column density along the line of sight closely matches models of the intergalactic medium, indicating that some FRBs are clean probes of the baryonic component of the cosmic web.
FLAG Review 2019 Aoki, S; Aoki, Y; Bečirević, D ...
The European physical journal. C, Particles and fields,
02/2020, Letnik:
80, Številka:
2
Journal Article
Recenzirano
Odprti dostop
We review lattice results related to pion, kaon, D-meson, B-meson, and nucleon physics with the aim of making them easily accessible to the nuclear and particle physics communities. More ...specifically, we report on the determination of the light-quark masses, the form factor f+(0) arising in the semileptonic K→π transition at zero momentum transfer, as well as the decay constant ratio fK/fπ and its consequences for the CKM matrix elements Vus and Vud. Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of SU(2)L×SU(2)R and SU(3)L×SU(3)R Chiral Perturbation Theory. We review the determination of the BK parameter of neutral kaon mixing as well as the additional four B parameters that arise in theories of physics beyond the Standard Model. For the heavy-quark sector, we provide results for mc and mb as well as those for D- and B-meson decay constants, form factors, and mixing parameters. These are the heavy-quark quantities most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. We review the status of lattice determinations of the strong coupling constant αs. Finally, in this review we have added a new section reviewing results for nucleon matrix elements of the axial, scalar and tensor bilinears, both isovector and flavor diagonal.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Studies were conducted to determine the effect of vermicompost on growth, physiological disorders, fruit yield and quality of ‘Chandler’ strawberry. For this, 4 levels of vermicompost (2.5, 5.0, 7.5 ...and 10.0
t
ha
−1) were supplemented with inorganic fertilizers to balance fertilizer requirement of strawberry under semi-arid region of northern India. The vermicompost was incorporated into top 10
cm layer of soil, which was supplemented on the basis of chemical analysis, with amount of inorganic N, P, K fertilizer calculated to equalize the recommended dose of nutrients. Vermicompost application increased plant spread (10.7%), leaf area (23.1%) and dry matter (20.7%), and increased total fruit yield (32.7%). Substitution of vermicompost drastically reduced the incidence of physiological disorders like albinism (16.1–4.5%); fruit malformation (11.5–4.0%) and occurrence of grey mould (10.4–2.1%) in strawberry indicating that vermicompost had significant role in reducing nutrient-related disorders and disease like
Botrytis rot, and thereby increasing the marketable fruit yield up to 58.6% with better quality parameters. Fruit harvested from plant receiving vermicompost were firmer, have higher TSS, ascorbic acid content and lower acidity, and have attractive colour. All these parameters appeared to be dose dependent and best results were achieved @ 7.5
t
ha
−1, however, beyond this dose of vermicompost, there was not significant influence on these parameters.
In pretreatment isolates of
M. tuberculosis
with decrements of the minimum inhibitory concentration of isoniazid or rifampin below the standard resistance breakpoint, higher MIC values were ...associated with a greater risk of relapse than lower MIC values.
FLAG Review 2019 Aoki, S.; Aoki, Y.; Bečirević, D. ...
The European physical journal. C, Particles and fields,
02/2020, Letnik:
80, Številka:
2
Journal Article
Recenzirano
Odprti dostop
We review lattice results related to pion, kaon,
D
-meson,
B
-meson, and nucleon physics with the aim of making them easily accessible to the nuclear and particle physics communities. More ...specifically, we report on the determination of the light-quark masses, the form factor
f
+
(
0
)
arising in the semileptonic
K
→
π
transition at zero momentum transfer, as well as the decay constant ratio
f
K
/
f
π
and its consequences for the CKM matrix elements
V
us
and
V
ud
. Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of
S
U
(
2
)
L
×
S
U
(
2
)
R
and
S
U
(
3
)
L
×
S
U
(
3
)
R
Chiral Perturbation Theory. We review the determination of the
B
K
parameter of neutral kaon mixing as well as the additional four
B
parameters that arise in theories of physics beyond the Standard Model. For the heavy-quark sector, we provide results for
m
c
and
m
b
as well as those for
D
- and
B
-meson decay constants, form factors, and mixing parameters. These are the heavy-quark quantities most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. We review the status of lattice determinations of the strong coupling constant
α
s
. Finally, in this review we have added a new section reviewing results for nucleon matrix elements of the axial, scalar and tensor bilinears, both isovector and flavor diagonal.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The frequency dependence of radio pulse arrival times provides a probe of structures in the intervening media. Demorest et al. was the first to show a short-term (∼100-200 days) reduction in the ...electron content along the line of sight to PSR J1713+0747 in data from 2008 (approximately MJD 54750) based on an apparent dip in the dispersion measure of the pulsar. We report on a similar event in 2016 (approximately MJD 57510), with average residual pulse-arrival times −3.0, −1.3, and −0.7 s at 820, 1400, and 2300 MHz, respectively. Timing analyses indicate possible departures from the standard −2 dispersive-delay dependence. We discuss and rule out a wide variety of potential interpretations. We find the likeliest scenario to be lensing of the radio emission by some structure in the interstellar medium, which causes multiple frequency-dependent pulse arrival-time delays.
Summary
Allergic bronchopulmonary aspergillosis (ABPA) is an immunological pulmonary disorder caused by hypersensitivity to Aspergillus fumigatus, manifesting with poorly controlled asthma, recurrent ...pulmonary infiltrates and bronchiectasis. There are estimated to be in excess of four million patients affected world‐wide. The importance of recognizing ABPA relates to the improvement of patient symptoms, and delay in development or prevention of bronchiectasis, one manifestation of permanent lung damage in ABPA. Environmental factors may not be the only pathogenetic factors because not all asthmatics develop ABPA despite being exposed to the same environment. Allergic bronchopulmonary aspergillosis is probably a polygenic disorder, which does not remit completely once expressed, although long‐term remissions do occur. In a genetically predisposed individual, inhaled conidia of A. fumigatus germinate into hyphae with release of antigens that activate the innate and adaptive immune responses (Th2 CD4+ T cell responses) of the lung. The International Society for Human and Animal Mycology (ISHAM) has constituted a working group on ABPA complicating asthma (www.abpaworkinggroup.org), which convened an international conference to summarize the current state of knowledge, and formulate consensus‐based guidelines for diagnosis and therapy. New diagnosis and staging criteria for ABPA are proposed. Although a small number of randomized controlled trials have been conducted, long‐term management remains poorly studied. Primary therapy consists of oral corticosteroids to control exacerbations, itraconazole as a steroid‐sparing agent and optimized asthma therapy. Uncertainties surround the prevention and management of bronchiectasis, chronic pulmonary aspergillosis and aspergilloma as complications, concurrent rhinosinusitis and environmental control. There is need for new oral antifungal agents and immunomodulatory therapy.
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