With the rapidly evolving field of prenatal testing, there is a growing need to provide support for women pursuing termination of pregnancy following the discovery of a fetal anomaly. Previous ...studies have documented that women in this situation often feel unsupported, but the type of resources desired by this population remains undetermined. We studied the awareness and utilization of support resources in 51 women at the time of the procedure, at 6 weeks, and at 3 months following the event. Though largely knowledgeable of existing resources at the time of the procedure, only 50 % admitted contemplating their individualized need for support. Most expected to rely on the support of family and friends. Additionally, 50 % expressed the desire to commemorate the pregnancy, though none wanted direct contact with their healthcare provider(s). Responses from the 6 weeks and 3 months assessments were consistent with previous literature as many women indicated not coping as expected and were unprepared for the psychological consequences following the procedure. Our findings indicate that women in these situations may not realize what their long-term support needs will be. They further indicate that guidelines for routine follow-up care should be established among healthcare providers that respect this population’s initial desires to avoid reminders of the pregnancy and promote a flexible timeframe for support uptake. Additional support resources that promote flexible uptake as well as meet the desires of anonymity and ease of access need to be developed for this population.
Background: Anemia is major public health concern and mainly affects young children, pregnant and postpartum women, and menstruating adolescent girls and women. As reported by WHO, 40% of all ...children aged 6–59 months, 37% of pregnant women and 30% of women 15–49 years of age are affected by anemia globally. The situation is even worse in India with the prevalence being 67%, 52.2% and 57% respectively, as reported by NFHS-V. Objective: To estimate prevalence of anemia and its severity stratified by age and gender in patients attending Rural Health Training Centre (RHTC), Jawan, Aligarh. Methodology: A retrospective observational study using routine clinical data of 402 patients attending general OPD of RHTC from January 1, 2022 to December 31, 2022 was performed. Pregnant females and patients who had more than one determination of hemoglobin during the study period were excluded from the study. Anemia was defined according to WHO criteria. Data was analyzed using SPSS version 20.0., descriptive statistics and Chi Square test were applied. P value Results: 40.5% of patients were males while 59.5% were females. The overall prevalence of anemia was found to be 93.3%. Anemia was most prevalent in children <5 years (95.7%). Females had significantly higher prevalence of anemia (97.4%) as compared to males (86.3%). (p<0.001) Conclusion: Prevalence of anemia was found to be very high in patients attending Rural Health Clinic. Targeted interventions like screening programmes, iron and folic acid supplementation and health education should be strengthened for decreasing prevalence of anemia especially in women and young children.
Background: Child undernutrition is a global health concern. Malnutrition continues to be one of the leading causes of morbidity and mortality worldwide, particularly in developing countries like ...India. As per the NFHS-V, the prevalence of stunting, wasting and underweight in under-five children stands at 35.5%, 19.3% and 32.1% respectively. Anthropometry has become a practical tool for evaluating the nutritional status of populations, particularly of children in developing countries & the nutritional status is the best indicator of global well-being of children. Objective: To describe the anthropometric profile and assess malnutrition using anthropometric measurements of under-five children attending pediatric OPD at Rural Health Training Centre (RHTC), Jawan under Department of Community Medicine, JNMCH, A.M.U., Aligarh (U.P.). Methodology: This is a retrospective study with secondary analysis of anthropometric data of 255 under five children attending pediatric clinic for the first time at RHTC, Jawan, under Department of Community Medicine from January 1, 2023, to June 30, 2023. Collected data were entered into Microsoft Excel and analyzed by using the software SPSS, version 20.0. Results: The median age of the children was 24 months. 52.2% of them were boys and 47.8% were girls. Severe wasting (weight-for-height<-3SD) and severe stunting (height-for-age<-3SD) was present in 4.3% and 10.2% of all children respectively and there was no significant difference among different age groups. Prevalence of underweight and stunting was highest in children less than 6 months. Conclusion: Undernutrition is common in under-five children and 10.2% of children had severe wasting. In order to prevent severe forms of undernutrition health education to caregivers on various forms of undernutrition is crucial. IEC activities and health education regarding infant and young child feeding (IYCF) should be strengthened, especially to caregivers of children less than 6 months.
Nanotechnology is a new star in the science horizon with many valuable applications and promises to offer. It includes the synthesis and utilization of nanostructure materials ranging from 1 to 100 ...nm. Mostly these materials are generally (or "could be") produced via the laborious and hazard-prone physical and chemical methods but the green synthesis approaches easier, safe and scalable have been recently developed. Among other metal oxides nanoparticles, Titanium oxide (TiO
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) nanoparticles have been mostly exploited for their photocatalytic, antimicrobial and antiparasitic applications. A diverse set of biological entities are used to reduce the precursor metal salt into respective nanoparticles. The secondary metabolites present in organisms such as plants or microbes are involved in the bio-reduction and capping processes. This article will provide an overview of the green synthesis of TiO
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NPs from different biological extracts such as plants, microbes and biological products as well as their potential applications.
Despite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The aim of this study was to determine the significance of preoperative MRI ...variables, both quantitative and qualitative, with regard to overall and progression-free survival in GBM.
We retrospectively identified 94 untreated GBM patients from the Cancer Imaging Archive who had pretreatment MRI and corresponding patient outcomes and clinical information in The Cancer Genome Atlas. Qualitative imaging assessments were based on the Visually Accessible Rembrandt Images feature-set criteria. Volumetric parameters were obtained of the specific tumor components: contrast enhancement, necrosis, and edema/invasion. Cox regression was used to assess prognostic and survival significance of each image.
Univariable Cox regression analysis demonstrated 10 imaging features and 2 clinical variables to be significantly associated with overall survival. Multivariable Cox regression analysis showed that tumor-enhancing volume (P = .03) and eloquent brain involvement (P < .001) were independent prognostic indicators of overall survival. In the multivariable Cox analysis of the volumetric features, the edema/invasion volume of more than 85 000 mm(3) and the proportion of enhancing tumor were significantly correlated with higher mortality (Ps = .004 and .003, respectively).
Preoperative MRI parameters have a significant prognostic role in predicting survival in patients with GBM, thus making them useful for patient stratification and endpoint biomarkers in clinical trials.
An electronic search of the literature was performed for reported cases of ototoxicity associated with the use of topical antibiotic ear drops in humans. The dosage, duration, and type of ototoxic ...preparations involved were recorded. Due to the scant quantity of low-quality information that is currently available, there was uncertainty about the usefulness of topical antibiotics in enhancing the resolution of ear discharge in patients with chronic suppurative otitis media. However, despite this uncertainty, there are some data to show that using topical antibiotics in comparison to a placebo or in conjunction with a systemic antibiotic may be useful. Additionally, there is ambiguity regarding the relative efficacy of various kinds of antibiotics; it is impossible to say with absolute certainty whether quinolones are superior to or inferior to aminoglycosides. Although the adverse impact profiles of these two classes of chemicals varied, there are not enough data from the included trials to draw any conclusions about them. Negative effects were generally underreported.
Dieulafoy's lesion accounts for 1%-2% of acute gastrointestinal (GI) bleeding cases, and approximately 2% of Dieulafoy's lesions are present in the colon. We report the case of an 83-year-old female ...who presented with recurrent gastrointestinal bleeding from colonic Dieulafoy's lesion located at the hepatic flexure. She initially presented four weeks prior with melena in the setting of Eliquis use for venous thrombosis, coronary artery disease, and end-stage renal disease. Upper endoscopy revealed esophagitis, gastritis, and duodenitis. Diagnostic colonoscopy and video capsule endoscopy both revealed blood in the colon without an identifiable source. During the second admission for recurrent melena with hemoglobin of 3.9 g/dL, Eliquis was discontinued, and the patient was resuscitated with three units of packed red blood cell transfusions. Repeat colonoscopy revealed a pulsating vessel with active oozing located at the hepatic flexure, consistent with a Dieulafoy's lesion. Hemostatic endoclips and bipolar electrocautery were applied to achieve complete hemostasis. Colonic Dieulafoy's lesions, albeit rare, should be considered in patients presenting with an acute obscure lower GI bleed. Primary hemostasis can be achieved with several endoscopic modalities including epinephrine, hemoclipping, thermocoagulation, or sclerotherapy.
Introduction: Thyroid swellings are one of the most commonly encountered lesions with most of the thyroid swellings being benign. The cancerous lesions of the thyroid also present as nodules or ...masses and pose a diagnostic challenge. The thyroid cytology reporting system has been inconsistent with the use of various terminologies. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was introduced in 2007 to bring about uniformity in reporting of thyroid lesions. Aim: This study aimed to compare conventional reporting with TBSRTC. Materials and Methods: A retrospective study was done in which 6 years of data were retrieved. Cytology slides were reviewed and categorized as per the TBSRTC and compared with other studies. Results: There were numerous categories in the conventional thyroid fine-needle aspiration cytology reporting system which has been reduced to six categories in TBSRTC. TBSRTC has also streamlined the reporting removing the confusion among cytologists and clinicians. Conclusion: TBSRTC is consistent and reproducible and should be used as a standard method of reporting.
Pregnancy termination for fetal anomaly (TFA) is a unique experience that can cause women to develop long‐term complicated grief. Although a woman's experience with her healthcare providers has been ...previously identified as an important factor in coping, studies have shown that many women report their health care as lacking to some extent. Given the overlap in women's needs and the practice scope of a genetic counselor (GC), this study aimed to examine how genetic counseling may impact coping and explore women's expectations of GCs pre‐ and post‐TFA. An online survey, which included the brief COPE and the short version of the Perinatal Grief Scale, was distributed among private online support groups. Appropriate statistical analysis tools, such as the Wilcoxon rank‐sum and t test, were utilized for quantitative analysis of the 124 responses, and inductive content analysis was utilized for qualitative analysis. Of those who underwent TFA within the last two years, women who saw a GC utilized active coping, planning, and positive reframing significantly more than women who did not see a GC (p = 0.001, p = 0.031, p = 0.027, respectively). GCs were perceived to have a positive impact on coping when providing information, objective care, emotional support, support resources, and follow‐up care; these practices encouraged confidence in their personal decision‐making and gave women hope for the future. This study not only identified key counseling roles for GCs prior to a TFA, but also demonstrated that genetic counseling prior to TFA may be beneficial to coping. Further studies are warranted to explore the needs of a more diverse population and to identify appropriate genetic counseling training methods to support women pursuing TFA.
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