Abstract
We explore neutrino emission from nonrotating, single-star models across six initial metallicities and 70 initial masses from the zero-age main sequence to the final fate. Overall, across ...the mass spectrum, we find metal-poor stellar models tend to have denser, hotter, and more massive cores with lower envelope opacities, larger surface luminosities, and larger effective temperatures than their metal-rich counterparts. Across the mass–metallicity plane we identify the sequence (initial CNO →
14
N →
22
Ne →
25
Mg →
26
Al →
26
Mg →
30
P →
30
Si) as making primary contributions to the neutrino luminosity at different phases of evolution. For the low-mass models we find neutrino emission from the nitrogen flash and thermal pulse phases of evolution depend strongly on the initial metallicity. For the high-mass models, neutrino emission at He-core ignition and He-shell burning depends strongly on the initial metallicity. Antineutrino emission during C, Ne, and O burning shows a strong metallicity dependence with
22
Ne(
α
,
n
)
25
Mg providing much of the neutron excess available for inverse-
β
decays. We integrate the stellar tracks over an initial mass function and time to investigate the neutrino emission from a simple stellar population. We find average neutrino emission from simple stellar populations to be 0.5–1.2 MeV electron neutrinos. Lower metallicity stellar populations produce slightly larger neutrino luminosities and average
β
decay energies. This study can provide targets for neutrino detectors from individual stars and stellar populations. We provide convenient fitting formulae and open access to the photon and neutrino tracks for more sophisticated population synthesis models.
Burmese python (
) is an invasive snake that has significantly affected ecosystems in southern Florida, United States. Aside from direct predation and competition, invasive species can also introduce ...nonnative pathogens that can adversely affect native species. The subfamily
(order
) is composed of positive-sense RNA viruses primarily found in reptiles. Some serpentoviruses, such as shingleback nidovirus, are associated with mortalities in wild populations, while others, including ball python nidovirus and green tree python nidovirus can be a major cause of disease and mortality in captive animals. To determine if serpentoviruses were present in invasive Burmese pythons in southern Florida, oral swabs were collected from both free-ranging and long-term captive snakes. Swabs were screened for the presence of serpentovirus by reverse transcription PCR and sequenced. A total serpentovirus prevalence of 27.8% was detected in 318 python samples. Of the initial swabs from 172 free-ranging pythons, 42 (24.4%) were positive for multiple divergent viral sequences comprising four clades across the sampling range. Both sex and snout-vent length were statistically significant factors in virus prevalence, with larger male snakes having the highest prevalence. Sampling location was statistically significant in circulating virus sequence. Mild clinical signs and lesions consistent with serpentovirus infection were observed in a subset of sampled pythons. Testing of native snakes (n = 219, 18 species) in part of the python range found no evidence of python virus spillover; however, five individual native snakes (2.3%) representing three species were PCR positive for unique, divergent serpentoviruses. Calculated pairwise uncorrected distance analysis indicated the newly discovered virus sequences likely represent three novel genera in the subfamily
This study is the first to characterize serpentovirus in wild free-ranging pythons or in any free-ranging North America reptile. Though the risk these viruses pose to the invasive and native species is unknown, the potential for spillover to native herpetofauna warrants further investigation.
Basophils form a distinct cell lineage within the hematopoietic cell family. In various myeloid neoplasms, including chronic myeloid leukemia, basophilia is frequently seen. Acute and chronic ...basophilic leukemias, albeit rare, have also been described. However, no generally accepted criteria and classification of basophilic leukemias have been presented to date. To address this unmet need, a series of Working Conferences and other meetings were organized between March 2015 and March 2016. The current article provides a summary of consensus statements from these meetings, together with proposed criteria to delineate acute basophilic leukemia (ABL) from chronic basophilic leukemia (CBL) and primary forms of the disease where no preceding myeloid malignancy is detected, from the more common 'secondary' variants. Moreover, the term hyperbasophilia (HB) is proposed for cases with a persistent peripheral basophil count ⩾1000 per μl of blood. This condition, HB, is highly indicative of the presence of an underlying myeloid neoplasm. Therefore, HB is an important checkpoint in the diagnostic algorithm and requires a detailed hematologic investigation. In these patients, an underlying myeloid malignancy is often found and is then labeled with the appendix -baso, whereas primary cases of ABL or CBL are very rare. The criteria and classification proposed in this article should facilitate the diagnosis and management of patients with unexplained basophilia and basophil neoplasms in routine practice, and in clinical studies.
Severe plastic deformation (SPD) processes offer the possibility of improving the mechanical properties of metallic materials by grain refinement. However, this great potential has so far mostly been ...applied on a laboratory scale or on small series. Equal-Channel Angular Pressing (ECAP) also enables to integrate the advantages in industrial processes with large output—so far, mainly for bars or thick plates. In this paper, we investigate the ECAP process for sheet metal. Preliminary investigations have shown that cracks form on the surface when aluminum AA5083 sheets are processed. To solve this problem, we determined the Johnson–Cook fracture criterion for the material and modeled the process numerically. The simulation was carried out with the superposition of a backpressure and subsequently implemented and validated experimentally. The semi-finished sheet metal products from the ECAP investigation were then mechanically characterized with microhardness measurements and tensile tests. In addition, the microstructure was investigated with Electron Back Scatter Diffraction (EBSD). Even comparatively small amounts of backpressure (10 MPa) already result in a significant suppression of the crack formation in the numerical and experimental investigations. The microhardness measurements indicate a more homogeneous strain distribution for a sufficient level of applied backpressure which enables the processing of crack-free sheets in multiple ECAP passes. As with ECAP of bulk materials, tensile tests on the processed sheets show a reduced elongation to failure (− 73%) but a significantly increased yield strength (+ 157%) compared to the initial condition of the material. Distinct substructures are found in the EBSD measurements and explain this behavior. The findings provide the basis for using ECAP on an application-oriented scale and demonstrate an advanced manufacturing method for the production of high-strength aluminum sheets.
The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an established risk factor for stress-related psychiatric disorders such as major depression. Drug discovery for FKBP51 has been ...hampered by the inability to pharmacologically differentiate against the structurally similar but functional opposing homolog FKBP52, and all known FKBP ligands are unselective. Here, we report the discovery of the potent and highly selective inhibitors of FKBP51, SAFit1 and SAFit2. This new class of ligands achieves selectivity for FKBP51 by an induced-fit mechanism that is much less favorable for FKBP52. By using these ligands, we demonstrate that selective inhibition of FKBP51 enhances neurite elongation in neuronal cultures and improves neuroendocrine feedback and stress-coping behavior in mice. Our findings provide the structural and functional basis for the development of mechanistically new antidepressants.
Severe plastic deformation (SPD) is a process to significantly improve the mechanical properties of materials by grain refinement. For forming at room temperature (RT), higher strengths can thus be ...achieved; for increased temperatures (HT), greater elongations can be achieved. This great potential has been chiefly applied only on laboratory scale due to a lack of industrial process design. Equal-channel angular pressing (ECAP) offers the possibility to integrate these advantages in industrial processes. This paper investigates a modified ECAP process for aluminum AA5083 sheet metal. Two passes of ECAP for sheet metal and an additional heat treatment were used. To study the material deformation on a micro-scale, in-situ synchrotron measurements at DESY (Hamburg) were performed to analyze the evolution of lattice strains and dislocation densities during tensile testing. The mechanical properties of the ECAP-processed sheet material reveal an increase in yield strength and a decrease in elongation at RT. Higher strains can be measured for the processed material at elevated test temperatures. In-situ diffraction results show a changed behavior of the ECAP sheet material compared to the reference material for both temperature regimes. These changes are based on the increased defect density in the material, which leads to increased strength at RT. At HT, dynamic recrystallization occurs during tensile testing, and the prevailing deformation mechanisms reconfigure. Electron backscatter diffraction (EBSD) and micrographs are used to interpret and supplement the observations. The findings provide the basis for the in-depth understanding of the deformation behavior of the material and help to apply the ECAP process on an industrial scale.
We report the complete GNO solar neutrino results for the measuring periods GNO III, GNO II, and GNO I. The result for GNO III (last 15 solar runs) is 54.3−9.3+9.9(stat)±2.3(syst)SNU(1σ) or ...54.3−9.6+10.2(incl. syst) SNU (1σ) with errors combined. The GNO experiment is now terminated after altogether 58 solar exposure runs that were performed between 20 May 1998 and 9 April 2003. The combined result for GNO (I+II+III) is 62.9−5.3+5.5(stat)±2.5(syst) SNU (1σ) or 62.9−5.9+6.0 SNU (1σ) with errors combined in quadrature. Overall, gallium based solar observations at LNGS (first in GALLEX, later in GNO) lasted from 14 May 1991 through 9 April 2003. The joint result from 123 runs in GNO and GALLEX is 69.3±5.5(incl. syst) SNU (1σ). The distribution of the individual run results is consistent with the hypothesis of a neutrino flux that is constant in time. Implications from the data in particle- and astrophysics are reiterated.
Neutron peripheral contamination in patients undergoing high-energy photon radiotherapy is considered as a risk factor for secondary cancer induction. Organ-specific neutron-equivalent dose ...estimation is therefore essential for a reasonable assessment of these associated risks. This work aimed to develop a method to estimate neutron-equivalent doses in multiple organs of radiotherapy patients. The method involved the convolution, at 16 reference points in an anthropomorphic phantom, of the normalized Monte Carlo neutron fluence energy spectra with the kerma and energy-dependent radiation weighting factor. This was then scaled with the total neutron fluence measured with passive detectors, at the same reference points, in order to obtain the equivalent doses in organs. The latter were correlated with the readings of a neutron digital detector located inside the treatment room during phantom irradiation. This digital detector, designed and developed by our group, integrates the thermal neutron fluence. The correlation model, applied to the digital detector readings during patient irradiation, enables the online estimation of neutron-equivalent doses in organs. The model takes into account the specific irradiation site, the field parameters (energy, field size, angle incidence, etc) and the installation (linac and bunker geometry). This method, which is suitable for routine clinical use, will help to systematically generate the dosimetric data essential for the improvement of current risk-estimation models.
Over the course of several decades, organic liquid scintillators have formed the basis for successful neutrino detectors. Gadolinium-loaded liquid scintillators provide efficient background ...suppression for electron antineutrino detection at nuclear reactor plants. In the Double Chooz reactor antineutrino experiment, a newly developed beta-diketonate gadolinium-loaded scintillator is utilized for the first time. Its large scale production and characterization are described. A new, light yield matched metal-free companion scintillator is presented. Both organic liquids comprise the target and "Gamma Catcher" of the Double Chooz detectors.
Our aim was to determine whether the intestinotrophic effects of GLP-2 are mediated by acute up-regulation of intestinal substrate utilization in TPN-fed piglets.
Twenty-four 12-day-old pigs, fitted ...with a portal flow probe and carotid, jugular and portal catheters, were fed by TPN for 7 days. On day 8, a group of pigs (n = 8) was infused intravenously with saline (control) for 4 hours and then with GLP-2 (500 pmol · kg
−1 · hour
−1, GLP-2) for 4 hours.
2H-glucose and
13C-phenylalanine were infused to estimate their kinetics and protein turnover. Another group (n = 8) received consecutive intravenous infusions of saline, GLP-2, and GLP-2 plus N
G
-Nitro-
l-arginine methyl ester (
l-NAME, 50 μmol · kg
−1 · hour
−1) for 4 hours each.
GLP-2 acutely increased portal-drained visceral (PDV) blood flow rate (+25%) and intestinal blood volume (+51%) in TPN-fed piglets. GLP-2 also increased intestinal constitutive nitric oxide synthase (NOS) activity and endothelial NOS protein abundance. GLP-2 acutely increased PDV glucose uptake (+90%) and net lactate production (+79%). Co-infusion of GLP-2 plus
l-NAME did not increase either PDV blood flow rate or glucose uptake. GLP-2 increased PDV indispensable amino acid uptake by 220% and protein synthesis by 125%, but did not decrease protein breakdown or phenylalanine oxidation.
We conclude that in TPN-fed neonatal pigs, GLP-2 acutely stimulates intestinal blood flow and glucose utilization, and this response is nitric oxide-dependent. These findings suggest that GLP-2 may play an important physiological role in the regulation of intestinal blood flow and that nitric oxide is involved in GLP-2 receptor function.
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