Destructive soft tissue mass in the maxilla/maxillary sinus Lanzel, Emily, DDS, MS; Syrbu, Sergei I., MD, PhD; Hellstein, John W., DDS, MS ...
Oral surgery, oral medicine, oral pathology and oral radiology,
06/2018, Letnik:
125, Številka:
6
Journal Article
Abstract Objectives To retrospectively study the prevalence of perineural invasion (PNI) in cases of mucoepidermoid carcinoma (MEC). The study evaluated if previously assessed PNI by original ...pathology reports would be increased by re-review of the originally hematoxylin-eosin-stained (H&E) slides as well as review of slides reacted immunohistochemically with S100 to enhance nerve visualization and whether is associated with clinical outcome. Study Design Thirty-one cases were reviewed for PNI with H&E stained slides as well as S-100 reacted slides. These results were compared to the original pathology report’s PNI status when available (13/31). Subject demographics and clinical outcome were collected from electronic medical records. Results PNI was identified in 23% (3/13) of tumors in the original reports, 13% (4/31) of the authors' re-review of the slides, and 29% (9/31) of cases reacted with S100. PNI and larger-diameter nerve involvement were significantly associated with death at 5-year follow-up. Conclusions Immunohistochemical enhancement improves the accuracy and speed of PNI determination. PNI is a significant factor in the survival outcome of cases of MEC.
Objective In 2005, the World Health Organization reclassified the parakeratinizing odontogenic keratocyst as a neoplasm. This article reviews the research leading to this reclassification, and ...validates a new survey tool that can be easily used to pool surgical and recurrence data from multiple offices. Study design All odontogenic lesions accessioned in the Iowa Surgical Oral Pathology Laboratory between 1949 and 2010 were identified from the database. A survey tool to assess treatment and follow-up was created. A total of 46 surgeons agreed to participate. Results A total of 70 keratocystic odontogenic tumors (KOTs) had documented recurrences at follow-up intervals ranging from 6 months to 5 years. Primary tumors that recurred ranged in size as measured by greatest radiographic diameter from 0.7 to 6 cm. Conclusions This survey tool is recommended as standard allowing treatment of cases by multiple practitioners to be compared retrospectively or prospectively.
ABSTRACT Background This narrative review of osteonecrosis of the jaw in patients with low bone mass receiving treatment with antiresorptive agents is based on an appraisal of the literature by an ...advisory committee of the American Dental Association Council on Scientific Affairs. It updates the committee’s 2008 advisory statement. Methods The authors searched MEDLINE for literature published between May 2008 (the end date of the last search) and February 2011. Results This report contains recommendations based on the findings of the literature search and on expert opinion that relate to general dentistry; periodontal disease management; implant placement and maintenance; oral and maxillofacial surgery; endodontics; restorative dentistry and prosthodontics; orthodontics; and C-terminal telopeptide testing and drug holidays. Conclusions The highest reliable estimate of antiresorptive agent–induced osteonecrosis of the jaw (ARONJ) prevalence is approximately 0.10 percent. Osteoporosis is responsible for considerable morbidity and mortality. Therefore, the benefit provided by antiresorptive therapy outweighs the low risk of developing osteonecrosis of the jaw. Clinical Implications An oral health program consisting of sound hygiene practices and regular dental care may be the optimal approach for lowering ARONJ risk. No validated diagnostic technique exists to determine which patients are at increased risk of developing ARONJ. Discontinuing bisphosphonate therapy may not lower the risk but may have a negative effect on low-bone-mass–treatment outcomes.
TERMINOLOGY: Author's response Hellstein, John W., DDS, MS
The Journal of the American Dental Association (1939),
2012, 2012-01-00, Letnik:
143, Številka:
1
Journal Article
PDF
