Knowledge of the neutrino flux produced by the Neutrinos at the Main Injector (NuMI) beamline is essential to the neutrino oscillation and neutrino interaction measurements of the MINERvA, MINOS+, ...NOvA and MicroBooNE experiments at Fermi National Accelerator Laboratory. We have produced a flux prediction which uses all available and relevant hadron production data, incorporating measurements of particle production off of thin targets as well as measurements of particle yields from a spare NuMI target exposed to a 120 GeV proton beam. The result is the most precise flux prediction achieved for a neutrino beam in the one to tens of GeV energy region. We have also compared the prediction to in situ measurements of the neutrino flux and find good agreement.
Elastic neutrino scattering on electrons is a precisely known purely leptonic process that provides a standard candle for measuring neutrino flux in conventional neutrino beams. Using a total sample ...of 810 neutrino-electron scatters after background subtraction, the measurement reduces the normalization uncertainty on the ν μ NuMI beam flux between 2 and 20 GeV from 7.6 to 3.9%. This is the most precise measurement of neutrino-electron scattering to date, will reduce uncertainties on MINER ν A's absolute cross section measurements, and demonstrates a technique that can be used in future neutrino beams such as long baseline neutrino facility.
The spectral resolution of a dispersive spectrograph is dependent on the width of the entrance slit. This means that astronomical spectrographs trade-off throughput with spectral resolving power. ...Recently, optical guided-wave transitions known as photonic lanterns have been proposed to circumvent this trade-off, by enabling the efficient reformatting of multimode light into a pseudo-slit which is highly multimode in one axis, but diffraction-limited in the other. Here, we demonstrate the successful reformatting of a telescope point spread function into such a slit using a three-dimensional integrated optical waveguide device, which we name the photonic dicer. Using the CANARY adaptive optics (AO) demonstrator on the William Herschel Telescope, and light centred at 1530 nm with a 160 nm full width at half-maximum, the device shows a transmission of between 10 and 20 per cent depending upon the type of AO correction applied. Most of the loss is due to the overfilling of the input aperture in poor and moderate seeing. Taking this into account, the photonic device itself has a transmission of 57 ± 4 per cent. We show how a fully-optimized device can be used with AO to provide efficient spectroscopy at high spectral resolution.
Background
Vitiligo, an autoimmune disorder characterised by skin depigmentation, is associated with reduced quality of life (QoL). Vitiligo may be under‐reported, in part because of misconceptions ...that it is a cosmetic disease.
Objectives
This survey sought to characterise vitiligo prevalence and explore the relationship between sociodemographic and clinical characteristics with QoL in a population‐based, multinational study.
Methods
Participants aged ≥18 years were recruited via an online panel in Europe, Japan and the USA to answer questions regarding skin disorders they may have experienced. Those reporting vitiligo (diagnosed or undiagnosed) or vitiligo signs (experiencing loss of skin colour but unaware of vitiligo and not diagnosed) were included in the analyses of vitiligo prevalence. Participants who self‐reported physician‐diagnosed vitiligo were given a broader survey to characterise disease progression, management and QoL (as measured with the Vitiligo‐specific QoL VitiQoL instrument).
Results
The total estimated vitiligo prevalence among 35 694 survey participants (Europe, n = 18 785; USA, n = 8517; Japan, n = 8392) was 1.3% (diagnosed, 0.6%; undiagnosed, 0.4%; vitiligo signs, 0.3%). Among 219 patients formally diagnosed with vitiligo (Europe, n = 150; USA, n = 48; Japan, n = 21), total VitiQoL scores were associated with age (P = 0.00017), disease extent (P < 0.0001), disease progression (P < 0.0001), disease management (P < 0.0001) and time since diagnosis (P = 0.0015). Behaviour scores varied based on skin phototype (P = 0.024) and ethnicity (P = 0.048). Higher total VitiQoL scores were reported in patients with head lesions (P = 0.027) and those with head and hand and/or wrist lesions (P = 0.018). Substantial high concern (rated 8–10 on an 11‐point Likert scale) for lesions was found across all body areas and varied with geographical region.
Conclusions
The vitiligo prevalence rate may be higher than previously reported, with a substantial proportion attributed to people who have not received a formal diagnosis. Among formally diagnosed patients with vitiligo, QoL was most severely impacted by more progressive and higher extent of disease.
Mimicking photosynthesis in generating chemical fuels from sunlight is a promising strategy to alleviate society's demand for fossil fuels. However, this approach involves a number of challenges that ...must be overcome before this concept can emerge as a viable solution to society's energy demand. Particularly in artificial photosynthesis, the catalytic chemistry that converts energy in the form of electricity into carbon‐based fuels and chemicals has yet to be developed. Here, we describe the foundational work and future prospects of an emerging and promising class of materials: metal‐ and covalent‐organic frameworks (MOFs and COFs). Within this context, these porous and tuneable framework materials have achieved initial success in converting abundant feedstocks (H2O and CO2) into chemicals and fuels. In this review, we first highlight key achievements in this direction. We then follow with a perspective on precisely how MOFs and COFs can perform in ways not possible with conventional molecular or heterogeneous catalysts. We conclude with a view on how spectroscopically probing MOF and COF catalysis can be used to elucidate reaction mechanisms and material dynamics throughout the course of reaction.
Final-state kinematic imbalances are measured in mesonless production of νμ+A→μ-+p+X in the MINERvA tracker. Initial- and final-state nuclear effects are probed using the direction of the μ- - p ...transverse momentum imbalance and the initial-state momentum of the struck neutron. Differential cross sections are compared to predictions based on current approaches to medium modeling. These models underpredict the cross section at intermediate intranuclear momentum transfers that generally exceed the Fermi momenta. As neutrino interaction models need to correctly incorporate the effect of the nucleus in order to predict neutrino energy resolution in oscillation experiments, this result points to a region of phase space where additional cross section strength is needed in current models, and demonstrates a new technique that would be suitable for use in fine-grained liquid argon detectors where the effect of the nucleus may be even larger.
We present double-differential measurements of antineutrino charged-current quasielastic scattering in the MINERvA detector. This study improves on a previous single-differential measurement by using ...updated reconstruction algorithms and interaction models and provides a complete description of observed muon kinematics in the form of a double-differential cross section with respect to muon transverse and longitudinal momentum. We include in our signal definition zero-meson final states arising from multinucleon interactions and from resonant pion production followed by pion absorption in the primary nucleus. We find that model agreement is considerably improved by a model tuned to MINERvA inclusive neutrino scattering data that incorporates nuclear effects such as weak nuclear screening and two-particle, two-hole enhancements.
Third-generation cephalosporin-resistant (3GC-R)
represent a major threat to human health. Here, we captured 288 3GC-R
clinical isolates from 264 patients presenting at a regional Australian hospital ...over a 14-month period. In addition to routine mass spectrometry and antibiotic sensitivity testing, isolates were examined using rapid (∼40-min) real-time PCR assays targeting the most common extended-spectrum β-lactamases (ESBLs;
and
groups, plus
,
, and an internal 16S rRNA gene control). AmpC CMY β-lactamase (
) prevalence was also examined.
(80.2%) and
(17.0%) were dominant, with
,
, and
infrequently identified. Ceftriaxone and cefoxitin resistance were identified in 97.0% and 24.5% of
and
isolates, respectively. Consistent with global findings in
, most (98.3%) isolates harbored at least one β-lactamase gene, with 144 (50%) harboring
group, 92 (31.9%) harboring
group, 48 (16.7%) harboring
, 133 (46.2%) harboring
, and 34 (11.8%) harboring
genes. A subset of isolates (
= 98) were subjected to whole-genome sequencing (WGS) to identify the presence of cryptic resistance determinants and to verify genotyping accuracy. WGS of β-lactamase-negative or carbapenem-resistant isolates identified uncommon ESBL and carbapenemase genes, including
and
, and confirmed all PCR-positive genotypes. We demonstrate that our PCR assays enable the rapid and cost-effective identification of ESBLs in the hospital setting, which has important infection control and therapeutic implications.
Faced with unresolved tensions between neutrino interaction measurements at few-GeV neutrino energies, current experiments are forced to accept large systematic uncertainties to cover discrepancies ...between their data and model predictions. The widely used pion production model in GENIE is compared to four MINERνA charged current pion production measurements using nuisance. Tunings, i.e., adjustments of model parameters, to help match GENIE to MINERνA and older bubble chamber data are presented. We find that scattering off nuclear targets as measured in MINERνA is not in good agreement with expectations based upon scattering off nucleon (hydrogen or deuterium) targets in existing bubble chamber data. An additional ad hoc correction for the low−Q2 region, where collective nuclear effects are expected to be large, is presented. While these tunings and corrections improve the agreement of GENIE with the data, the modeling is imperfect. The development of these tunings within the nuisance framework allows for straightforward extensions to other neutrino event generators and models, and allows omitting and including new datasets as they become available.
Neutrino induced coherent charged pion production on nuclei, ν¯μA→μ±π∓A, is a rare inelastic interaction in which the four-momentum squared transferred to the nucleus is nearly zero, leaving it ...intact. We identify such events in the scintillator of MINERvA by reconstructing |t| from the final state pion and muon momenta and by removing events with evidence of energetic nuclear recoil or production of other final state particles. We measure the total neutrino and antineutrino cross sections as a function of neutrino energy between 2 and 20 GeV and measure flux integrated differential cross sections as a function of Q2, Eπ, and θπ. The Q2 dependence and equality of the neutrino and antineutrino cross sections at finite Q2 provide a confirmation of Adler’s partial conservation of axial current hypothesis.
PDF
