With the pervasiveness of racism, some scholars have interrogated the role of discourse in perpetuating the racial status quo. While research has denoted how prominent leaders and policies advance ...deficit-laden characterizations of minoritized groups that reify racial hierarchies, how racial discourse is mobilized in day-to-day politics remains less understood. This study investigates this phenomenon by examining the racial appeals used by charter management organizations as they garner support. It finds that charter management organizations used color-evasive discourse and variable racial narratives to build the case for their organizations with funders, families, and school board members. This code-switching points to the strategic use of racial discourse in local politics while demonstrating how racial power can be manifested in the pursuit of resources.
Life begins with a switch in genetic control from the maternal to the embryonic genome during zygotic genome activation (ZGA). Despite its importance, the essential regulators of ZGA remain largely ...unknown in mammals. On the basis of de novo motif searches, we identified the orphan nuclear receptor Nr5a2 as a key activator of major ZGA in mouse two-cell embryos. Nr5a2 is required for progression beyond the two-cell stage. It binds to its motif within
retrotransposable elements found in cis-regulatory regions of ZGA genes. Chemical inhibition suggests that 72% of ZGA genes are regulated by Nr5a2 and potentially other orphan nuclear receptors. Nr5a2 promotes chromatin accessibility during ZGA and binds nucleosomal DNA in vitro. We conclude that Nr5a2 is an essential pioneer factor that regulates ZGA.
In the face of growing critiques, charter management organizations (CMOs) increasingly contend with criticism as they maintain their presence in districts, particularly with school board members who ...often serve as gatekeepers for charter authorization. Yet, little is known about how CMOs navigate these politically muddy waters in local settings. The localized political maneuvers of CMOs are the central focus of this case study, which demonstrates how CMOs in one city deployed strategic discourse to buffer anticipated critiques and assuage concerns though questions as to the equitable and democratic character of their actions and rhetoric remain.
Background/Context: The business and philanthropic sectors have been a persistent force in shaping U.S. schools. Recently, they have used their resources to advance policies that embody newer ...principles of industry--reforms that suggest that competition, choice, and deregulation can spur improvement and effectiveness. This has most notably included deep investments in the proliferation of charter schools, surfacing questions as to the sector's reliance on private dollars as well as the equitable and democratic impact of advancing this manifestation of neoliberal reform. Purpose/Objective/Research Question/Focus of Study: While scholars have elucidated the role of business and philanthropic funding in promoting charter schools, less is known about how the well-substantiated connections between charters and the private sector have been facilitated or how discourse--the ideas, representations, and argumentation conveyed in acts of communication--is mobilized to create a rationale for support. To date, research has typically examined the discourse and messaging intended for families navigating choice settings. Yet, how these depictions are crafted for donors, who typically inhabit positions of economic and social power and are critical actors in charter growth, remain comparatively less understood. Research Design: This study fills this empirical gap and investigates the tactics used to solicit donor investment by charter management organizations (CMOs). It uses a conceptual framework that synthesizes tenets from the research on neoliberal policy networks and the sociology of race to enable a multifaceted analysis of the discursive tactics used to secure donor support while attending to the often-nuanced ways in which race may be invoked in those efforts. Methodologically, this study follows an embedded case study design to investigate the tactics deployed by a population of CMOs in Northern California and relies on observational and documentary data to examine how CMOs design and execute donor outreach and the resonant messages they aim to elevate. Conclusions/Recommendations: I find that CMOs elevated business-friendly themes related to workforce preparation, impact, and return on investment in their outreach and at times commodified their constituents by offering their labor as exchangeable resources to elevate donor profiles. Simultaneously, CMOs advanced color-evasive discourse, relying on deficit-laden racial narratives to create a reinforcing and complementary rationale for intervention. These findings suggest that CMOs relied on market and racialized logics as the persuasive fodder for donor investment, leaving the economic and racial status quo--and the democratic and equity implications it perpetuates--unchallenged.
Charter management organizations (CMOs) have increasingly had to respond to questions surrounding their organizations—particularly in the context of the broader social awakening around systemic ...injustices and evidence of their racially inequitable practices. This study investigated how CMOs counteracted criticisms and managed perception by characterizing their organizations as socially and racially conscious. It compared social media content for one CMO population during two time periods that surround the 2016 election: 2014 to 2016 and 2017 to 2019. Findings suggest that the CMOs have increasingly characterized themselves as socially conscious, but their attentiveness to issues of race and racism remained temporally and topically bounded. The article concludes with a discussion of how CMOs’ evolving discourse may influence public perception and considers how CMOs perpetuate a form of neoliberal multiculturalism that normalizes market reform under the discursive cover of a bounded articulation of equity and racial justice.
Mutualistic interactions, those that are naturally beneficial for both interacting species, are recurrently found in ecosystems. Observations of natural systems show that if we draw mutualistic ...relationships as links between species, the resulting mutualistic network of interactions displays a widespread particular ordering called nestedness. In such an ordering, the mutualistic partners of a given species conform a subset of the partners of all species with larger degree, that is, of those species having more interactions. On the other hand, theoretical works show that a nested structure has a positive impact on a number of relevant features of mutualistic communities ranging from species coexistence to structural stability and biodiversity. However, how nestedness emerges and what are its determinants, are still open challenges that have led to multiple debates to date. Here we show, by applying a theoretical approach to the analysis of 167 real mutualistic networks, that nestedness is not an irreducibly macroscopic feature but an entropic consequence of the degree sequences (number of mutualistic interactions of each species). Remarkably, we find that an outstanding majority of the analyzed networks does not show statistically significant nestedness. These findings point to the need of revising previous claims about the role of nestedness and might contribute to expand our understanding of how evolution shapes mutualistic interactions and communities by placing the focus on the node-dependent properties rather than on global quantities.
We present an extensive study of the joint effects of heterogeneous social agents and their heterogeneous social links in a bounded confidence opinion dynamics model. The full phase diagram of the ...model is explored for two different network's topologies and compared to two opposed extreme cases: on one hand, the heterogeneous agents constitute a mixed population and on the other, their interactions are modeled by a lattice. The results show that when agents prone to compromise coexist with close-minded ones, the steady state of the dynamics shows coexistent phases. In particular, unlike the case of homogeneous agents in networks, or heterogeneous agents in a fully mixed population, it is possible that the society ends up in consensus around one extreme opinion. Moreover, during the dynamics, the consensus may be overturned from one extreme to the other of the opinion space. We also show that the standard order parameter, the normalized average size of the largest opinion cluster, may be misleading in this case, as it hides the existence of these phases. The phase where the opinion of the society is overturned does not require the presence of agents with special characteristics, (stubborn, extremists, etc.); it results from the interplay of agents which have agreed on an extreme opinion with the remaining group that holds the opposite one. Among the former, some may be prone to compromise with other agents which are out of the majority group, these agents, according to their location in the network, may act like bridges between the two groups and slowly attract the whole society to the other extreme.
It has been suggested that some individuals may present genetic susceptibility to SARS‐CoV‐2 infection, with particular research interest in variants of the ACE2 and TMPRSS2 genes, involved in viral ...penetration into cells, in different populations and geographic regions, although insufficient information is currently available. This study addresses the apparently reasonable hypothesis that variants of these genes may modulate viral infectivity, making some individuals more vulnerable than others. Through whole‐exome sequencing, the frequency of exonic variants of the ACE2, TMPRSS2, and Furin genes was analyzed in relation to presence or absence of SARS‐CoV‐2 infection in a familial multiple sclerosis cohort including 120 individuals from Madrid. The ACE2 gene showed a low level of polymorphism, and none variant was significantly associated with SARS‐CoV‐2 infection. These variants have previously been detected in Italy. While TMPRSS2 is highly polymorphic, the variants found do not coincide with those described in other studies, with the exception of rs75603675, which may be associated with SARS‐CoV‐2 infection. The synonymous variants rs61735792 and rs61735794 showed a significant association with infection. Despite the limited number of patients with SARS‐CoV‐2 infection, some variants, especially in TMPRSS2, may be associated with COVID‐19.
Use of preformed metal‐organic polyhedra (MOPs) as supermolecular building blocks (SBBs) for the synthesis of metal‐organic frameworks (MOFs) remains underexplored due to lack of robust ...functionalized MOPs. Herein we report the use of polycarboxylate cuboctahedral RhII‐MOPs for constructing highly‐connected MOFs. Cuboctahedral MOPs were functionalized with carboxylic acid groups on their 12 vertices or 24 edges through coordinative or covalent post‐synthetic routes, respectively. We then used each isolated polycarboxylate RhII‐MOP as 12‐c cuboctahedral or 24‐c rhombicuboctahedral SBBs that, upon linkage with metallic secondary building units (SBUs), afford bimetallic highly‐connected MOFs. The assembly of a pre‐synthesized 12‐c SBB with a 4‐c paddle‐wheel SBU, and a 24‐c SBB with a 3‐c triangular CuII SBU gave rise to bimetallic MOFs having ftw (4,12)‐c or rht (3,24)‐c topologies, respectively.
Two different post‐synthetic routes have been followed to functionalize pre‐synthesized RhII‐based cuboctahedral metal–organic polyhedra (MOPs) with carboxylic acid groups, either on their 12 metal sites (vertices) or on their 24 linkers (edges). Such isolated MOPs serve as highly connected (12‐c and 24‐c) supermolecular building blocks, for the formation of two new bimetallic RhCu‐MOF structures.
The mitogen-activated protein kinase (MAPK) family is an important bridge in the transduction of extracellular and intracellular signals in different responses at the cellular level. Within this MAPK ...family, the p38 kinases can be found altered in various diseases, including cancer, where these kinases play a fundamental role, sometimes with antagonistic mechanisms of action, depending on several factors. In fact, this family has an immense number of functionalities, many of them yet to be discovered in terms of regulation and action in different types of cancer, being directly involved in the response to cancer therapies. To date, three main groups of MAPKs have been identified in mammals: the extracellular signal-regulated kinases (ERK), Jun N-terminal kinase (JNK), and the different isoforms of p38 (α, β, γ, δ). In this review, we highlight the mechanism of action of these kinases, taking into account their extensive regulation at the cellular level through various modifications and modulations, including a wide variety of microRNAs. We also analyze the importance of the different isoforms expressed in the different tissues and their possible role as biomarkers and molecular targets. In addition, we include the latest preclinical and clinical trials with different p38-related drugs that are ongoing with hopeful expectations in the present/future of developing precision medicine in cancer.
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