Threshold Inverter Quantizer (TIQ) is an innovative idea in the construction of flash ADC, which can effectively replace the reference voltage circuit, resistive or capacitive voltage divider and ...differential comparator array in a conventional flash ADC by an internal reference comparator array made of CMOS inverters. The inverter switching voltage serving as the internal reference voltage, this architecture offers large improvements in chip area, power consumption and operating speed of the ADC. Variations of the inverter switching voltage due to its sensitivity to operating temperature and process variations causes imperfections in this ADC designs. This paper presents the thermal dependencies TIQ based flash ADC architecture. The complete circuit is modelled in cadence virtuoso simulation suite with gpdk 180 nm design library.
Gadilam river basin has gained its importance due to the presence of Neyveli Lignite open cast mines and other industrial complexes. It is also due to extensive depressurization of Cuddalore aquifer, ...and bore wells for New Veeranam Scheme are constructed downstream of the basin. Geochemical indicators of groundwater were used to identify the chemical processes that control hydrogeochemistry. Chemical parameters of groundwater such as pH, electrical conductivity, total dissolved solids, sodium (Na ⁺ ), potassium (K ⁺ ), calcium (Ca ⁺ ), magnesium (Mg ⁺ ), bicarbonate graphic removed , sulfate graphic removed , phosphate graphic removed , and silica (H₄SiO₄) were determined. Interpretation of hydrogeochemical data suggests that leaching of ions followed by weathering and anthropogenic impact controls the chemistry of the groundwater. Isotopic study reveals that recharge from meteoric source in sedimentary terrain and rock-water interaction with significant evaporation prevails in hard rock region.
Scrub typhus is associated with outbreaks of acute encephalitis syndrome in Uttar Pradesh, India. A case-control study indicated that children residing, playing, or visiting fields; living with ...firewood stored indoors; handling cattle fodder; and practicing open defecation were at increased risk for scrub typhus. Communication messages should focus on changing these behaviors.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated ...proteins from the membrane, chromatin, or protein complexes. The resulting changes in protein or RNA content are an important means for plants to control protein homeostasis and thereby adapt to shifting environmental conditions. The activity and targeting of CDC48 are controlled by adaptor proteins, of which the plant ubiquitin regulatory X (UBX) domain-containing (PUX) proteins constitute the largest family. Emerging knowledge on the structure and function of PUX proteins highlights that these proteins are versatile factors for plant homeostasis and adaptation that might inspire biotechnological applications.
The present study has carried out with an objective of determining the activity concentrations of two radionuclides namely polonium-210 (
210
Po) and lead-210 (
210
Pb) in smoke tobacco products ...(cigarette, bidi and cigar) and smokeless tobacco products (chewing tobacco and snuff) consumed in Tiruchirappalli District, Tamil Nadu (India) and their annual committed effective dose to tobacco consumers. The concentration of
210
Po was always higher than that of
210
Pb in all the analyzed tobacco products. It also revealed that 79% of Annual committed effective dose comes from
210
Po and about 21% from
210
Pb. Maximum concentration (13.2 mBq g
−1
) of
210
Po recorded in cigarette and lowest concentration was observed in snuff (6.4 mBq g
−1
). The highest mean committed effective dose of
210
Po and
210
Pb in various tobacco products were found in cigarette followed by bidi, cigar, chewing tobacco and snuff. The study revealed that the tobacco products available in Tiruchirappalli District contain a relatively lower concentration of radionuclides when compared to other regional studies. Since this kind of study in India is fragmentary, the present study has generated a base data for the first time for entire Tiruchirappalli District.
Abstract This study emphasizes the usage of Silica Fume (SF) and Marble Sludge Powder (MSP) as a partial replacement for fly ash in Fibre Reinforced Foamed Concrete (FRFC). The compressive strength ...for various samples was analyzed using Artificial Neural Network (ANN) methods. In this research work, the utilization of silica fume, fly ash, marble sludge powder, polypropylene fiber, and foaming agent in fiber-reinforced foamed concrete is presented and a sincere attempt has been made to use silica fume and marble sludge powder for the replacement of fly ash with various percentages. In addition to that polypropylene fiber (PPF) was used in various proportions of 0%, 0.1%, 0.2%, 0.3%, 0.4%, and 0.5%. The Feed Forward Propagation (FFP) network of the machine learning method with one hidden layer was taken as the ANN structure of FRFC. In this ANN work, cement, silica fume, fly ash, marble sludge powder, foaming agent, water, and polypropylene fiber were used as input parameters and compressive strength is the output parameter. The correlation coefficient with the ANN methods was found as 0.940 for compressive strength. In machine learning techniques, the ANN method was found to be accurate in estimating and analyzing strength prediction responses with effective parameters.
Introduction:
The important role of micronutrient deficiencies in aging-related disorders including dementia is becoming increasingly evident. However, information on their burden in India is scarce, ...especially, among aging and rural communities.
Methods:
Prevalence of vitamin D, B12 and folic acid deficiency was measured in an ongoing, aging cohort, from rural India–Srinivaspura Aging Neurosenescence and COGnition (SANSCOG) study cohort. Serum level estimation of vitamin D, B12 and folic acid, using chemiluminescence immunoassay, was performed on 1648 subjects (872 males, 776 females).
Results:
Mean vitamin D, B12 and folic acid levels were 23.4 ± 10.6 ng/ml, 277.4 ± 194.4 pg/ml and 6 ± 3.5 ng/ml), respectively. Prevalence of low vitamin D (<30 ng/ml), vitamin D deficiency (<20 ng/ml), B12 deficiency (<200 pg/ml) and folic acid deficiency (<3 ng/ml) were 75.7, 39.1, 42.3, and 11.1%, respectively. Significantly more women had vitamin D deficiency, whereas more men had folic acid deficiency. Women belonging to the oldest age group (≥75 years) had the maximum burden of low vitamin D (94.3%) and folic acid deficiency (21.8%).
Discussion:
Older, rural-dwelling Indians have high burden of vitamin D and B12 deficiencies, which is concerning given the potentially negative consequences on cognition, immunity and frailty in the aging population. Urgent public health strategies are needed to address this issue and prevent or mitigate adverse consequences.
The mechanism of efflux is a tour-de-force in the bacterial armoury that has thwarted the development of novel antibiotics. We report the discovery of a novel chemical series with potent ...antibacterial properties that was engineered to overcome efflux liability. Compounds liable to efflux specifically via the Resistance Nodulation and cell Division (RND) pump, AcrAB-TolC were chosen for a hit to lead progression. Using structure-based design, the compounds were optimised to lose their binding to the efflux pump, thereby making them potent on wild-type bacteria. We discovered these compounds to be pro-drugs that require activation in E. coli by specific bacterial nitroreductases NfsA and NfsB. Hit to lead chemistry led to the generation of compounds that were potent on wild-type and multi-drug resistant clinical isolates of E. coli, Shigella spp., and Salmonella spp. These compounds are bactericidal and efficacious in a mouse thigh infection model.
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