English has been spoken in Ireland for over 800 years, making Irish English the oldest variety of the language outside Britain. This 2007 book traces the development of English in Ireland, both north ...and south, from the late Middle Ages to the present day. Drawing on authentic data ranging from medieval literature to authentic contemporary examples, it reveals how Irish English arose, how it has developed, and how it continues to change. A variety of central issues are considered in detail, such as the nature of language contact and the shift from Irish to English, the sociolinguistically motivated changes in present-day Dublin English, the special features of Ulster Scots, and the transportation of Irish English to overseas locations as diverse as Canada, the United States, and Australia. Presenting a comprehensive survey of Irish English at all levels of linguistics, this book will be invaluable to historical linguists, sociolinguists, syntacticians and phonologists alike.
The Handbook of Language Contact offers systematic coverage of the major issues in this field – ranging from the value of contact explanations in linguistics, to the impact of immigration, to ...dialectology – combining new research from a team of globally renowned scholars, with case studies of numerous languages. -An authoritative reference work exploring the major issues in the field of language contact: the study of how language changes when speakers of distinct speech varieties interact -Brings together 40 specially-commissioned essays by an international team of scholars -Examines language contact in societies which have significant immigration populations, and includes a fascinating cross-section of case studies drawing on languages across the world -Accessibly structured into sections exploring the place of contact studies within linguistics as a whole; the value of contact studies for research into language change; and language contact in the context of work on language and society -Explores a broad range of topics, making it an excellent resource for both faculty and students across a variety of fields within linguistics
The notion of a 'standard' variety of English has been the subject of a considerable body of research. Studies have tended to focus on the standard features of British and American English. However, ...more recently interest has turned to the other varieties of English that have developed around the world and the ways in which these have also been standardised. This volume provides the first book-length exploration of 'standard Englishes', with chapters on areas as diverse as Canada, the Caribbean, Africa, Asia, New Zealand and the South Pacific. This is a timely and important topic, edited by a well-known scholar in the field, with contributions by the leading experts on each major variety of English discussed. The book presents in full the criteria for defining a standard variety, and each chapter compares standards in both spoken and written English and explores the notion of register within standard varieties.
The second edition of the definitive reference on contact studies and linguistic change-provides extensive new research and original case studies Language contact is a dynamic area of contemporary ...linguistic research that studies how language changes when speakers of different languages interact. Accessibly structured into three sections, The Handbook of Language Contact explores the role of contact studies within the field of linguistics, the value of contact studies for language change research, and the relevance of language contact for sociolinguistics. This authoritative volume presents original findings and fresh research directions from an international team of prominent experts. Thirty-seven specially-commissioned chapters cover a broad range of topics and case studies of contact from around the world. Now in its second edition, this valuable reference has been extensively updated with new chapters on topics including globalization, language acquisition, creolization, code-switching, and genetic classification. Fresh case studies examine Romance, Indo-European, African, Mayan, and many other languages in both the past and the present. Addressing the major issues in the field of language contact studies, this volume: Includes a representative sample of individual studies which re-evaluate the role of language contact in the broader context of language and society Offers 23 new chapters written by leading scholars Examines language contact in different societies, including many in Africa and Asia Provides a cross-section of case studies drawing on languages across the world The Handbook of Language Contact, Second Edition is an indispensable resource for researchers, scholars, and students involved in language contact, language variation and change, sociolinguistics, bilingualism, and language theory.
Donor organ shortage is the main limitation to liver transplantation as a treatment for end‐stage liver disease and acute liver failure. Liver regenerative medicine may in the future offer an ...alternative form of therapy for these diseases, be it through cell transplantation, bioartificial liver (BAL) devices, or bioengineered whole organ liver transplantation. All three strategies have shown promising results in the past decade. However, before they are incorporated into widespread clinical practice, the ideal cell type for each treatment modality must be found, and an adequate amount of metabolically active, functional cells must be able to be produced. Research is ongoing in hepatocyte expansion techniques, use of xenogeneic cells, and differentiation of stem cell‐derived hepatocyte‐like cells (HLCs). HLCs are a few steps away from clinical application, but may be very useful in individualized drug development and toxicity testing, as well as disease modeling. Finally, safety concerns including tumorigenicity and xenozoonosis must also be addressed before cell transplantation, BAL devices, and bioengineered livers occupy their clinical niche. This review aims to highlight the most recent advances and provide an updated view of the current state of affairs in the field of liver regenerative medicine. Stem Cells 2017;35:42–50
Decellularization and recellularization process for the creation of bioengineered livers: along with cell transplantation and bioartificial liver systems, the most promising alternative to orthotopic, allogeneic whole‐organ liver transplantation that regenerative medicine has to offer.
Mononucleated and binucleated polyploid hepatocytes (4n, 8n, 16n and higher) are found in all mammalian species, but the functional significance of this conserved phenomenon remains unknown. ...Polyploidization occurs through failed cytokinesis, begins at weaning in rodents and increases with age. Previously, we demonstrated that the opposite event, ploidy reversal, also occurs in polyploid hepatocytes generated by artificial cell fusion. This raised the possibility that somatic 'reductive mitoses' can also happen in normal hepatocytes. Here we show that multipolar mitotic spindles form frequently in mouse polyploid hepatocytes and can result in one-step ploidy reversal to generate offspring with halved chromosome content. Proliferating hepatocytes produce a highly diverse population of daughter cells with multiple numerical chromosome imbalances as well as uniparental origins. Our findings support a dynamic model of hepatocyte polyploidization, ploidy reversal and aneuploidy, a phenomenon that we term the 'ploidy conveyor'. We propose that this mechanism evolved to generate genetic diversity and permits adaptation of hepatocytes to xenobiotic or nutritional injury.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Audio recordings of English are available from the first half of the twentieth century and thus complement the written data sources for the recent history of the language. This book is the first to ...bring together a team of globally recognised scholars to document and analyse these early recordings in a single volume. Looking at examples of regional varieties of English from England, Scotland, Ireland, the USA, Canada and other anglophone countries, the volume explores both standard and vernacular varieties, and demonstrates how accents of English have changed between the late nineteenth century and the present day. The socio-phonetic examinations of the recordings will be of interest to scholars of historical linguistics, the history of the English language, language variation and change, phonetics, and phonology.
Adeno-associated viruses (AAV) have evolved to exploit the dynamic reorganization of host cell machinery during co-infection by adenoviruses and other helper viruses. In the absence of helper ...viruses, host factors such as the proteasome and DNA damage response machinery have been shown to effectively inhibit AAV transduction by restricting processes ranging from nuclear entry to second-strand DNA synthesis. To identify host factors that might affect other key steps in AAV infection, we screened an siRNA library that revealed several candidate genes including the PHD finger-like domain protein 5A (PHF5A), a U2 snRNP-associated protein. Disruption of PHF5A expression selectively enhanced transgene expression from AAV by increasing transcript levels and appears to influence a step after second-strand synthesis in a serotype and cell type-independent manner. Genetic disruption of U2 snRNP and associated proteins, such as SF3B1 and U2AF1, also increased expression from AAV vector, suggesting the critical role of U2 snRNP spliceosome complex in this host-mediated restriction. Notably, adenoviral co-infection and U2 snRNP inhibition appeared to target a common pathway in increasing expression from AAV vectors. Moreover, pharmacological inhibition of U2 snRNP by meayamycin B, a potent SF3B1 inhibitor, substantially enhanced AAV vector transduction of clinically relevant cell types. Further analysis suggested that U2 snRNP proteins suppress AAV vector transgene expression through direct recognition of intact AAV capsids. In summary, we identify U2 snRNP and associated splicing factors, which are known to be affected during adenoviral infection, as novel host restriction factors that effectively limit AAV transgene expression. Concurrently, we postulate that pharmacological/genetic manipulation of components of the spliceosomal machinery might enable more effective gene transfer modalities with recombinant AAV vectors.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Keeping in Touch Hickey, Raymond
2019, 2019-11-28, Letnik:
10
eBook
Emigrant letters provide a valuable source of data in tracing the development of varieties of English. This has to do with the vernacular nature of these letters, written by speakers who had a lower ...level of education and whose speech and writing was not guided by considerations of standardness or conformity to external norms of language.
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