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zadetkov: 58
1.
  • motifbreakR: an R/Bioconduc... motifbreakR: an R/Bioconductor package for predicting variant effects at transcription factor binding sites
    Coetzee, Simon G; Coetzee, Gerhard A; Hazelett, Dennis J Bioinformatics, 12/2015, Letnik: 31, Številka: 23
    Journal Article
    Recenzirano
    Odprti dostop

    Functional annotation represents a key step toward the understanding and interpretation of germline and somatic variation as revealed by genome-wide association studies (GWAS) and The Cancer Genome ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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2.
  • Comprehensive functional an... Comprehensive functional annotation of 77 prostate cancer risk loci
    Hazelett, Dennis J; Rhie, Suhn Kyong; Gaddis, Malaina ... PLOS genetics, 01/2014, Letnik: 10, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics, but the causal links between increased genetic risk and onset/progression of disease processes remain to be ...
Celotno besedilo
Dostopno za: DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK

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3.
  • ELMER v.2: an R/Bioconducto... ELMER v.2: an R/Bioconductor package to reconstruct gene regulatory networks from DNA methylation and transcriptome profiles
    Silva, Tiago C; Coetzee, Simon G; Gull, Nicole ... Bioinformatics, 06/2019, Letnik: 35, Številka: 11
    Journal Article
    Recenzirano
    Odprti dostop

    DNA methylation has been used to identify functional changes at transcriptional enhancers and other cis-regulatory modules (CRMs) in tumors and other disease tissues. Our R/Bioconductor package ELMER ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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4.
  • CRISPR-mediated deletion of... CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops
    Guo, Yu; Perez, Andrew A; Hazelett, Dennis J ... Genome Biology, 10/2018, Letnik: 19, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Recent genome-wide association studies (GWAS) have identified more than 100 loci associated with increased risk of prostate cancer, most of which are in non-coding regions of the genome. ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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5.
  • Granulocyte-Monocyte Progen... Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes
    Yáñez, Alberto; Coetzee, Simon G.; Olsson, Andre ... Immunity (Cambridge, Mass.), 11/2017, Letnik: 47, Številka: 5
    Journal Article
    Recenzirano
    Odprti dostop

    Granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs) produce monocytes during homeostasis and in response to increased demand during infection. Both progenitor ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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6.
  • ONECUT2 is a targetable mas... ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis
    Rotinen, Mirja; You, Sungyong; Yang, Julie ... Nature medicine, 12/2018, Letnik: 24, Številka: 12
    Journal Article
    Recenzirano
    Odprti dostop

    Treatment of prostate cancer (PC) by androgen suppression promotes the emergence of aggressive variants that are androgen receptor (AR) independent. Here we identify the transcription factor ONECUT2 ...
Celotno besedilo
Dostopno za: NUK, SBMB, UL, UM, UPUK

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7.
  • Non-coding somatic mutation... Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer
    Corona, Rosario I; Seo, Ji-Heui; Lin, Xianzhi ... Nature communications, 04/2020, Letnik: 11, Številka: 1
    Journal Article
    Recenzirano
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    The functional consequences of somatic non-coding mutations in ovarian cancer (OC) are unknown. To identify regulatory elements (RE) and genes perturbed by acquired non-coding variants, here we ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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8.
  • GENAVi: a shiny web applica... GENAVi: a shiny web application for gene expression normalization, analysis and visualization
    Reyes, Alberto Luiz P; Silva, Tiago C; Coetzee, Simon G ... BMC genomics, 10/2019, Letnik: 20, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    The development of next generation sequencing (NGS) methods led to a rapid rise in the generation of large genomic datasets, but the development of user-friendly tools to analyze and visualize these ...
Celotno besedilo
Dostopno za: DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK

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9.
  • Nucleosome positioning and ... Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells
    Rhie, Suhn Kyong; Hazelett, Dennis J; Coetzee, Simon G ... BMC genomics, 05/2014, Letnik: 15, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    The precise nature of how cell type specific chromatin structures at enhancer sites affect gene expression is largely unknown. Here we identified cell type specific enhancers coupled with gene ...
Celotno besedilo
Dostopno za: DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK

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10.
  • Motor neuron expression of ... Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila , TDP-43 loss of function model of ALS
    Chang, Jer-Cherng; Hazelett, Dennis J; Stewart, Judith A ... Brain research, 10/2014, Letnik: 1584
    Journal Article, Conference Proceeding
    Recenzirano
    Odprti dostop

    Abstract Dysfunction of the RNA-binding protein, TDP-43, is strongly implicated as a causative event in many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). TDP-43 is ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK

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zadetkov: 58

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