There exist about 3.7σ positive and 2.4σ negative deviations in the muon and electron anomalous magnetic moments (g−2). Also, some ratios for lepton universality in τ decays have almost 2σ deviations ...from the Standard Model. In this paper, we propose a lepton-specific inert two-Higgs-doublet model. After imposing all the relevant theoretical and experimental constraints, we show that these lepton anomalies can be explained simultaneously in many parameter spaces with m > 200 GeV and mA(mH±) > 500 GeV for appropriate Yukawa couplings between leptons and inert Higgs. The key point is that these Yukawa couplings for μ and τ/e have opposite sign.
This study establishes the first organocatalytic enantioselective synthesis of axially chiral N,N′‐bisindoles via chiral phosphoric acid‐catalyzed formal (3+2) cycloadditions of indole‐based ...enaminones as novel platform molecules with 2,3‐diketoesters, where de novo indole‐ring formation is involved. Using this new strategy, various axially chiral N,N′‐bisindoles were synthesized in good yields and with excellent enantioselectivities (up to 87 % yield and 96 % ee). More importantly, this class of axially chiral N,N′‐bisindoles exhibited some degree of cytotoxicity toward cancer cells and was derived into axially chiral phosphine ligands with high catalytic activity. This study provides a new strategy for enantioselective synthesis of axially chiral N,N′‐bisindoles using asymmetric organocatalysis and is the first to realize the applications of such scaffolds in medicinal chemistry and asymmetric catalysis.
An organocatalytic enantioselective synthesis of axially chiral N,N′‐bisindoles has been established via chiral phosphoric acid‐catalyzed formal (3+2) cycloaddition of indole‐based enaminones with 2,3‐diketoesters. This study provides a new strategy for the highly selective synthesis of axially chiral N,N′‐bisindoles and shows the successful application of such skeletons in medicinal and synthetic chemistry.
In the framework of the type II two-Higgs-doublet model with a singlet scalar dark matter S, we study the dark matter observables, the electroweak phase transition, and the gravitational wave signals ...by such strongly first order phase transition after imposing the constraints of the LHC Higgs data. We take the heavy CP-even Higgs boson H as the only portal between the dark matter and standard model (SM) sectors, and find that the LHC Higgs data and dark matter observables require mS and mH to be larger than 130 GeV and 360 GeV for mA=600 GeV in the case of the 125 GeV Higgs boson with the SM-like coupling. Next, we carve out some parameter space where a strongly first order electroweak phase transition can be achieved, and find benchmark points for which the amplitudes of gravitational wave spectra reach the sensitivities of the future gravitational wave detectors.
Traditional supply chain management faces challenges such as low level of information sharing and lack of transparency. Due to the features such as tamper-proof, reliability and traceability, the ...blockchain technology enhances the trust among stakeholders and enables transparent transactions and open collaboration, which can reduce the risk of supply chain disruptions. Accordingly, blockchain technology-based supply chain management has attracted more attention from academics and practitioners. However, existing review studies mainly focus on different industries or topics and lack a more comprehensive analysis. Therefore, this paper presents a systematic review integrating bibliometric analysis with theme analysis to understand the current research state in BT-SCM and discuss its future research trends. On the one hand, VOSviewer is used to conduct bibliometric analysis to explore the influences of existing studies from six aspects: publication year, author, country, keyword, journal, and article citation. On the other hand, the functional application of BT-SCM is discussed from logistics traceability, supply chain finance, supply chain collaboration, sustainable management and risk management to determine the research status, and the enablers and barriers of blockchain application in SCM are summarised to facilitate practitioners to adopt BT, and finally the potential research directions are proposed for scholars in this field.
A
bstract
A light pseudoscalar of the lepton-specific 2HDM can enhance the muon g-2, but suffer from various constraints easily, such as the 125.5 GeV Higgs signals, non-observation of additional ...Higgs at the collider and even
B
s
→
μ
+
μ
−
. In this paper, we take the light CP-even Higgs as the 125.5 GeV Higgs, and examine the implications of those observables on a pseudoscalar with the mass below the half of 125.5 GeV. Also the other relevant theoretical and experimental constraints are considered. We find that the pseudoscalar can be allowed to be as low as 10 GeV, but the corresponding tan
β
, sin(
β
−
α
) and the mass of charged Higgs are strongly constrained. In addition, the surviving samples favor the wrong-sign Yukawa coupling region, namely that the 125.5 GeV Higgs couplings to leptons have opposite sign to the couplings to gauge bosons and quarks.
The recent outbreak of Novel Coronavirus Disease (COVID-19) is reminiscent of the SARS outbreak in 2003. We aim to compare the severity and mortality between male and female patients with COVID-19 or ...SARS.
We extracted the data from: (1) a case series of 43 hospitalized patients we treated, (2) a public data set of the first 37 cases of patients who died of COVID-19 and 1,019 patients who survived in China, and (3) data of 524 patients with SARS, including 139 deaths, from Beijing in early 2003.
Older age and a high number of comorbidities were associated with higher severity and mortality in patients with both COVID-19 and SARS. Age was comparable between men and women in all data sets. In the case series, however, men's cases tended to be more serious than women's (
= 0.035). In the public data set, the number of men who died from COVID-19 is 2.4 times that of women (70.3 vs. 29.7%,
= 0.016). In SARS patients, the gender role in mortality was also observed. The percentage of males were higher in the deceased group than in the survived group (
= 0.015).
While men and women have the same prevalence, men with COVID-19 are more at risk for worse outcomes and death, independent of age.
Due to the strong constraint from the LUX experiment, the scalar portal dark matter cannot generally explain a gamma-ray excess in the galactic center by the annihilation of dark matter to bb¯. With ...the motivation of eliminating the tension, we add a scalar dark matter to the aligned two-Higgs-doublet model, and focus on a simplified scenario, which has two main characteristics: (i) The heavy CP-even Higgs is the discovered 125 GeV Higgs boson, which has the same couplings to the gauge bosons and fermions as the SM Higgs. (ii) Only the light CP-even Higgs mediates the dark matter interactions with SM particles, which have no couplings to WW and ZZ, but have the independent couplings to the up-type quarks, down-type quarks and charged leptons. We find that the tension between 〈σv〉SS→bb¯ and the constraint from LUX induced by the scalar portal dark matter can go away for the isospin-violating dark matter–nucleon coupling with −1.0<fn/fp<0.7, and the constraints from the Higgs search experiments and the relic density of Planck are also satisfied.
We study the CDF
W
-mass, muon
g
-
2
, and dark matter observables in a local
U
(
1
)
L
μ
-
L
τ
model in which the new particles include three vector-like leptons (
E
1
,
E
2
,
N
), a new gauge boson
...Z
′
, a scalar
S
(breaking
U
(
1
)
L
μ
-
L
τ
), a scalar dark matter
X
I
and its partner
X
R
. We find that the CDF
W
-mass disfavors
m
E
1
=
m
E
2
=
m
N
or
s
L
=
s
R
=
0
where
s
L
(
R
)
is mixing parameter of left (right)-handed fields of vector-like leptons. A large mass splitting between
E
1
and
E
2
is favored when the differences between
s
L
and
s
R
becomes small. The muon
g
-
2
anomaly can be simultaneously explained for appropriate difference between
m
E
1
(
s
L
)
and
m
E
2
(
s
R
)
, and some regions are excluded by the diphoton signal data of the 125 GeV Higgs. Combined with the CDF
W
-mass, muon
g
-
2
anomaly and other relevant constraints, the correct dark matter relic density is mainly obtained in two different scenarios: (i)
X
I
X
I
→
Z
′
Z
′
,
S
S
for
m
Z
′
(
m
S
)
<
m
X
I
and (ii) the co-annihilation processes for
m
i
n
(
m
E
1
,
m
E
2
,
m
N
,
m
X
R
)
close to
m
X
I
. Finally, we use the direct searches for
2
ℓ
+
E
T
miss
event at the LHC to constrain the model, and show the allowed mass ranges of the vector-like leptons and dark matter.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Endomorphins have shown great promise as pharmaceutics for the treatment of pain. We have previously confirmed that novel endomorphin analogues CEMR-1 and CEMR-2 behaved as potent μ agonists and ...displayed potent antinociceptive activities at the supraspinal and peripheral levels. The present study was undertaken to evaluate the antinociceptive properties of CEMR-1 and CEMR-2 following intrathecal (i.t.) administration. Furthermore, their antinociceptive tolerance and opioid-like side effects were also determined.
The spinal antinociceptive effects of CEMR-1 and CEMR-2 were determined in a series of pain models, including acute radiant heat paw withdrawal test, spared nerve injury-induced neuropathic pain, complete Freund's adjuvant-induced inflammatory pain, visceral pain and formalin pain. Antinociceptive tolerance was evaluated in radiant heat paw withdrawal test.
Spinal administration of CEMR-1 and CEMR-2 produced potent and prolonged antinociceptive effects in acute pain. CEMR-1 and CEMR-2 may produce their antinociception through distinct μ receptor subtypes. These two analogues also exhibited significant analgesic activities in neuropathic, inflammatory, visceral and formalin pain at the spinal level. It is noteworthy that CEMR-1 showed non-tolerance-forming analgesic properties, while CEMR-2 exhibited substantially reduced antinociceptive tolerance. Furthermore, both analogues displayed no or reduced side effects on conditioned place preference response, physical dependence, locomotor activity and gastrointestinal transit.
The present investigation demonstrated that CEMR-1 and CEMR-2 displayed potent and long-lasting antinociception with a favourable side effect profile at the spinal level. Therefore, CEMR-1 and CEMR-2 might serve as promising analgesic compounds with minimal opioid-like side effects.
We examine the parameter space of the two-Higgs-doublet model of type II after imposing the relevant theoretical and experimental constraints from the precision electroweak data, B-meson decays, and ...the LHC run I and run II data. We find that the searches for Higgs bosons via the τ+τ−, WW, ZZ, γγ, hh, hZ, HZ, and AZ channels can give strong constraints on the CP-odd Higgs A and heavy CP-even Higgs H, and the parameter space excluded by each channel is respectively carved out in detail assuming that either mA or mH are fixed to 600 or 700 GeV in the scans. The surviving samples are discussed in two different regions. (i) In the standard model–like coupling region of the 125 GeV Higgs, mA is allowed to be as low as 350 GeV, and a strong upper limit is imposed on tanβ. mH is allowed to be as low as 200 GeV for the appropriate values of tanβ, sin(β−α), and mA, but is required to be larger than 300 GeV for mA=700 GeV. (ii) In the wrong-sign Yukawa coupling region of the 125 GeV Higgs, the bb¯→A/H→τ+τ− channel can impose the upper limits on tanβ and sin(β−α), and the A→hZ channel can give the lower limits on tanβ and sin(β−α). mA and mH are allowed to be as low as 60 and 200 GeV, respectively, but 320 GeV<mA<500 GeV is excluded for mH=700 GeV.
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