One of the most serious complications of COVID-19 is the development of uncontrolled production of cytokines that poses a major factor contributing to COVID-19 morbidity and mortality. The exact ...effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on clinical and biochemical course of in patients with underlying immune compromised conditions is not well known with recent available data. The present letter aimed to draw attention to COVID-19 in immune deficiency.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Coronavirus disease-2019 (COVID-19) became a serious public health problem and caused a rapid pandemic. Fever, dry cough, and dyspnea are the most common symptoms of COVID-19. In addition to the ...respiratory symptoms, gastrointestinal manifestations of COVID-19 are also increasingly recognized. Herein, the authors present a patient with COVID-19 complicated with acute pancreatitis.
Cryptococcal meningitis (CM), as a life-threatening opportunistic infection, often is among cases with cell-mediated immunodeficiencies, such as AIDS, hematologic malignancies, and solid organ ...transplant recipients. Cryptococcal meningitis in healthy individuals is uncommon, and its detection in immunocompetent cases may be tricky because the presentation is generally more indolent than the traditional meningitis presentation, leading to late diagnosis and potential sequels. We present a CM case in an immunocompetent Iranian male patient who was treated successfully.
A20-year-old woman with fever (39 °C) and chill was referred to our emergency department. She had noticeable jaundice and scleral icterus. She also reported a two-day history of epigastric pain ...radiating to the right upper quadrant, a mild sore throat, and urine discoloration. In the primary laboratory findings, elevated liver enzymes were detected, and abdominal sonography showed splenomegaly (131 mm) and gallbladder wall thickening (9 mm). Based on the clinical, laboratory, and imaging findings, the diagnosis of acalculous cholecystitis was made.
Key Clinical Message
Invasive candidiasis may be one of the serious complications of transurethral lithotripsy. Candiduria before this procedure should be assessed, and antifungals should be ...prescribed.
This case is about a 44‐year‐old diabetic female patient who, after trans‐urethral lithotripsy with double‐J stent insertion, was diagnosed with Candida pneumonia and Candida endophthalmitis.
Nowadays, Acinetobacter baumannii is resistant to almost all available antibiotics. The evaluation of synergistic effects between the antibiotics against this pathogen is among the efforts to ...counteract its antimicrobial resistance. This study aimed to evaluate possible synergistic effect of colistin and ampicillin/sulbactam (separately) with several antibiotics against clinical isolates of multi-drug resistant (MDR) A. baumannii.
Acinetobacter baumannii strains were isolated from biological samples of hospitalized patients with any type of nosocomial infection related to this pathogen. Only MDR strains (resistance to at least three classes of antibiotics including cephalosporins, fluoroquinolones, and aminoglycosides) were included in the study. After determining the minimum inhibitory concentration (MIC) of antibiotics against the isolates by broth microdilution test, the checkerboard method was used for evaluation of any possible synergistic effect of both colistin and ampicillin/sulbactam with several other antibiotics.
Twenty isolates underwent synergy test for colistin and 20 isolates for ampicillin/sulbacatam. Doxycycline (55%), azithromycin (35%), and co-trimoxazole (35%) had the most frequency of synergistic effect with colistin. On the other hand, amikacin and gentamicin (55%), doxycycline (50%), co-trimoxazole (45%), azithromycin (40%), and cefepime (40%) had the most frequency of synergistic effect with ampicillin/sulbactam. No antagonistic effect was observed for both antibiotics.
Colistin and ampicillin/sulbactam have substantial synergistic effect with several antibiotics especially doxycycline, co-trimoxazole, azithromycin, and amikacin (with ampicillin/sulbactam) against MDR strains of Acinetobacter baumannii.