Controlling the interaction between localized optical and mechanical excitations has recently become possible following advances in micro- and nanofabrication techniques. So far, most experimental ...studies of optomechanics have focused on measurement and control of the mechanical subsystem through its interaction with optics, and have led to the experimental demonstration of dynamical back-action cooling and optical rigidity of the mechanical system. Conversely, the optical response of these systems is also modified in the presence of mechanical interactions, leading to effects such as electromagnetically induced transparency (EIT) and parametric normal-mode splitting. In atomic systems, studies of slow and stopped light (applicable to modern optical networks and future quantum networks) have thrust EIT to the forefront of experimental study during the past two decades. Here we demonstrate EIT and tunable optical delays in a nanoscale optomechanical crystal, using the optomechanical nonlinearity to control the velocity of light by way of engineered photon-phonon interactions. Our device is fabricated by simply etching holes into a thin film of silicon. At low temperature (8.7 kelvin), we report an optically tunable delay of 50 nanoseconds with near-unity optical transparency, and superluminal light with a 1.4 microsecond signal advance. These results, while indicating significant progress towards an integrated quantum optomechanical memory, are also relevant to classical signal processing applications. Measurements at room temperature in the analogous regime of electromagnetically induced absorption show the utility of these chip-scale optomechanical systems for optical buffering, amplification, and filtering of microwave-over-optical signals.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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► Toxoplasmosis is a significant public health problem in the US with more than 1 million people newly infected each year. ► Seroprevalence in pigs and chickens from non-biosecure ...management systems is high. ► Clinical disease, especially abortion, and high seroprevalence occurs in sheep and goats. ► Beef cattle do not appear to be important in the epidemiology of Toxoplasma or in transmission to humans. ► Type II and Type III clonal lineages and atypical genotypes predominate in food animals in the US.
Toxoplasmosis, caused by Toxoplasma gondii, is one of the most common parasitic infections of humans and other warmblooded animals. It has been found worldwide and nearly one-third of humans have been exposed to the parasite. Congenital infection occurs when a woman becomes infected during pregnancy and transmits the parasite to the foetus. Besides congenital infection, humans become infected by ingesting food or water contaminated with sporulated oocysts from infected cat faeces or through ingestion of tissue cysts in undercooked or uncooked meat. Food animals (pigs, chickens, lambs and goats) become infected by the same routes, resulting in meat products containing tissue cysts, which can then infect consumers. Toxoplasma infection is common in food animals in the United States. Implementation of management factors such as biosecure confinement housing are important in reducing the levels of infection in animals destined for human consumption.
In 101 patients with refractory large B-cell lymphoma, anti-CD19 chimeric antigen receptor (CAR) T-cell therapy (axicabtagene ciloleucel) resulted in an overall response rate of 82%, with a 52% ...survival at 18 months, despite serious toxic effects.
Parker Solar Probe (PSP) observations of a small dispersive event on 2022 February 27 and 28 indicate scatter-free propagation as the dominant transport mechanism between the low corona and greater ...than 35 solar radii. The event occurred during unique orbital conditions that prevailed along specific flux tubes that PSP encountered repeatedly between 25 and 35 Rs during outbound orbit 11. This segment of the PSP orbit exhibits almost stationary angular motion relative to the rotating solar surface, such that in the rotating frame, PSP’s motion is essentially radial. The time dispersion often observed in impulsive solar energetic particle (SEP) events continues in this case down to velocities including the core solar-wind ion velocities. Especially at the onset of this event, the 3He content is much larger than the usual SEP abundances seen in the energy range from ∼100 keV to several MeV for helium. Later in the event, iron is enhanced. The compositional signatures suggest this to be an example of an acceleration mechanism for generating the seed energetic particles required by shock (or compression) acceleration models in SEP events to account for the enrichment of various species above solar abundances in such events. A preliminary search of similar orbital conditions over the PSP mission has not revealed additional such events, although favorable conditions (isolated impulsive acceleration and well-ordered magnetic field connection with minimal magnetic field fluctuation) that would be required are infrequently realized, given the small fraction of the PSP trajectory that meets these observation conditions.
Abstract
Large laser facilities have recently enabled material characterization at the pressures of Earth and Super-Earth cores. However, the temperature of the compressed materials has been largely ...unknown, or solely relied on models and simulations, due to lack of diagnostics under these challenging conditions. Here, we report on temperature, density, pressure, and local structure of copper determined from extended x-ray absorption fine structure and velocimetry up to 1 Terapascal. These results nearly double the highest pressure at which extended x-ray absorption fine structure has been reported in any material. In this work, the copper temperature is unexpectedly found to be much higher than predicted when adjacent to diamond layer(s), demonstrating the important influence of the sample environment on the thermal state of materials; this effect may introduce additional temperature uncertainties in some previous experiments using diamond and provides new guidance for future experimental design.
Abstract
Background
Clinical research on nutritional and metabolic interventions in critically ill patients is heterogenous regarding time points, outcomes and measurement instruments used, impeding ...intervention development and data syntheses, and ultimately worsening clinical outcomes. We aimed to identify and develop a set of core outcome domains and associated measurement instruments to include in all research in critically ill patients.
Methods
An updated systematic review informed a two-stage modified Delphi consensus process (domains followed by instruments). Measurement instruments for domains considered ‘essential’ were taken through the second stage of the Delphi and a subsequent consensus meeting.
Results
In total, 213 participants (41 patients/caregivers, 50 clinical researchers and 122 healthcare professionals) from 24 countries contributed. Consensus was reached on time points (30 and 90 days post-randomisation). Three domains were considered ‘essential’ at 30 days (survival, physical function and Infection) and five at 90 days (survival, physical function, activities of daily living, nutritional status and muscle/nerve function). Core ‘essential’ measurement instruments reached consensus for survival and activities of daily living, and ‘recommended’ measurement instruments for physical function, nutritional status and muscle/nerve function. No consensus was reached for a measurement instrument for Infection. Four further domains met criteria for ‘recommended,’ but not ‘essential,’ to measure at 30 days post-randomisation (organ dysfunction, muscle/nerve function, nutritional status and wound healing) and three at 90 days (frailty, body composition and organ dysfunction).
Conclusion
The CONCISE core outcome set is an internationally agreed minimum set of outcomes for use at 30 and 90 days post-randomisation, in nutritional and metabolic clinical research in critically ill adults.
The Parker Solar Probe was launched on 2018 August 12 and completed its second orbit on 2019 June 19 with perihelion of 35.7 solar radii. During this time, the Energetic Particle Instrument-Hi ...(EPI-Hi, one of the two energetic particle instruments comprising the Integrated Science Investigation of the Sun, IS IS) measured seven proton intensity increases associated with stream interaction regions (SIRs), two of which appear to be occurring in the same region corotating with the Sun. The events are relatively weak, with observed proton spectra extending to only a few MeV and lasting for a few days. The proton spectra are best characterized by power laws with indices ranging from −4.3 to −6.5, generally softer than events associated with SIRs observed at 1 au and beyond. Helium spectra were also obtained with similar indices, allowing He/H abundance ratios to be calculated for each event. We find values of 0.016-0.031, which are consistent with ratios obtained previously for corotating interaction region events with fast solar wind ≤600 km s−1. Using the observed solar wind data combined with solar wind simulations, we study the solar wind structures associated with these events and identify additional spacecraft near 1 au appropriately positioned to observe the same structures after some corotation. Examination of the energetic particle observations from these spacecraft yields two events that may correspond to the energetic particle increases seen by EPI-Hi earlier.
Betatron radiation from laser wakefield accelerators is an ultrashort pulsed source of hard, synchrotron-like x-ray radiation. It emanates from a centimetre scale plasma accelerator producing GeV ...level electron beams. In recent years betatron radiation has been developed as a unique source capable of producing high resolution x-ray images in compact geometries. However, until now, the short pulse nature of this radiation has not been exploited. This report details the first experiment to utilize betatron radiation to image a rapidly evolving phenomenon by using it to radiograph a laser driven shock wave in a silicon target. The spatial resolution of the image is comparable to what has been achieved in similar experiments at conventional synchrotron light sources. The intrinsic temporal resolution of betatron radiation is below 100 fs, indicating that significantly faster processes could be probed in future without compromising spatial resolution. Quantitative measurements of the shock velocity and material density were made from the radiographs recorded during shock compression and were consistent with the established shock response of silicon, as determined with traditional velocimetry approaches. This suggests that future compact betatron imaging beamlines could be useful in the imaging and diagnosis of high-energy-density physics experiments.
Weight regain after weight loss is one of the most significant challenges to successful obesity treatment. Regular exercise has long been touted as a strategy for weight loss maintenance, but the ...lack of clear evidence in clinical trials has caused some to question its effectiveness. In this review, we present the arguments both questioning and in support of exercise as an obesity therapeutic. Our purpose is to bring clarity to the literature, present a unified perspective, and identify the gaps in knowledge that need to be addressed in future studies. Critical questions remain including sex differences, individual variability and compensatory behaviors in response to exercise, exercise adherence, the role of energy flux and the molecular mechanisms mediating the beneficial effects of exercise after weight loss and during weight regain. Future research should focus on these critical questions to provide a more complete understanding of the potential benefits of exercise on weight loss maintenance.
•Presents arguments questioning & supporting exercise as an obesity therapeutic.•Provides clarity to the literature & presents a unified perspective.•Identifies the gaps in knowledge to be addressed in future studies.
The Swift Gamma-Ray Burst Mission Gehrels, N; Chincarini, G; Giommi, P ...
The Astrophysical journal,
08/2004, Letnik:
611, Številka:
2
Journal Article
Recenzirano
Odprti dostop
The Swift mission, scheduled for launch in 2004, is a multiwavelength observatory for gamma-ray burst (GRB) astronomy. It is a first-of-its-kind autonomous rapid-slewing satellite for transient ...astronomy and pioneers the way for future rapid-reaction and multiwavelength missions. It will be far more powerful than any previous GRB mission, observing more than 100 bursts yr super(-1) and performing detailed X-ray and UV/optical afterglow observations spanning timescales from 1 minute to several days after the burst. The objectives are to (1) determine the origin of GRBs, (2) classify GRBs and search for new types, (3) study the interaction of the ultrarelativistic outflows of GRBs with their surrounding medium, and (4) use GRBs to study the early universe out to z > 10. The mission is being developed by a NASA-led international collaboration. It will carry three instruments: a new-generation wide-field gamma-ray (15-150 keV) detector that will detect bursts, calculate 1arcmin-4arcmin positions, and trigger autonomous spacecraft slews; a narrow-field X-ray telescope that will give 5arc sec positions and perform spectroscopy in the 0.2-10 keV band; and a narrow-field UV/optical telescope that will operate in the 170-600 nm band and provide 0!!3 positions and optical finding charts. Redshift determinations will be made for most bursts. In addition to the primary GRB science, the mission will perform a hard X-ray survey to a sensitivity of approx1 mcrab (approx2 x 10 super(-11) ergs cm super(-2) s super(-1) in the 15-150 keV band), more than an order of magnitude better than HEAO 1 A-4. A flexible data and operations system will allow rapid follow-up observations of all types of high-energy transients, with rapid data downlink and uplink available through the NASA TDRSS system. Swift transient data will be rapidly distributed to the astronomical community, and all interested observers are encouraged to participate in follow- up measurements. A Guest Investigator program for the mission will provide funding for community involvement. Innovations from the Swift program applicable to the future include (1) a large-area gamma-ray detector using the new CdZnTe detectors, (2) an autonomous rapid-slewing spacecraft, (3) a multiwavelength payload combining optical, X-ray, and gamma-ray instruments, (4) an observing program coordinated with other ground-based and space-based observatories, and (5) immediate multiwavelength data flow to the community. The mission is currently funded for 2 yr of operations, and the spacecraft will have a lifetime to orbital decay of approx8 yr.
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