The mono-dentate ligands, 3-aminomethyl-
N-phthalimido-pyridine (L
1) and 3-amino-
N-phthalimido-pyridine (L
2), were synthesised using a solvent-free melt method. These ligands were then used to ...access three pairs of functionalised luminescent Re
I complexes of the generic type
fac-{Re(CO)
3(diimine)(L
n
)}(BF
4). The photophysical studies show that the visible emission from each of the six complexes is
3MLCT at room temperature. Within each pair of complexes the precise energy of the emission was subtly dependent upon the axial ligand, L
n
with luminescence lifetimes in the range 121–288
ns.
The mono-dentate ligands, 3-aminomethyl-
N-phthalimido-pyridine (L
1) and 3-amino-
N-phthalimido-pyridine (L
2), were synthesised using a solvent-free melt method. These ligands were then used to access three pairs of functionalised luminescent Re
I complexes of the generic type
fac-{Re(CO)
3(diimine)(L
n
)}(BF
4) where diimine
=
4,4′-dimethyl-2,2′-bipyridine (
dmb); 2,2′-bipyridine (
bpy); 1,10-phenanthroline (
phen). X-ray crystallography has been used to structurally characterise five of the complexes showing that in the cases of the L
1 species the phthalimide unit is adjacent to and co-planar with the coordinated diimine ligand. Solution state UV–Vis absorption, electrochemistry and IR studies confirm that the proposed formulations and coordination modes exist in solution. The photophysical studies show that the visible emission from each of the six complexes is
3MLCT at room temperature. Within each pair of complexes the precise energy of the emission was subtly dependent upon the axial ligand, L
n
with luminescence lifetimes in the range 121–288
ns.
Imidazo1,2-apyrimidines and imidazo1,2-b1,2,4triazines are ligands for the benzodiazepine binding site of GABAA receptors that are functionally selective for the α2/α3 subtypes over the α1 subtype. ...SAR studies to optimise this functional selectivity, pharmacokinetic and behavioural data are described.
Imidazo1,2-apyrimidines and imidazo1,2-b1,2,4triazines are ligands for the benzodiazepine binding site of GABAA receptors that are functionally selective for the α2/α3 subtypes over the α1 subtype. SAR studies to optimise this functional selectivity, pharmacokinetic and behavioural data are described.
A rearrangement reaction involving the indole nucleus was investigated using stereochemical markers and low-temperature NMR experiments. Treatment of ...(3S,4S)-3-hydroxy-4-(2-phenyl-1H-indol-3-yl)-piperidine-1-carboxylic acid benzyl ester (>90% ee) with diethylaminosulfur trifluoride gave stereospecifically (3S,4S)-4-fluoro-3-(2-phenyl-1H-indol-3-yl)-piperidine-1-carboxylic acid benzyl ester (>90% ee) with complete regioselectivity. The initial formation of a reactive spirocyclopropyl-3H-indole intermediate is believed to be responsible for the stereo- and regiochemical outcome of the reaction.
Clinical and anatomic factors predictive of a favorable response to renal revascularization performed for renal function salvage remain poorly defined. To clarify decision making in such patients we ...reviewed a contemporary experience of surgical renal artery revascularization (RAR) performed primarily for preservation of renal function.
Between June 1990 and March 2001 (ensuring 1 year minimum follow-up), 96 patients with renal insufficiency (serum creatinine Cr concentration >or=1.5 mg/dL) and hypertension underwent RAR for preservation of renal function. Study end points included early and late renal function response, progression to dialysis dependence, and long-term survival. Variables potentially associated with these end points were assessed with univariate analysis, Cox regression analysis, and logistic regression analysis, and survival was assessed with the Kaplan-Meier method.
Perioperative failure of RAR occurred in 3 patients (3%), with perioperative mortality in 4 patients (4.1%); thus 92 patients were available for long-term follow-up (mean, 39 months). Mean patient age was 70 +/- 9 years with a mean baseline Cr of 2.6 mg/dL (range, 1.5-7.8 mg/dL). Operative management consisted of aortorenal bypass in 38% of patients, extraanatomic bypass in 38% of patients, and endarterectomy in 24% of patients; 32% of patients required combined aortic revascularization and RAR, and 27% underwent bilateral RAR. At hospital discharge renal function had improved (20% decrement in Cr) in 41 (43%) patients, including 7 patients who were removed from dialysis; remained unchanged in 40 (41%) patients; and declined (20% increase in Cr) in 15 (16%) patients. At last follow-up renal function was either improved or unchanged in 72% of patients. Predictors of a favorable response to RAR at last follow-up included stable Cr at hospital discharge (odds ratio OR, 7.1; 95% confidence interval CI, 2.5-21.8; P =.0004) and decreased Cr at hospital discharge (OR, 16; 95% CI, 1.6-307.8; P <.0001); bilateral renal artery repair (OR, 3.1; 95% CI, 0.9-10.6; P =.07) approached clinical significance. Predictors of worsened excretory function at last follow-up included decline of renal function at hospital discharge (OR, 28.9; 95% CI, 5.0-165.4; P =.0002), intervention to treat unilateral renal artery stenosis (OR, 3.8; 95% CI, 0.8-16.6; P =.05), and level of baseline Cr (OR, 3.0; 95% CI, 1.0-4.0; P =.04). Progression to dialysis occurred in 16 (17%) patients. Dialysis-free survival at 5 years was 50%, and overall actuarial survival at 5 years was 59%. Predictors of progression to dialysis during follow-up included treatment of complete renal artery occlusion (OR, 6.2; 95% CI, 1.3-29.5; P =.02), early failure of RAR (OR, 3.1; 95% CI, 0.7-14.2; P =.04) and baseline Cr (OR, 2.9; 95% CI, 1.3-6.1; P =.006).
Long-term clinical success in the preservation of renal function, noted in 70% of patients, can be predicted by the initial response to RAR and by anatomic factors, in particular, bilateral repair. While extreme (mean Cr >or=3.2 mg/dL) renal dysfunction generally is predictive of poor long-term outcome, a subset of patients will experience favorable results, even to the extent of rescue from dialysis. These results may facilitate clinical decision making in the application of RAR for renal function salvage.
Background
When traditional approaches to waitlist management are unsuccessful, service managers and providers must consider alternatives.
Purpose
To describe how the model of human performance ...technology was used to address an extensive pediatric waitlist.
Methods
Data were obtained from in-depth interviews with clinicians, educators, and parents and analyzed according to the model.
Findings
The need for a paradigm shift from a linear model of service delivery to a continuum of service was identified which could meet the unique needs of each child and family. Services include information, education, and supports, and all are grounded in principles of family-centred care.
Implications
The model of human performance technology provided a systematic approach with which to reveal the reason for extensive wait times for pediatric occupational therapy service. The model suggested a paradigm shift from a linear model of care to a continuum of care grounded in family-centred care. Implementation and evaluation of this new care model are ongoing.
Monetary union in Europe started in 1999. Originally published in 1999, this book contains eleven papers and three review essays, which analyse a spectrum of empirical, theoretical, institutional and ...political aspects of the design and impact of fiscal policy in EMU. The contributors are some of the most experienced analysts in the field. Topics covered include the need for and consequences of fiscal coordination, constraints on national deficits and debt levels (the Stability Pact), and the role of fiscal federalism and insurance. The importance of coordinating fiscal and monetary policies is also considered in depth. This book will be of value to anyone with an interest in EMU and the development of European fiscal policy.
BARBARA K. GOLD Brodie, Megan; Buck, Thomas; Lucido, Michael ...
The Classical world,
07/2012, Letnik:
105, Številka:
4
Journal Article
Recenzirano
Prima femina quae primos commentarios philologicos patriae nostrae edidit, praecipua inter Caryatides quae sustinent sodalitatem philologicam patriae nostrae, olim praeses et semper praesidium huius ...societatis, studia classica servavit, famam fecit.9 Plaudamus igitur Barbara K. Gold.
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