Axillary lymph node (LN) metastasis is the most important predictor of overall recurrence and survival in patients with breast cancer, and accurate assessment of axillary LN involvement is an ...essential component in staging breast cancer. Axillary management in patients with breast cancer has become much less invasive and individualized with the introduction of sentinel LN biopsy (SLNB). Emerging evidence indicates that axillary LN dissection may be avoided in selected patients with node-positive as well as node-negative cancer. Thus, assessment of nodal disease burden to guide multidisciplinary treatment decision making is now considered to be a critical role of axillary imaging and can be achieved with axillary US, MRI, and US-guided biopsy. For the node-positive patients treated with neoadjuvant chemotherapy, restaging of the axilla with US and MRI and targeted axillary dissection in addition to SLNB is highly recommended to minimize the false-negative rate of SLNB. Efforts continue to develop prediction models that incorporate imaging features to predict nodal disease burden and to select proper candidates for SLNB. As methods of axillary nodal evaluation evolve, breast radiologists and surgeons must work closely to maximize the potential role of imaging and to provide the most optimized treatment for patients.
The facile fabrication of thin and foldable self‐healing electronics on a poly(vinyl alcohol)/cellulose nanocrystal (PVA/CNC) composite film is reported. The self‐healing property of the PVA/CNC ...nanocomposite film can be activated by spraying water on the film surface, via dynamic formation of hydrogen bonding. The self‐healing efficiency of PVA/CNC is influenced by the content of CNC in the film, pH of the spraying solution, and the temperature. Via vacuum filtration and pattern transfer techniques, both a supercapacitor and a temperature sensor are fabricated on the same PVA/CNC film using gold nanosheet (AuNS) and polyaniline/multiwalled nanotube (PANI/MWCNT) electrodes. The fabricated supercapacitor with a gel‐type electrolyte exhibits a high electrochemical performance, and the thermoresistive temperature sensor shows a linear sensitivity with a fast response. Both devices exhibit superior mechanical stability and self‐healing property over 100 repetitive folding and five repetitive healing cycles, respectively, retaining the device performance owing to the percolated network of the conductive materials. This work demonstrates that our paper‐like thin PVA/CNC film‐based self‐healable devices can serve as highly durable and deformable electronics with longevity.
A paper‐like, thin, foldable, and self‐healable electronic based on poly(vinyl alcohol)/cellulose nanocrystal (PVA/CNC) nanocomposite film shows a water‐stimulated self‐healing property due to dynamic hydrogen bonding formation. A high‐performance planar supercapacitor and thermoresistive temperature sensor fabricated on the PVA/CNC substrate exhibits a high electrical self‐healing property after complete bisection as well as high mechanical stability under repetitive folding deformation.
Following curative liver resection (LR), resectable tumor recurrence in patients with preserved liver function leads to deciding between a repeat LR and a salvage liver transplantation (LT), if a ...donor’s liver is available. This retrospective study compared survival outcomes and recurrence pattern following salvage living donor LT (LDLT) and repeat LR in patients with recurrent hepatocellular carcinoma (HCC). We reviewed the medical records of patients who underwent repeat LR (n = 163) or LDLT (n = 84) for recurrent HCC following curative resections, between January 2005 and December 2017 at a single institution. A 1:1 propensity score matching led to 42 patients per group. Disease‐specific and recurrence‐free survival were significantly better in the salvage LDLT group than in the repeat LR group (p = .042; HR = 2.40; 95% CI, 0.69–6.00 and p < .001; HR = 4.23; 95% CI, 2.05–8.71, respectively). Despite significant differences in recurrence patterns between the two groups (p = .019), the patient death rates, after recurrence, were similar for both groups (p = .760). This study indicates that salvage LDLT is superior to repeat LR for treating patients with transplantable, intrahepatic HCC recurrence, even in patients with Child‐Pugh class A liver cirrhosis.
Salvage living donor liver transplantation is superior to repeat liver resection to treat patients with transplantable, recurrent intrahepatic hepatocellular carcinoma, even in patients with Child–Pugh class A liver cirrhosis.
•‘PF1, 6 and CS lifting Frame’ and ‘Sector lifting Tool’ are designed and manufactured by Korea Domestic Agency (KODA).•The lifting tools were designed considering 2 times payload according to EN ...standard.•The structural integrity of lifting tools was verified by load test considering 1.5 times payload at least over 15 min.•The payloads of 1566 tones and 2028 tones were applied using hydraulic cylinders and customized jig structure.•All lifting tools were successfully withstood under required test load without defect or plastic deformation.
Korea Domestic Agency (ITER Korea, KODA) has procured 44 kind's assembly tools for ITER project. The assembly tools are classified by the steel structure, lifting table and lifting accessory. ‘PF 1, 6 and Central Solenoid Lifting Frame’ (CS Lifting Frame) and ‘Sector Lifting Tool’ (SLT) are the representative assembly tool classified the lifting accessory. The assembly tools handle the heavy component which over 1,000 tones for payload. In this reason, the verification of the strength of the tools is very important and the integrity of lifting accessory tools was verified by not only structural analysis but also load test at factory under 1.5 times the payload for minimum 15 min. It is the requirements of the technical specification. The main role of PF 1, 6 and CS Lifting Frame is to lift and transfer the ITER components (PF1 coil, PF6 coil and CS coil) from the assembly hall to the tokamak fit and their temporary support positions. The CS coil is heaviest component in payloads handled by CS Lifting Frame. The weight is about 1,000 tones and CS Lifting Frame was verified by 1,500 tones load test. Sector Lifting Frame is to lift and transfer the 40° sector module from Sector Sub-Assembly Tool (SSAT) to tokamak fit. The sector module consists of Vacuum Vessel (VV), VV Thermal Shield and Two Toroidal Flied Coils. The total weight of the sector module is about 1,300 tones and Sector Lifting Frame was verified by 2,000 tones load test. The load test was carried out according to test procedure approved by IO. This paper describes the overall test method, customized test JIG and result of the lifting tools for handling heavy components of ITER.
Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME) that play an important role in cancer progression. Although the mechanism by which CAFs promote ...tumorigenesis has been well investigated, the underlying mechanism of CAFs activation by neighboring cancer cells remains elusive. In this study, we aim to investigate the signaling pathways involved in CAFs activation by gastric cancer cells (GC) and to provide insights into the therapeutic targeting of CAFs for overcoming GC.
Alteration of receptor tyrosine kinase (RTK) activity in CAFs was analyzed using phospho-RTK array. The expression of CAFs effector genes was determined by RT-qPCR or ELISA. The migration and invasion of GC cells co-cultured with CAFs were examined by transwell migration/invasion assay.
We found that conditioned media (CM) from GC cells could activate multiple receptor tyrosine kinase signaling pathways, including ERK, AKT, and STAT3. Phospho-RTK array analysis showed that CM from GC cells activated PDGFR tyrosine phosphorylation, but only AKT activation was PDGFR-dependent. Furthermore, we found that connective tissue growth factor (CTGF), a member of the CCN family, was the most pronouncedly induced CAFs effector gene by GC cells. Knockdown of CTGF impaired the ability of CAFs to promote GC cell migration and invasion. Although the PDGFR-AKT pathway was pronouncedly activated in CAFs stimulated by GC cells, its pharmacological inhibition affected neither CTGF induction nor CAFs-induced GC cell migration. Unexpectedly, the knockdown of SRC and SRC-family kinase inhibitors, dasatinib and saracatinib, significantly impaired CTGF induction in activated CAFs and the migration of GC cells co-cultured with CAFs. SRC inhibitors restored the reduced expression of epithelial markers, E-cadherin and Zonula Occludens-1 (ZO-1), in GC cells co-cultured with CAFs, as well as CAFs-induced aggregate formation in a 3D tumor spheroid model.
This study provides a characterization of the signaling pathways and effector genes involved in CAFs activation, and strategies that could effectively inhibit it in the context of GC. Video Abstract.
Machine learning (ML) has quickly emerged in synthetic organic chemistry to predict reaction outcomes such as yields and stereoselectivities. Notably, recent applications of the ML approach showed ...powerful performance in solving various chemical problems. However, the requirement of numerous descriptors and large datasets hampers the general use by non‐specialists. In this study, simple ML models were developed by utilizing easily available 13C‐NMR chemical shifts of the substrates as familiar descriptors to predict the site‐selectivity of geminal chlorofluorination of unsymmetrical 1,2‐dicarbonyl compounds. We identified that the feed‐forward neural network (FNN) model provides higher accuracy compared to other algorithms. Then, better prediction performance was acquired through streamlined models using minimal, only empirically relevant descriptors.
In this study, we propose the direct diagnosis of thyroid cancer using a small probe. The probe can easily check the abnormalities of existing thyroid tissue without relying on experts, which reduces ...the cost of examining thyroid tissue and enables the initial self-examination of thyroid cancer with high accuracy. A multi-layer silicon-structured probe module is used to photograph light scattered by elastic changes in thyroid tissue under pressure to obtain a tactile image of the thyroid gland. In the thyroid tissue under pressure, light scatters to the outside depending on the presence of malignant and positive properties. A simple and easy-to-use tactile-sensation imaging system is developed by documenting the characteristics of the organization of tissues by using non-invasive technology for analyzing tactile images and judging the properties of abnormal tissues.
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