We report a case of human Dirofilaria repens infection in a woman in Slovenia who had concomitant pleural and subcutaneous manifestations of the infection. This case report illustrates the clinical ...course of a severe symptomatic parasitic infection that had multisystemic manifestations.
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DOBA, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Common inflammatory ground links obesity, insulin resistance, and asthma. As recognition of their interplay, one worsening the natural course of the other, is recognised, questions remain about how ...to adequately address them altogether to improve clinical outcomes. The present manuscript sheds light on the problem, describing possible pathophysiological links, clinical views, and therapeutic challenges, raising questions about what remains to be done, and calling for multidisciplinary treatment of these patients to detect diseases early and adequately address them before they become full-blown and deteriorate their health and quality of life.
Introduction: The most common etiology of hypercapnic respiratory failure is chronic obstructive pulmonary disease (COPD). However, the differential diagnosis also includes neuromuscular disorders. ...We studied the specificity of reduced amplitude phrenic nerve compound motor action potential (CMAP) to diagnose neuromuscular disorders. Methods: A group of patients with advanced COPD were recruited prospectively and compared with controls. Phrenic nerve CMAPs were measured bilaterally using supraclavicular surface stimulation and bipolar recording (G1: 5 cm above the xiphoid; G2: 16 cm from G1). Results: A group of 20 patients (15 men) and a group of 29 controls (15 men) were included. Phrenic nerve CMAPs of patients with COPD had significantly longer latency and higher amplitude. Conclusion: Our study demonstrates that patients with hypercapnic respiratory failure and reduced phrenic nerve CMAP amplitude most probably have a neuromuscular disorder affecting the diaphragm and not COPD or another lung disorder. Muscle Nerve 47: 504–509, 2013
We report 2 cases of bilateral lung transplantation for nonresolving coronavirus disease 2019 associated respiratory failure. In the first patient, the severe acute respiratory syndrome coronavirus 2 ...infection caused acute respiratory distress syndrome requiring prolonged extracorporeal membrane oxygenation support; in the second patient, coronavirus disease 2019 resulted in irreversible pulmonary fibrosis requiring only ventilatory support. The 2 cases represent the 2 ends of the spectrum showing significant differences in preoperative and postoperative courses.
Summary Introduction Chitotriosidase (CTO) is a human chitinolytic enzyme secreted by activated macrophages and polymorphonuclear neutrophils. Albeit not specific for sarcoidosis, it is increased in ...over 90% of patients with active disease. The aims of this study were to correlate CTO measurements with clinical assessment of sarcoidosis and to test CTO as a marker of sarcoidosis relapse. Methods 95 patients were followed-up for 24–60 months. Serial CTO measurements were performed every 3–6 months and correlated to clinical symptoms, lung function (FVC and DLco) and chest X-ray. In 38 patients clinical outcome status (COS) at 5 years was determined. Results Initial CTO levels were significantly higher in patients with impaired FVC/DLco ( p = 0.011 for both) but there was no correlation with standard chest X-ray stages. Patients with Loefgren's syndrome had significantly lower initial and control CTO level compared to other patients ( p = 0.011 and p = 0.001, respectively). At follow-up there was a positive correlation of CTO and deterioration of clinical symptoms ( p < 0.001), chest X-ray ( p < 0.001) and FVC/DLco ( p = 0.012 and p = 0.086, respectively). Control CTO levels were significantly lower in no disease groups versus minimal or persistent disease group as defined by COS ( p = 0.003 and p < 0.001, respectively). At relapse CTO increased for 100% or more from baseline value in 12/14 patients. Conclusions It was shown that CTO correlates with certain sarcoidosis phenotypes (Loefgren's syndrome, COS) and that serial measurements of CTO correlate with clinical symptoms, chest radiographs and lung function.
Najpogostejši simptomi in znaki okužbe z virusom SARS-CoV-2 so vročina, kašelj, slabo počutje s hudo splošno oslabelostjo, izguba vonja in okusa ter glavobol. Pri nekaterih bolnikih s pljučnico pri ...covidu-19 opažamo hitro poglabljajočo se hipoksemijo, ki je ne spremlja občutek pomanjkanja zraka oziroma dušenja. Bolnik ne čuti povečanega dihalnega dela. Imenujemo jo »tiha hipoksemija« in je lahko življenje ogrožajoča. Predstavljamo primera dveh bolnikov s pljučnico, povezano s covidom-19, tiho hipoksemijo in hitro napredujočim dihalnim popuščanjem ter razpravljamo o možnih patofizioloških vzrokih.
Here, we present the case of a 28‐year‐old woman who developed severe and progressive thymoma‐associated constrictive bronchiolitis with bronchiectasis, despite undergoing thymectomy. The disease was ...further complicated by radiation‐induced organizing pneumonia (RIOP), which developed after adjuvant radiotherapy (RT) for Masaoka stage II thymoma. The patient was successfully treated with an urgent lung transplantation (LTx) for irreversible respiratory failure.
We present the case of a 28‐year‐old woman with thymoma who developed severe progressive thymoma‐associated constrictive bronchiolitis with bronchiectasis and a radiation‐induced organizing pneumonia following adjuvant radiation therapy. The patient was successfully treated with urgent lung transplantation for irreversible respiratory failure.
Kronične bolezni pljuč so eden vodilnih vzrokov obolevnosti in umrljivosti. Pri delu bolnikov kljub priporočeni terapiji ne dosežemo vselej zadovoljivega odgovora. Makrolidni antibiotiki so zaradi ...protivnetnih in antibiotičnih sposobnosti dobili svoje mesto pri dolgotrajnemu zdravljenju številnih kroničnih boleznih pljuč. Makrolidni antibiotiki zmanjšujejo nastanek biofilma, zmanjšujejo adherenco in mobilnost bakterij, vplivajo na izražanje tesnih stikov, spremenijo sestavo izmečka (mukusa) in povečajo občutljivost bakterij za druge antibiotike. Številne klinične raziskave so predvsem pri boleznih dihalnih poti pokazale pozitivne učinke za kakovost življenja in zmanjšale število poslabšanj. Pri uporabi moramo biti pazljivi na stranske učinke, predvsem pa kritični pri izbiri bolnikov za takšno zdravljenje, saj dolgotrajno jemanje makrolidnih antibiotikov vpliva na bakterijsko odpornost v širši populaciji.
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