The process of implementing early detection of lung cancer with low-dose CT (LDCT) in Germany has gained significant momentum in recent years. It is expected that the ordinance of the Federal ...Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection (BMUV) on early detection of lung cancer, which has been commented on by the professional societies, will come into effect by the end of 2023. Based on this regulation, the Federal Joint Committee (G-BA) will set up a program for early lung cancer detection with LDCT in the near future. In this position paper, the specialist societies involved in lung cancer screening present concrete cornerstones for a uniform, structured and quality-assured early detection program for lung cancer in Germany to make a constructive contribution to this process.
Wearable sweat biosensensing technology has dominantly relied on techniques which place planar-sensors or fluid-capture materials directly onto the skin surface. This 'on-skin' approach can result in ...sample volumes in the μL regime, due to the roughness of skin and/or due to the presence of hair. Not only does this increase the required sampling time to 10's of minutes or more, but it also increases the time that sweat spends on skin and therefore increases the amount of analyte contamination coming from the skin surface. Reported here is a first demonstration of a new paradigm in sweat sampling and sensing, where sample volumes are reduced from the μL's to nL's regime, and where analyte contamination from skin is reduced or even eliminated. A micro-porous membrane is constructed such that it is porous to sweat only. To complete a working device, first placed onto skin is a cosmetic-grade oil, secondly this membrane, and thirdly the sensors. As a result, spreading of sweat is isolated to only regions above the sweat glands before it reaches the sensors. Best case sampling intervals are on the order of several minutes, and the majority of hydrophilic (low oil solubility) contaminants from the skin surface are blocked.
In vitro
validation of this new approach is performed with an improved artificial skin including human hair.
In vivo
tests show strikingly consistent results, and reveal that the oil/membrane is robust enough to even allow horizontal sliding of a sensor.
Reported here is a new paradigm in sweat sampling and sensing, where sample volumes are dramatically reduced and where analyte contamination from the skin surface is mitigated.
Dye adsorption plays a crucial role in dye-sensitized solar cells. Herein, we demonstrate an
in situ
liquid-phase analytical technique to quantify in real time adsorption of dye and coadsorbates on ...flat and mesoporous TiO
2
films. For the first time, a molar ratio of co-adsorbed Y123 and chenodeoxycholic acid has been measured.
An
in situ
liquid-phase QCM-D technique is demonstrated to quantify in real time adsorption of dye and coadsorbates on flat and mesoporous TiO
2
films for dye sensitized solar cells.
Dye adsorption plays a crucial role in dye-sensitized solar cells. Herein, we demonstrate an in situliquid-phase analytical technique to quantify in real time adsorption of dye and coadsorbates on ...flat and mesoporous TiO sub(2) films. For the first time, a molar ratio of co-adsorbed Y123 and chenodeoxycholic acid has been measured.
We compare different models of a quantum theory of four-dimensional lattice gravity based on Regge's original proposal. From Monte Carlo simulations we calculate two-point functions between ...geometrical quantities and estimate the masses of the corresponding interaction particles.
We performed a retrospective analysis of 204 patients who underwent large loop excision of the transformation zone (LLETZ) to determine whether women who have a negative LLETZ (no cervical ...intra-epithelial neoplasia (CIN) present) are at a lower risk of developing further abnormal cytology or CIN than women whose LLETZ is positive (CIN present). Overall 69 of the LLETZ samples were negative (34%) and 135 were positive (66%). The mean duration of negative cytology during follow up was 25·4 months (negative LLETZ) and 21·2 months (positive LLETZ) ( P =0·03). In the negative LLETZ group, cytology did not miss any cases of persistent CIN at the 6-month follow-up visit and 39 repeat punch biopsies were all negative. There were 3/69 cases (4·3%) in the negative LLETZ group and 13/135 (9·6%) in the positive LLETZ group of persistent disease (CIN diagnosed at or as a result of the 6-month follow-up). Following a negative 6-month review, one woman developed an abnormal smear in the negative LLETZ group (1/66=1·5%) compared with 10 women (10/122=8·1%) in the positive LLETZ group. Recurrent CIN (CIN subsequently diagnosed following a negative 6-month review) was seen in 0/69 cases (0%) in the negative LLETZ group and 4/135 (3·2%) in the positive LLETZ group. We conclude that women who undergo a negative LLETZ may represent a low-risk group for developing further cytological and histological abnormalities.
The phase structure of pure Regge gravity Beirl, W.; Hauke, A.; Homolka, P. ...
Nuclear physics. Section B, Proceedings supplement,
03/1996, Letnik:
47, Številka:
1
Journal Article
Recenzirano
Odprti dostop
We examine the phase structure of pure Regge gravity in four dimensions and compare our Monte Carlo results with
Z
2-link Regge-theory as well as with another formulation of lattice gravity derived ...from group theoretical considerations. Within all three models we find an extension of the well-defined phase to negative gravitational coupling and a new phase transition. In contrast to the well-known transition at positive coupling there is evidence for a continuous phase transition which might be essential for a possible continuum limit.
Background Intrahepatic cholangiocarcinoma (ICC) is a rare primary liver malignancy. Until now, outcomes and prognostic factors after liver resection for these tumors have not been well-documented. ...Study Design Between April 1998 and December 2006, a total of 158 patients underwent surgical exploration in our institution for intended liver resection of ICC. Prospectively collected data of patients undergoing liver resection (n = 83) were analyzed with regard to preoperative findings, operative details, perioperative morbidity and mortality, pathologic findings, outcomes measured by tumor recurrence and survival, and prognostic factors for outcomes. Results Tumors were solitary in 47 patients. R0 resections were achieved in 53 patients. Vascular infiltration and lymph node metastasis were detected in 41% and 34%, respectively. After resection, the calculated 1-, 3-, and 5-year-survival rates were 71%, 38%, and 21%, respectively, with corresponding rates of 83%, 50%, and 30% in R0 resections. For 14 variables evaluated, only gender (p = 0.008), Union Internationale Contre le Cancer stage (p = 0.014), and R classification (p = 0.001) showed predictive value in the multivariate Cox proportional hazard regression. Conclusions Results presented outline that an R0 resection leads to substantially prolonged survival in ICC and represents the considerable input of the surgeon to the outcomes of these patients. Union Internationale Contre le Cancer stage remains an important factor.
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