Resident memory T cells (T
) reside in the lung epithelium and mediate protective immunity against respiratory pathogens. Although lung CD8
T
have been extensively characterized, the properties of ...CD4
T
remain unclear. Here we determined the transcriptional signature of CD4
T
, identified by the expression of CD103, retrieved from human lung resection material. Various tissue homing molecules were specifically upregulated on CD4
T
, whereas expression of tissue egress and lymph node homing molecules were low. CD103
T
expressed low levels of T-bet, only a small portion expressed Eomesodermin (Eomes), and although the mRNA levels for Hobit were increased, protein expression was absent. On the other hand, the CD103
T
showed a Notch signature. CD4
CD103
T
constitutively expressed high transcript levels of numerous cytotoxic mediators that was functionally reflected by a fast recall response, magnitude of cytokine production, and a high degree of polyfunctionality. Interestingly, the superior cytokine production appears to be because of an accessible interferon-γ (IFNγ) locus and was partially because of rapid translation of preformed mRNA. Our studies provide a molecular understanding of the maintenance and potential function of CD4
T
in the human lung. Understanding the specific properties of CD4
T
is required to rationally improve vaccine design.
Background & Aims: Detection of adenomas is an important goal of colonoscopy. Narrow band imaging (NBI) might highlight adenomas and lead to higher rates of adenoma detection. Methods: This was a ...randomized controlled trial of colonoscopy withdrawal in white light versus NBI in 434 patients aged 50 years or older with intact colons. All examinations were performed by a single experienced endoscopist with a known high detection rate of adenomas using high-definition, wide-angle (170° field of view) colonoscopes. Results: There was no difference in the percent of patients with ≥1 adenoma for the entire cohort in white light (67%) versus NBI (65%) ( P = .61) or in the subset of 257 patients with indication screening (58% vs 57%; P = .91). Both the prevalences of adenomas and the numbers of adenomas per colonoscopy are the highest ever reported in colonoscopy studies. The high prevalence rates of adenomas were accounted for by detection of large numbers of adenomas, including flat adenomas, which were ≤5 mm. Conclusions: NBI did not result in better detection of adenomas by an endoscopist with a known high detection rate using white light. This result does not exclude a possible benefit of NBI in reducing variation between endoscopists in detection of adenomas. The very high adenoma detection rate in this study suggests that high definition should be directly tested for its effect on detection of adenomas.
This article expands our current understanding of the digital divide by examining differences in individuals' IT skills acquisition. In the last two decades scholars have gradually refined the ...conceptualization of the digital divide, moving from a dichotomous model mainly based on access, to a multidimensional model accounting for differences in usage levels and actors' perspectives. Digital divide views tend to focus on groups of users and user characteristics and focus less on different processes of use. As models of the digital divide became more complex, research focused on deepening the understanding of demographic and socioeconomic differences between adopters and non-adopters. While IT literacy is an important factor in digital divide research, and studies examine user characteristics with respect to IT literacy, few studies make the process of basic IT literacy acquisition their main focal point (Selwyn, 2005). This perspective furthers our thinking by expanding the notion of user characteristics beyond demographic and socioeconomic differences to differences in the processes leading to internet use. Based on a dataset referring to an Italian region, this paper presents a metaphorical interpretation of the digital divide in general and explores the process of IT skills acquisition in particular. Our analysis shows the key role of self-learning and the presence of three distinct approaches in IT skills acquisition leading to different needs in terms of policy. We argue that these preliminary results are a useful starting point for the design of more effective and sophisticated digital inclusion policies.
Arguably, the act of reaching constitutes one of the most devoted lines of contemporary developmental research. In addition to the underlying dynamical characteristics of motor coordination, a key ...element in programming is limb selection, a phenomenon (handedness) that has so far resisted any reasonable unified explanation. From a more contemporary view, two factors appear to have the most influence on hand selection for a given task: motor dominance and attentional information related to task demands. This study was designed to determine what factor(s) influence choice of limb for reaching in hemispace in reference to motor dominance, object proximity, and a hemispheric bias favoring use of the hand on the same side as the stimulus. Strong right-handed children were asked to reach and retrieve a small object across right and left hemispace locations beginning with the arms uncrossed and arms-crossed. With the arms-crossed condition, an imagined and actual movement execution was administered. Results from the uncrossed condition supported previous reported findings for adults and children. That is, participants responded ipsilaterally using the hand on the same side as the stimulus, thus supporting the case for object proximity and hemispheric bias. However, in the arms-crossed condition the vast majority of participants preferred keeping the limbs crossed in response to right and left hemispace stimuli, which leads to the suggestion that object proximity rather than hemispheric bias was the driving factor in this context. The behavioral pattern for imagined and actual movement was not significantly different. Overall, the findings add to the growing acceptance that limb selection is task and context dependent, rather than a biologically based invariant feature of motor behavior.
Lateralized Effects on Reaching by Children Gabbard, Carl; Helbig, Casi Rabb; Gentry, Vickie
Developmental neuropsychology,
01/2001, Letnik:
19, Številka:
1
Journal Article
Recenzirano
This study examined the limb selection profiles of children for a reach-to-grasp task presented in various positions of hemispace. Underlying questions focused on the use of attentional information ...and lateralized effects in motor programming for reaching movements. As expected, both right- and left-handed groups used their dominant limb more frequently at the midline and in their own ipsilateral hemispace. However, in response to stimuli presented in contralateral (to the dominant limb) hemispace, both groups switched to using their nondominant limbs at significant levels. As a general comparison, right-handers exhibited greater use of their dominant limb, but arguably, motor dominance in this context may have intervened with the participant's ability to use attentional information to produce a more efficient response. Overall, these findings address the phenomenon associated with motor dominance and use of attentional information in programming.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
We investigated Nb/Ni bilayers prepared by magnetron sputtering on glass subtrates. The quality of the films was characterized by small‐angle X‐ray diffraction analysis. The thickness of the layers ...was determined by the Rutherford backscattering spectrometry (RBS). For specimens with constant Nb layer thickness we observed distinct oscillations of the superconducting critical temperature upon increasing the thickness of the Ni layer. The results are interpreted in terms of Fulde‐Ferrell‐Larkin‐Ovchinnikov (FFLO) like inhomogeneous superconducting pairing in the ferromagnetic Ni Layer.
Scholars from different disciplines have recently studied a phenomenon called “the digital divide”. Since many of the new government information technology initiatives are based on Internet ...technologies and require the use of the Internet by citizens, understanding the digital divide (and consequently, the potential demand) is important for e-government scholars. For some researchers, the divide is not a problem and Internet access is the only relevant determinant of Internet use (access divide). For other researchers, the divide is rooted in more fundamental social differences and opportunities (multi-dimensional divide). Using data from the Piedmont region in Italy, this paper tests these two competing views of the digital divide. Overall, the models based on a multi-dimensional view have greater explanatory power and provide evidence about the relevance of multiple factors affecting both Internet access and Internet use. For instance, females use the Internet for a smaller number of activities than males. Individuals with more formal education and who can speak English use the Internet more. Finally, individuals with more experience using a PC and the Internet itself also use the Internet to perform a broader range of activities.
PDF
