Plastic is one of the widely used materials in day to day activity in our life and involves a contribution to society. Plastic is a non-gradable material, remains in the soil and polluting the ...environment. Plastic pyrolysis is a novel technique to convert waste plastic into fuel. This work aims to analyze and simulate a mini reactor for the plastic pyrolysis process. The mini reactor is designed by 3D CAD and analyzed by ANSYS software. This mini reactor is designed to pyrolyze low-Density Poly Ethylene (LDPE) to withstand 650 °C. This work demonstrated the potential of finite element analysis of pyrolysis setup to determine thermal stress and strains. Maximum and minimum thermal stress and strain values developed inside the mini reactor for converting plastic waste into fuel were 127 MPa, 158 MPa, 0.001329, and 0.001649, respectively.
Interest in THz technology is growing, with projects such as the Atacama large millimeter array (ALMA) astronomical observatory, biohazard remote detection, high frequency radar and other detection ...systems. This paper presents the design, fabrication and test results of a 1.6 THz superconducting phonon-cooled NbN hot electron bolometer. Elements of the mixer design, including simulation results and S-parameters, are presented. A novel fabrication process, the suspended sidewall nano patterned stencil (SSNaPS) procedure, along with unique thin silicon backside processing, is used to create these THz mixers. For the phonon-cooled mixer, a receiver noise temperature of 3474 K and a mixer noise temperature of 613 K were obtained. DC characterization and RF test results are discussed.
Antineoplastic Agents, 120. Pancratium littorale Pettit, George R; Gaddamidi, Venkatswamy; Herald, Delbert L ...
Journal of natural products (Washington, D.C.),
11/1986, Letnik:
49, Številka:
6
Journal Article
Recenzirano
The bulbs of Pancratium littorale collected in Hawaii were found to contain a new phenanthridone biosynthetic product designated pancratistatin (4a) that proved to be effective (38-106% life ...extension at 0.75-12.5 mg/kg dose levels) against the murine P-388 lymphocytic leukemia. Pancratistatin also markedly inhibited (ED50, 0.01 microgram/ml) growth of the P-388 in vitro cell line and in vivo murine M-5076 ovary sarcoma (53-84% life extension at 0.38-3.0 mg/kg). An X-ray crystal structure determination of pancratistatin monomethyl ether (4c) and a detailed high resolution (400 MHz) nmr study of pancratistatin and its pentaacetate (4b) completed assignment of structure 4a. Companion antineoplastic constituents of P. littorale were found to be narciclasine (2c) and its 7-deoxy derivative (2a). The structure of 7-deoxynarciclasine (2c) was also confirmed by an X-ray crystallographic analysis.
Bioassay (P388 lymphocytic leukemia cell line and human cancer cell lines)-guided separation of an extract prepared from the stem bark and twigs of the previously uninvestigated Ruprechtia tangarana ...led to the isolation of a new isocarbostyril designated ruprechstyril (1), secalonic acid A (2), 2'-O-methylevernic acid (3), 3,3',4-tri-O-methylflavellagic acid (4), lichexanthone (5), methyl asterrate (6), and 3beta,22E,24S-stigmasta-5,22-dien-3-ol (7). Only secalonic acid A exhibited cancer cell and microbial growth inhibition. The structure of ruprechstyril (1) was determined by HRMS and 1D and 2D NMR spectra and confirmed by single-crystal X-ray analysis. The structures and absolute stereochemistry of five of the other compounds were also established by X-ray crystal structure determination.
The blue marine sponge cribrostatins 1 (1, 8.8 × 10
−6
% yield) and 2 (2, 3.1 × 10
−6
% yield) active against the P388 lymphocytic leukemia cell line (ED
50
1.58 and 2.73 μg/mL respectively) have ...been isolated. The previously known isoquinolinequinones mimosamycin (3), renierone (4), and O-demethylrenierone (5) were also isolated and shown to display activity against the P388 cell line (ED
50
0.73, 2.75, and 8.36 μg/mL, respectively). Importantly, both cribrostatin 1 and mimosamycin showed selective activity against all of the nine human melanoma cell lines employed by the U.S. National Cancer Institute. Structural determinations were accomplished utilizing high field nuclear magnetic resonance (400 MHz) and mass spectral studies. Confirmation of the cribrostatin 1 structure was achieved by X-ray crystallographic techniques.
As an extension of structure-activity relationship studies of pancratistatin (1), various techniques were first evaluated for separating the mixtures of 7-deoxynarciclasine (2b) and ...7-deoxy-trans-dihydronarciclasine (3a) isolated from Hymenocallis littoralis. An efficient solution for that otherwise difficult separation then allowed the lactam carbonyl group of protected (4c and 5c) alcohols 2b and 3a to be reduced employing lithium aluminum hydride. Cleavage (TBAF followed by H2SO4) of the silyl ester/acetonide protected 6a gave amine 8. X-ray crystal structure determinations were employed to confirm the structures of 3,4-acetonide-5-aza-6-deoxynarciclasine (6b), 5-aza-6-deoxynarciclasine (8a), and 5-aza-6-deoxy-trans-dihydronarciclasine (9a, 9b). Against the murine P388 lymphocytic leukemia and a panel of human cancer cell lines, the parent natural products, 7-deoxynarciclasine (2b) and 7-deoxy-trans-dihydronarciclasine (3a), were found to generally be more cancer cell growth inhibitory (GI50 0.1 to <0.01 microg/mL) than the compounds with structural modifications such as amine 8 by a factor of 10 or more. The trans ring juncture of isocarbostyril 3a proved to be an important modification of narciclasine (2a) for improving cancer cell growth inhibition in this series.
