Nearly a century ago it was recognized that radiation absorption by stellar matter controls the internal temperature profiles within stars. Laboratory opacity measurements, however, have never been ...performed at stellar interior conditions, introducing uncertainties in stellar models. A particular problem arose when refined photosphere spectral analysis led to reductions of 30-50 per cent in the inferred amounts of carbon, nitrogen and oxygen in the Sun. Standard solar models using the revised element abundances disagree with helioseismic observations that determine the internal solar structure using acoustic oscillations. This could be resolved if the true mean opacity for the solar interior matter were roughly 15 per cent higher than predicted, because increased opacity compensates for the decreased element abundances. Iron accounts for a quarter of the total opacity at the solar radiation/convection zone boundary. Here we report measurements of wavelength-resolved iron opacity at electron temperatures of 1.9-2.3 million kelvin and electron densities of (0.7-4.0) × 10(22) per cubic centimetre, conditions very similar to those in the solar region that affects the discrepancy the most: the radiation/convection zone boundary. The measured wavelength-dependent opacity is 30-400 per cent higher than predicted. This represents roughly half the change in the mean opacity needed to resolve the solar discrepancy, even though iron is only one of many elements that contribute to opacity.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
The first systematic study of opacity dependence on atomic number at stellar interior temperatures is used to evaluate discrepancies between measured and modeled iron opacity J. E. Bailey et al., ...Nature (London) 517, 56 (2015)NATUAS0028-083610.1038/nature14048. High-temperature (>180 eV) chromium and nickel opacities are measured with ±6%-10% uncertainty, using the same methods employed in the previous iron experiments. The 10%-20% experiment reproducibility demonstrates experiment reliability. The overall model-data disagreements are smaller than for iron. However, the systematic study reveals shortcomings in models for density effects, excited states, and open L-shell configurations. The 30%-45% underestimate in the modeled quasicontinuum opacity at short wavelengths was observed only from iron and only at temperature above 180 eV. Thus, either opacity theories are missing physics that has nonmonotonic dependence on the number of bound electrons or there is an experimental flaw unique to the iron measurement at temperatures above 180 eV.
We report a precision measurement of the parity-violating asymmetry APV in the elastic scattering of longitudinally polarized electrons from 208Pb. We measure APV= 550 ± 16 (stat) ±8 (syst) parts per ...billion, leading to an extraction of the neutral weak form factor FW(Q2= 0.00616 GeV2) = 0.368 ± 0.013. Combined with our previous measurement, the extracted neutron skin thickness is Rn-Rp= 0.283 ± 0.071 fm. The result also yields the first significant direct measurement of the interior weak density of 208Pb: ρ$^0_W$ = -0.0796 ± 0.0036(exp) ± 0.0013(theo) fm-3 leading to the interior baryon density ρ$^0_b$ = 0.1480 ± 0.0036(exp) ± 0.0013(theo) fm-3. Finally, the measurement accurately constrains the density dependence of the symmetry energy of nuclear matter near saturation density, with implications for the size and composition of neutron stars.
While the terrestrial aurorae are known to be driven primarily by the interaction of the Earth's magnetosphere with the solar wind, there is considerable evidence that auroral emissions on Jupiter ...and Saturn are driven primarily by internal processes, with the main energy source being the planets' rapid rotation. Prior observations have suggested there might be some influence of the solar wind on Jupiter's aurorae and indicated that auroral storms on Saturn can occur at times of solar wind pressure increases. To investigate in detail the dependence of auroral processes on solar wind conditions, a large campaign of observations of these planets has been undertaken using the Hubble Space Telescope, in association with measurements from planetary spacecraft and solar wind conditions both propagated from 1 AU and measured near each planet. The data indicate a brightening of both the auroral emissions and Saturn kilometric radiation at Saturn close in time to the arrival of solar wind shocks and pressure increases, consistent with a direct physical relationship between Saturnian auroral processes and solar wind conditions. At Jupiter the correlation is less strong, with increases in total auroral power seen near the arrival of solar wind forward shocks but little increase observed near reverse shocks. In addition, auroral dawn storms have been observed when there was little change in solar wind conditions. The data are consistent with some solar wind influence on some Jovian auroral processes, while the auroral activity also varies independently of the solar wind. This extensive data set will serve to constrain theoretical models for the interaction of the solar wind with the magnetospheres of Jupiter and Saturn.
BACKGROUND
Assessing couple fecundity on a nation-wide basis without excluding couples who eventually remain infertile is challenging. Our aim was to describe couple fecundity (in terms of frequency ...of involuntary infertility) among the general population living in France.
METHODS
We used a current-duration design. A random sample of 64 262 households was selected in 2007–2008, allowing us to identify 15 810 women aged 18–44 years. Eligible women (n= 1089) were those having regular sexual intercourse with a male partner, not using any method of contraception and not having delivered in the previous 3 months. These women reported information on the current duration of unprotected intercourse (CDUI, the time elapsed between the start of the period of unprotected intercourse and the time of inclusion in the study). The CDUI distribution was used to estimate the frequency of involuntary infertility, using a newly developed statistical technique that does not require couples to be followed up until the end of the period of unprotected intercourse.
RESULTS
CDUI was defined for 867 women. An estimated 46% of couples had no detected pregnancy conceived during the first 6 months of unprotected intercourse 95% confidence interval (CI), 36–56%. The proportions of couples with no detected pregnancy within 12 and 24 months were 24% (19–30%) and 11% (8–14%), respectively.
CONCLUSIONS
These results constitute one of the few descriptions of the fecundity of a nation-wide representative sample of couples from the general population, not limited to couples who eventually conceived or to those resorting to medical help.
Abstract
Investigations of the origin and evolution of the Milky Way disc have long relied on chemical and kinematic identifications of its components to reconstruct our Galactic past. Difficulties ...in determining precise stellar ages have restricted most studies to small samples, normally confined to the solar neighbourhood. Here, we break this impasse with the help of asteroseismic inference and perform a chronology of the evolution of the disc throughout the age of the Galaxy. We chemically dissect the Milky Way disc population using a sample of red giant stars spanning out to 2 kpc in the solar annulus observed by the Kepler satellite, with the added dimension of asteroseismic ages. Our results reveal a clear difference in age between the low- and high-α populations, which also show distinct velocity dispersions in the V and W components. We find no tight correlation between age and metallicity nor α/Fe for the high-α disc stars. Our results indicate that this component formed over a period of more than 2 Gyr with a wide range of M/H and α/Fe independent of time. Our findings show that the kinematic properties of young α-rich stars are consistent with the rest of the high-α population and different from the low-α stars of similar age, rendering support to their origin being old stars that went through a mass transfer or stellar merger event, making them appear younger, instead of migration of truly young stars formed close to the Galactic bar.
Summary
Since the discovery of the lectin pathway of complement activation, numerous clinical cohorts have been examined for one or more proteins, with the intention of uncovering the functions of ...the proteins or with the aim of discovering new biomarkers or diagnostic tools. To unveil the abnormal, it is pivotal to know the normal. Our aim was to describe the concentrations of the 11 known proteins of the lectin pathway in serum and plasma and to uncover possible gender differences, age and diurnal variations, which must be taken into account for investigation in different cohorts. We examined the concentrations of all lectin pathway proteins mannan‐binding lectin (MBL), H‐ficolin, L‐ficolin, M‐ficolin, collectin‐K1, collectin‐L1, MBL‐associated serine protease 2 (MASP‐2), MASP‐3, MBL‐associated protein of 44 kDa (MAp44) and MAp19 in 300 Danish blood donors in serum and ethylenediamine tetraacetic acid (EDTA) plasma in established assays, and we further developed a new assay to measure MASP‐1 in the same samples. We found significant differences in concentrations between serum and plasma for all proteins except for MBL and MASP‐3. H‐ficolin, M‐ficolin and MAp19 displayed convincing diurnal variation. H‐ficolin, in particular, halved from morning to the middle of the night. There were gender differences for most proteins, whereas age did not seem to influence concentration. The present study underlines the necessity of considering which material to use, correct matching and a trial design that takes the nature of the protein into account in order for the outcome of cohort studies to have significant relevance.
To unveil the abnormal, it is pivotal to know the normal. The article aims to describe the concentrations of the eleven known proteins of the lectin pathway in serum and plasma and to uncover variables, which should be taken into account for investigations in future cohort studies.
Turgencin A, a potent antimicrobial peptide isolated from the Arctic sea squirt
, consists of 36 amino acid residues and three disulfide bridges, making it challenging to synthesize. The aim of the ...present study was to develop a truncated peptide with an antimicrobial drug lead potential based on turgencin A. The experiments consisted of: (1) sequence analysis and prediction of antimicrobial potential of truncated 10-mer sequences; (2) synthesis and antimicrobial screening of a lead peptide devoid of the cysteine residues; (3) optimization of in vitro antimicrobial activity of the lead peptide using an amino acid replacement strategy; and (4) screening the synthesized peptides for cytotoxic activities. In silico analysis of turgencin A using various prediction software indicated an internal, cationic 10-mer sequence to be putatively antimicrobial. The synthesized truncated lead peptide displayed weak antimicrobial activity. However, by following a systematic amino acid replacement strategy, a modified peptide was developed that retained the potency of the original peptide. The optimized peptide
displayed bactericidal activity, with minimal inhibitory concentrations of 7.8 µg/mL against
and 3.9 µg/mL against
, and no cytotoxic effects against mammalian cells. Preliminary experiments indicate the bacterial membranes as immediate and primary targets.
This study reports the isolation of two novel cysteine-rich antibacterial peptides, turgencin A and turgencin B, along with their oxidized derivatives, from the Arctic marine colonial ascidian
. The ...peptides are post-translationally modified, containing six cysteines with an unusual disulfide connectivity of Cys
-Cys
, Cys
-Cys
, and Cys
-Cys
and an amidated C-terminus. Furthermore, the peptides contain methionine residues resulting in the isolation of peptides with different degrees of oxidation. The most potent peptide, turgencin A
with one oxidized methionine, displayed antimicrobial activity against both Gram-negative and Gram-positive bacteria with a minimum inhibitory concentration (MIC) as low as 0.4 µM against selected bacterial strains. In addition, the peptide inhibited the growth of the melanoma cancer cell line A2058 (IC
= 1.4 µM) and the human fibroblast cell line MRC-5 (IC
= 4.8 µM). The results from this study show that natural peptides isolated from marine tunicates have the potential to be promising drug leads.
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