The main goal of this paper is to provide an insight into the characteristics of young people in the “reformed” system of higher education of Serbia, i.e. the evaluation of their possibilities and ...obstacles in the realization of their own educational interests. Namely, considering that the Bologna Process has placed a student at the center of academic space, our intent was to examine whether this “space” in our country really fulfills all the conditions necessary for development of individual potentials of students or young people still being treated as a homogeneous group that does not influence the institutions. In this respect, the paper presents a secondary analysis of relevant researches, which served as an adequate basis for assessing the main challenges students in Serbia are facing, their diverse needs as strategic actors of higher education, and potential deviations from basic ideas of the Bologna Process, which have led to problems students are confronting today. More specifically, with this analysis, we have tried to examine two quite specific assumptions about the problems of youth in the system of higher education in Serbia: first, that the possibility for young people to adapt the conditions of studying to their own needs is still limited by the strict institutional standards and conservatism of the academic community, and secondly that such a position is not a consequence of the nature of the Bologna Process, but rather the absence of the application of its fundamental principles. Finally, we note that the nature of this work is not merely descriptive, since our idea was not only to point to current problems but also to offer possible solutions that would improve the conditions for studying in Serbia.
Osnovni je cilj ovoga rada pružanje uvida u neke od ključnih karakteristika rodnih, partnerskih i seksualnih odnosa unutar društva socijalističke Jugoslavije. U tom smislu rad predstavlja prikaz ...određenih društveno - povijesnih podataka dobivenih analizom odabrane literature vezane uz navedenu tematiku. Ipak, priroda ovoga rada nije isključivo deskriptivna, budući da je namjera bila da se dostupnim podacima ispita primjenjivost teorije patrijarhata Sylvije Walby na istraživani slučaj. Shodno tome, cilj je testirati hipotezu o zamjeni privatnoga patrijarhata njegovom javnom formom, i to kroz provjeru dvije pretpostavke: slabljenje patrijarhalnih odnosa u domaćinstvu te nailazak liberalizacije na polju seksualnoga morala, kako u smislu njegove depatrijarhalizacije, tako i u pogledu rušenja heteroseksualne normativnosti.
Introduction
Sarcoidosis is a multiorgan, multisystem chronic disease of unknown etiology and unpredictable course. Health status is reduced in sarcoidosis and assessing it is a difficult multitask ...effort due to many faces this disease might have. Recently, a new questionnaire for assessing health status in sarcoidosis was developed by a group of authors from England–King’s Sarcoidosis Questionnaire (KSQ). The benefit of KSQ is the ability to develop the best care plan for the patient, as well as to differentiate the efficacy of the administered treatment.
Objective
The aim of this study was to validate the KSQ in Serbian speaking population of sarcoidosis patients. The test itself is a modular, multi-organ health status measure for patients with sarcoidosis for use in clinic and the evaluation of therapies. The correlation of KSQ with different clinical course of sarcoidosis (acute vs chronic disease) and with the clinical outcome status (COS) in sarcoidosis was also investigated.
Methods
A total of 159 biopsy positive sarcoidosis patients participated in this study. The average age of the participants was 49.67, majority was female (67.3%) and majority had only pulmonary form of sarcoidosis (71.7%). KSQ ‐ new disease-specific health status instrument, was compared with 5 other already existing instruments already used and validated in sarcoidosis (Saint George Respiratory Questionnaire- SGRQ, Daily Activity List -DAL, Fatigue Assessment Scale- FAS, Medical Research Council dyspnea scale–MRC, Borg Dyspnea Scale and 15D as general questionnaire.
Results
KSQ has significant correlation with other quality of life questionnaires already used in sarcoidosis. Translated version of KSQ shows significant internal reliability, similar to the original KSQ. Serbian version of KSQ has significant correlation with different clinical course of sarcoidosis and with COS as well. The translated version of KSQ is reliable sarcoidosis specific instrument for assessing health status in these patients.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Until now, a proper biomarker(s) to evaluate sarcoidosis activity has not been recognized. The aims of this study were to evaluate the sensitivity and specificity of the two biomarkers of sarcoidosis ...activity already in use (serum angiotensin converting enzyme – ACE and serum chitotriosidase) in a population of 430 sarcoidosis patients. The activities of these markers were also analyzed in a group of 264 healthy controls.
Four hundred and thirty biopsy positive sarcoidosis patients were divided into groups with active and inactive disease, and groups with acute or chronic disease. In a subgroup of 55 sarcoidosis patients, activity was also assessed by F-18 fluorodeoxyglucose positron emission tomography (
F-FDG-PET) scanning. Both serum chitotriosidase and ACE levels showed non-normal distribution, so nonparametric tests were used in statistical analysis.
Serum chitotriosidase activities were almost 6 times higher in patients with active sarcoidosis than in healthy controls and inactive disease. A serum chitotriosidase value of 100 nmol/mL/h had the sensitivity of 82.5% and specificity of 70.0%. A serum ACE activity cutoff value of 32.0 U/L had the sensitivity of 66.0% and the specificity of 54%. A statistically significant correlation was obtained between the focal granulomatous activity detected on
F-FDG PET/CT and serum chitotriosidase levels, but no such correlation was found with ACE. The levels of serum chitotriosidase activity significantly correlated with the disease duration (
<0.0001). Also, serum chitotriosidase significantly correlated with clinical outcome status (COS) categories (ρ=0.272,
=0.001).
Serum chitotriosidase proved to be a reliable biomarker of sarcoidosis activity and disease chronicity.
Sarcoidosis is a multiorgan, multisystem chronic disease of unknown etiology and unpredictable course. Health status is reduced in sarcoidosis and assessing it is a difficult multitask effort due to ...many faces this disease might have. Recently, a new questionnaire for assessing health status in sarcoidosis was developed by a group of authors from England-King's Sarcoidosis Questionnaire (KSQ). The benefit of KSQ is the ability to develop the best care plan for the patient, as well as to differentiate the efficacy of the administered treatment. The aim of this study was to validate the KSQ in Serbian speaking population of sarcoidosis patients. The test itself is a modular, multi-organ health status measure for patients with sarcoidosis for use in clinic and the evaluation of therapies. The correlation of KSQ with different clinical course of sarcoidosis (acute vs chronic disease) and with the clinical outcome status (COS) in sarcoidosis was also investigated. A total of 159 biopsy positive sarcoidosis patients participated in this study. The average age of the participants was 49.67, majority was female (67.3%) and majority had only pulmonary form of sarcoidosis (71.7%). KSQ - new disease-specific health status instrument, was compared with 5 other already existing instruments already used and validated in sarcoidosis (Saint George Respiratory Questionnaire- SGRQ, Daily Activity List -DAL, Fatigue Assessment Scale- FAS, Medical Research Council dyspnea scale-MRC, Borg Dyspnea Scale and 15D as general questionnaire. KSQ has significant correlation with other quality of life questionnaires already used in sarcoidosis. Translated version of KSQ shows significant internal reliability, similar to the original KSQ. Serbian version of KSQ has significant correlation with different clinical course of sarcoidosis and with COS as well. The translated version of KSQ is reliable sarcoidosis specific instrument for assessing health status in these patients.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The aim of this study was to use a Serbian-language version of the disease-specific, self-report Sarcoidosis Health Questionnaire (SHQ), which was designed and originally validated in the United ...States, to assess health status in sarcoidosis patients in Serbia, as well as validating the instrument for use in the country.
This was a cross-sectional study of 346 patients with biopsy-confirmed sarcoidosis. To evaluate the health status of the patients, we used the SHQ, which was translated into Serbian for the purposes of this study. We compared SHQ scores by patient gender and age, as well as by disease duration and treatment. Lower SHQ scores indicate poorer health status.
The SHQ scores demonstrated differences in health status among subgroups of the sarcoidosis patients evaluated. Health status was found to be significantly poorer among female patients and older patients, as well as among those with chronic sarcoidosis or extrapulmonary manifestations of the disease. Monotherapy with methotrexate was found to be associated with better health status than was monotherapy with prednisone or combination therapy with prednisone and methotrexate.
The SHQ is a reliable, disease-specific, self-report instrument. Although originally designed for use in the United States, the SHQ could be a useful tool for the assessment of health status in various non-English-speaking populations of sarcoidosis patients.
Cough is frequent symptom in sarcoidosis and its impact on patient's quality of life (QoL) has not been adequately addressed so far.
The goal of this study was to determine the significant predictors ...of cough-specific and generic QoL in sarcoidosis patients.
In the prospective study 275 sarcoidosis patients administered Patient Reported Outcomes instruments for measurement of dyspnea (Borg and MRC scales) and fatigue (Fatigue Assessment Scale (FAS) and Daily Activity List (DAL)), as well as patients' QoL (cough-specific Leicester Cough Questionnaire (LCQ) and generic tool - 15D). The LCQ contains 3 domains covering physical, psychological and social aspects of chronic cough. Pulmonary function tests (spirometry and diffusing capacity for carbon monoxide) and serum angiotensin converting enzyme (sACE) were also measured.
Dyspnea measured by Borg scale and impairment of daily activities determined by DAL instrument as well as sACE were the strongest predictors of all cough-specific QoL domains. Mental aspect of patients' fatigue was significantly correlated with all domains except with psychological LCQ domain. Regarding the generic QoL, the following significant predictors were: dyspnea measured by MRC scale, overall fatigue determined by FAS and physical domain of the LCQ.
It is important to measure both cough-specific and generic QoL in sarcoidosis patients since they measure different health aspects and their predictors can be different. We demonstrated that physical domain of cough-specific QoL is significant predictor of generic QoL.
.
Introduction: Cough is frequent symptom in sarcoidosis and there are no specifi c tools for measurement of its severity in Serbia. Aim: the goal of this study was to translate and validate the ...Serbian version of the Leices-ter Cough Questionnaire (LCQ) in a population of sarcoidosis patients. Methods: After the LCQ forward-backward translation process, in the cross-sectional study in 275 (180 female) sarcoidosis patients Serbian version of the LCQ was administered together with other standardized instruments for measurement of Patient Reported Outcomes (PROs)-symptoms of dyspnea (assessed by MRC and Borg scales) and fatigue (measured by Fatigue Assessment Scale and List of Daily Activities), and patients' health status (assessed by generic tool-15D). Pulmonary function tests (spirometry and diff using capacity for carbon monoxide) were also measured. Results: Serbian LCQ version showed excellent internal consistency (Cronbach's Alpha of its diff erent scores ranged between 0.901 for physical domain and 0.951 for the total score). Concurent validity assessed by correlations of all LCQ scores with other PROs and pulmonary function tests was very good, since all these correlations were statistically signifi cant. Conclusions: Our results confi rmed that the Serbian version of LCQ is a valid instrument to monitor the infl uence of chronic cough on quality of life in sarcoidosis patients.
Introduction. The most frequent clinical outcomes in sarcoidosis patients are
typically focused on the objective measurements of functions of the involved
organs, but, generally, they do not take ...into account the individual
perception of patients? everyday functioning. The aim of this study was to
determine the type of association between the subjective disease outcomes and
other objective conventional parameters in patients with sarcoidosis.
Material and Methods. In the cross-sectional study including 172 sarcoidosis
patients (122 females), quality of life was measured by a generic instrument,
i.e. fifteen-dimensional measure of health-related quality of life together
with a respiratory specific instrument, i.e. St George?s Respiratory
Questionnaire; symptoms of fatigue were measured by Fatigue Scale and dyspnea
was measured by the Basal Dyspnea Index. Body-mass index and the course of
the disease (acute vs. chronic) were also evaluated. Pulmonary function was
assessed by spirometry. Results. Acute sarcoidosis was present in 48 (28%)
patients. Mean body mass index was 27.01?5.2. Only 20 (12%) patients had
lower forced expiratory volume in one second values (<80%) that indicated the
existance of obstructive ventilatory impairment. Multivariate linear
regression analysis revealed that body mass index, clinical course of disease
and spirometric parameter forced expiratory volume in one second were the
significant predictors (R2=0.929, p<0.01) of sarcoidosis related fatigue
(B=0.061, B=0.406, B=0.452; respectively). Body mass index and forced
expiratory volume in one second were the only parameters that significantly
predicted both patients? quality of life (R2=0.932; B=0.017, B=0.263) and
dyspnea (R2=0.847; B=0.025, B=0.668). Conclusions. It is important to measure
both subjective patient-reported outcomes and objective disease parameters in
sarcoidosis since they represent different aspects of the disease. All
applied measuring instruments for the examined subjective outcomes
demonstrated good measuring properties.
nema
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