. Chao C, Klein NP, Velicer CM, Sy LS, Slezak JM, Takhar H, Ackerson B, Cheetham TC, Hansen J, Deosaransingh K, Emery M, Liaw K‐L, Jacobsen SJ (Kaiser Permanente Southern California, Pasadena, CA; ...Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California, Oakland, CA; Merck Research Laboratories, Upper Gwynedd, PA; South Bay Medical Center, Kaiser Permanente Southern California, Los Angeles, CA; and Kaiser Permanente Southern California, Downey, CA, USA). Surveillance of autoimmune conditions following routine use of quadrivalent human papillomavirus vaccine. J Intern Med 2012; 271: 193–203.
Objective. An observational safety study of the quadrivalent human papillomavirus vaccine (HPV4) in women was conducted. This report presents findings from autoimmune surveillance.
Design. Subjects were followed for 180 days after each HPV4 dose for new diagnoses of 16 prespecified autoimmune conditions.
Setting. Two managed care organizations in California.
Subjects. Number of 189 629 women who received ≥1 dose of HPV4 between 08/2006 and 03/2008.
Outcome. Potential new‐onset autoimmune condition cases amongst HPV4 recipients were identified by electronic medical records. Medical records of those with ≥12‐month health plan membership prior to vaccination were reviewed by clinicians to confirm the diagnosis and determine the date of disease onset. The incidence of each autoimmune condition was estimated for unvaccinated women at one study site using multiple imputations and compared with that observed in vaccinated women. Incidence rate ratios (IRR) were calculated. Findings were reviewed by an independent Safety Review Committee (SRC).
Results. Overall, 1014 potential new‐onset cases were electronically identified; 719 were eligible for case review; 31–40% were confirmed as new onset. Of these, no cluster of disease onset in relation to vaccination timing, dose sequence or age was found for any autoimmune condition. None of the estimated IRR was significantly elevated except Hashimoto’s disease IRR = 1.29, 95% confidence interval: 1.08–1.56. Further investigation of temporal relationship and biological plausibility revealed no consistent evidence for a safety signal for autoimmune thyroid conditions. The SRC and the investigators identified no autoimmune safety concerns in this study.
Conclusions. No autoimmune safety signal was found in women vaccinated with HPV4.
Glaciers and ice streams flowing over sediment beds commonly have a layer of ice‐rich debris adhered to their base, known as a “frozen fringe,” but its impact on basal friction is unknown. We ...simulated basal slip over granular beds with a cryogenic ring shear device while ice infiltrated the bed to grow a fringe, and measured the frictional response under different effective stresses and slip speeds. Frictional resistance increased with increasing slip speed until it plateaued at the frictional strength of the till, closely resembling the regularized Coulomb slip law associated with clean ice over deformable beds. We hypothesize that this arises from deformation in a previously unidentified zone of weakly frozen sediments at the fringe's base, which is highly sensitive to temperature and stress gradients. We show how a rheologic model for ice‐rich debris coupled with the thermomechanics of fringe growth can account for the regularized Coulomb behavior.
Plain Language Summary
Many glaciers move by sliding over sediment beds. As the glacier flows downslope, ice can infiltrate the underlying sediments, forming a layer of ice‐rich debris attached at the glacier's base. We investigated how this frozen fringe impacts glacier motion by simulating glacier slip in a cold‐room facility with a specialized ring shear device. We recreated glacier conditions, sliding ice over granular beds to form the fringe, and then assessed how frictional resistance at the slip interface varied under different stresses and ice speeds. We found that frozen fringe influences the relationship between ice speed and frictional resistance, known as the “slip law.” As ice speed increased, basal friction increased to a threshold that matches the strength of the ice‐free sediment bed—mirroring the “regularized Coulomb slip law” inferred for clean ice over soft beds. We attribute this behavior to deformation in a weakly frozen zone at the base of the frozen fringe and show how this behavior can be incorporated into existing parameterizations of glacier slip.
Key Points
Ring shear experiments show frozen fringe alters basal slip dynamics for soft‐bedded glaciers
Deformation in a zone of weakly frozen sediments within the fringe leads to a regularized Coulomb slip response
Hospital staff are often exposed to stressful psychosocial working conditions and report high levels of stress and burnout, which may negatively impact the safety of employees and patients. Managers ...hold unique knowledge of workplace conditions and needs of employees, but leadership interventions to improve the well-being of managers and employees in hospital settings are scarce. This study evaluates the effects of a leadership intervention based on a health-oriented leadership approach on the well-being and psychosocial work environment aspects of managers and employees.
The study is designed as a randomized, waitlist-controlled trial with two groups (intervention and waitlist control group) and measurements at baseline, 6- and 12-month follow-up. We aim to include 200 frontline managers in Danish hospital settings and their approximately 5,000 employees. The leadership training comprises five full day modules and four smaller group-training sessions over a period of 5 months. The main aim is to improve stress, burnout, self-care, and perceived level of staff-care among managers and employees. Sickness absence will also be assessed at both manager and employee level. In addition, several psychosocial factors will be assessed at the employee level. A quantitative and qualitative process evaluation will also be conducted.
Action towards supporting the mental health of hospital employees is important to maintain a strong healthcare system. There is increasing recognition that best practice in workplace mental health requires an integrated approach that prevents harm and promotes positive mental health. There is also increasing understanding of the key role managers' play in maintaining well-being within the workplace, however they often report a lack of knowledge and skills to promote employee mental health. The current leadership training program has been developed for frontline managers working in a hospital setting. The aim is to increase managers' application of strategies to facilitate a healthy psychosocial work environment to benefit well-being and mental health among staff and managers themselves.
The study was retrospectively registered on November 21, 2022 in Clinical Trial.gov with identifier: NCT05623371.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Context. The rapid neutron-capture process, which created about half of the heaviest elements in the solar system, is believed to have been unique. Many recent studies have shown that this uniqueness ...is not true for the formation of lighter elements, in particular those in the atomic number range 38 < Z < 48. Among these, palladium (Pd) and especially silver (Ag) are expected to be key indicators of a possible second r-process, but until recently they have been studied only in a few stars. We therefore target Pd and Ag in a large sample of stars and compare these abundances to those of Sr, Y, Zr, Ba, and Eu produced by the slow (s-) and rapid (r-) neutron-capture processes. Hereby we investigate the nature of the formation process of Ag and Pd. Aims. We study the abundances of seven elements (Sr, Y, Zr, Pd, Ag, Ba, and Eu) to gain insight into the formation process of the elements and explore in depth the nature of the second r-process. Methods. By adopting a homogeneous one-dimensional local thermodynamic equilibrium (1D LTE) analysis of 71 stars, we derive stellar abundances using the spectral synthesis code MOOG, and the MARCS model atmospheres. We calculate abundance ratio trends and compare the derived abundances to site-dependent yield predictions (low-mass O-Ne-Mg core-collapse supernovae and parametrised high-entropy winds), to extract characteristics of the second r-process. Results. The seven elements are tracers of different (neutron-capture) processes, which in turn allows us to constrain the formation process(es) of Pd and Ag. The abundance ratios of the heavy elements are found to be correlated and anti-correlated. These trends lead to clear indications that a second/weak r-process, is responsible for the formation of Pd and Ag. On the basis of the comparison to the model predictions, we find that the conditions under which this process takes place differ from those for the main r-process in needing lower neutron number densities, lower neutron-to-seed ratios, and lower entropies, and/or higher electron abundances. Conclusions. Our analysis confirms that Pd and Ag form via a rapid neutron-capture process that differs from the main r-process, the main and weak s-processes, and charged particle freeze-outs. We find that this process is efficiently working down to the lowest metallicity sampled by our analysis (Fe/H = − 3.3). Our results may indicate that a combination of these explosive sites is needed to explain the variety in the observationally derived abundance patterns.
Immune abnormalities have been described in some individuals with autism spectrum disorders (ASDs) as well as their family members. However, few studies have directly investigated the role of ...prenatal cytokine and chemokine profiles on neurodevelopmental outcomes in humans. In the current study, we characterized mid-gestational serum profiles of 22 cytokines and chemokines in mothers of children with ASD (N=415), developmental delay (DD) without ASD (N=188), and general population (GP) controls (N=428) using a bead-based multiplex technology. The ASD group was further divided into those with intellectual disabilities (developmental/cognitive and adaptive composite score<70) (ASD+ID, N=184) and those without (composite score⩾70) (ASD-noID, N=201). Levels of cytokines and chemokines were compared between groups using multivariate logistic regression analyses, adjusting for maternal age, ethnicity, birth country and weight, as well as infant gender, birth year and birth month. Mothers of children with ASD+ID had significantly elevated mid-gestational levels of numerous cytokines and chemokines, such as granulocyte macrophage colony-stimulating factor, interferon-γ, interleukin-1α (IL-1α) and IL-6, compared with mothers of children with either ASD-noID, those with DD, or GP controls. Conversely, mothers of children with either ASD-noID or with DD had significantly lower levels of the chemokines IL-8 and monocyte chemotactic protein-1 compared with mothers of GP controls. This observed immunologic distinction between mothers of children with ASD+ID from mothers of children with ASD-noID or DD suggests that the intellectual disability associated with ASD might be etiologically distinct from DD without ASD. These findings contribute to the ongoing efforts toward identification of early biological markers specific to subphenotypes of ASD.
Biomedical research projects deal with data management requirements from multiple sources like funding agencies' guidelines, publisher policies, discipline best practices, and their own users' needs. ...We describe functional and quality requirements based on many years of experience implementing data management for the CRC 1002 and CRC 1190. A fully equipped data management software should improve documentation of experiments and materials, enable data storage and sharing according to the FAIR Guiding Principles while maximizing usability, information security, as well as software sustainability and reusability.
We introduce the modular web portal software menoci for data collection, experiment documentation, data publication, sharing, and preservation in biomedical research projects. Menoci modules are based on the Drupal content management system which enables lightweight deployment and setup, and creates the possibility to combine research data management with a customisable project home page or collaboration platform.
Management of research data and digital research artefacts is transforming from individual researcher or groups best practices towards project- or organisation-wide service infrastructures. To enable and support this structural transformation process, a vital ecosystem of open source software tools is needed. Menoci is a contribution to this ecosystem of research data management tools that is specifically designed to support biomedical research projects.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
What is the extent and scale of local adaptation (LA)? How quickly does LA arise? And what is its underlying molecular basis? Our review and meta-analysis on salmonid fishes estimates the frequency ...of LA to be ∼55-70%, with local populations having a 1.2 times average fitness advantage relative to foreign populations or to their performance in new environments. Salmonid LA is evident at a variety of spatial scales (for example, few km to>1000 km) and can manifest itself quickly (6-30 generations). As the geographic scale between populations increases, LA is generally more frequent and stronger. Yet the extent of LA in salmonids does not appear to differ from that in other assessed taxa. Moreover, the frequency with which foreign salmonid populations outperform local populations (∼23-35%) suggests that drift, gene flow and plasticity often limit or mediate LA. The relatively few studies based on candidate gene and genomewide analyses have identified footprints of selection at both small and large geographical scales, likely reflecting the specific functional properties of loci and the associated selection regimes (for example, local niche partitioning, pathogens, parasites, photoperiodicity and seasonal timing). The molecular basis of LA in salmonids is still largely unknown, but differential expression at the same few genes is implicated in the convergent evolution of certain phenotypes. Collectively, future research will benefit from an integration of classical and molecular approaches to understand: (i) species differences and how they originate, (ii) variation in adaptation across scales, life stages, population sizes and environmental gradients, and (iii) evolutionary responses to human activities.
We measure cross-beam energy transfer (CBET) saturation by ion heating in a gas-jet plasma characterized using Thomson scattering. A wavelength-tunable ultraviolet (UV) probe laser beam interacts ...with four intense UV pump beams to drive large-amplitude ion-acoustic waves. For the highest-intensity interactions, the power transfer to the probe laser drops, demonstrating ion-acoustic wave saturation. Over this time, the ion temperature is measured to increase by a factor of 7 during the 500-ps interaction. Particle-in-cell simulations show ion trapping and a subsequent ion heating consistent with measurements. Linear kinetic CBET models are found to agree well with the observed energy transfer when the measured plasma conditions are used.
Background
Atrial fibrillation (AF) detection and treatment are key elements to reduce recurrence risk in cryptogenic stroke (CS) with underlying arrhythmia. The purpose of the present study was to ...assess the predictors of AF in CS and the utility of existing AF-predicting scores in The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study.
Method
The NOR-FIB study was an international prospective observational multicenter study designed to detect and quantify AF in CS and cryptogenic transient ischaemic attack (TIA) patients monitored by the insertable cardiac monitor (ICM), and to identify AF-predicting biomarkers. The utility of the following AF-predicting scores was tested: AS5F, Brown ESUS-AF, CHA
2
DS
2
-VASc, CHASE-LESS, HATCH, HAVOC, STAF and SURF.
Results
In univariate analyses increasing age, hypertension, left ventricle hypertrophy, dyslipidaemia, antiarrhythmic drugs usage, valvular heart disease, and neuroimaging findings of stroke due to intracranial vessel occlusions and previous ischemic lesions were associated with a higher likelihood of detected AF. In multivariate analysis, age was the only independent predictor of AF. All the AF-predicting scores showed significantly higher score levels for AF than non-AF patients. The STAF and the SURF scores provided the highest sensitivity and negative predictive values, while the AS5F and SURF reached an area under the receiver operating curve (AUC) > 0.7.
Conclusion
Clinical risk scores may guide a personalized evaluation approach in CS patients. Increasing awareness of the usage of available AF-predicting scores may optimize the arrhythmia detection pathway in stroke units.
The accuracy of stellar masses and radii determined from asteroseismology is not known! We examine this issue for giant stars by comparing classical measurements of detached eclipsing binary systems ...(dEBs) with asteroseismic measurements from the Kepler mission. For star clusters, we extrapolate measurements of dEBs in the turn‐off region to the red giant branch and the red clump where we investigate the giants as an ensemble. For the field stars, we measure dEBs with an oscillating giant component. These measurements allow a comparison of masses and radii calculated from a classical eclipsing binary analysis to those calculated from asteroseismic scaling relations and/or other asteroseismic methods. Our first results indicate small but significant systematic differences between the classical and asteroseismic measurements. In this contribution we show our latest results and summarize the current status and future plans. We also stress the importance of realizing that for giant stars mass cannot always be translated to age, since an unknown fraction of these evolved through a blue straggler phase with mass transfer in a binary system. Rough estimates of how many such stars to expect are given based on our findings in the open clusters NGC 6819 and NGC 6791.
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