We perform direct numerical simulations of an unstably stratified turbulent channel flow to address the effects of buoyancy on the boundary layer dynamics and mean field quantities. We systematically ...span a range of parameters in the space of friction Reynolds number (
$\mathit{Re}_{{\it\tau}}$
) and Rayleigh number (
$\mathit{Ra}$
). Our focus is on deviations from the logarithmic law of the wall due to buoyant motion. The effects of convection in the relevant ranges are discussed, providing measurements of mean profiles of velocity, temperature and Reynolds stresses as well as of the friction coefficient. A phenomenological model is proposed and shown to capture the observed deviations of the velocity profile in the log-law region from the non-convective case.
The dynamics of inertial particles in turbulence is modelled and investigated by means of direct numerical simulation of an axisymmetrically expanding homogeneous turbulent strained flow. This flow ...can mimic the dynamics of particles close to stagnation points. The influence of mean straining flow is explored by varying the dimensionless strain rate parameter
$Sk_{0}/{\it\epsilon}_{0}$
from 0.2 to 20, where
$S$
is the mean strain rate,
$k_{0}$
and
${\it\epsilon}_{0}$
are the turbulent kinetic energy and energy dissipation rate at the onset of straining. We report results relative to the acceleration variances and probability density functions for both passive and inertial particles. A high mean strain is found to have a significant effect on the acceleration variance both directly by an increase in the frequency of the turbulence and indirectly through the coupling of the fluctuating velocity and the mean flow field. The influence of the strain on the normalized particle acceleration probability distribution functions is more subtle. For the case of a passive particle we can approximate the acceleration variance with the aid of rapid-distortion theory and obtain good agreement with simulation data. For the case of inertial particles we can write a formal expression for the accelerations. The magnitude changes in the inertial particle acceleration variance and the effect on the probability density function are then discussed in a wider context for comparable flows, where the effects of the mean flow geometry and of the anisotropy at small scales are present.
We describe Lagrangian measurements of water droplets in grid generated wind tunnel turbulence at a Taylor Reynolds number of R(lambda)=250 and an average Stokes number (St) of approximately 0.1. The ...inertial particles are tracked by a high speed camera moving along the side of the tunnel at the mean flow speed. The standardized acceleration probability density functions of the particles have spread exponential tails that are narrower than those of a fluid particles (St approximately 0) and there is a decrease in the acceleration variance with increasing Stokes number. A simple vortex model shows that the inertial particles selectively sample the fluid field and are less likely to experience regions of the fluid undergoing the largest accelerations. Recent direct numerical simulations compare favorably with these first measurements of Lagrangian statistics of inertial particles in highly turbulent flows.
The role of turbulence in droplet growth in clouds is controversial, in part because of the difficulty of studying underlying processes in the cloud environment, and in part because of the difficulty ...of achieving real cloud conditions in controlled laboratory or computational studies. This paper is a synthesis of research on turbulence effects on cloud droplets that includes field and laboratory studies. Results from cloud measurements show that the turbulence exhibits similar internal intermittency to that observed in the laboratory, and in direct numerical simulations. We explore the consequences of this by relating measurements of droplet accelerations in the laboratory, to conditions observed in the clouds. We show that there is a strong likelihood of droplet accelerations in clouds exceeding the acceleration due to gravity. We discuss these observations in terms of the dynamics of droplets, including velocity statistics and clustering, and their influence on droplet growth.
Humoral Immune Response to SARS-CoV-2 in Iceland Gudbjartsson, Daniel F; Norddahl, Gudmundur L; Melsted, Pall ...
The New England journal of medicine,
10/2020, Letnik:
383, Številka:
18
Journal Article
Recenzirano
Odprti dostop
This large comparative study of the Icelandic population showed that the humoral response did not decline within 4 months after infection, that 44% of persons who had been infected had not been ...diagnosed with qPCR, and that the infection fatality risk was 0.3%.
From hot-wire anemometer measurements in active-grid wind-tunnel turbulence we have determined the Reynolds number dependence of the velocity derivative moments, the mean-squared pressure gradient, ...$\chi$, and the normalized acceleration variance, $a_0$, over the Reynolds number range $100\,{\leq}\,R_\lambda\,{\leq}\,900$. The values of $\chi$ and $a_0$ were obtained from the fourth-order velocity structure functions. The derivative moments show power-law dependence on Reynolds number and the exponent is the same with or without shear. In particular, we find the derivative kurtosis, $K_{\partial u/\partial x }\,{\sim}\,R_\lambda^{0.39}$, and there is no evidence of the transition that has been observed in this quantity in some recent work. We find that at high Reynolds numbers, $\chi$ and $a_0$ tend to values similar to those obtained by direct particle tracking measurements and by direct numerical simulation. However, at lower Reynolds number our estimates of $\chi$ and $a_0$ appear to be affected by the evaluation technique which imposes strict requirements on local homogeneity and isotropy.
Homogeneous, approximately isotropic turbulence at two Taylor-scale Reynolds numbers, Rλ=50, 190, with a mean transverse temperature gradient is passed through an axisymmetric contraction. The ...effects of the straining on the velocity field, and on the passive scalar field, are investigated within the contraction as are the effects of releasing the strain in the post-contraction region. Components of the fluctuating velocity and scalar gradient covariance are measured in order to understand their relation to the large-scale anisotropy of the flow. The scale-dependent spectral evolution of the scalar is also determined. A tensor model is constructed to predict the evolution of the fluctuating scalar gradient covariance. The model constants are determined in the post-contraction relaxation region, where the flow geometry does not vary. The model is shown to perform well throughout the flow, even in the contraction in which the geometry varies. Rapid distortion theory is applied to the scalar field in the contraction, and its solutions are compared to the experimental results.
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls ...throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes (P = 2.1 × 10−9). This was replicated in a Danish cohort (P = 4.8 × 10−3) and in a US cohort (P = 3.3 × 10−9). Compared with non-carriers, heterozygous and homozygous carriers of the at-risk alleles (38% and 7% of the population, respectively) have relative risks of 1.45 and 2.41. This corresponds to a population attributable risk of 21%. The TCF7L2 gene product is a high mobility group box-containing transcription factor previously implicated in blood glucose homeostasis. It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region ...initially identified through a study of Icelandic families. Allele −8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 × 10−11). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of ∼8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Deletions and reciprocal duplications of the chromosome 16p13.1 region have recently been reported in several cases of autism and mental retardation (MR). As genomic copy number variants found in ...these two disorders may also associate with schizophrenia, we examined 4345 schizophrenia patients and 35,079 controls from 8 European populations for duplications and deletions at the 16p13.1 locus, using microarray data. We found a threefold excess of duplications and deletions in schizophrenia cases compared with controls, with duplications present in 0.30% of cases versus 0.09% of controls (P=0.007) and deletions in 0.12 % of cases and 0.04% of controls (P>0.05). The region can be divided into three intervals defined by flanking low copy repeats. Duplications spanning intervals I and II showed the most significant (P = 0.00010) association with schizophrenia. The age of onset in duplication and deletion carriers among cases ranged from 12 to 35 years, and the majority were males with a family history of psychiatric disorders. In a single Icelandic family, a duplication spanning intervals I and II was present in two cases of schizophrenia, and individual cases of alcoholism, attention deficit hyperactivity disorder and dyslexia. Candidate genes in the region include NTAN1 and NDE1. We conclude that duplications and perhaps also deletions of chromosome 16p13.1, previously reported to be associated with autism and MR, also confer risk of schizophrenia.
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