Epithelial-mesenchymal transition (EMT) is characterised by the loss of cell-to-cell adhesion and gaining of mesenchymal phenotypes. Epithelial-mesenchymal transition is proposed to occur in various ...developmental processes and cancer progression. 'Cadherin switch', a process in which cells shift to express different isoforms of the cadherin transmembrane protein and usually refers to a switch from the expression of E-cadherin to N-cadherin, is one aspect of EMT and can have a profound effect on tumour invasion/metastasis. The aim of this study was to investigate the clinicopathological significance of EMT-related proteins and cadherin switch in extrahepatic cholangiocarcinoma (EHCC).
We investigated the association between altered expression of 12 EMT-related proteins and clinical outcomes in patients with EHCC (n=117) using immunohistochemistry on tissue microarrays.
Univariate and multivariate analyses revealed that, in addition to N classification (P=0.0420), the expression of E-cadherin (P=0.0208), N-cadherin (P=0.0038) and S100A4 (P=0.0157) was each an independent and a significant prognostic factor. We also demonstrated that cadherin switch was independently associated with poor prognosis (P=0.0143) in patients with EHCC.
These results may provide novel information for selection of patients with EHCC who require adjuvant therapy and strict surveillance.
The gamma strength function and level density of 1^{-} states in ^{96}Mo have been extracted from a high-resolution study of the (pover →, pover →^{'}) reaction at 295 MeV and extreme forward angles. ...By comparison with compound nucleus γ decay experiments, this allows a test of the generalized Brink-Axel hypothesis in the energy region of the pygmy dipole resonance. The Brink-Axel hypothesis is commonly assumed in astrophysical reaction network calculations and states that the gamma strength function in nuclei is independent of the structure of the initial and final state. The present results validate the Brink-Axel hypothesis for ^{96}Mo and provide independent confirmation of the methods used to separate gamma strength function and level density in γ decay experiments.
.
Physical studies of electric dipole excitations in atomic nuclei
e.g.
the structure of pygmy dipole resonances and isovector giant dipole resonances are attracting much attention recently. In this ...article, we describe a technical development in the coincidence measurement of the excitation processes with the Grand Raiden high-resolution magnetic spectrometer and the
γ
-decay processes by the CAGRA and SC
γ
LLA efficient
γ
-detector arrays at the Research Center for Nuclear Physics at Osaka University. Specifically, we describe how we developed a new beamline (GRAF), for
γ
detection at the target position by placing the spectrometer at an angle of
4
.
5
-
19
.
0
∘
and by transporting the primary beam to a well-shielded beam dump. Experimental conditions and representative data are shown for each of the two
γ
-detector arrays.
Abstract
Various factors influence each other in an ion source. Therefore, when operating an ion source, it is necessary to optimize and adjust various parameters. This time, we performed an ...experiment to automize adjustment that maximizes the brightness of the beam using machine learning. By automatically adjusting 4 parameters, we succeeded in finding a point with a beam brightness of 4.32 × 10
-6
mA/(imm mrad)
2
in 25 steps. This shows that automatic adjustment using Bayesian optimization is feasible.
Background and Objective
The biochemical effects of an over‐the‐counter (OTC) medication were studied, which consists of a single‐tuft brush containing cetylpyridinium chloride as a bactericidal ...agent, dipotassium glycyrrhizate as an anti‐inflammatory drug and allantoin as a promoter of cell proliferation and wound healing, for delivery to hardly brushed sites.
Material and Methods
This randomized controlled double‐blind study was performed in 61 subjects with chronic periodontitis in supportive periodontal therapy phase (test group: n = 27; placebo group: n = 28; dropout: n = 6). The OTC medication was self‐applied twice a day for 12 wk to two molars with probing pocket depths of 4–6 mm. Biochemical indicators were evaluated at baseline and 12 wk using the suspension array system for eight cytokines and chemokines (interleukin IL‐1β, IL‐1ra, IL‐4, IL‐6, IL‐8, IL‐10, monocyte chemoattractant protein‐1 and tumor necrosis factor TNF‐α) in gingival crevicular fluid.
Results
The levels of IL‐1β, IL‐6, IL‐8 and TNF‐α remained significantly lower in the test group compared to the placebo group. In the placebo group, when the probing pocket depth at baseline was 4 mm, IL‐1β increased, particularly in the second molar tooth, and the greatest increase was seen when PPD at baseline was 5–6 mm. In the test group, IL‐1β decreased markedly in cases with furcation involvement and low bleeding on probing at baseline. In both groups, IL‐1β, IL‐6 and TNF‐α were closely correlated with each other.
Conclusion
This OTC medication is biochemically effective for steady chronic periodontitis in the supportive periodontal therapy phase.
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