Abstract
The ocean temperature response to tropical cyclones (TCs) is important for TC development, local air–sea interactions, and the global air–sea heat budget and transport. The modulation of the ...upper ocean vertical temperature structure after a fast-moving TC was studied at the observation stations in the northern South China Sea, including TCs Kalmaegi (2014), Rammasun (2014), Sarika (2016), and Haima (2016). The upper ocean temperature and heat response to the TCs mainly depended on the combined effect of mixing and vertical advection. Mixing cooled the sea surface and warmed the subsurface, while upwelling (downwelling) reduced (increased) the subsurface warm anomaly and cooled (warmed) the deeper ocean. An ideal parameterization that depends on only the nondimensional mixing depth (
H
E
), nondimensional transition layer thickness (
H
T
), and nondimensional upwelling depth (
H
U
) was able to roughly reproduce sea surface temperature (SST) and upper ocean heat change. After TCs, the subsurface heat anomalies moved into the deeper ocean. The air–sea surface heat flux contributed little to the upper ocean temperature anomaly during the TC forcing stage and did not recover the surface ocean back to pre-TC conditions more than one and a half months after the TC. This work shows how upper ocean temperature and heat content varies by a TC, indicating that TC-induced mixing modulates the warm surface water into the subsurface, and TC-induced advection further modulates the warm water into the deeper ocean and influences the ocean heat budget.
Significance Statement
Tropical cyclones can cause a strong ocean response that modulates the upper ocean temperature structure and contributes to the local heat budget and transport. This manuscript shows how mixing and vertical advection modulate upper ocean temperature after four fast-moving tropical cyclones, and then gives a parameterization of how sea surface temperature and upper ocean heat change depend on the two mechanisms. The temperature anomalies can propagate into deeper ocean after the tropical cyclones, and sea surface heat flux is not important for upper ocean temperature response during a tropical cyclone. These results show how the upper ocean temperature responses to a tropical cyclone, and influences the local heat budget.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Diffuse large B‐cell lymphoma (DLBCL) is a clinically aggressive and heterogenous disease. Although most patients can be cured by immunochemotherapy, 30% to 40% patient will ultimately develop ...relapsed or refractory disease. Here, we investigated the molecular landscapes of patients with diverse responses to R‐CHOP. We performed capture‐based targeted sequencing on baseline samples of 105 DLBCL patients using a panel consisting of 112 lymphoma‐related genes. Subsequently, 81 treatment‐naïve patients with measurable disease and followed for over 1 year were included for survival analysis. Collectively, the most commonly seen mutations included IGH fusion (69%), PIM1(33%), MYD88 (29%), BCL2 (29%), TP53 (29%), CD79B (25%) and KMT2D (24%). Patients with TP53 mutations were more likely to have primary refractory disease (87.0% vs 50.0%, P = .009). For those with TP53 disruptive mutations, 91.7% patients were in the primary refractory group. Interestingly, BCL‐2 somatic hypermutation was only seen in patients without primary refractory disease (P = .014). In multivariate analysis, BCL‐2 amplification (hazard ratio HR = 2.94, P = .022), B2M mutation (HR = 2.99, P = .017) and TP53 mutation (HR = 3.19, P < .001) were independently associated with shorter time to progression (TTP). Furthermore, TP53 mutations was correlated with worse overall survival (P = .049). Next, we investigated mutation landscape in patients with wild‐type (WT) TP53 (n = 58) and found that patients harboring MYD88 L265P had significantly inferior TTP than those with WT or non‐265P (P = .046). Our study reveals the mutation spectrum of treatment‐naive Chinese DLBCL patients. It also confirms the clinical significance of TP53 mutations and indicates the prognostic value of MYD88 L265P in TP53 WT patients.
What's new?
A significant percentage of diffuse large B‐cell lymphoma (DLBCL) patients will develop relapse or refractory disease from immunochemotherapy. In this study, the authors surveyed the molecular landscape of patients with diverse responses to the standard immunochemotherapy regimen, R‐CHOP. The findings demonstrated the clinical significance of TP53 mutation, BCL‐2 amplification, and B2M mutation. This study also revealed the prognostic potential of MYD88 L265P in wt TP53 patients, suggesting that the mutation could be used as a biomarker to stratify DLBCL patients. The new genomic framework contributes to elucidating the molecular attributes that may affect response to R‐CHOP treatment in DLBCL patients.
Cervical carcinosarcoma is an extremely rare type of neoplasm that lacks standard of care. Preclinical and clinical evidence has suggested that cryoablation in combination with immunotherapy may ...result in a synergistic effect, generating a more robust immune response to distant lesions. A few clinical trials have evaluated the efficacy of such combination treatment in a variety of solid tumors, but with conflicting results. This report describes the first clinical efficacy of cryoablation followed by pembrolizumab observed in a patient with tumor mutational burden (TMB)‐high metastatic cervical carcinosarcoma that was negative for programmed cell death protein 1 expression, microsatellite instability stable, and had mutations in DNA polymerase epsilon (POLE). She had achieved complete response (CR) after 3 months of pembrolizumab treatment and had maintained CR as of the time of submission of this manuscript, with a progression‐free survival of 11 months and counting. The case exhibited an exceptional response to cryoablation followed by pembrolizumab, potentially attributed to mutations in POLE, which lead to an extremely high TMB. This report paves the avenue for establishing treatment regimens for patients with TMB‐high cervical carcinosarcoma.
Key Points
Owing to its rarity, cervical carcinosarcoma has not been well characterized, and currently, there is no standard of care for this disease.
This report describes the first case of clinical efficacy of cryoablation followed by pembrolizumab observed in a patient with tumor mutational burden‐high metastatic cervical carcinosarcoma.
The case exhibited an exceptional response (maintained CR as of the time of submission of this article: 11 months) to cryoablation followed by pembrolizumab.
This is the first POLE‐mutated cervical carcinosarcoma case.
This article presents the first case showing the clinical efficacy of cryoablation followed by pembrolizumab observed in a patient with tumor mutational burden‐high metastatic cervical carcinosarcoma.
Objective
KRAS mutation plays a critical role in the initiation and development of non‐small cell lung cancer (NSCLC). KRAS‐mutant patients exhibit diverse response to chemotherapy. KRAS co‐mutation ...subtypes and their prognosis value in advanced Chinese NSCLC patients remain largely elusive.
Methods
A total of 1126 Chinese advanced NSCLC patients from Xiangya hospital were screened by capture‐based ultra‐deep sequencing for KRAS mutation between January 2015 and December 2016. Survival analyses were performed using Kaplan‐Meier analysis.
Results
Among the patients screened, 84 cases were detected with KRAS mutation (7.5%). All of them were non‐squamous NSCLC and received pemetrexed plus platinum as the first‐line treatment. The most frequent KRAS co‐mutation genes were TP53 (29%), TP53/LKB1 (19%), and LKB1 (14%). Our data revealed that patients with KRAS co‐mutation had poorer prognosis in comparison with those harboring single KRAS mutation. Furthermore, patients with KPL (KRAS mutated with TP53 and LKB1) subtype, which was a novel subtype, had the shortest progression‐free survival (PFS) in all types of KRAS co‐mutation patients (P < .0001). The PFS and overall survival (OS) of patients with KRASG12D mutation were inferior than those with KRASG12C mutation or KRASG12V mutation. Patients in KRASG>T type had significantly longer survival than those in KRASG>C type or KRASG>A type.
Conclusion
Our study revealed that concurrent genomic alterations can further stratify KRAS‐mutant lung adenocarcinoma patients into various subgroups with distinctive therapeutic responses and differential survival outcomes. The KPL is a novel and less responsive subtype among KRAS‐mutated NSCLC, and further investigation of effective treatment for this subtype is warranted.
Our study revealed that concurrent genomic alterations can further stratify KRAS‐mutant lung adenocarcinoma patients into various subgroups with distinctive therapeutic responses and differential survival outcomes. The KPL is a novel and less responsive subtype among KRAS‐mutated NSCLC, and further investigation of effective treatment for this subtype is warranted.
Inkjet-printing was used to prepare a flexible and transparent humidity sensor with a Ti3C2/Ag hybrid as the humidity-sensitive film and poly(diallyldimethylammonium chloride) (PDDA) as the adhesive ...layer. The sensor demonstrates an ultrahigh sensitivity (106 800%), a rapid response (80 ms), and excellent bending resistance. We demonstrate that an array of sensors can track moving fingers in a non-contact way and map the distance of the fingers away from the sensor surface. Therefore, our humidity sensors have great potential for novel human–machine interfacing such as touchless control of electronics and collision control between robots and humans in a cobot setting.
We report on the generation of large energy, widely wavelength tunable pulses in an erbium-doped fiber laser passively Q-switched by a topological insulator saturable absorber (TI-SA). The TI-SA is ...prepared through an optical deposition method. Its saturating intensity and modulation depth are measured to be about 57 MW/cm 2 and 22%, respectively. We show that the high modulation depth of TI-SA allows the generation of stable Q-switched pulses with per-pulse energy up to 1.5 μJ and its broadband saturable absorption favors the tunable Q-switching operation from 1510.9 nm to 1589.1 nm. Our study suggests that TI: Bi 2 Te 3 could be a promising saturable absorber for both the high energy and broadband optical applications.
Speech emotion recognition (SER) is a difficult task due to the complexity of emotions. The SER performances are heavily dependent on the effectiveness of emotional features extracted from the ...speech. However, most emotional features are sensitive to emotionally irrelevant factors, such as the speaker, speaking styles, and environment. In this letter, we assume that calculating the deltas and delta-deltas for personalized features not only preserves the effective emotional information but also reduces the influence of emotionally irrelevant factors, leading to reduce misclassification. In addition, SER often suffers from the silent frames and emotionally irrelevant frames. Meanwhile, attention mechanism has exhibited outstanding performances in learning relevant feature representations for specific tasks. Inspired by this, we propose a three-dimensional attention-based convolutional recurrent neural networks to learn discriminative features for SER, where the Mel-spectrogram with deltas and delta-deltas are used as input. Experiments on IEMOCAP and Emo-DB corpus demonstrate the effectiveness of the proposed method and achieve the state-of-the-art performance in terms of unweighted average recall.
Similar to graphene and black phosphorus (BP), 2D transition metal carbides and nitrides (MXenes) are of great interest in a variety of fields, such as energy storage and conversion, sensors, ...electromagnetic interference (EMI) shielding, and photothermal therapy due to their excellent conductivity and hydrophilicity, large specific capacitance, high photothermal effect, and superior electrochemical performance. To further broaden applicable ranges beyond their existing boundaries and fully exploit these potentials, functional 2D MXene nanostructures in recent years have been rationally designed and developed by various approaches, such as doping strategies, surface functionalization, and hybridization, for next‐generation devices with the merits of low power consumption, intelligence, and high‐integration chips. This review provides an overview of the synthetic routes and fundamental properties of functional 2D MXene nanostructures, including surface‐modified 2D MXenes and mixed‐dimensional MXene‐based heterostructures, highlights the state‐of‐the‐art progress in the applications of functional 2D MXene nanostructures with regard to energy storage and conversion, catalysis, sensors, photodetectors, EMI shielding, degradation, and biomedical applications, and presents the challenges and perspectives in these burgeoning fields. It is hoped that this review will inspire more efforts toward fundamental research on new functional 2D MXene‐based devices to satisfy the growing requirements for next‐generation systems.
This review summarizes the synthetic routes and fundamental properties of functional 2D MXene, highlights the state‐of‐the‐art progresses of the versatile applications of functional 2D MXene, and presents the challenges and perspectives in these burgeoning fields. It is anticipated that this review will inspire more efforts toward fundamental research on new functional 2D MXene‐based devices for next‐generation systems.
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