Genetic analysis involving 2035 patients with a myeloproliferative disorder identified eight genomic subgroups with distinct clinical phenotypes, risk of leukemic transformation, and event-free ...survival.
We present two epochs of near-infrared spectroscopy of the candidate red supergiant counterpart to RX J004722.4–252051, a ULX in NGC 253. We measure radial velocities of the object and its ...approximate spectral type by cross-correlating our spectra with those of known red supergiants. Our VLT/X-shooter spectrum is best matched by that of early M-type supergiants, confirming the red supergiant nature of the candidate counterpart. The radial velocity of the spectrum, taken on 2014 August 23, is 417 ± 4 km s−1. This is consistent with the radial velocity measured in our spectrum taken with Magellan/MMIRS on 2013 June 28, of 410 ± 70 km s−1, although the large error on the latter implies that a radial velocity shift expected for a black hole of tens of M⊙ can easily be hidden. Using nebular emission lines we find that the radial velocity due to the rotation of NGC 253 is 351 ± 4 km s−1 at the position of the ULX. Thus the radial velocity of the counterpart confirms that the source is located in NGC 253, but also shows an offset with respect to the local bulk motion of the galaxy of 66 ± 6 km s−1. We argue that the most likely origin for this displacement lies either in a SN kick, requiring a system containing a ≳ 50 M⊙ black hole, and/or in orbital radial velocity variations in the ULX binary system, requiring a ≳ 100 M⊙ black hole. We therefore conclude that RX J004722.4–252051 is a strong candidate for a ULX containing a massive stellar black hole.
Sustainable global energy production is back-stopped by hydropower which is responsible for a significant share of the green energy produced worldwide. Hydropower, however, does not come without some ...environmental impacts but has worked to reduce those impacts. Here, we discuss the historical, legislative, and design configurations of hydropower facilities located in three of the world’s most important producers: Brazil, Canada, and Norway. The background is intended to inform the collection of scientific papers from each country aimed at assessing and improving the sustainability of hydropower production that form the core of this special issue on sustainable hydropower. We review the development and key legislative history for hydropower in each country and point out the common backgrounds and interests each nation has in the continued sustainable development of its hydropower resources.
We exploit Atacama Large Millimeter Array (ALMA) 870 μm observations of sub-millimetre sources in the Extended Chandra Deep Field South to investigate the far-infrared properties of high-redshift ...sub-millimetre galaxies (SMGs). Using the precisely located 870 μm ALMA positions of 99 SMGs, together with 24μm and radio imaging, we deblend the Herschel/SPIRE imaging to extract their far-infrared fluxes and colours. The median redshifts for ALMA LESS (ALESS) SMGs which are detected in at least two SPIRE bands increases with wavelength of the peak in their spectral energy distributions (SEDs), with z = 2.3 ± 0.2, 2.5 ± 0.3 and 3.5 ± 0.5 for the 250, 350 and 500 μm peakers, respectively. 34 ALESS SMGs do not have a >3σ counterpart at 250, 350 or 500 μm. These galaxies have a median photometric redshift derived from the rest-frame UV–mid-infrared SEDs of z = 3.3 ± 0.5, which is higher than the full ALESS SMG sample; z = 2.5 ± 0.2. We estimate the far-infrared luminosities and characteristic dust temperature of each SMG, deriving L
IR = (3.0 ± 0.3) × 1012 L⊙ (SFR = 300 ± 30 M⊙ yr−1) and T
d = 32 ± 1 K. The characteristic dust temperature of these high-redshift SMGs is ΔT
d = 3–5 K lower than comparably luminous galaxies at z = 0, reflecting the more extended star formation in these systems. We show that the contribution of S
870 μm ≥ 1 mJy SMGs to the cosmic star formation budget is 20 per cent of the total over the redshift range z ∼ 1–4. Adopting an appropriate gas-to-dust ratio, we estimate a typical molecular mass of the ALESS SMGs of
$M_{\rm H_2}$
= (4.2 ± 0.4) × 1010 M⊙. Finally, we show that SMGs with S
870 μm > 1 mJy (L
IR ≳ 1012 L⊙) contain ∼ 10 per cent of the z ∼ 2 volume-averaged H2 mass density.
Novel targeted and immunotherapeutic agents have revolutionized systemic melanoma management. We note differing rates of distant brain control as well as overall survival following systemic treatment ...and stereotactic radiosurgery (SRS) in melanoma brain metastases management. These data support further research to determine the potential synergistic effect between these agents with SRS.
The effect of immunologic and targeted agents on intracranial response rates in patients with melanoma brain metastases (MBMs) is not yet clearly understood. This report analyzes outcomes of intact MBMs treated with single-session stereotactic radiosurgery (SRS) and anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors(i), BRAFi, or conventional chemotherapy.
Patients were included if MBMs were treated with single-session SRS within 3 months of receiving systemic therapy. The primary end point of this study was distant MBM control. Secondary end points were local MBM control defined as a >20% volume increase on follow-up MRI, systemic progression-free survival, overall survival (OS) from both SRS and cranial metastases diagnosis, and neurotoxicity. Images were reviewed alongside two neuro-radiologists at our institution.
Ninety-six patients were treated to 314 MBMs over 119 SRS treatment sessions between January 2007 and August 2015. No significant differences were noted in age (P = 0.27), gender (P = 0.85), treated gross tumor volume (P = 0.26), or the diagnosis-specific graded prognostic assessment (P = 0.51) between the treatment cohorts. Twelve-month Kaplan–Meier (KM) distant MBM control rates were 38%, 21%, 20%, 8%, and 5% (P = 0.008) for SRS with anti-PD-1 therapies, anti-CTLA-4 therapy, BRAF/MEKi, BRAFi, and conventional chemotherapy, respectively. No significant differences were noted in the KM local MBM control rates among treatment groups (P = 0.25). Treatment with anti-PD-1 therapy, anti-CTLA-4 therapy, or BRAF/MEKi significantly improved OS on both univariate and multivariate analyses when compared with conventional chemotherapy.
In our institutional analysis of patients treated with SRS and various systemic immunologic and targeted melanoma agents, significant differences in distant MBM control and OS are noted. Prospective evaluation of the potential synergistic effect between these agents and SRS is warranted.
Coral-reef ecosystems are experiencing frequent and severe disturbance events that are reducing global coral abundance and potentially overwhelming the natural capacity for reefs to recover. While ...mitigation strategies for climate warming and other anthropogenic disturbances are implemented, coral restoration programmes are being established worldwide as an additional conservation measure to minimise coral loss and enhance coral recovery. Current restoration efforts predominantly rely on asexually produced coral fragments—a process with inherent practical constraints on the genetic diversity conserved and the spatial scale achieved. Because the resilience of coral communities has hitherto relied on regular renewal with natural recruits, the scaling-up of restoration programmes would benefit from greater use of sexually produced corals, which is an approach that is gaining momentum. Here we review the present state of knowledge of scleractinian coral sexual reproduction in the context of reef restoration, with a focus on broadcast- spawning corals. We identify key knowledge gaps and bottlenecks that currently constrain the sexual production of corals and consider the feasibility of using sexually produced corals for scaling-up restoration to the reef- and reef-system scales.
We present H-band spectra of the candidate counterparts of five ultraluminous X-ray sources (ULXs; two in NGC 925, two in NGC 4136 and Holmberg II X-1) obtained with Keck/MOSFIRE (Multi-Object ...Spectrometer for Infra-Red Exploration). The candidate counterparts of two ULXs (J022721+333500 in NGC 925 and J120922+295559 in NGC 4136) have spectra consistent with (M-type) red supergiants (RSGs). We obtained two epochs of spectroscopy of the candidate counterpart to J022721+333500, separated by 10 months, but discovered no radial velocity variations with a 2σ upper limit of 40 km s−1. If the RSG is the donor star of the ULX, the most likely options are that either the system is seen at low inclination (<40°) or the black hole mass is less than 100 M⊙, unless the orbital period is longer than 6 years, in which case the obtained limit is not constraining. The spectrum of the counterpart to J120922+295559 shows emission lines on top of its stellar spectrum, and the remaining three counterparts do not show absorption lines that can be associated with the atmosphere of a star; their spectra are instead dominated by emission lines. Those counterparts with RSG spectra may be used in the future to search for radial velocity variations, and, if those are present, determine dynamical constraints on the mass of the accretor.
Noncompliance with radiotherapy (RT) protocol guidelines has been linked to inferior clinical outcomes. We performed a meta-analysis of cooperative group trials to examine the association between RT ...quality assurance (QA) deviations and disease control and overall survival (OS).
We searched MEDLINE and the Cochrane Central Register of Controlled Trials for multi-institutional trials that reported clinical outcomes in relation to RT QA results. Hazard ratios (HRs) describing the association between RT protocol noncompliance and patient outcomes were extracted directly from the original studies or calculated from survival curves. Inverse variance meta-analyses were performed to assess the association between RT QA deviations and OS. A second meta-analysis tested the association between RT QA deviations and secondary outcomes, including local or locoregional control, event-free survival, and relapse. Random-effects models were used in cases of statistically significant (P < .10) effect heterogeneity. The Egger test was used to detect publication bias. All statistical tests were two-sided.
Eight studies (four pediatric, four adult) met all inclusion criteria and were incorporated into this analysis. The frequency of RT QA deviations ranged from 8% to 71% (median = 32%). In a random-effects model, RT deviations were associated with a statistically significant decrease in OS (HR of death = 1.74, 95% confidence interval CI = 1.28 to 2.35; P < .001). A similar effect was seen for secondary outcomes (HR of treatment failure = 1.79, 95% CI = 1.15 to 2.78; P = .009). No evidence of publication bias was detected.
In clinical trials, RT protocol deviations are associated with increased risks of treatment failure and overall mortality.
Quantitative participatory exploration of the many complex issues surrounding cross-sectoral climate change impacts, vulnerability and adaptation under uncertain futures is dependent on the ...provision, in some form, of scenarios and scenario outputs. However, the normal provision by the research community of pre-defined scenario outputs results in a lack of flexibility for stakeholders regarding choice of climate models, scenarios, scenario quantification and output indicators which in turn can lead to a lack of trust. This Special Issue describes the development and application of a web-based interactive simulation and display environment, called the CLIMSAVE Integrated Assessment (IA) Platform, which provides a holistic (cross-sectoral, climate and socio-economic change) modelling framework. The IA Platform guides the user through simulation of (1) potential impacts under scenarios of climate and/or socio-economic change, (2) identification of sectoral and multi-sectoral vulnerability ‘hotspots’ either before or after adaptation, (3) the potential for adaptation to reduce impacts within the capital constraints of the selected scenario(s), and (4) the cost-effectiveness of adaptation measures. The Special Issue explores how the IA Platform has been: (i) designed to provide a user-friendly, intuitive and facilitating, rather than predictive or prescriptive, environment for users; and (ii) utilised to quantitatively explore a diverse range of uncertain futures across Europe.
In this paper, we present the results of the first systematic search for counterparts to nearby ultraluminous X-ray sources (ULXs) in the near-infrared (NIR). We observed 62 ULXs in 37 galaxies ...within 10 Mpc and discovered 17 candidate NIR counterparts. The detection of 17 out of 62 ULX candidates points to intrinsic differences between systems that show and those that do not show infrared emission. For six counterparts, we conclude from the absolute magnitudes and – in some cases – additional information such as morphology and previously reported photometric or spectroscopic observations, that they are likely background active galactic nuclei or ULXs residing in star clusters. 11 counterparts have absolute magnitudes consistent with them being single red supergiant stars. Alternatively, these systems may have larger accretion discs that emit more NIR light than the systems that we do not detect. Other scenarios such as emission from a surrounding nebula or from a compact radio jet are also possible, although for Holmberg II X-1 the NIR luminosity far exceeds the expected jet contribution. The 11 possible red supergiant counterparts are excellent candidates for spectroscopic follow-up observations. This may enable us to measure the mass function in these systems if they are indeed red supergiant donor stars where we can observe absorption lines.
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